Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas

Recurrences of Hodgkin's Lymphoma (HL) 5 years after the initial therapy are rare. The aim of this study is to report a single centre experience of the clinical characteristics, outcome, and toxicity of pts who experienced very late relapses, defined as relapses that occurred 5 or more years after the achievement of first complete remission. Of 532 consecutive pts with classical HL treated at our Institute from 1985 to 1999, 452 pts (85%) achieved a complete remission. Relapse occurred in 151 pts: 135 (29.8%) within 5 years and 16 over 5 years (3.5%, very late relapses). Very late relapses occurred after a median disease-free interval of 7 years (range: 5–18). Salvage treatment induced complete remission in 14 pts (87.5%). At a median of 4 years after therapy for very late relapse, 10 pts (63%) are still alive and free of disease and 6 (37%) died (1 from progressive HL, 1 from cardiac disease, 1 from thromboembolic disease, 1 from HCV reactivation, and 2 from bacterial infection). The probability of failure-free survival at 5 years was 75%. The majority of deaths are due to treatment-related complications. Therapy regimens for very late relapse HL are warranted to minimize complications

ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force

The ATP-sensitive K-channels (KATP) are distributed in the tissues coupling metabolism with K ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1), and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR variants that confer distinct physiological properties on the channel. An high expression/activity of the sarco-KATP channel is observed in various rat fast-twitch muscles, characterized by elevated muscle strength, while a low expression/activity is observed in the slow twitch muscles characterized by reduced strength and frailty. Down-regulation of the KATP subunits of fast-twitch fibers is found in conditions characterized by weakness and frailty. KCNJ11 gene knockout mice have reduced glycogen, lean phenotype, lower body fat, and weakness. KATP channel is also a sensor of muscle atrophy. The KCNJ11 gene is located on BTA15, close to a QTL for meat tenderness, it has also a role in glycogen storage, a key mechanism of the postmortem transformation of muscle into meat. The role of KCNJ11 gene in muscle function may underlie an effect of KCNJ11 genotypes on meat tenderness, as recently reported. The fiber phenotype and genotype are important in livestock production science. Quantitative traits including meat production and quality are influenced both by environment and genes. Molecular markers can play an important role in the genetic improvement of animals through breeding strategies. Many factors influence the muscle Warner-Bratzler shear force including breed, age, feeding, the biochemical, and functional parameters. The role of KCNJ11gene and related genes on muscle tenderness will be discussed in the present review

Results and complications of bilateral limb lengthening in achondroplasia: a retrospective analysis

BackgroundAchondroplasia is one of the main causes of disharmonic dwarfism. Patients with achondroplasia might have physical and psychological limitations due to their disproportionate stature. Surgical limb lengthening is the only practical option available to achieve a stature comparable to normal population range. The purpose of this study is to analyze results and complications of our lengthening protocol.MethodsA retrospective analysis was performed on 33 patients with achondroplasia (21 females and 12 males) undergoing simultaneous bilateral tibia or femur lengthening in four surgical stages from 2017 to 2021 (46 lengthening procedures, with a total of 56 tibias and 36 femurs). For each patient, patients’ characteristics and antero-posterior and lateral radiographs were obtained. The following parameters were analyzed: duration of lengthening with external fixator, amount of lengthening, complications or events that influenced outcomes and the healing index (HI).ResultsThe average tibial and femoral gain was 7.9 cm and 6.9 cm, respectively. The tibiae achieved better results than the femurs (p = 0.005). Nineteen complications were reported for 92 segments (20.7%), and the variables influencing complications were: step (p = 0.002) and fixation duration (p = 0.061).ConclusionsBilateral parallel lower limb lengthening in four surgical steps may be a viable technique in patients with achondroplasia

Introducing the Bulletin of Atmospheric Science and Technology

The rapid technological development of the past few decades has allowed for an unprecedented wealth of data about ourselves and our planet. The cost reduction of space platforms, the microelectronic revolution and the nearly exponential increase in computer power have been generating novel opportunities to explore and understand the world around us. Tools and theoretical approaches, capable of putting together all the insights we may possibly gain from all these new streams of data in a multidisciplinary framework, are still being developed. We are hence faced with both a unique challenge and an opportunity to make a significant progress in many scientific fields, first and foremost in the atmospheric and climate sciences. We are pleased to announce here the launch of the Bulletin of Atmospheric Science and Technology (BAST), a new peer-reviewed journal which is meant to bridge this gap in the broad area of the atmospheric sciences. The journal encourages a cross-disciplinary approach with an emphasis on new sensor technologies and systems, combined observational and modeling techniques, innovative numerical methods, data analysis, and retrieval techniques. BAST offers a platform to share new ideas and fresh developments to stimulate research activities focusing on urban, coastal, marine, rural, and mountain environments. Particular attention will be given to cross-disciplinary studies, especially those involving citizens for the collection of crowd-sourced data and those devoted to the characterization of uncertainties and homogenization of methods. BAST aims at connecting weather and climate communities using both observational and modeling approaches, creating a forum hosting discussion and brainstorming activities. The journal also hopes to attract contributions reporting approaches or techniques from other scientific fields that can be applicable to atmospheric sciences, as well as contributions where technological developments are discussed alongside with their scientific and societal impacts. In this sense BAST will provide a new platform to support the technological revolution towards a climate-smart society through the collection and exploitation of big data. The journal will give visibility to international experiments and projects in atmospheric science and technology, illustrating preliminary or consolidated results from these initiatives. Additional fields of interest are : environmental protection; observation, understanding, and modeling of hazardous and extreme events and mitigation of their impacts; development of new sensing tools integrating satellite information with surface or airborne measurements; operation of unmanned and remotely piloted air vehicles equipped with sensors of small size and weight, especially remote sensors, pushing electro-optical-mechanical components towards a continuously increasing miniaturization. Research articles, Review articles, Technical reports, Brief reports, Letters and News are welcome. While keeping the focus of the journal on scientific research, the “Bulletin” format provides appropriate visibility to contributions from the operational side, i.e., meteorological services and private companies developing sensors and products of interest to the atmospheric science and technology community. Below we provide a more detailed description of the topics that will be emphasized and fostered in BAST

Data from: Development of chloroplast genomic resources for Cynara

In this study, new chloroplast (cp) resources were developed for the genus Cynara, using whole cp genomes from 20 genotypes, by means of high-throughput sequencing technologies. Our target species included seven globe artichokes, two cultivated cardoons, eight wild artichokes, and three other wild Cynara species (C. baetica, C. cornigera, and C. syriaca). One complete cp genome was isolated using short reads from a whole genome sequencing project, while the others were obtained by means of long-range PCR, for which primer pairs are provided here. A de novo assembly strategy, combined with a reference based assembly allowed us to reconstruct each cp genome. Comparative analyses among the newly sequenced genotypes and two additional Cynara cp genomes (“Brindisino” artichoke and C. humilis) retrieved from public databases revealed 126 parsimony informative characters and 258 singletons in Cynara, for a total of 384 variable characters. Thirty-nine SSR loci and 34 other INDEL events were detected. After data analysis, 37 primer pairs for SSR amplification were designed, and these molecular markers were subsequently validated in our Cynara genotypes. Phylogenetic analysis based on all cp variable characters provided the best resolution when compared to what was observed using only parsimony informative characters, or only short “variable” cp regions. The evaluation of the molecular resources obtained from this study led us to support the “super-barcode” theory and consider the total cp sequence of Cynara as a reliable and valuable molecular marker for exploring species diversity and examining variation below the species level

Stress Fracture of the Ulna in an Elite Ice Dancer

Stress fracture of the ulna is a rare overuse injury often arising from repetitive excessive forearm rotation. Here we report the first case of ulnar stress fracture in a female ice dancer. Diagnosis was made by history and physical examination, with the aid of imaging studies (plain x-ray, computed tomography, and magnetic resonance imaging), and biomechanical analysis of forearm pronation and supination. Following identification and modification of the causal technical element, the ice dancer was able to continue training and competing without cessation of activity. Treatment was with a 30-day course of capacitively coupled bone stimulation to promote fracture healing, confirmed on radiography and magnetic resonance imaging. Such injuries to ice dancers may be prevented at the planning stage of technical elements in the dance program if coaches place more attention on the potentially deleterious effects of difficult positions the lifted dancer must sustain to reward points on the technical elements score

Cynara MSA for phylogeny

Cynara MSA for phylogen

Cynara MSA

Cynara MS