PROJECT SCHEDULING BY A HEURISTIC ALGORITHM UNDER LIMITED RESOURCE IN THE CONSTRUCTION INVESTMENTS

A proper use of the resources has become the prime target of the economy circles nowadays. In this connection, an optimal use of the resources in the construction industry is of a great importance. In a construction project, a vast number of processes are involved and each of them requires many different resources, namely, labor, machinery, materials, finance, etc. The size of the construction projects is relatively large and these projects are fairly complicated. One should not think that the resources are to be available at the desired time and at a prescribed amount during the process of the implementation of the project. Therefore, use of the resources also needs a stage of planning. These projects can conveniently programmed by the so-called resource constrained project scheduling techniques. In this work, an algorithm based on a heuristic approach with priority rules was developed in the Visual Basic language and tested on a project applied to the construction of building for primary school in Turkey. The project comprises 79 activities each involving 11 differentresources. Different programs for the cases of constrained and unconstrained resources were developed. The overall period it takes the project to be completed was found to be 226 days for the case of unconstrained resources and 260 days for the case of under constrained resources

Exploring transcriptomic signatures in sudden unexplained death (SUD) cases

Background Molecular autopsy in sudden unexplained death (SUD) has successfully identifed pathogenic variants in cardiovascular genes in a substantial proportion of cases, contributing to prevention strategies in family members. However, many SUD cases remain genetically unresolved, prompting investigations into other omics technologies to better understand the pathogenic mechanisms leading to a sudden death event. In this study, whole transcriptome sequencing was performed on heart samples from 43 SUD cases and 17 heart-healthy controls, with the aim to identify disease-specific transcriptome signatures in sudden unexplained death. Results PCA based on the top 500 genes with the highest variance among the samples showed no clear separation between SUD and controls or among the three SUD subgroups. DESeq2 identifed 1,676 differentially expressed genes between SUD and controls with significantly upregulated genes involved in biological processes such as angiogenesis, blood vessel development, vasculogenesis and cell adhesion. Pathway analysis of the differentially expressed genes showed that most were downregulated and involved in amide/peptide biosynthesis and fatty acid metabolism. Additional analysis of SUD subgroups revealed unique gene expression patterns and highlighted differentially expressed genes within each subgroup. Conclusion Gene expression analysis of SUD heart tissue is a promising approach to identify cardiac disease-related pathways to further understand the pathological mechanisms leading to a sudden death event. However, due to the heterogeneity of the SUD cases and the unclear phenotype, further studies in larger cohorts are needed

Budd-chiari syndrome and renal arterial neurysms due to behcet disease: a rare association

Behcet’s disease is a multisystemic vasculitis of unknown etiology with a chronic relapsing course. Vasculitis in Behcet’s disease with predominant vascular involvement is the only vasculitis that affects both arteries and veins of any size. Involvement of the renal artery and inferior vena cava is rare among the arteries and veins, respectively. When disease affect the veins, it is in the form of thrombosis. Arterial complications include  aneurysms, stenosis and occlusions. Both rupture of arterial aneurysm and occlusion of suprahepatic veins,  causing Budd-Chiari syndrome, are associated with a high mortality rate. Vascular involvement is more common in male patients than in female patients. Men and patients with a younger age of onset present with a more severe prognosis. In this case report, we describe a very rare cause of intrarenal arterial aneurysm’s rupture with  previous Budd-Chiari syndrome due to Behcet’s disease and successful angiographic embolization of actively bleeding aneurysm

Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

Cataloged from PDF version of article.The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP285 and 309 genotypes across 25 different ethnic populations (>10.000 individuals), the incidence of SNP285C was 6-8% across European populations except for Finns (1.2%) and Saami (0.3%). The incidence decreased towards the Middle-East and Eastern Russia, and SNP285C was absent among Han Chinese, Mongolians and African Americans. Interhaplotype variation analyses estimated SNP285C to have originated about 14,700 years ago (95% CI: 8,300 - 33,300). Both this estimate and the geographical distribution suggest SNP285C to have arisen after the separation between Caucasians and modern day East Asians (17,000 - 40,000 years ago). We observed a strong inverse correlation (r = -0.805; p < 0.001) between the percentage of SNP309G alleles harboring SNP285C and the MAF for SNP309G itself across different populations suggesting selection and environmental adaptation with respect to MDM2 expression in recent human evolution. In conclusion, we found SNP285C to be a pan-Caucasian variant. Ethnic variation regarding distribution of SNP285C needs to be taken into account when assessing the impact of MDM2 SNPs on cancer risk

Why Is Sexuality Important for Patients with Stomas?

Stoma, bağırsak sistemive üriner sistem ile ilgili çeşitli hastalıklar nedeniyle boşaltımı sağlamak için bağırsağın geçici ya da sürekli olarakkarın duvarına ağızlaştırıldığı yapay bir açıklıktır. Endikasyon ne olursa olsun, stoma açılması bireyin fizyolojik, sosyal ve psikolojik açıdanyaşamının etkilenmesine yol açar. Fiziksel hasar, çirkinleşme, beden fonksiyonlarında azalma, kişisel hijyende değişim ile sonuçlanan stoma,bireyin yaşamında çok derin değişikliklere neden olabilmektedir. Bu değişiklikler nedeniyle birey çekiciliğinin azaldığını hissedebilmekte,cinsel yaşamında yetersizlik duygusu yaşayabilmektedir. Stomalı birey yaşadığı bu sorunları sağlık personeli ile konuşmakta ve sorusormakta güçlük çekmektedir. Hemşireler tarafından da göz ardı edilen cinsellik stomalı bireyin yaşamını ciddi anlamda etkilemektedir.Ayrıca bireyin yaşadığı fizyolojik sorunların verilen uygun bakım, eğitim ve danışmanlıkla azaldığı ancak göz ardı edildiği için cinselsorunların devam ettiği bilinmektedir. Bu nedenle, stoma nedeniyle bireyin cinsel yaşamı ile ilgili problemlerinin öncelikli sorunlar arasındaele alınması gerekmektedir. Stoma is an artificial opening to the abdominal wall, due to various diseases related to the gastrointestinal system intestine and uriner systemto provide drainage; can be temporarily or permanently. Regardless of the indication stoma affects people life physiological, social andpsychological. Stoma causes profound changes in person's life because of resulting physical damage, disfigurement, loss of bodily function,and change in personel hygiene. Because of these changes, person thinks that his attractiveness had decreased and feels inability in sexuallife. Person with stoma have difficulties in asking questions and talking about his sexual problems with health practioner. Sexuality haveserious negative impact on person with stoma, also neglected by the nurses. It is also known person's physiological problems can decreasewith appropriate care, training and consulting but sexual problems continue because of neglecting.Thats why person's problems related tosexual life should be addressed priority problems

FARKLI DEPREM BÖLGELERİ VE FARKLI ZEMİN SINIFLARININ KABA YAPI MALİYETİNE ETKİSİ

Bir yapının genel güvenliği, zemin, proje, üretim, uygulama ve denetim gibi öğelerin bir bütün halinde kaliteli ve doğru olarak gerçekleşmesi ile sağlanabilir. Bunun yanında mühendislik; kalite, estetik ve ekonomiyi optimum şekilde kullanma sanatı olarak da ifade edilebilir. Bu çalışmada; konut türü betonarme bir binanın taşıyıcı sistem maliyetinin; deprem bölgelerine ve zemin sınıfına bağlı değişimi incelenmiştir. Çalışmada üç farklı proje 5 katlı olarak incelenmiştir. Projelerin dört farklı zemin sınıfına ve dört farklı deprem bölgesine göre statik ve betonarme analizi yapılmıştır. Her bir veriye göre analizi yapılan projelerin beton, demir ve kalıp metrajları yapılmıştır. Bu şekilde yapıların kaba inşaat maliyetleri hesaplanmıştır. Zemin sınıfına ve deprem bölgesine göre projelerin maliyet değişimi regresyon analizi ile incelenmiştir. Genel olarak zemin sınıfı Z1 ile Z4 arasında % 22 düzeylerinde; 1. Bölge ve 4. Bölge arasında % 14 düzeylerinde maliyet değişimi görülmüştür

Analytical and artificial neural network models to estimate the discharge coefficient for ogee spillway

In this study, analytical and Artificial Neural Network (ANN) model were used for determine the discharge coefficient of Ogee Spillways. For this aim, discharge coefficients of 11 different heads were calculated by using a test flume having 7.5 cm width, 15 cm depth and 5 m length, in the laboratory. Discharge coefficients were also computed by the formula for the same heads measured in the laboratory to investigate the accuracy of experimental setup. An ANN model was set by using the experimental results in order to estimate the discharge coefficient. Then, the performance of the ANN model was investigated. As the result, the coefficient of determination between ANN model and experimental setup is found R2= 0.98. ANN model is show a good consistency with experimental results