Validação da aplicação do modelo TPACK associado às habilidades de consciência fonológica e conhecimento de letras para educadoras de crianças pré-escolares

Objective. This study aimed to validate an instrument that allows knowing the perception nursery educators have about their disciplinary, pedagogical, and technological knowledge when they incorporate ICT in teaching two skills that underlie learning to read and write: phonological awareness and letter knowledge. Methodology. This research was a non-experimental, cross-sectional, quantitative study. A Likert-type survey, composed of 54 items that collect information from seven dimensions considered by the TPACK model, was used as an instrument. Thirty nursery educators participated in this study; they work with children of Transition level (early childhood education) from municipal schools in Penco, province of Concepción, Chile. For the validation of the instrument, the expert judgment technique was used, according to the method of Lawshe (1975) and the modifications made by Tristán-López (2008); for its reliability, the internal consistency coefficient Cronbach’s alpha was considered. Results. The main results indicate that the scale has high reliability and significant positive correlations, which indicates that it is a valid tool to be used as a diagnostic instrument that will identify the weaknesses and strengths of nursery educators in terms of their knowledge regarding the use of ICT for educational purposes in written language.Objetivo. Este estudio tuvo como propósito validar un instrumento que permita conocer la percepción que tienen las educadoras de párvulos sobre sus conocimientos disciplinares, pedagógicos y tecnológicos cuando incorporan las TIC en la enseñanza de habilidades que subyacen al aprendizaje de la lectura y escritura: conciencia fonológica y conocimiento de letras. Metodología. Este estudio se enmarca en un enfoque cuantitativo no experimental de tipo transversal. Se utilizó como instrumento, una encuesta tipo Likert, compuesta de 54 ítems que recopilan información de siete dimensiones que consideran el modelo TPACK. En esta investigación participaron 30 educadoras de párvulos que se desempeñan en el nivel Transición, de escuelas municipales de la comuna de Penco, provincia de Concepción, Chile. Para la validación del instrumento se utilizó la técnica de juicio experto, según el método de Lawshe (1975) y las modificaciones realizadas por Tristán-López (2008) y para su fiabilidad se consideró el coeficiente de consistencia interna alfa de Cronbach. Resultados. Los principales resultados indican que la escala presenta una alta fiabilidad y correlaciones significativas positivas, lo que indica que es una herramienta válida para ser utilizada como instrumento de tipo diagnóstico que permitirá identificar debilidades y fortalezas de las educadoras de parvularios en cuanto a sus conocimientos frente al uso de las TIC para fines educativos en el lenguaje escrito.Objetivo. O objetivo deste estudo foi validar um instrumento que permita conhecer a percepção que as educadoras de crianças têm sobre seus conhecimentos disciplinares, pedagógicos e tecnológicos ao incorporar as TIC no ensino de habilidades subjacentes ao aprendizado da leitura e da escrita: consciência fonológica e conhecimento das letras. Metodologia. Este estudo segue uma abordagem quantitativa não experimental de tipo transversal. Utilizou-se como instrumento um levantamento do tipo Likert, composto por 54 itens que coletam informações de sete dimensões consideradas pelo modelo TPACK. Participaram desta pesquisa 30 professoras de escolas maternais que atuam no nível Transitório, de escolas municipais da comunidade de Penco, província de Concepción, Chile, para a validação do instrumento foi utilizada a técnica de julgamento por especialistas, segundo o método de Lawshe (1975) e as modificações feitas por Tristán-López (2008) e por sua confiabilidade, foi considerado o coeficiente de consistência interna alfa de Cronbach. Resultados. Os principais resultados indicam que a escala apresenta uma alta confiabilidade e correlações positivas significativas, o que indica que é uma ferramenta válida para ser utilizada como instrumento de diagnóstico que identificará fragilidades e potencialidades das educadoras da infância quanto ao seu conhecimento do uso das TIC para fins educativos em linguagem escrita

El efecto del liderazgo transformacional en las variables de resultados en la industria restaurantera

This article aims at showing the relationships between the imensions of leadership and outcomes through the correlation  coefficient r  of  Pearson.  The research  was  carried  out  at  restaurants  in Nuevo Vallarta in the municipality of Bahia de Banderas, Nayarit, Mexico, with a total of 43 cases observed.  The  findings  indicate  that,  of the  27  pairs  that  are  grouped  in  relations  between  the leadership and the results correlated significantly 15 of them that mean the 55.56% of the possible combinations. In the aggregate, 80% of the observed significative relationships with the outcome variables are given in  transformational  leadership  and  the  remaining  20% in  the  transactional leadershipEl presente artículo, tiene por objeto,  mostrar las relaciones existentes entre las dimensiones del liderazgo y los resultados a través del coeficiente de correlación r de Pearson. La investigación se llevó a cabo en los restaurantes de Nuevo Vallarta en el municipio de Bahía de Banderas, Nayarit, México, con un total de 43 casos observados. Los hallazgos indican que, de los 27 binomios en que se agrupan las relaciones entre el liderazgo y los resultados correlacionan significativamente 15 de ellos que significan el 55.56% de las posibles combinaciones. De forma agregada, el 80% de las relaciones significativas observadas con las variables de resultado se dan en el liderazgo transformacional y el 20% restante en el liderazgo transaccional

Propuesta para la implementación de un sistema de información que permita la obtención de datos en forma real de los productos químicos de la empresa Lipesa Colombia S.A.

El presente proyecto de grado propone la implementación de un sistema de información, en el área de inventarios, de la empresa LIPESA COLOMBIA S.A., que le permita obtener información en tiempo real que facilite la toma de decisiones en los procesos de compras, producción y distribución de sus productos químicos.Especialista en Gerencia LogísticaEspecializació

Ex Vivo and In Vivo Anti-inflammatory Evaluations of Modulated Flavanones Solutions

Abstract: Interest has developed in natural molecules due to their clinically proven effects on skin deseases. Flavanones display several biological activities, and recently have been the focus of studies due to their anti-inflammatory effect. To improve their pharmacological profile four flavanones (A, B, C and D), were synthesized by structural modification of one natural flavanone 1 (semi-systematic name: (2S)-5,7-dihydroxy-6-prenylflavanone) extracted from Eysenhardtia platycarpa. The hydroalcoholic flavanone solutions (FS) were assayed to investigated their anti-inflammatory effect on two in vivo cutaneous inflammation models. Materials and methods: the topical anti-inflammatory effect of FS were evaluated against models of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema and arachidonic acid (AA) in rat ear edema. Results: The vinylogous cyclized derivative (flavanone D) caused edema inhibition in the TPA- induced models with an inhibition of 96.27 ± 1.93 %; equally effective and potent in inhibiting the mouse ear edema as Indometacine had been. In addition, the AA-induced increase in ear thickness was reduced the most by the topical application of modulated ether (flavanone B). Conclusions: The in vivo and histology results suggest that flavanones B and D are effective as a topical anti-inflammatory agents in inflammatory processes. Thus, this new compounds represents a promising agent for the management of skin diseases with an inflammatory component

In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments

The increasing number of skin cancer cases worldwide and the adverse side effects of current treatments have led to the search for new anticancer agents. In this present work, the anticancer potential of the natural flavanone 1, extracted from Eysenhardtia platycarpa, and four flavanone derivatives 1a-d obtained by different reactions from 1 was investigated by an in silico study and through cytotoxicity assays in melanoma (M21), cervical cancer (HeLa) cell lines and in a non-tumor cell line (HEK-293). The free compounds and compounds loaded in biopolymeric nanoparticles (PLGA NPs 1, 1a-d) were assayed. A structure-activity study (SAR) was performed to establish the main physicochemical characteristics that most contribute to cytotoxicity. Finally, ex vivo permeation studies were performed to assess the suitability of the flavanones for topical administration. Results revealed that most of the studied flavanones and their respective PLGA NPs inhibited cell growth depending on the concentration; 1b should be highlighted. The descriptors of the energetic factor were those that played a more important role in cellular activity. PLGA NPs demonstrated their ability to penetrate (Qp of 17.84-118.29 micrograms) and be retained (Qr of 0.01-1.44 g/gskin/cm2) in the skin and to exert their action for longer. The results of the study suggest that flavanones could offer many opportunities as a future anticancer topical adjuvant treatment

PLGA Nanoparticles Containing Natural Flavanones for Ocular Inflammation

Flavanones are natural compounds that display anti-inflammatory activity. The aimof this work was to prepare PLGA nanoparticles (NPs) containing natural flavanones I ((2S)-5,7-dihydroxy-6-methyl-8-(3-methyl-2-buten-1-il)-2-phenyl-2,3-dihydro-4H-1-Benzopyran-4-one) andII (2S)-5,7-dihydroxy-2-(40-methoxyphenyl)-6-methyl-8-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-1-Benzopyran-4-one) (NP I and NP II, respectively) so as to evaluate their potential for topical antiinflammatoryocular therapy. An in silico study was carried out using the Molinspiration® and PASSOnline web platforms before evaluating the in vitro release study and the ex vivo porcine corneaand sclera permeation. The HPLC analytical method was also established and validated. Finally, thein vitro anti-inflammatory efficacy of NPs was studied in the HCE-2 model. The flavanones I and IIcould be released following a kinetic hyperbolic model. Neither of the two NPs was able to permeatethrough the tissues. NP I and NP II were found to be respectful of any changes in the tissues’morphology, as evidenced by histological studies. In HCE-2 cells, NP I and NP II were not cytotoxicat concentrations up to 25 M. NP I showed higher anti-inflammatory activity than NP II, being ableto significantly reduce IL-8 production in LPS-treated HCE-2 cells. In summary, ocular treatmentwith NP I and NP II could be used as a promising therapy for the inhibition of ocular inflammation

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

POR UNA CULTURA DE PAZ: UNA MIRADA DESDE LAS CIENCIAS DE LA CONDUCTA

En
 virtud
 de
 lo
 anterior,
 los
 estudiosos
 de
 las
 ciencias
 de
 la
 conducta
 
de
 la
 Universidad
Autónoma 
del
 Estado 
de 
México,

ante 
la
persistencia
 y 
proliferación
 de
 estos 
hechos
 en
 diversas
 partes
 del
Mundo
 y
 de
 nuestro 
país 
en 
particular, se
 convocó
 a
 los
 estudiosos
 interesados
 y
 a
 la
 sociedad
 en
 general
 a
 presentar
 trabajos
 para
 analizar,
 debatir
 y
 proponer
 estrategias
 de
 acción
 y
 dirección,
 que
 fortalezcan
 una
 convivencia y bienestar con sentido humanista para una cultura de paz. El
 presente
 texto
 es
 producto
 de 
esta convocatoria 
que
 recoge 
los
trabajos 
de 

los
 interesados 
en 
la
 temática,

 de
 diferentes 
países
(España,
Argentina,
Cuba,
Brasil,
Costa
 Rica
 y
 México)
 retomando
 con
 ello
 sus
 experiencias
 relativas
 al
 estudio,
 análisis,
 comprensión
 e
 instrumentación
 de
 la
 cultura
 de
 paz
 en
 los
 distintos
 ámbitos
 institucionales
 en
 los
 que
 participan:
 educativo,
 salud,
 penitenciario,
 social,
laboral,
familia,
alimentario,
psicológico,
por 
mencionar 
algunos.
 El
 presente
 libro,
 propicia
 un
 espacio
 de
 reflexión,
 diálogo
 y
 posicionamiento
 de
 las 
ciencias 
de 
la 
conducta
 para 
la 
apropiación,
análisis,
debate
 y 
propuestas 
que
 fortalezcan 
una
 cultura
 de 
paz
 a
través
 de 
la
 convivencia 
y
 el 
bienestar
 social 
con
 sentido 
humanista.
El
 sistema 
económico
 neoliberal
 y 
el 
proceso
 de 
globalización 
han
 contribuido
al
 logro
 de
 avances
 significativos
 en
 la
 ciencia
 y
 la
 tecnología,
 pero
 también
 han
 propiciado
 la
 polarización
 de
 las
 sociedades
 lo
 que
 ha
 impactado
 de
 manera
 negativa
 a
 la
 sociedad
 en
 su
 conjunto,
 pero
 en
 mayor
 medida
 a
 los grupos
 vulnerables. Dicha
 polarización
 ha
 traído
 consigo
 un
 desarrollo
 desigual
 del
 mundo
 que
 se
 expresa
 de
 diferentes
 maneras
 tanto
 en
 países
 desarrollados
 como
 en
 los
 llamados
 del
 tercer
 mundo,
 en
 donde
 no
 están
 satisfechas
 las
 necesidades
 humanas 
elementales
 de
 todos 
los
sectores 
de 
la 
población,
siempre 
falta 
algo. 
Si 
a
 esto 
le
 sumamos 
los
conflictos
 internacionales por
 diferentes
 motivos
 que
 enfrentan
 algunas
 naciones,
 una
 insuficiente
 cobertura
 educativa
 y
 de
 salud,

 desempleo
 y
 pobreza 
extrema,
 entre 
otras
 cosas; 
estamos
 frente
 a
retos 
de
 gran
 envergadura
 para
 los
 gobiernos,
 para
 los
 estudiosos
 y
 para
 la
 sociedad
 civil
 en
 general. Uno 
de 
los
 intentos
 para
 frenar 
y prevenir 
la
 agudización
 de 
estas 
problemáticas
 es
 la
 cultura 
de 
paz,
cuyo
 estudio
y propuestas 
han 
ido 
avanzando 
en 
diferentes
 sentidos 
y 
de 
manera 
favorable,
el 
tema 
está 
presente 
en 
diferentes 
Organismos
 Internacionales
 como
 la
 ONU,
 la
 UNESCO,
 la
 OCDE,
 El
 Banco
 Mundial,
 entre
 otros.
 Pero
 falta 
mucho 
por 
hacer.Universidad Autónoma del Estado de Méxic

Experiencias en el aula: cuarto encuentro de prácticas pedagógicas innovadoras.

Cuarto encuentro de prácticas pedagógicas innovadoras, evento que se llevo a cabo los días 7 y 8 de Octubre de 2019

Experiencias en el aula: cuarto encuentro de prácticas pedagógicas innovadoras.

Cuarto encuentro de prácticas pedagógicas innovadoras, evento que se llevo a cabo los días 7 y 8 de Octubre de 2019