Listen to Librarians: Highlighted Core Competencies for Librarianship from the Perspectives of Working Librarians

Librarianship is constantly confronted with unexpected and quickly evolving sociotechnical challenges, yet the documents that define the core professional competencies for librarians are infrequently updated. Based upon survey responses collected from 383 working librarians located in the United States, we describe a set of gaps between current competency guidelines and current library realities with regard to practice, management, communication, career development, relations, and personal attributes. We argue that professional library organizations, educators, and policymakers could formulate more relevant and impactful core competency documents by deliberately integrating the on-the-ground insights of librarians&rsquo; lived experience. &nbsp;</p

Workset Creation for Scholarly Analysis and Data Capsules (WCSA+DC): Laying the foundations for secure computation with copyrighted data in the HathiTrust Research Center, Phase I

The primary objective of the WCSA+DC project is the seamless integration of the workset model and tools with the Data Capsule framework to provide non-consumptive research access HathiTrust’s massive corpus of data objects, securely and at scale, regardless of copyright status. That is, we plan to surmount the copyright wall on behalf of scholars and their students. Notwithstanding the substantial preliminary work that has been done on both the WCSA and DC fronts, they are both still best characterized as being in the prototyping stages. It is our intention to that this proposed Phase I of the project devote an intense two-year burst of effort to move the suite of WCSA and DC prototypes from the realm of proof-of-concept to that of a firmly integrated at-scale deployment. We plan to concentrate our requested resources on making sure our systems are as secure and robust at scale as possible. Phase I will engage four external research partners. Two of the external partners, Kevin Page (Oxford) and Annika Hinze (Waikato) were recipients of WCSA prototyping sub-awards. We are very glad to propose extending and refining aspects of their prototyping work in the context of WCSA+DC. Two other scholars, Ted Underwood (Illinois) and James Pustejovsky (Brandeis) will play critical roles in Phase I as active participants in the development and refinement of the tools and systems from their particular user-scholar perspectives: Underwood, Digital Humanities (DH); Pustejovsky, Computational Linguistics (CL). The four key outcomes and benefits of the WCSA+DC, Phase I project are: 1. The deployment of a new Workset Builder tool that enhances search and discovery across the entire HTDL by complementing traditional volume-level bibliographic metadata with new metadata derived from a variety of sources at various levels granularity. 2. The creation of Linked Open Data resources to help scholars find, select, integrate and disseminate a wider range of data as part of their scholarly analysis life-cycle. 3. A new Data Capsule framework that integrates worksets, runs at scale, and does both in a secure, non-consumptive, manner. 4. A set of exemplar pre-built Data Capsules that incorporate tools commonly used by both the DH and CL communities that scholars can then customize to their specific needs.Andrew W. Mellon Foundation, grant no. 41500672Ope

Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

Background Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response. Methods We did hierarchical cluster analysis using five common symptoms associated with primary Sjögren's syndrome (pain, fatigue, dryness, anxiety, and depression), followed by multinomial logistic regression to identify subgroups in the UK Primary Sjögren's Syndrome Registry (UKPSSR). We assessed clinical and biological differences between these subgroups, including transcriptional differences in peripheral blood. Patients from two independent validation cohorts in Norway and France were used to confirm patient stratification. Data from two phase 3 clinical trials were similarly stratified to assess the differences between subgroups in treatment response to hydroxychloroquine and rituximab. Findings In the UKPSSR cohort (n=608), we identified four subgroups: Low symptom burden (LSB), high symptom burden (HSB), dryness dominant with fatigue (DDF), and pain dominant with fatigue (PDF). Significant differences in peripheral blood lymphocyte counts, anti-SSA and anti-SSB antibody positivity, as well as serum IgG, κ-free light chain, β2-microglobulin, and CXCL13 concentrations were observed between these subgroups, along with differentially expressed transcriptomic modules in peripheral blood. Similar findings were observed in the independent validation cohorts (n=396). Reanalysis of trial data stratifying patients into these subgroups suggested a treatment effect with hydroxychloroquine in the HSB subgroup and with rituximab in the DDF subgroup compared with placebo. Interpretation Stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments. Our data have important implications for clinical management, trial design, and therapeutic development. Similar stratification approaches might be useful for patients with other chronic immune-mediated diseases. Funding UK Medical Research Council, British Sjogren's Syndrome Association, French Ministry of Health, Arthritis Research UK, Foundation for Research in Rheumatology

A united statement of the global chiropractic research community against the pseudoscientific claim that chiropractic care boosts immunity.

BACKGROUND: In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports. MAIN BODY: We reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response. CONCLUSION: In their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection