Quasi-Real Indexing-- The Pareto-Efficient Solution to Inflation Indexing

In a pure-exchange economy with one good, stochastic aggregate demand and supply, and consumers having the same relative-risk aversion, Pareto efficiency requires each individual’s consumption to be proportional to aggregate supply. While neither nominal contracts nor pure inflation- indexed contracts provide this proportionality, quasi-real contracts do. Quasi-real contracts adjust for aggregate-demand-caused inflation but not for aggregate-supply-caused inflation, causing their real obligations to be proportional to aggregate supply. When consumers differ in their relative risk aversion, or experience stochastic utility or endowment shocks, they will need insurance and other risk-transfer contracts in addition to quasi-real contracts.inflation indexing, quasi-real indexing

Sounding the Alarm on Inflation Indexing and Strict Inflation Targeting

Unanticipated inflation or deflation causes one party of a nominal contract to gain at the expense of the other party, an effect absent in macroeconomic models with one representative consumer or with consumers having identical consumption. In this paper's general dynamic and stochastic equilibrium model, diverse consumers maximize risk-averse utility and rent labor and land to profit-maximizing firms. Both inflation indexing and strict inflation targeting are Pareto inefficient. When Pareto sharing of changes of aggregate supply is proportional, nominal contracts under perfect nominal income targeting are Pareto efficient, while quasi-real contracts are Pareto efficient regardless.inflation indexing, inflation targeting, quasi-real indexing, nominal income targeting

Exploration of Health Care Needs Among Sudanese Refugee Women

Many Sudanese refugees that have resettled in the United States have experienced severe trauma and loss during their migration, as well as physical, social, and psychological struggles in their continued adaptation to living in a new country. This study explored the healthcare needs of Sudanese women as they transition to living in the United States. Community-Based Collaborative Action Research (CBCAR) provided a framework for the study. Qualitative descriptive design using focus groups was utilized to explore the healthcare needs of Sudanese Women. Eighteen women participated in the study, which consisted of five educational sessions that were immediately followed by five audio-taped focus groups. The educational seminars presented topics such as parenting skills, preventative health practices, childhood illnesses, and emotional well-being. Focus groups allowed for a confidential setting in which women were able to reflect on the information presented, as well as verbalize topics that they would like to receive more education on in the future. Three themes were identified that reflected experience of Sudanese women. These included being pulled between two worldviews in ways of parenting and communicating with children, multiple difficulties maneuvering within the US health care system, and internal struggles in meeting emotional needs in their transition to living in the United States. This study may contribute to the empowerment of Sudanese women by providing them with a greater understanding and ability to maneuver within the US healthcare system. This partnering interchange may also increase nursing knowledge in offering culturally competent care to the Sudanese community and other refugee populations that have resettled in the United States.University of Kansas School of Nursing. Bachelor of Science in Nursing Honors Progra

Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia

Background: Uraemia leads to a number of metabolic and hormonal disorders including defective carbohydrate metabolism. Endocannabinoids exert their effect on insulin and glucagon secretion via activation of specific receptors named CB1 and CB2. For this reason and the absence of reports on location and immunoreactivity of CB1, CB2 receptors compared to immunoreactivity of insulin- and glucagon-secreting cells in experimental uraemia, the author decided to investigate this issue. The aim of the present study was the immunohistochemical localisation and evaluation of cannabinoid receptors (CB1, CB2), insulin and glucagon in the pancreatic islets of uraemic rats. Materials and methods: Fragments of the rat’s pancreas were collected 28 days after surgical resection of one kidney and removal of 70% of the other kidney cortex. Paraffin-embedded sections were stained with haematoxylin-eosin and immunohistochemical reactions were performed with the use of a specific antibody against CB1-, CB2-receptors, insulin and glucagon. Results: It was revealed the decreased immunoreactivity of the CB1 receptor and higher intensity of the immunohistochemical reaction against CB2 receptor as compared to the value in the control animals. Significantly higher immunoreactivity of glucagon-positive cells and weaker immunoreactivity of insulin-positive cells were observed in pancreatic islets of uraemic rats. Conclusions: The obtained results indicate the involvement of cannabinoid receptors in the pathomechanism of carbohydrate metabolism disorders, associated with abnormal secretion of hormones by the α and β cells in uraemia

Macrofungi of the Bieszczady Mountains

The Bieszczady Mts, a mountain range in SE Poland, is a hot spot of fungal richness and diversity in Poland. This paper summarizes 5 years of studies in the Bieszczady Mts, as well as previously published research. A total of 1,377 macromycetes taxa were found, including many (464) which were protected, red-listed, or very rare in Poland. Thirty-eight taxa (nine Ascomycota and 29 Basidiomycota) have been reported in Poland for the first time: Agrocybe gibberosa, Auriporia aurulenta, Bolbitius variicolor, Bulgariella pulla, Chaetosphaerella phaeostroma, Clitocybe subspadicea, Clitopilus passeckerianus, Cortinarius anomalus var. subcaligatus, C. fervidus, C. flexipes var. inolens, C. sylvae-norvegicae, Cudoniella tenuispora, Entoloma bisporigerum, E. olorinum, E. poliopus var. parvisporigerum, E. sericeoides, Galerina caulocystidiata, Gymnopilus josserandii, Hymenoscyphus subferrugineus, Hypholoma olivaceotinctum, Inocybe queletii, Laccaria altaica, Lactarius romagnesii, L. rostratus, Mycena epipterygia var. atroviscosa, M. epipterygia var. candida, M. polygramma f. candida, Octavianina lutea, O. mutabilis, Pachyella violaceonigra, Panaeolus papilionaceus var. capitatocystis, Phaeocollybia jennyae, Psathyrella almerensis, Pyrenopeziza inornata, Scutellinia torrentis, Tricholoma basirubens, Tricholomopsis flammula, and Vibrissea decolorans. For all new taxa, short descriptions based on the collected material have been provided

Fabrication development for high-level nuclear waste containers for the tuff repository; Phase 1 final report

This final report completes Phase 1 of an engineering study of potential manufacturing processes for the fabrication of containers for the long-term storage of nuclear waste. An extensive literature and industry review was conducted to identify and characterize various processes. A technical specification was prepared using the American Society of Mechanical Engineers Boiler & Pressure Vessel Code (ASME BPVC) to develop the requirements. A complex weighting and evaluation system was devised as a preliminary method to assess the processes. The system takes into account the likelihood and severity of each possible failure mechanism in service and the effects of various processes on the microstructural features. It is concluded that an integral, seamless lower unit of the container made by back extrusion has potential performance advantages but is also very high in cost. A welded construction offers lower cost and may be adequate for the application. Recommendations are made for the processes to be further evaluated in the next phase when mock-up trials will be conducted to address key concerns with various processes and materials before selecting a primary manufacturing process. 43 refs., 26 figs., 34 tabs

Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes

Stem cell-derived cardiomyocytes represent unique tools for cell- and tissue-based regenerative therapies, drug discovery and safety, and studies of fundamental heart-failure mechanisms. However, the degree to which stem cell-derived cardiomyocytes compare to mature cardiomyocytes is often debated. We reasoned that physiological metrics of engineered cardiac tissues offer a means of comparison. We built laminar myocardium engineered from cardiomyocytes that were differentiated from mouse embryonic stem cell-derived cardiac progenitors or harvested directly from neonatal mouse ventricles, and compared their anatomy and physiology in vitro. Tissues assembled from progenitor-derived myocytes and neonate myocytes demonstrated similar cytoskeletal architectures but different gap junction organization and electromechanical properties. Progenitor-derived myocardium had significantly less contractile stress and slower longitudinal conduction velocity than neonate-derived myocardium, indicating that the developmental state of the cardiomyocytes affects the electromechanical function of the resultant engineered tissue. These data suggest a need to establish performance metrics for future stem cell applications

Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells

Understanding the molecular pathways regulating cardiogenesis is crucial for the early diagnosis of heart diseases and improvement of cardiovascular disease. During normal mammalian cardiac development, collagen and calcium-binding EGF domain-1 (Ccbe1) is expressed in the first and second heart field progenitors as well as in the proepicardium, but its role in early cardiac commitment remains unknown. Here we demonstrate that during mouse embryonic stem cell (ESC) differentiation Ccbe1 is upregulated upon emergence of Isl1- and Nkx2.5- positive cardiac progenitors. Ccbe1 is markedly enriched in Isl1-positive cardiac progenitors isolated from ESCs differentiating in vitro or embryonic hearts developing in vivo. Disruption of Ccbe1 activity by shRNA knockdown or blockade with a neutralizing antibody results in impaired differentiation of embryonic stem cells along the cardiac mesoderm lineage resulting in a decreased expression of mature cardiomyocyte markers. In addition, knockdown of Ccbe1 leads to smaller embryoid bodies. Collectively, our results show that CCBE1 is essential for the commitment of cardiac mesoderm and consequently, for the formation of cardiac myocytes in differentiating mouse ESCs.Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BD/82280/2011]; FCT [SFRH/BPD/46506/2008, CEDOC/2015/36/iNOVA4Health/Multi/04462, SFRH/BPD/87114/2012, PTDC/SAU-ENB/121095/2010, HMSP-ICT/0039/2013]; Fundacao para a Ciencia e Tecnologia / Ministerio da Educacao e Ciencia [UID/Multi/04462/2013]; FEDER under the PT2020 Partnership Agreemen

Onto new horizons:Insights from the WeObserve project to strengthen the awareness, acceptability and sustainability of Citizen Observatories in Europe

WeObserve delivered the first European-wide Citizen Observatory (CO) knowledge platform to share best practices, to address challenges and to inform practitioners, policy makers and funders of COs. We present key insights from WeObserve activities into leveraging challenges to create interlinked solutions, connecting with international frameworks and groups, advancing the field through communities of practice and practitioner networks, and fostering an enabling environment for COs. We also discuss how the new Horizon Europe funding programme can help to further advance the CO concept, and vice versa, how COs can provide a suitable mechanism to support the ambitions of Horizon Europe