Toward Psycho-robots

We try to perform geometrization of psychology by representing mental states, >, by points of a metric space, >. Evolution of ideas is described by dynamical systems in metric mental space. We apply the mental space approach for modeling of flows of unconscious and conscious information in the human brain. In a series of models, Models 1-4, we consider cognitive systems with increasing complexity of psychological behavior determined by structure of flows of ideas. Since our models are in fact models of the AI-type, one immediately recognizes that they can be used for creation of AI-systems, which we call psycho-robots, exhibiting important elements of human psyche. Creation of such psycho-robots may be useful improvement of domestic robots. At the moment domestic robots are merely simple working devices (e.g. vacuum cleaners or lawn mowers) . However, in future one can expect demand in systems which be able not only perform simple work tasks, but would have elements of human self-developing psyche. Such AI-psyche could play an important role both in relations between psycho-robots and their owners as well as between psycho-robots. Since the presence of a huge numbers of psycho-complexes is an essential characteristic of human psychology, it would be interesting to model them in the AI-framework

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with BrS and 10,001 controls, and identified 21 association signals at 12 loci (10 new). Single nucleotide polymorphism (SNP)-heritability estimates indicate a strong polygenic influence. Polygenic risk score analyses based on the 21 susceptibility variants demonstrate varying cumulative contribution of common risk alleles among different patient subgroups, as well as genetic associations with cardiac electrical traits and disorders in the general population. The predominance of cardiac transcription factor loci indicates that transcriptional regulation is a key feature of BrS pathogenesis. Furthermore, functional studies conducted on MAPRE2, encoding the microtubule plus-end binding protein EB2, point to microtubule-related trafficking effects on NaV1.5 expression as a new underlying molecular mechanism. Taken together, these findings broaden our understanding of the genetic architecture of BrS and provide new insights into its molecular underpinnings

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with BrS and 10,001 controls, and identified 21 association signals at 12 loci (10 new). Single nucleotide polymorphism (SNP)-heritability estimates indicate a strong polygenic influence. Polygenic risk score analyses based on the 21 susceptibility variants demonstrate varying cumulative contribution of common risk alleles among different patient subgroups, as well as genetic associations with cardiac electrical traits and disorders in the general population. The predominance of cardiac transcription factor loci indicates that transcriptional regulation is a key feature of BrS pathogenesis. Furthermore, functional studies conducted on MAPRE2, encoding the microtubule plus-end binding protein EB2, point to microtubule-related trafficking effects on Na1.5 expression as a new underlying molecular mechanism. Taken together, these findings broaden our understanding of the genetic architecture of BrS and provide new insights into its molecular underpinnings

Les activités pratiquées dans l’enceinte de Bellevue

International audienc

ARD V., BRÉHARD S., DONNART K., DUFRAISSE A., DUPONT C., FOUÉRÉ P., LINTON J., POLLONI A., 2022 – Les activités pratiquées dans l’enceinte de Bellevue, 485.

International audienc

Beg ar Loued, Molène Island, Finistère (France), an Early Bronze Age insular settlement. Between autarchy and openness to outside world.

International audienc

Simulating a Human Society: the Challenges

Simulating a human society is a very complex interdisciplinary problem. In this paper, we try to show some important aspects to create inhabited worlds where virtual people can interact, co-operate, perceive the world and the society. Main aspects are flexible motion control, perception of the real and the virtual world, and high-level behavior. Concepts are illustrated in the case-study of emergent crowds