11 research outputs found
Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase
Exposure of macrophages to an enzymatically inactive macrophage mannose receptor ligand augments killing of Candida albicans
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Regulation of macrophage function by human recombinant myeloperoxidase
Myeloperoxidase is an enzyme which is found in the azurophilic granules of neutrophils and is associated with bactericidal, fungicidal, and tumoricidal activity. The present studies show that human recombinant myeloperoxidase (rec-MyPo) can regulate a number of macrophage (Mφ) capacities and functions. Macrophages from mice exposed to rec-MyPo in vitro released reactive oxygen intermediates, tumor necrosis factor alpha (TNFα), and interferon α/β (IFNα/β). Enhanced target cell killing was also demonstrated with TNFα sensitive but not TNFα insensitive cells. Intravenous injection of rec-MyPo induced high titers of systemic TNFα and IFNα/β. These results indicate that MyPo can function as an immunomodulator both in vitro and in vivo. Because of these actions, it is apparent that MyPo represents a previously unrecognized endogenous immunomodulator. © 1993.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
The endothelium and cytokine secretion: The role of peroxidases as immunoregulators
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Enzymatically Inactive Eosinophil Peroxidase Inhibits Proinflammatory Cytokine Transcription and Secretion by Macrophages
Neutrophilic myeloperoxidase-macrophage interactions perpetuate chronic inflammation associated with experimental arthritis
SCOPUS: ar.jinfo:eu-repo/semantics/publishe