Las competencias de las administraciones locales españolas en materia de aguas

Sumario: I. Pese a la ausencia de competencias sustantivas en materia de dominio público hidráulico, las entidades locales ejercen funciones en la materia y participan en los órganos de la administración pública del agua.— ii. El abastecimiento de agua potable, alcantarillado y saneamiento de aguas residuales como servicios públicos municipales. Competencias municipales en estas materias y concurrencia con competencias estatales y autonómicas.— iii. La competencia local para emitir las autorizaciones relativas a vertidos indirectos a aguas superficiales. La sentencia del tribunal supremo de 18 de octubre de 2006 y el real decreto ley 4/2007, de 13 de abril

Educación personalizada a través de la Web mediante la utilización de estámdares educativos y tecnologías de la Web Semántica

Para conseguir la personalización de la enseñanza asistida por computador o e-learning es necesario la división de los cursos en Objetos Educativos. Dichos Objetos Educativos deberán estar lo suficientemente documentados con metadatos para poder almacenarlos y gestionarlos en repositorios. Dichos metadatos deberán seguir unos estándares para que pueda ser entendido por cualquier sistema. En este proyecto se propone un estudio de dichos esquemas y una herramienta, MetaRDF. MetaRDF es una herramienta para la creación y edición de metadatos. Los esquemas utilizados en dicha herramienta son DC (Dublín Core), LOM (Learning Object Model) y LOMe (esquema basado en LOM propuesto en este proyecto para e-Aula). La clasificación descriptiva ofrecida por los estándares de metadatos se cumplimenta mediante taxonomías, que aportan significado a los contenidos, iniciando el camino hacia la web semántica. [ABSTRACT] To achieve the e-learning personalization the courses are required to be divide into Learning Objects. These Learning Objects have to be documented enough with metadata so it is possible to store and manage them in repositories. This metadata will have to follow some standards so any system can understand them. In this proyect, a study of these standards and a tool, Meta RDF, are proposed. MetaRDF is a tool for metadata creation and edition. The standard used in this tool are DC (Dublin Core), LOM (Learning Object Model) and LOMe ( and adaptation for e-Aula based in LOM). The descriptive classification offered by the metadata standards are cumplimented by the taxonomies, which give meaning to the content, starting the way that goes to the semantic Web

Galaxy Pairs in the 2dF Survey I. Effects of Interactions in the Field

We study galaxy pairs in the field selected from the 100 K public release of the 2dF galaxy redshift survey. Our analysis provides a well defined sample of 1258 galaxy pairs, a large database suitable for statistical studies of galaxy interactions in the local universe, $z \le 0.1$. Galaxy pairs where selected by radial velocity ($\Delta V$) and projected separation ($r_{\rm p}$) criteria determined by analyzing the star formation activity within neighbours (abridged). The ratio between the fractions of star forming galaxies in pairs and in isolation is a useful tools to unveil the effects of having a close companion. We found that about fifty percent of galaxy pairs do not show signs of important star formation activity (independently of their luminosities) supporting the hypothesis that the internal properties of the galaxies play a crucial role in the triggering of star formation by interactions.Comment: 9 pages, 11 Postscript figures. Submitted to MNRAS. Revised versio

The first comprehensive micro use-wear analysis of an early Acheulean assemblage (Thiongo Korongo, Olduvai Gorge, Tanzania)

Probably, one of the biggest questions about the Acheulean is focused on the functional aspects of its lithic industry and, more specifically, its link to subsistence activities developed by hominins during the Early Stone Age. Historically, tecno-functional research on ESA techno-complex has focused on the role played by flakes and LCT in the processing of animal carcasses, but less attention has been payed to other possible activities related with subsistence and tool making. Previous traceological studies on African Lower Paleolithic lithic industries have shown the complexity of activities made with the earliest lithic tools, including not only the processing of animal carcasses, but also activities dedicated to processing wood, non-woody plants and underground storage organs (USOs). In this paper we present the use-wear results obtained from the analysis of the Early Acheulean lithic tools with potentially functional edges which are part of the lithic assemblage from the Thiongo Korongo archaeological site (TK) (Olduvai Gorge, Tanzania). The three main levels of the archaeological site, TKSF, TKLSC and TKLF, have been used as samples. From 466 lithic artefacts analyzed, 16 pieces present sufficient preservation of use related traces that are able to clearly identify the activities developed when compared with experimental reference collections. As a result, we have identified activities mainly related with the cutting and scraping of wood and non-woody plants, including USOs. In addition, some pieces have also presented traces indicating the processing of animal carcasses. These data provides important information about different activities developed in TK by early hominids, allowing us to make broader inferences about the different subsistence activities carried out during the Acheulean in Eastern Africa.Depto. de Prehistoria, Historia Antigua y ArqueologíaFac. de Geografía e HistoriaTRUEMinisterio de Ciencia e Innovación (MICINN)pu

Inhibition of nervous necrosis virus replication by Shewanella putrefaciens Pdp11 extract

One of the most relevant infectious diseases affecting farmed fish is the viral encephalopathy and retinopathy, caused by the nervous necrosis virus (NNV). The two commercial vaccines available against this virus have been designed to protect European seabass against the infection with a particular NNV species, RGNNV. Therefore, the development of strategies to protect different fish species against different viruses is a key issue for the aquaculture industry. In this regard, there are numerous studies focused on the use of probiotics, although their antiviral activity has been poorly investigated. Shewanella putrefaciens Pdp11, SpPdp11, is a probiotic with proven positive effects on gilthead seabream and Senegalese sole, protecting those species against several bac- terial pathogens; however, its antiviral activity remains to be investigated. The current study is a step forward in the use of probiotics against viral infections, evaluating the anti-RGNNV activity of sonicated-SpPdp11 extracts both, in vitro and in vivo. According to our results, SpPdp11 extracts compromised RGNNV multiplication in E11 cells, affecting viral assembly and/or exit rather than genome replication. Furthermore, this antiviral activity may be produced by the capacity of the SpPdp11-extract to induce an immune response in treated cells. This antiRGNNV activity has been confirmed in vivo, since 82% of fish fed with the SpPdp11-supplemented diet survived an experimental-RGNNV infection, whereas the survival rate of fish fed with the control diet was 64%. These results suggest that SpPdp11-supplemented feeding can be a promising prophylactic tool against RGNNV and encourage further research on other fish species and viral pathogens.This study has been supported by the projects P18-RT-1067 (Proyecto de Excelencia, Junta de Andalucia, Regional Government) and PID2020-113637RB-C22 (MINECO/AEI/FEDER, UE) (Spanish Government). Daniel Álvarez-Torres has been granted by the project PTA2020-018984-I. Funding for open access charge: Universidad de Málaga/CBUA

Preliminary use-wear analysis results of the Early Acheulean site of Thiongo Korongo (Olduvai Gorge,Tanzania) (Abstract)

Depto. de Prehistoria, Historia Antigua y ArqueologíaFac. de Geografía e HistoriaTRUEpu

Assessing functionality during the early Acheulean in level TKSF at Thiongo Korongo site (Olduvai Gorge, Tanzania)

To understand the identity of the early Acheulean, it is necessary to discriminate between the variables that influenced the selection of technological strategies. Functionality of the archaeological sites is crucial in assessing the manufacturing strategies of lithic tools. To achieve this goal, analysis of the post-depositional processes must be evaluated. When bone remains have been preserved, anthropic animal processing can be identified through zooarchaeological and taphonomic analyses, and the spatial relationships among all the components can also be assessed, especially when bone surface is not sufficiently preserved. There are two levels present at Thiongo Korongo, ~1.3 Ma, TKLF and TKSF. These are in autochthonous position with no significant temporal diachrony but with substantial technological differences in the manufacturing of the lithic tools, which enables the analysis of the influence of human activities on technological behaviour. In order to evaluate this issue at TKSF, we present lithic, faunal, taphonomic, fabric, and spatial analyses. An assemblage of megaherbivores, among which Sivatherium is outstanding, dominate the TKSF faunal remains. Cortical preservation is poor; there is no intervention of carnivores, the rate of green fractures is low, and a few cut marks on size 5 and 3b animals were identified. Hence, apparently human intervention on the fauna was not intensive. Spatial and geostatistical analyses hints of a specific area where megaherbivores were processed by humans. Through wear use and biomarker analyses on stone tools, we are currently trying to understand the activities that were carried out in the remaining paleosurface. At paleosurface TKLF, the main anthropogenic input could be related to activities other than animal resource exploitation, in which large handaxes were necessary. Without the assessment of site functionality and chronological context, this data could have lead to the differences observed at TKLF and TKSF being attributed to different Acheulean stages

Generación de materiales gráficos para el aprendizaje sobre el etiquetado de los alimentos, a través de la metología ApS

Depto. de Nutrición y Ciencia de los AlimentosFac. de FarmaciaFALSEsubmitte

BNIP3 Is Involved in Muscle Fiber Atrophy in Late-Onset Pompe Disease Patients

Late-onset Pompe disease (LOPD) is a rare genetic disorder produced by mutations in the GAA gene and is characterized by progressive muscle weakness. LOPD muscle biopsies show accumulation of glycogen along with the autophagic vacuoles associated with atrophic muscle fibers. The expression of molecules related to muscle fiber atrophy in muscle biopsies of LOPD patients was studied using immunofluorescence and real-time PCR. BCL2 and adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a well-known atrogene, was identified as a potential mediator of muscle fiber atrophy in LOPD muscle biopsies. Vacuolated fibers in LOPD patient muscle biopsies were smaller than nonvacuolated fibers and expressed BNIP3. The current data suggested that BNIP3 expression is regulated by inhibition of the AKT-mammalian target of rapamycin pathway, leading to phosphorylation of Unc-51 like autophagy activating kinase 1 (ULK1) at Ser317 by AMP-activated protein kinase. Myoblasts and myotubes obtained from LOPD patients and age-matched controls were studied to confirm these results using different molecular techniques. Myotubes derived from LOPD patients were likewise smaller and expressed BNIP3. Conclusively, transfection of BNIP3 into control myotubes led to myotube atrophy. These findings suggest a cascade that starts with the inhibition of the AKT-mammalian target of rapamycin pathway and activation of BNIP3 expression, leading to progressive muscle fiber atrophy. These results open the door to potential new treatments targeting BNIP3 to reduce its deleterious effects on muscle fiber atrophy in Pompe disease.Peer reviewe

Universidad y sociedad: comunicación e integración en empresas e instituciones públicas y organizaciones no lucrativas. Nuevos avances

Depto. de Teorías y Análisis de la ComunicaciónFac. de Ciencias de la InformaciónFALSEsubmitte