The comprehensive analysis of milling stability and surface location error with considering the dynamics of workpiece

Cutting movement is still one of the main means to obtain the desired machined surface. As the most representative cutting method in subtractive manufacturing, milling is widely used in industrial production. However, the chatter induced by the dynamic interaction between machine tool and process not only reduces the accuracy of the machined workpiece, but also increases the tool wear and affects the rotary accuracy of the spindle. The stability lobe diagram can provide stable machining parameters for the technicians, and it is currently an effective way to avoid chatter. In fact, the dynamic interaction between the machine tool and process is very complicated, which involves the machine tool, milling tool, workpiece and fixture. The induced mechanism of chatter depends on different machining scenarios and is not entirely dependent on the vibration modes of milling tool. Therefore, it is important to obtain stable machining parameters and to know the dynamic surface location error distribution, which can ensure machining quality and improve machining efficiency. In this dissertation, two methods for constructing stability lobe diagram are first introduced, and then two machining scales, macro milling and micro milling, are studied. For the macro-milling scale, the dynamic response of the in-process workpiece with time-varying modal parameters during the material removal process is analyzed. The stability lobe diagrams for thin-walled workpiece and general workpiece with continuous radial immersion milling are established respectively. Besides, the cumulative surface location error distribution is also studied and verified for the general workpiece. For the micro-milling scale, the dynamics at the micro-milling tool point is obtained by means of the receptance coupling substructure analysis method. The stability lobe diagram and surface location error distribution are analyzed under different restricted/free tool overhang lengths. The relationship between measurement results and burrs is further explained by cutting experiments, and the difference between the two milling scales is compared in the end

Book review: Spirit of rebellion. Labor and religion in the new cotton south

International audienceThis article provides formal definitions characterizing well-formed composition of components in order to guarantee their safe deployment and execution. Our work focuses on the structural aspects of component composition; it puts together most of the concepts common to many component models, but never formalized as a whole. Our formalization characterizes correct component architectures made of functional and non-functional aspects, both structured as component assemblies. Interceptor chains can be used for a safe and controlled interaction between the two aspects. Our well-formed components guarantee a set of properties ensuring that the deployed component system has a correct architecture and can run safely. Finally, those definitions constitute the formal basis for our Eclipse-based environment for the development and specification of component-based applications

Stability enhancement and chatter suppression in continuous radial immersion milling

Acknowledgments The authors would like to thank the Federal Ministry of Economic Affairs and Energy (BMWi) and the AIF Projekt GmbH for funding this scientific paper as part of the research project "UltrahardMill" of the central Innovation Programme for SMEs. The authors appreciate Dr.-Ing. Michael Löser and Dipl.-Ing. Zhongyan Zhu from TU Dresden for discussing and modifying the content of the manuscript. Besides, Mr. Daniel Schmidt from Fraunhofer Institute for Machine Tools and Forming Technology (IWU) provided us with lots of generous help to carry out the experiments.Peer reviewedPostprin

Identification of Conserved miRNAs in Solanum Lycopersicum Response to Long-term RPM-treatment

Abstract-T o identify the miRNAs associated with the simulated microgravity response in plants and to ascertain the regulation network mediated by miRNAs under simulated microgravity conditions, we constructed a miRNA library by direct cloning method and analyzed the library. Six conserved Solanum lycopersicum miRNAs were identified for the first time in Solanum lycopersicum under simulated microgravity condition. Gene ontology analysis showed that most of the predicted targeted genes were involved in organelle part, transcription factor, signal transduction and metabolic process, implying a complicated relationship among the external signal, internal transduction and final phenotype. Cis-elements located in the upstream sequences of each miRNA were identified and their roles in gene regulation were investigated. In the study, miRNAs were identified in S. lycopersicum for the first time under long-term simulated microgravity condition, which will help reveal the regulation mechanism mediated by miRNAs under simulated microgravity condition and adaptation to Earth's gravity

Geology, U-Pb geochronology and stable isotope geochemistry of the Heihaibei gold deposit in the southern part of the Eastern Kunlun Orogenic Belt, China : A granitic intrusion-related gold deposit?

The Heihaibei gold deposit is a newly discovered gold deposit in the southern part of the Eastern Kunlun Orogenic Belt. Its most distinctive features are that the gold mineralization is hosted in monzogranite, and that the presence of pre-ore (possibly syn-ore) monzogranite and post-ore gabbro allows to constrain the minerali-zation's formation age. Zircons from the monzogranites yield U-Pb ages of 454 +/- 3 Ma, while zircons separated from the gabbro dikes cutting the monzogranites and gold mineralized body yield U-Pb ages of 439 +/- 3 Ma, which is interpreted to be the minimum age of the Au mineralizing event. Combined with the regional geological background, we proposed that the Heihaibei Au mineralization occurred during the subduction stage of the Early Paleozoic Proto-Tethys ocean. The ore assemblage is dominated by pyrite, arsenopyrite and native gold. The hydrothermal alteration that has led to the peculiar enrichment of Au is not systematically distributed and displays no clear concentric zoning pattern. The main mineralization formed during three stages: the K-feldspar-quartz-pyrite (Py1)-arsenopyrite-sericite-epidote stage (I), the quartz-pyrite (Py2)-native gold-chlorite stage (II), and the quartz-carbonate stage (III). The main gold mineralization occurred during stage II. Fluid inclusion homogenization temperature and salinities decrease from stage I (Th., 268-412 C; W., 6.87-16.63 wt% NaCl equiv.) to stage II (Th., 183-288 C; W., 3.69-14.84 wt% NaCl equiv.). The 818O and 8D values (818OH2O = 4.9 to 9.7%o; 8DV-SMOW =-84.1%o to -81.1%o) of quartz samples from stage I and stage II are comparable to a magmatic-hydrothermal ore-forming fluid that possibly underwent fluid-rock interaction with the Nachitai Group metamorphic rocks during the early ore-forming stage. The relatively uniform 834S values (834SV-CDT = 7.7 to 8.5%o) are slightly elevated compared to magmatic 834S values, but could be derived from a magma if a significant crustal melt component is present. Moreover, the 834S values are within the S isotopic composition range of a granitic reservoir, suggesting that they are probably inherited from the Heihaibei monzogranites. The Pb and Hf isotope compositions imply a close genetic association between the gold mineralization and granitic magmatism, which are both the products of the mixing of crustal and mantle sources. The trace element compositions of pyrite provide additional evidence that the gold mineralization in the Heihaibei deposit was related to the magmatism. Compared with the typical characteristics of orogenic gold and intrusion-related gold systems (IRGS) deposits, the Heihaibei gold deposit may instead be classified as a granitic intrusion-related gold deposit.Peer reviewe

Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates

Toxoplasma gondii (T. gondii) is a nucleated intracellular parasitic protozoan with a broad host selectivity. It causes toxoplasmosis in immunocompromised or immunodeficient patients. The currently available treatments for toxoplasmosis have significant side effects as well as certain limitations, and the development of vaccines remains to be explored. Animal venoms are considered to be an important source of novel antimicrobial agents. Some peptides from animal venoms have amphipathic alpha-helix structures. They inhibit the growth of pathogens by targeting membranes to produce lethal pores and cause membrane rupture. Venom molecules generally possess immunomodulatory properties and play key roles in the suppression of pathogenic organisms. Here, we summarized literatures of the last 15 years on the interaction of animal venom peptides with T. gondii and attempt to explore the mechanisms of their interaction with parasites that involve membrane and organelle damage, immune response regulation and ion homeostasis. Finally, we analyzed some limitations of venom peptides for drug therapy and some insights into their development in future studies. It is hoped that more research will be stimulated to turn attention to the medical value of animal venoms in toxoplasmosis

Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2

G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important regulatory protein in the inflammatory immune response (IIR) by maintaining the balance between the function of inflammatory immune cells and non-conventional inflammatory immune cells and regulating inflammatory immune cell infiltration, inflammatory cytokine secretion, and the signaling associated with endothelial function. However, the imbalance of GRK2 expression and activity plays an important role in the development of IIR-related diseases, such as hypertension, heart failure, Alzheimer’s disease, type 2 diabetes mellitus, insulin resistance, rheumatoid arthritis, thyroid cancer, multiple sclerosis, and liver cancer. Small molecule GRK2 inhibitors, including balanol, Takeda inhibitors, paroxetine and derivatives, M119 and gallein, peptides, RNA aptamers, Raf kinase inhibitory protein, and microRNAs, that can directly inhibit GRK2 kinase activity have been identified by different strategies. This review discusses recent progress in one of the hallmark molecular abnormalities of GRK2 in IIR-related diseases and explores the soft regulation of IIR by innovative drugs reducing the excessive activity of GRK2 to basal levels, without damaging normal physiological function, to ameliorate inflammatory disorders

Was the extended rainy winter of 2018/2019 over the Middle and Lower reaches of the Yangtze River driven by anthropogenic forcing?

Anthropogenic forcing reduced the probability of rainfall amount in the extended rainy winter of 2018/19 over the middle and lower reaches of the Yangtze River, China, by ~19%, but exerted no influence on the excessive rainy days, based on HadGEM3-GA6-N216 ensembles. Instead the natural variability played a large and important role in this event