Hipercolesterolemia pura como factor de riesgo para síndrome de Manguito Rotador en pacientes atendidos en el Hospital I EsSalud La Esperanza

Determinar si la hipercolesterolemia pura es factor de riesgo para síndrome de manguito rotador en pacientes atendidos en el Hospital I EsSalud La Esperanza. Material y métodos: Se llevó a cabo un estudio analítico, retrospectivo, de casos y controles en el que se incluyeron a 93 pacientes según criterios de selección, los cuales se dividieron en 2 grupos: con o sin síndrome del manguito del rotador; aplicándose el odds ratio, y la prueba estadística Chi Cuadrado. Resultados: La frecuencia de diabetes mellitus e hipertrigliceridemia fueron significativamente mayores en el grupo de pacientes con síndrome del manguito del rotador (p<0.05), la frecuencia de hipercolesterolemia pura en pacientes con síndrome de manguito rotador fue de 71%, la frecuencia de hipercolesterolemia pura en pacientes sin síndrome de manguito rotador fue de 32%, la hipercolesterolemia es factor de riesgo para síndrome del manguito de rotador con un odds ratio de 5.13 el cual fue significativo (p<0.05), en el análisis multivariado se reconoce a las variables: diabetes mellitus, hipertrigliceridemia e hipercolesterolemia pura como factores de riesgo para síndrome del manguito de rotador. Conclusión: La hipercolesterolemia pura es factor de riesgo para síndrome de manguito rotador en pacientes atendidos en el Hospital I EsSalud La Esperanza. (Nivel de evidencia II. 2).To determine if pure hypercholesterolemia is a risk factor for rotator cuff syndrome in patients who are treated at the I EsSalud La Esperanza Hospital. Material and methods: An analytical, retrospective, case-control study was carried out in which 93 patients were included according to selection criteria, who were divided into 2 groups: with or without rotator cuff syndrome; applying the odds ratio, and the Chi-square statistical test. Results: The frequency of diabetes mellitus and hypertriglyceridemia were significantly higher in the group of patients with rotator cuff syndrome (p<0.05), the frequency of pure hypercholesterolemia in patients with rotator cuff syndrome was 71%, the frequency of hypercholesterolemia pure in patients without rotator cuff syndrome was 32%, hypercholesterolemia is a risk factor for rotator cuff syndrome with an odds ratio of 5.13 which was significant (p<0.05), in the multivariate analysis the variables are recognized diabetes mellitus, hypertriglyceridemia and pure hypercholesterolemia as risk factors for rotator cuff syndrome. Conclusion: pure hypercholesterolemia is a risk factor for rotator cuff syndrome in patients who are treated at the I EsSalud La Esperanza Hospital. (Level of evidence II. 2).Tesi

Fish, Creagrutus melasma (Ostariophysi, Characiformes, Characidae): new Venezuelan distribution records

Non

Foster Kennedy Syndrome Due to Meningioma Growth during Pregnancy

Tumors of the olfactory groove may cause unilateral optic atrophy with contralateral papilledema and anosmia (Foster Kennedy syndrome). We describe a case of a young pregnant woman with Foster Kennedy syndrome due to an olfactory groove meningioma

A VLA search for young protostars embedded in dense cores

Four dense cores, L1582A, L1689A, B133 and B68, classified as prestellar in terms of the absence of detectable NIR emission, are observed at radio wavelengths to investigate whether they nurture very young protostars. No definite young protostars were discovered in any of the four cores observed. A few radio sources were discovered close to the observed cores, but these are most likely extragalactic sources or YSOs unrelated to the cores observed. In L1582A we discovered a weak radio source near the centre of the core with radio characteristics and offset from the peak of the submillimeter emission similar to that of the newly discovered protostar in the core L1014, indicating a possible protostellar nature for this source. This needs to be confirmed with near- and/or mid-infrared observations (e.g. with Spitzer). Hence based on the current observations we are unable to confirm unequivocally that L1582A is starless. In L1689A a possible 4.5-sigma radio source was discovered at the centre of the core, but needs to be confirmed with future observations. In B133 a weak radio source, possibly a protostar, was discovered at the edge of the core on a local peak of the core submm emission, but no source was detected at the centre of the core. Thus, B133 is probably starless, but may have a protostar at its edge. In B68 no radio sources were discovered inside or at the edge of the core, and thus B68 is indeed starless. Four more radio sources with spectral indices characteristic of young protostars were discovered outside the cores but within the extended clouds in which these cores reside. Conclusions: We conclude that the number of cores misclassified as prestellar is probably very small and does not significantly alter the estimated lifetime of the prestellar phase.Comment: Accepted by A&

An improved system for estradiol-dependent regulation of gene expression in yeast

BACKGROUND: Saccharomyces cerevisiae is widely utilized in basic research as a model eukaryotic organism and in biotechnology as a host for heterologous protein production. Both activities demand the use of highly regulated systems, able to provide accurate control of gene expression in functional analysis, and timely recombinant protein synthesis during fermentative production. The tightly regulated GAL1-10 promoter is commonly used. However, induction of the GAL system requires the presence of the rather expensive inducer galactose and the absence of glucose in the culture media. An alternative to regulate transcription driven by GAL promoters, free of general metabolic changes, is the incorporation of the hybrid Gal4-ER-VP16 protein developed by D. Picard. This chimeric protein provides galactose-independent activation of transcription from GAL promoters in response to β-estradiol, even in the presence of glucose. However, constitutive expression of this transactivator results in relatively high basal activity of the GAL promoters, therefore limiting the gene expression capacity that is required for a number of applications. RESULTS: In order to improve this expression tool, we have introduced additional regulatory elements allowing a simultaneous control of both the abundance and the intrinsic activity of the Gal4-ER-VP16 chimeric transactivator. The most efficient combination was obtained by placing the coding sequence of the hybrid activator under the control of the GAL1 promoter. This configuration results in an amplification feedback loop that is triggered by the hormone, and ultimately leads to the enhanced regulation of recombinant genes when these are also driven by a GAL1 promoter. The basal expression level of this system is as low as that of native GAL-driven genes in glucose-containing media. CONCLUSION: The feedback regulatory loop that we have engineered allows a 250-fold induction of the regulated gene, without increasing the basal activity of the target promoter, and achieving a 12-fold higher regulation efficiency than the previous configuration

Passive detection of rank-one signals with a multiantenna reference channel

In this work we consider a two-channel passive detection problem, in which there is a surveillance array where the presence/absence of a target signal is to be detected, and a reference array that provides a noise-contaminated version of the target signal. We assume that the transmitted signal is an unknown rank-one signal, and that the noises are uncorrelated between the two channels, but each one having an unknown and arbitrary spatial covariance matrix. We show that the generalized likelihood ratio test (GLRT) for this problem rejects the null hypothesis when the largest canonical correlation of the sample coherence matrix between the surveillance and the reference channels exceeds a threshold. Further, based on recent results from random matrix theory, we provide an approximation for the null distribution of the test statistic.The work of I. Santamaría was supported by the Spanish Government through grants PRX14/0028 (Estancias de Movilidad de Profesores, Ministerio de Educación) and by project RACHEL (TEC2013-47141-C4-3-R) funded by the Ministerio de Economía y Competitividad (MINECO). The work of L. Scharf and D. Cochran was supported in part by a sub-contract with Matrix Research for research sponsored by the Air Force Research Laboratory under contract FA8650-14-D-1722

Procedimientos básicos para la titularización de activos, aplicable a los originadores.

Ante la búsqueda del desarrollo económico y financiero de las empresas de hoy en día, se han creado nuevos mecanismos de financiamiento que sirvan de ayuda para alcanzar su visión de liderazgo y desarrollo. De allí que surge una nueva fuente llamada titularización de activos; la cual no es más que el procedimiento mediante el cual una empresa, llamada originadora, puede transformar sus activos líquidos, susceptibles de titularización, en valores comerciales o títulos valores a través de una sociedad de propósito especial, llamada sociedad titularizadora. De acuerdo a lo anterior, dado que esta opción de financiamiento es nueva en el país, se carece de un documento que detalle de forma ordena y sencilla los procedimientos básicos para la titularización de activos aplicable a las empresas originadoras. Ante tal situación se realizó este trabajo con el objetivo de proponer un documento que reúna dichos procedimientos y ayudar a las empresas originadoras a su implementación. La investigación se desarrolló bajo el enfoque hipotético-deductivo empleando un estudio de tipo analítico explicativo, lo que implicó establecer objetivos de investigación. Para este efecto se procedió a la recopilación de información mediante instrumentos y técnicas de investigación, como el cuestionario estructurado, guía de entrevistas y la clasificación bibliográfica, a fin de registrar los aspectos relevantes del problema y obtener el análisis respectivo de la misma para formular un diagnóstico. El estudio mostró, que la principal causa considerada por la cual la población encuestada desconoce sobre la titularización de activos y su aplicación, es la falta de un documento que contenga los procedimientos básicos para la titularización de activos a ser aplicados por el originador. En consecuencia se sugiere el uso del presente documento, el cual está orientado al desarrollo de los procedimientos básicos aplicables a los originadores en cuanto a aspectos legales, financieros y contables de la titularización de activos, y de este modo fortalecer el conocimiento de las empresas originadoras ante esta nueva alternativa de financiamiento

Las ocupaciones humanas del sitio arqueológico de Santa Inés, Laguna de Tagua Tagua, Chile central

The study of archaeological and bioanthropological evidence from the SantaInés site (central Chile), together with new radiocarbon dates available, haveallowed us to define this site as a residential settlement with several occupationalevents associated with funerary practices. The first occupations correspond tomid-to-late Holocene hunter-gatherers, while the last event to the Early CeramicPeriod. Santa Inés presents strong affinities to the Cuchipuy site located in thevicinity. As a whole, they formed part of a settlement pattern clustered along theshoreline of the Tagua Tagua basin and its lake-basin resources.El estudio de las evidencias arqueológicas y bioantropológicas del sitio arqueológicode Santa Inés, situado en la ex laguna de Tagua Tagua (Chile Central), y sus nuevasedades radiocarbónicas, han permitido definir este sitio como un asentamientohabitacional con varios eventos ocupacionales asociados a prácticas funerarias. Lasprimeras ocupaciones corresponderían a cazadores-recolectores del Holoceno Medio yTardío y el último a un evento del Alfarero Temprano. Poseen fuertes afinidades con elcercano asentamiento de Cuchipuy. Como conjunto constituyeron parte de un patrónde asentamiento en torno a los recursos lacustres de la cuenca de Tagua Tagua