Use of deoxycorticosterone pivalate by veterinarians: A western european survey

open9siThis research was supported by FCT—Fundação para a Ciência e Tecnologia IP, grant UIDB/00276/2020This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observa-tional cross-sectional study was conducted using an online survey, translated into four languages and disseminated to veterinary affiliates and mailing lists in six countries of Western Continental Europe. Respondents were tasked to share their therapeutic approach to hypoadrenocorticism, whether they preferred DOCP or fludrocortisone and the specific practical use of DOCP. One-hundred and eighty-four responses were included. Of these, 79.9% indicated that they preferred prescribing DOCP over fludrocortisone as a first-line treatment for mineralocorticoid supplementation. A total of 154 respondents had used DOCP at least once. Eighty percent of those who reported their initial dosage prescribed 2.2 mg/kg. After starting DOCP, 68.2% of the respondents assess electrolytes 10 and 25 days after administration following manufacturer instructions. In stable dogs, electrolytes are monitored quarterly, monthly, semi-annually, and annually by 44.2%, 34.4%, 16.9%, and 4.6% of respondents respectively. When treatment adjustment is required, 53% prefer to reduce dosage while 47% increase the interval between doses. Overall, DOCP is the preferred mineralocorticoid supple-mentation among WEV. Reported variability underlies the need to investigate the best strategies for DOCP use and therapeutic adjustments.openRebocho R.; Dominguez-Ruiz M.; Englar R.E.; Arenas C.; Perez-Alenza M.D.; Corsini A.; Fracassi F.; Bennaim M.; Leal R.O.Rebocho R.; Dominguez-Ruiz M.; Englar R.E.; Arenas C.; Perez-Alenza M.D.; Corsini A.; Fracassi F.; Bennaim M.; Leal R.O

Studying the electronic and charge transport properties of two cyclocarbazole derivates

Molecular systems have proven to be efficient active materials in electronics, being possible alternatives to the inorganic semiconductors used nowadays in electronic devices. For this reason, organic electronics has emerged as a research field with great potential and interest. In this project, an experimental and theoretical study of two carbazole-based macrocycles is presented (Figure 1). Specifically, we investigated the impact of the inclusion of acetylene groups on the electronic and molecular structures of these macrocycles, as well as their potential as charge transporting materials. The first studied compound (Cz) is composed by four carbazole groups linked at their para position with respect to the nitrogen atom[1]. In the second compound (ACz), the carbazole units are connected through ethynylene groups[2]. For this study, Raman and UV-Vis absorption spectroscopies have been used in combination with theoretical calculations based on the density functional theory (DFT). In addition, the two studied compounds have been implemented in organic field-effect transistors (OFETs), to assess their potential as active materials in organic electronics. Overall, the inclusion of ethynylene groups as π-conjugated spacers is found to be a good strategy to improve the electronic delocalization in macrocycles.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The omega rho pi coupling in the VMD model revisited

We determine the value of the \omega -\rho- \pi mesons coupling (g_{\omega\rho\pi}), in the context of the vector meson dominance model, from radiative decays, the \omega \rightarrow 3\pi decay width and the e^+e^- \rightarrow 3\pi cross section. For the last two observables we consider the effect of either a heavier resonance (\rho'(1450)) or a contact term. A weighted average of the results from the set of observables yields g_{\omega\rho\pi} =14.7 \pm 0.1 GeV^{-1} in absence of those contributions, and g_{\omega\rho\pi} =11.9 \pm 0.2 GeV^{-1} or g_{\omega\rho\pi} =11.7 \pm 0.1 GeV^{-1} when including the \rho' or contact term respectively. The inclusion of these additional terms makes the estimates from the different observables to lay in a more reduced range. Improved measurements of these observables and the \rho'(1450) meson parameters are needed to give a definite answer on the pertinence of the inclusion of this last one in the considered processes.Comment: 14 pages, 5 figures. Extended analysis including SND and CMD2 data. References added. Matches published versio

Magnesium in Kidney Function and Disease—Implications for Aging and Sex—A Narrative Review

Magnesium (Mg) has a vital role in the human body, and the kidney is a key organ in the metabolism and excretion of this cation. The objective of this work is to compile the available evidence regarding the role that Mg plays in health and disease, with a special focus on the elderly population with chronic kidney disease (CKD) and the eventual sex differences. A narrative review was carried out by executing an exhaustive search in the PubMed, Scopus, and Cochrane databases. Ten studies were found in which the role of Mg and sex was evaluated in elderly patients with CKD in the last 10 years (2012–2022). The progression of CKD leads to alterations in mineral metabolism, which worsen as the disease progresses. Mg can be used as a coadjuvant in the treatment of CKD patients to improve glomerular filtration, but its use in clinical applications needs to be further characterized. In conclusion, there’s a need for well-designed prospective clinical trials to advise and standardize Mg supplementation in daily clinical practice, taking age and sex into consideration

Decay constants of P and D-wave heavy-light mesons

We investigate decay constants of P and D-wave heavy-light mesons within the mock-meson approach. Numerical estimates are obtained using the relativistic quark model. We also comment on recent calculations of heavy-light pseudo-scalar and vector decay constants.Comment: REVTeX, 22 pages, uses epsf macro, 8 postscript figures include

A Polyextreme Hydrothermal System Controlled by Iron: The Case of Dallol at the Afar Triangle

One of the latest volcanic features of the Erta Ale range at the Afar Triangle (NE Ethiopia) has created a polyextreme hydrothermal system located at the Danakil depression on top of a protovolcano known as the dome of Dallol. The interaction of the underlying basaltic magma with the evaporitic salts of the Danakil depression has generated a unique, high-temperature (108 °C), hypersaline (NaCl supersaturated), hyperacidic (pH values from 0.1 to −1.7), oxygen-free hydrothermal site containing up to 150 g/L of iron. We find that the colorful brine pools and mineral patterns of Dallol derive from the slow oxygen diffusion and progressive oxidation of the dissolved ferrous iron, the iron-chlorine/-sulfate complexation, and the evaporation. These inorganic processes induce the precipitation of nanoscale jarosite-group minerals and iron(III)- oxyhydroxides over a vast deposition of halite displaying complex architectures. Our results suggest that life, if present under such conditions, does not play a dominant role in the geochemical cycling and mineral precipitation at Dallol as opposed to other hydrothermal sites. Dallol, a hydrothermal system controlled by iron, is a present-day laboratory for studying the precipitation and progressive oxidation of iron minerals, relevant for geochemical processes occurring at early Earth and Martian environmentsThis work received funding from the European Research Council under the Programme (FP7/2007-2013)/ERC Grant Agreement 340863 (Prometheus) and from MINECO, ref CGL2016-78971-P, AEI/FEDER, UE”

Virgin olive oil reduces blood pressure in hypertensive elderly subjects

Background and aims: Hypertension is one of the most important risk factors for coronary heart disease. Recent studies have pointed out the possibility that virgin olive oil may lower blood pressure in hypertensive subjects. However, until the date there is scarce information regarding elderly people. The present study was designed to assess the effect of dietary virgin olive oil on blood pressure in medically-treated hypertensive elderly patients. Methods: 31 medically-treated hypertensive (HT) elderly patients and 31 normotensive (NT) elderly volunteers participated in a randomized sequential dietary intervention. Subjects consumed diets enriched in sunflower oil (SO) or virgin olive oil (VOO) for four weeks each with a four-week washout period between them. Results: VOO reduced total and LDL-cholesterol in NT but not in HT (p<0.01) and the concentrations were lower than in the group consuming SO. In contrast, no significant differences were found in the levels of tocopherols among the groups studied. Ironinduced oxidation of LDL resulted in a complete loss of monoacylglycerols (MG) and diacylglycerols (DG) and a reduction in triacylglycerols (TG) (60-80%), which was found to be greater in HT (p<0.01) with no effect of diet. VOO consumption normalized systolic pressure in the HT group (136 ± 10 mmHg) compared to SO (150 ± 8 mmHg). Conclusion: dietary VOO proved to be helpful in reducing the systolic pressure of treated HT elderly subjects. However, a greater resistance to the lowering effect of VOO of total and LDL-cholesterol and a greater susceptibility to TG oxidation was detected in these patients.Facultad de Ciencias Veterinaria

Producción de lipasas por la levadura Yarrowia lipolytica

Yarrowia lipolytica es una levadura dimórfica que secreta gran cantidad de proteínas al medio de cultivo, entre ellas: proteasas - alcalinas, neutras y ácidas -, ribonucleasas, fosfatasas y lipasas. Las lipasas son enzimas importantes en el metabolismo de ácidos grasos, catalizando la hidrolisis de triglicéridos a ácidos grasos y glicerol