Transit shapes and self organising maps as a tool for ranking planetary candidates : application to Kepler and K2

A crucial step in planet hunting surveys is to select the best candidates for follow up observations, given limited telescope resources. This is often performed by human ‘eyeballing’, a time consuming and statistically awkward process. Here we present a new, fast machine learning technique to separate true planet signals from astrophysical false positives. We use Self Organising Maps (SOMs) to study the transit shapes of Kepler and K2 known and candidate planets. We find that SOMs are capable of distinguishing known planets from known false positives with a success rate of 87.0%, using the transit shape alone. Furthermore, they do not require any candidates to be dispositioned prior to use, meaning that they can be used early in a mission’s lifetime. A method for classifying candidates using a SOM is developed, and applied to previously unclassified members of the Kepler KOI list as well as candidates from the K2 mission. The method is extremely fast, taking minutes to run the entire KOI list on a typical laptop. We make Python code for performing classifications publicly available, using either new SOMs or those created in this work. The SOM technique represents a novel method for ranking planetary candidate lists, and can be used both alone or as part of a larger autovetting code

Detecting Circumbinary Exoplanets: Understanding Transit Timing

We have derived and tested a simple analytical model for placing limits on the transit timing variations of circumbinary exoplanets. These are generally of days in magnitude, dwarfing those found in multi-planet systems. The derived method is fast, efficient and is accurate to approximately 1% in predicting limits on the possible times of transits over a 3-year campaig

Function2Gene: A gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge

<p>Abstract</p> <p>Background</p> <p>Many common disorders have multiple genetic components which convey increased susceptibility. SNPs have been used to identify genetic components which are associated with a disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power.</p> <p>Results</p> <p>We present a set of programs which implement a novel method for searching for disease-associated genes using prior information to select and order genes from publicly available databases by their prior likelihood of association with the disease. These programs were used in a published study of childhood-onset SLE which yielded novel associations with modest sample size.</p> <p>Conclusion</p> <p>Using prior information to decrease the size of the problem space to an amount commensurate with available samples and resources while maintaining appropriate power enables researchers to increase their likelihood of discovering reproducible associations.</p

Revisiting the Kepler field with TESS: Improved ephemerides using TESS 2min data

Up to date planet ephemerides are becoming increasingly important as exoplanet science moves from detecting exoplanets to characterising their architectures and atmospheres in depth. In this work ephemerides are updated for 22 Kepler planets and 4 Kepler planet candidates, constituting all Kepler planets and candidates with sufficient signal to noise in the TESS 2min dataset. A purely photometric method is utilised here to allow ephemeris updates for planets even when they do not posses significant radial velocity data. The obtained ephemerides are of very high precision and at least seven years 'fresher' than archival ephemerides. In particular, significantly reduced period uncertainties for Kepler-411d, Kepler-538b and the candidates K00075.01/K00076.01 are reported. O-C diagrams were generated for all objects, with the most interesting ones discussed here. Updated TTV fits of five known multiplanet systems with significant TTVs were also attempted (Kepler-18, Kepler-25, Kepler-51, Kepler-89, and Kepler-396), however these suffered from the comparative scarcity and dimness of these systems in TESS. Despite these difficulties, TESS has once again shown itself to be an incredibly powerful follow-up instrument as well as a planet-finder in its own right. Extension of the methods used in this paper to the 30min-cadence TESS data and TESS extended mission has the potential to yield updated ephemerides of hundreds more systems in the future.Comment: 13 pages, 11 figures, 4 tables, accepted for publication in MNRA

Some biomechanical aspects of the carpal tunnel

Previously presented evidence indicates that carpal tunnel syndrome is related to compression of the median nerve inside the carpal tunnel. Biomechanical arguments in which the extrinsic finger flexor tendons inside the carpal tunnel are characterized as a frictionless pulley-belt mechanism are presented to show quantitatively how wrist size, wrist position and hand position affect forces on the tendons and their adjacent structures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23744/1/0000716.pd

An investigation of the relationship between displacements of the finger and wrist joints and the extrinsic finger flexor tendons

Several investigators have developed biomechanical models of finger flexor tendon displacements during pinching or gripping exertions of hands. Landsmeer has developed the most comprehensive set of models for this purpose. This paper describes experiments in which various sized cadaver hands were used to statistically evaluate the Landsmeer models. In so doing, the effects of hand and wrist anthropometry are included. The results indicate that the tendons displace in relation to joint positions as described by that Landsmeer model in which the tendon is depicted as sliding over the curved articular surface of the proximal bone of the joint. Joint thickness effects were found to modify the parameters in the model as intuitively expected. An empirical prediction model of the anthropometric effects was developed. Further, the tendon displacements for various wrist orientations were expressed empirically for the first time and were shown to be consistent with expected anatomical considerations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22712/1/0000267.pd

AN ONLINE MATHEMATICS AND STATISTICS REFRESHER PROGRAM FOR THE COVID-19 ERA AND BEYOND

In February 2021, the Mathematics Education Support Hub at Western Sydney University delivered, for the first time, its long-established mathematics and statistics refresher program for commencing students wholly online. The process of completely replacing its face-to-face program with a series of online self-directed learning modules was complex, not least due to the constraints imposed by COVID-19. Planning and development started in October 2020, with a staged rebuilding of existing content in basic algebra, trigonometry, calculus and statistics. The aim was to achieve more than the mere construction of a digital ‘text book’ consisting of modularised sets of static files. The development was guided by design choices such as content chunking, use of video and interactive learning visualisations, and facilitation of self-checking via mastery quizzes (created using the mathematical e-assessment system Numbas). In this presentation, we shall discuss the pedagogical, curricular, and technical challenges that arose during the development of the online refresher program, and the steps taken to ensure the new learning modules were accessible and effective, together with an analysis of data collected during and after the running of the program (survey responses, learning resource interaction, quiz attempts and Zoom attendance)

Microbial Diffraction Gratings as Optical Detectors for Heavy Metal Pollutants

As a significant industrial pollutant, cadmium is implicated as the cause of itai-itai disease. For biological detection of cadmium toxicity, an assay device has been developed using the motile response of the protozoa species, Tetrahymena pyriformis. This mobile protozoa measures 50 microns in diameter, swims at 10 body lengths per second, and aggregates into macroscopically visible patterns at high organism concentrations. The assay demonstrates a Cd(+2) sensitivity better than 1 micro-M and a toxicity threshold to 5 micro-M, thus encouraging the study of these microbial cultures as viable pollution detectors. Using two-dimensional diffraction patterns within a Tetrahymena culture, the scattered light intensity varies with different organism densities (population counts). The resulting density profile correlates strongly with the toxic effects at very low dosages for cadmium (less than 5 ppm) and then for poison protection directly (with nickel and copper antagonists competing with cadmium absorption). In particular, copper dosages as low as 0.1-0.5 mM Cu have shown protective antagonism against cadmium, have enhanced density variability for cultures containing 1 mM Cd(+2) and therefore have demonstrated the sensitivity of the optical detection system. In this way, such microbial diffraction patterns give a responsive optical measure of biological culture changes and toxicity determination in aqueous samples of heavy metals and industrial pollutants

Vitamin A supplementation in Tanzania: the impact of a change in programmatic delivery strategy on coverage.

BACKGROUND\ud \ud Efficient delivery strategies for health interventions are essential for high and sustainable coverage. We report impact of a change in programmatic delivery strategy from routine delivery through the Expanded Programme on Immunization (EPI+) approach to twice-yearly mass distribution campaigns on coverage of vitamin A supplementation in Tanzania\ud \ud METHODS\ud \ud We investigated disparities in age, sex, socio-economic status, nutritional status and maternal education within vitamin A coverage in children between 1 and 2 years of age from two independent household level child health surveys conducted (1) during a continuous universal targeting scheme based on routine EPI contacts for children aged 9, 15 and 21 months (1999); and (2) three years later after the introduction of twice-yearly vitamin A supplementation campaigns for children aged 6 months to 5 years, a 6-monthly universal targeting scheme (2002). A representative cluster sample of approximately 2,400 rural households was obtained from Rufiji, Morogoro Rural, Kilombero and Ulanga districts. A modular questionnaire about the health of all children under the age of five was administered to consenting heads of households and caretakers of children. Information on the use of child health interventions including vitamin A was asked.\ud \ud RESULTS\ud \ud Coverage of vitamin A supplementation among 1-2 year old children increased from 13% [95% CI 10-18%] in 1999 to 76% [95%CI 72-81%] in 2002. In 2002 knowledge of two or more child health danger signs was negatively associated with vitamin A supplementation coverage (80% versus 70%) (p = 0.04). Nevertheless, we did not find any disparities in coverage of vitamin A by district, gender, socio-economic status and DPT vaccinations.\ud \ud CONCLUSION\ud \ud Change in programmatic delivery of vitamin A supplementation was associated with a major improvement in coverage in Tanzania that was been sustained by repeated campaigns for at least three years. There is a need to monitor the effect of such campaigns on the routine health system and on equity of coverage. Documentation of vitamin A supplementation campaign contacts on routine maternal and child health cards would be a simple step to facilitate this monitoring