Tests of the Las Campanas Distant Cluster Survey from Confirmation Observations for the ESO Distant Cluster Survey

The ESO Distant Cluster Survey (EDisCS) is a photometric and spectroscopic study of the galaxy cluster population at two epochs, z~0.5 and z~0.8, drawn from the Las Campanas Distant Cluster Survey (LCDCS). We report results from the initial candidate confirmation stage of the program and use these results to probe the properties of the LCDCS. Of the 30 candidates targeted, we find statistically significant overdensities of red galaxies near 28. Of the ten additional candidates serendipitously observed within the fields of the targeted 30, we detect red galaxy overdensities near six. We test the robustness of the published LCDCS estimated redshifts to misidentification of the brighest cluster galaxy (BCG) in the survey data, and measure the spatial alignment of the published cluster coordinates, the peak red galaxy overdensity, and the brightest cluster galaxy. We conclude that for LCDCS clusters out to z~0.8, 1) the LCDCS coordinates agree with the centroid of the red galaxy overdensity to within 25'' (~150 h^{-1} kpc) for 34 out of 37 candidates with 3\sigma galaxy overdensities, 2) BCGs are typically coincident with the centroid of the red galaxy population to within a projected separation of 200 h^{-1} kpc (32 out of 34 confirmed candidates), 3) the red galaxy population is strongly concentrated, and 4) the misidentification of the BCG in the LCDCS causes a redshift error >0.1 in 15-20% of the LCDCS candidates. These findings together help explain the success of the surface brightness fluctuations detection method.Comment: 10 pages, 9 figures, accepted for publication in the November 10 issue of Ap

Wide-Field Survey of Globular Clusters in M31. II. Kinematics of the Globular Cluster System

We present a kinematic analysis of the globular cluster(GC) system in M31. Using the photometric and spectroscopic database of 504 GCs, we have investigated the kinematics of the M31 GC system. We find that the all GC system shows strong rotation, with rotation amplitude of v_rot~190km/s, and that a weak rotation persists even for the outermost samples at |Y|>5kpc. The rotation-corrected velocity dispersion for the GC system is estimated to be sigma_{p,r}~130km/s, and it increases from sigma_{p,r}~120km/s at |Y|<1kpc to sigma_{p,r}~150km/s at |Y|>5kpc. These results are very similar to those for the metal-poor GCs. This shows that there is a dynamically hot halo in M31 that is rotating but primarily pressure-supported. We have identified 50 "friendless" GCs, and they appear to rotate around the major axis of M31. For the subsamples of metal-poor and metal-rich GCs, we have found that the metal-rich GCs are more centrally concentrated than the metal-poor GCs, and both subsamples show strong rotation. For the subsamples of bright and faint GCs, it is found that the rotation for the faint GCs is stronger than that for the bright GCs. We have identified 56 GCs and GC candidates with X-ray detection. It is found that the majority of X-ray emitting GCs follow the disk rotation, and that the redder, more metal-rich, and brighter GCs are more likely to be detected as X-ray emitting GCs. We have derived a rotation curve of M31 using the GCs at |Y|<0.6kpc. We have estimated the dynamical mass of M31 using `Projected Mass Estimator(PME)' and `Tracer Mass Estimator(TME)'. We finally discuss the implication of these results and compare the kinematics of GCs with that of planetary nebulae in M31.Comment: 62 pages, 26 figues, Accepted by Ap

The History of Flow Chemistry at Eli Lilly and Company

Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman Kwart Rearrangement, Claisen rearrangement, hydroformylation, and thermal imidazole cyclization. Next, flow chemistry was used to enable safe scale up of hazardous chemistries to manufacturing plants. Examples included high pressure hydrogenation, aerobic oxidation, and Grignard formation reactions. More recently, flow chemistry was used in Small Volume Continuous (SVC) processes, where highly potent oncolytic molecules were produced by fully continuous processes at about 10 kg/day including reaction, extraction, distillation, and crystallization, using disposable equipment contained in fume hoods

An Unbiased Survey of 500 Nearby Stars for Debris Disks: A JCMT Legacy Program

We present the scientific motivation and observing plan for an upcoming detection survey for debris disks using the James Clerk Maxwell Telescope. The SCUBA-2 Unbiased Nearby Stars (SUNS) Survey will observe 500 nearby main sequence and sub-giant stars (100 of each of the A, F, G, K and M spectral classes) to the 850 micron extragalactic confusion limit to search for evidence of submillimeter excess, an indication of circumstellar material. The survey distance boundaries are 8.6, 16.5, 22, 25 and 45 pc for M, K, G, F and A stars, respectively, and all targets lie between the declinations of -40 deg to 80 deg. In this survey, no star will be rejected based on its inherent properties: binarity, presence of planetary companions, spectral type or age. This will be the first unbiased survey for debris disks since IRAS. We expect to detect ~125 debris disks, including ~50 cold disks not detectable in current shorter wavelength surveys. A substantial amount of complementary data will be required to constrain the temperatures and masses of discovered disks. High resolution studies will likely be required to resolve many of the disks. Therefore, these systems will be the focus of future observational studies using a variety of observatories to characterize their physical properties. For non-detected systems, this survey will set constraints (upper limits) on the amount of circumstellar dust, of typically 200 times the Kuiper Belt mass, but as low as 10 times the Kuiper Belt mass for the nearest stars in the sample (approximately 2 pc).Comment: 11 pages, 7 figures (3 color), accepted by the Publications of the Astronomical Society of the Pacifi

First Results from HaloSat – A CubeSat to Study the Hot Galactic Halo

HaloSat is the first CubeSat for astrophysics funded by NASA\u27s Science Mission Directorate and is designed to map soft X-ray oxygen line emission across the sky in order to constrain the mass and spatial distribution of hot gas in the Milky Way. HaloSat will help determine if hot halos with temperatures near a million degrees bound to galaxies make a significant contribution to the cosmological budget of the normal matter (baryons). HaloSat was deployed from the International Space Station in July 2018 and began routine science operations in October 2018. We describe the on-orbit performance including calibration of the X-ray detectors and initial scientific results including an observation of a halo field and an observation of solar wind charge exchange emission from the helium-focusing cone

Unraveling the effects of management and climate on carbon fluxes of U.S. croplands using the USDA Long-Term Agroecosystem (LTAR) network

Understanding the carbon fluxes and dynamics from a broad range of agricultural systems has the potential to improve our ability to increase carbon sequestration while maintaining crop yields. Short-term, single-location studies have limited applicability, but long-term data from a network of many locations can provide a broader understanding across gradients of climate and management choices. Here we examine eddy covariance measured carbon dioxide (CO2) fluxes from cropland sites across the United States Department of Agriculture’s Long-Term Agroecosystem Research (LTAR) network. The dataset was collected between 2001 and 2020, spanning 13 sites for a total of 182 site-years. Average seasonal patterns of net ecosystem CO2 exchange (NEE), gross primary productivity (GPP), and ecosystem respiration (Reco) were determined, and subsequent regression analysis on these “flux climatologies” was used to identify relationships to mean annual temperature (MAT), mean annual precipitation (MAP), cropping systems, and management practices. At rainfed sites, carbon fluxes were better correlated with MAP (r2 ≤ 0.5) than MAT (r2 ≤ 0.22). Net carbon balance was different among cropping systems (p \u3c 0.001), with the greatest net carbon uptake occurring in sugarcane (Saccharum spp. hybrids) and the least in soybean (Glycine max) fields. Crop type had a greater effect on carbon balance than irrigation management at a Nebraska site. Across cropping systems, grain crops often had higher GPP and were more likely to have net uptake when compared to legume crops. This multi-site analysis highlights the potential of the LTAR network to further carbon flux research using eddy covariance measurements

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Age-related neurodegenerative disease has been mechanistically linked with mitochondrial dysfunction via damage from reactive oxygen species produced within the cell. We determined whether increased mitochondrial oxidative stress could modulate or regulate two of the key neurochemical hallmarks of Alzheimer's disease (AD): tau phosphorylation, and ß-amyloid deposition. Mice lacking superoxide dismutase 2 (SOD2) die within the first week of life, and develop a complex heterogeneous phenotype arising from mitochondrial dysfunction and oxidative stress. Treatment of these mice with catalytic antioxidants increases their lifespan and rescues the peripheral phenotypes, while uncovering central nervous system pathology. We examined sod2 null mice differentially treated with high and low doses of a catalytic antioxidant and observed striking elevations in the levels of tau phosphorylation (at Ser-396 and other phospho-epitopes of tau) in the low-dose antioxidant treated mice at AD-associated residues. This hyperphosphorylation of tau was prevented with an increased dose of the antioxidant, previously reported to be sufficient to prevent neuropathology. We then genetically combined a well-characterized mouse model of AD (Tg2576) with heterozygous sod2 knockout mice to study the interactions between mitochondrial oxidative stress and cerebral Aß load. We found that mitochondrial SOD2 deficiency exacerbates amyloid burden and significantly reduces metal levels in the brain, while increasing levels of Ser-396 phosphorylated tau. These findings mechanistically link mitochondrial oxidative stress with the pathological features of AD