426 research outputs found
Predicted Colors and Flux Densities of Protostars in the Herschel PACS and SPIRE Filters
Upcoming surveys with the Herschel Space Observatory will yield far-IR
photometry of large samples of young stellar objects, which will require
careful interpretation. We investigate the color and luminosity diagnostics
based on Herschel broad-band filters to identify and discern the properties of
low-mass protostars. We compute a grid of 2,016 protostars in various physical
congurations, present the expected flux densities and flux density ratios for
this grid of protostars, and compare Herschel observations of three protostars
to the model results. These provide useful constraints on the range of colors
and fluxes of protostar in the Herschel filters. We find that Herschel data
alone is likely a useful diagnostic of the envelope properties of young starsComment: Part of HOPS KP papers to the Herschel special A&A issu
Event categories in the EDELWEISS WIMP search experiment
Four categories of events have been identified in the EDELWEISS-I dark matter
experiment using germanium cryogenic detectors measuring simultaneously charge
and heat signals. These categories of events are interpreted as electron and
nuclear interactions occurring in the volume of the detector, and electron and
nuclear interactions occurring close to the surface of the detectors(10-20 mu-m
of the surface). We discuss the hypothesis that low energy surface nuclear
recoils,which seem to have been unnoticed by previous WIMP searches, may
provide an interpretation of the anomalous events recorded by the UKDMC and
Saclay NaI experiments. The present analysis points to the necessity of taking
into account surface nuclear and electron recoil interactions for a reliable
estimate of background rejection factors.Comment: 11 pages, submitted to Phys. Lett.
Background discrimination capabilities of a heat and ionization germanium cryogenic detector
The discrimination capabilities of a 70 g heat and ionization Ge bolometer
are studied. This first prototype has been used by the EDELWEISS Dark Matter
experiment, installed in the Laboratoire Souterrain de Modane, for direct
detection of WIMPs. Gamma and neutron calibrations demonstrate that this type
of detector is able to reject more than 99.6% of the background while retaining
95% of the signal, provided that the background events distribution is not
biased towards the surface of the Ge crystal. However, the 1.17 kg.day of data
taken in a relatively important radioactive environment show an extra
population slightly overlapping the signal. This background is likely due to
interactions of low energy photons or electrons near the surface of the
crystal, and is somewhat reduced by applying a higher charge-collecting inverse
bias voltage (-6 V instead of -2 V) to the Ge diode. Despite this
contamination, more than 98% of the background can be rejected while retaining
50% of the signal. This yields a conservative upper limit of 0.7
event.day^{-1}.kg^{-1}.keV^{-1}_{recoil} at 90% confidence level in the 15-45
keV recoil energy interval; the present sensitivity appears to be limited by
the fast ambient neutrons. Upgrades in progress on the installation are
summarized.Comment: Submitted to Astroparticle Physics, 14 page
The EDELWEISS Experiment : Status and Outlook
The EDELWEISS Dark Matter search uses low-temperature Ge detectors with heat
and ionisation read- out to identify nuclear recoils induced by elastic
collisions with WIMPs from the galactic halo. Results from the operation of 70
g and 320 g Ge detectors in the low-background environment of the Modane
Underground Laboratory (LSM) are presented.Comment: International Conference on Dark Matter in Astro and Particle Physics
(Dark 2000), Heidelberg, Germany, 10-16 Jul 2000, v3 minor revision
SICANE: a Detector Array for the Measurement of Nuclear Recoil Quenching Factors using Monoenergetic Neutron Beam
SICANE is a neutron scattering multidetector facility for the determination
of the quenching factor (ratio of the response to nuclear recoils and to
electrons) of cryogenic detectors used in direct WIMP searches. Well collimated
monoenergetic neutron beams are obtained with inverse (p,n) reactions. The
facility is described, and results obtained for the quenching factors of
scintillation in NaI(Tl) and of heat and ionization in Ge are presented.Comment: 30 pages, Latex, 11 figures. Submitted to NIM
Differences between <i>Trypanosoma brucei gambiense</i> groups 1 and 2 in their resistance to killing by Trypanolytic factor 1
<p><b>Background:</b> The three sub-species of <i>Trypanosoma brucei</i> are important pathogens of sub-Saharan Africa. <i>T. b. brucei</i> is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. <i>T. b. rhodesiense</i> and <i>T. b. gambiense</i> are able to resist lysis by TLF. There are two distinct sub-groups of <i>T. b. gambiense</i> that differ genetically and by human serum resistance phenotypes. Group 1 <i>T. b. gambiense</i> have an invariant phenotype whereas group 2 show variable resistance. Previous data indicated that group 1 <i>T. b. gambiense</i> are resistant to TLF-1 due in-part to reduced uptake of TLF-1 mediated by reduced expression of the TLF-1 receptor (the haptoglobin-hemoglobin receptor (<i>HpHbR</i>)) gene. Here we investigate if this is also true in group 2 parasites.</p>
<p><b>Methodology:</b> Isogenic resistant and sensitive group 2 <i>T. b. gambiense</i> were derived and compared to other T. brucei parasites. Both resistant and sensitive lines express the <i>HpHbR</i> gene at similar levels and internalized fluorescently labeled TLF-1 similar fashion to <i>T. b. brucei</i>. Both resistant and sensitive group 2, as well as group 1 <i>T. b. gambiense</i>, internalize recombinant APOL1, but only sensitive group 2 parasites are lysed.</p>
<p><b>Conclusions:</b> Our data indicate that, despite group 1 <i>T. b. gambiense</i> avoiding TLF-1, it is resistant to the main lytic component, APOL1. Similarly group 2 <i>T. b. gambiense</i> is innately resistant to APOL1, which could be based on the same mechanism. However, group 2 <i>T. b. gambiense</i> variably displays this phenotype and expression does not appear to correlate with a change in expression site or expression of <i>HpHbR</i>. Thus there are differences in the mechanism of human serum resistance between <i>T. b. gambiense</i> groups 1 and 2.</p>
Calibration of the EDELWEISS Cryogenic Heat-and-ionisation Germanium Detectors for Dark Matter Search
Several aspects of the analysis of the data obtained with the cryogenic
heat-and-ionisation Ge detectors used by the EDELWEISS dark matter search
experiment are presented. Their calibration, the determination of their energy
threshold, fiducial volume and nuclear recoil acceptance are detailed.Comment: 27 pages, Latex, 11 figures. Submitted to NIM
Final results of the EDELWEISS-I dark matter search with cryogenic heat-and-ionization Ge detectors
The final results of the EDELWEISS-I dark matter search using cryogenic
heat-and-ionization Ge detectors are presented. The final data sample
corresponds to an increase by a factor five in exposure relative to the
previously published results. A recoil energy threshold of 13 keV or better was
achieved with three 320g detectors working simultaneously over four months of
stable operation. Limits on the spin-independent cross-section for the
scattering of a WIMP on a nucleon are derived from an accumulated fiducial
exposure of 62 kg.d.Comment: 42 pages, 16 figures, submitted to Physical Review D, 1 figure and 2
references added, some little changes in the tex
Too little but not too late: Results of a literature review to improve routine immunization programs in developing countries
<p>Abstract</p> <p>Background</p> <p>Globally, immunization services have been the center of renewed interest with increased funding to improve services, acceleration of the introduction of new vaccines, and the development of a health systems approach to improve vaccine delivery. Much of the credit for the increased attention is due to the work of the GAVI Alliance and to new funding streams. If routine immunization programs are to take full advantage of the newly available resources, managers need to understand the range of proven strategies and approaches to deliver vaccines to reduce the incidence of diseases. In this paper, we present strategies that may be used at the sub-national level to improve routine immunization programs.</p> <p>Methods</p> <p>We conducted a systematic review of studies and projects reported in the published and gray literature. Each paper that met our inclusion criteria was rated based on methodological rigor and data were systematically abstracted. Routine-immunization – specific papers with a methodological rigor rating of greater than 60% and with conclusive results were reported.</p> <p>Results</p> <p>Greater than 11,000 papers were identified, of which 60 met our inclusion criteria and 25 papers were reported. Papers were grouped into four strategy approaches: bringing immunizations closer to communities (n = 11), using information dissemination to increase demand for vaccination (n = 3), changing practices in fixed sites (n = 4), and using innovative management practices (n = 7).</p> <p>Conclusion</p> <p>Immunization programs are at a historical crossroads in terms of developing new funding streams, introducing new vaccines, and responding to the global interest in the health systems approach to improving immunization delivery. However, to complement this, actual service delivery needs to be strengthened and program managers must be aware of proven strategies. Much was learned from the 25 papers, such as the use of non-health workers to provide numerous services at the community level. However it was startling to see how few papers were identified and in particular how few were of strong scientific quality. Further well-designed and well-conducted scientific research is warranted. Proposed areas of additional research include integration of additional services with immunization delivery, collaboration of immunization programs with new partners, best approaches to new vaccine introduction, and how to improve service delivery.</p
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