23 research outputs found
Base de datos multicĂ©ntrica de hemorragia subaracnoidea espontĂĄnea del Grupo de Trabajo de PatologĂa Vascular de la Sociedad Española de NeurocirugĂa: presentaciĂłn,criterios de inclusiĂłn y desarrollo de una base de datos en internet = Spontaneous Subarachnoid Haemorrhage multicenter database from the Group for the Study of Vascular Pathology of the Spanish Society for Neurosurgery: Presentation, inclusion criteria and development of an internet-based registry
IntroducciĂłn. La hemorragia subaracnoidea (HSA) continĂșa siendo una de las enfermedades de interĂ©s neuroquirĂșrgico de mĂĄs alta morbilidad y mortalidad. Su estudio es clave a la hora de mejorar la atenciĂłn de estos enfermos en nuestro medio. Con este fin el Grupo de Trabajo de PatologĂa Vascular de la SENEC decidiĂł la creaciĂłn de una base de datos multicĂ©ntrica para su estudio. Material y mĂ©todos. Se incluyen en esta base de datos todos los casos de hemorragia subaracnoidea espontĂĄnea ingresados en los centros participantes de forma prospectiva desde Noviembre del año 2004 hasta Noviembre del 2007. Se decidieron de forma consensuada los campos a recoger incluyendo edad, antecedentes personales, caracterĂsticas clĂnicas, caracterĂsticas radiolĂłgicas y del aneurisma, tipo de tratamiento y complicaciones de la enfermedad, evoluciĂłn segĂșn la escala de evoluciĂłn de Glasgow (GOS) al alta y a los seis meses asĂ como el resultado angiogrĂĄfico del tratamiento. Todos los campos se recogieron en un formulario rellenable a travĂ©s de una pĂĄgina web segura. Resultados. En los tres años en los que ha estado activa la base se han recogido un total de 1149 casos de HSA espontĂĄnea recogidos por 14 centros participantes. Se ha estimado que es necesario aproximadamente un tiempo de 3.4 minutos para rellenar cada caso. En cuanto a sus caracterĂsticas generales la serie es similar a otras series hospitalarias no seleccionadas. La edad media de los enfermos incluidos es de unos 55 años y la relaciĂłn mujer:hombre 4:3. En cuanto a la gravedad del sagrado inicial un 32% de los enfermos se encontraba en mal grado clĂnico (WFNS = 4 Ăł 5). El 5% de los pacientes fallecieron antes de realizarse una angiografĂa que confirmara el origen aneurismĂĄtico del sangrado. Se confirmĂł el origen aneurismĂĄtico en el 76% de los pacientes mientras que en el 19% no se encontrĂł ninguna lesiĂłn vascular responsable del sangrado, siendo clasificados como HSA idiopĂĄtica. En los pacientes en los que se detectĂł un aneurisma su tratamiento fue endovascular en el 47% de los casos, quirĂșrgico en el 39, mixto en el 3% y no recibieron tratamiento de su aneurisma el 11% de los pacientes por fallecimiento precoz. En cuanto a su evoluciĂłn, la mortalidad global de la serie se sitĂșa en el 22%. SĂłlo el 40% de los enfermos con HSA aneurismĂĄtica presentaron una buena evoluciĂłn (GOS=5). Conclusiones. La HSA espontĂĄnea continĂșa siendo una enfermedad con alta morbilidad y mortalidad. Esta base de datos puede ser un instrumento para conocer mejor sus caracterĂsticas en nuestro medio y mejorar sus resultados, ya que se trata de una serie multicĂ©ntrica hospitalaria no seleccionada. SerĂa pues recomendable que esta base constituyera el germen de un registro nacional de HSA espontĂĄnea.
Introduction. Subarachnoid haemorrhage is one of the most severe neurosurgical diseases. Its study is crucial for improving the care of these patients in our environment. With this goal the Group for the Study of Neurovascular Pathology of the Spanish Society for Neurosurgery (SENEC) decided to create a multicenter registry for the study of this disease. Materials and methods. In this database we have prospectively included all cases with spontaneous subarachnoid haemorrhage admitted to the participant hospitals from November 2004 to November 2007. The fields to be included in the database were selected by consensus, including age, past medical history, clinical characteristics at admission, radiological characteristics including presence or absence of an aneurysm and its size and location, type and complications of the aneurysm treatment, outcome assessed by the Glasgow Outcome Scale (GOS) at discharge and six months after the bleeding as well as the angiographic result of the aneurysm treatment. All fields were collected by means of an electronic form posted in secure web page. Results. During the three years of study a total of 1149 patients have been included by 14 Hospitals. The time needed to fill in a patient in the registry is approximately 3.4 minutes. This series of patients with spontaneous SAH is similar to other non-selected in-hospital series of SAH. The mean age of the patients is 55 years and there is a 4:3 female to male ratio. In relation to the severity of the bleeding 32% of the patients were in poor clinical grade at admission (WFNS 4 or 5). 5% of the patients died before angiography could be performed. An aneurysm was confirmed as the origin of the bleeding in 76% of the patients (aSAH), while in 19% of the patients no lesion was found in the angiographic studies and were thus classified as idiopathic subarachnoid hemorrhage (ISAH). Of those patients with aSAH, 47% were treated endovascularly, 39% surgically, 3% received a combined treatment and 11% did not receive any treatment for their aneurysm because of early death. Regarding outcome, there is a 22% mortality in the series. Only 40% of the patients with aSAH reached a good outcome at discharge (GOS = 5). Conclusions. Spontaneous SAH continues to be a disease with high morbidity and mortality. This database can be an ideal instrument for improving the knowledge about this disease in our environment and to achieve better results. It would be desirable that this database could in the future be the origin of a national registry of spontaneous SAH
Una exposiciĂłn virtual muestra una investigaciĂłn sobre los comunales pastoriles de Castril, Santiago y Pontones.
Entre 2017 y 2019, el proyecto EXPLORA (PatrimonializaciĂłn socio-ecolĂłgica en comunales de España y Marruecos), constituido por un equipo interdisciplinar liderado por investigadores de la Universitat AutĂČnoma de Barcelona en colaboraciĂłn estrecha con la EstaciĂłn Experimental del ZaidĂn-CSIC de Granada, llevĂł a cabo una investigaciĂłn sobre la organizaciĂłn comunal de los pastos de montaña de Castril (Granada), Santiago de la Espada y Pontones (JaĂ©n). Los resultados de este trabajo forman parte ahora de una exposiciĂłn temporal en el Museo Virtual de EcologĂa Humana. Inaugurada en marzo de este año, estarĂĄ disponible en la red de manera permanente, e incluye tanto fotografĂas como material audiovisual. Su tĂtulo es Territorios de vida en el filo. Comunales pastoriles de las montañas del MediterrĂĄneo en el siglo XXI
Silver clusters of five atoms as highly selective antitumoral agents through irreversible oxidation of thiols
Low atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation of sulfur to S+6. Ag5 catalytic activity increases with different oxidant species in the order O2 âȘ H2O2 < OHâą. Selective oxidation of thiols on the cysteine residues of glutathione and thioredoxin is the primary mechanism human cells have to maintain redox homeostasis. Contingent upon oxidant concentration, Ag5 catalyzes the irreversible oxidation of glutathione and thioredoxin, triggering apoptosis. Modification of the intracellular environment to a more oxidized state to mimic conditions within cancer cells through the expression of an activated oncogene (HRASG12V) or through ARID1A mutation, sensitizes cells to Ag5 mediated apoptosis. While cancers evolve to evade treatments designed to target pathways or genetic mutations that drive them, they cannot evade a treatment that takes advantage of aberrant redox homeostasis, which is essential for tumor progression and metastasis. Ag5 has antitumor activity in mice with orthotopic lung tumors reducing primary tumor size, and the burden of affected lymphatic nodes. The findings suggest the unique intracellular redox chemistry of Ag5 may lead to new redox-based approaches to cancer therapyThis research was partially supported by 1) âla Caixaâ Foundation, Ref. LCF/PR/PR12/11070003 to F.D. and M.A.L.Q.; 2) Ministerio de Ciencia, InnovaciĂłn y Universidades (MAT2017-89678-R, AEI/FEDER, UE) to F.D. and A.V.; 3) the ConsellerĂa de EducaciĂłn (Xunta de Galicia), Grants No. Grupos Ref. Comp. ED431C 2017/22, ED431C 2019/13 and AEMAT-ED431E2018/08 to M.A.L.Q.; and ED431C 2019/13 to A.V. This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme (Bac-To-Fuel) under Grant Agreement No. 825999 (M.A.L.Q.). J.C.H. acknowledge financial support from European Union's Horizon 2020 research and innovation programme under grant agreement no. 823717-ESTEEM3, and the MICIIN (projects PID2019-107578GA-100 and PID-110018GA-100). J.M.D, L.J.G., and F.G.R. thank to the ANPCyT (PICT 2015-2285 and 2017-3944), UNLP (Project 11/X790) and the partial support by the LaboratĂłrio Nacional de Luz SĂncrotron (LNLS, Brazil) under proposal SXS-20180280. G.B. acknowledges the CINECA Award N. IsC51, year 2017, under the ISCRA initiative, for the availability of high-performance computing resources and support. D.B. expresses gratitude for a postdoctoral grant from Xunta de Galicia, Spain (POS-A/2013/018). B.D. expresses gratitude for a predoctoral grant from MICINN, Spain (BES-2016-076765). F.D. and A.V. also acknowledged Xunta de Galicia (Centro singular de investigaciĂłn de Galicia accreditation 2019-2022 ref ED431G 2019/02) and the European Union (European Regional Development Fund â ERDF). Work in M.P.M.'s lab was supported by the Medical Research Council UK (MC_U105663142). T.G.C. gratefully acknowledges the technical assistance of MarĂa JosĂ© Otero-Fraga (FIDIS)S
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic