Microstructure and impact toughness of high-strength low-alloy steel after tempforming

The effects of temperature and degree of tempforming deformation on the microstructure and impact toughness of high-strength low-alloy 25KhGMT steel have been considered. Tempforming forms a lamellar microstructure composed of grains and subgrains that are strongly elongated along the rolling directio

Effect of multiple forging and annealing on microstructure and mechanical properties of a high-manganese steel

The effect of multiple forging and annealing on the microstructure and mechanical properties of a high-manganese steel is considered. An austenitic high-manganese steel, Fe-0.03C-28Mn-1.5Al (all in wt.%), with an average grain size of about 37 qm was used as th initial material in this study. Multiple forging at room temperature was carried out up to a total true strain of 2. Multiple forging was accompanied by deformation twinning and resulted in significant strengthening. The steel samples subjected to multiple forging demonstrate an increase in the strength properties with an increase in the total strain, while elongation decrease

The Microstructure and Strength of UFG 6060 alloy after superplastic deformation at a lower homologous temperature

The paper reports on the features of low-temperature superplasticity of the heat-treatable aluminum Al-Mg-Si alloy in the ultrafine-grained state at temperatures below 0.5 times the melting point as well as on its post-deformation microstructure and tensile strengt

Paragraph: A graph-based structural variant genotyper for short-read sequence data

Accurate detection and genotyping of structural variations (SVs) from short-read data is a long-standing area of development in genomics research and clinical sequencing pipelines. We introduce Paragraph, an accurate genotyper that models SVs using sequence graphs and SV annotations. We demonstrate the accuracy of Paragraph on whole-genome sequence data from three samples using long-read SV calls as the truth set, and then apply Paragraph at scale to a cohort of 100 short-read sequenced samples of diverse ancestry. Our analysis shows that Paragraph has better accuracy than other existing genotypers and can be applied to population-scale studies. © 2019 The Author(s)

Prospects for usage of predatory mite Neoseiulus californicus (MCGREGOR, 1954) (order Mesostigmata: subfamily, Amblyseiinae, family Phytoseiidae)

The predatory mite Neoseiulus californicus (MCGREGOR, 1954) is used as a specialized acariphage on vegetable, flower and berry crops. In protected ground, N. californicus is one of the effective carnivores of spider mites (Tetranychidae), the intensity of attacks depends on the temperature. The predator prefers to consume immature individuals of T. uirticae, often ignoring adult female mites. Simultaneously, predaceous organism does not express preferences between eggs and T. urticae nymphs. However, as the density of the spider mite population increases, the predatory mite shifts its diet from the eggs of the victim to larvae and nymphs. Adult females N. californicus exhibit a type 2 functional response to both eggs and T. urticae nymphs. Pyrethroid and avermectin drugs are highly toxic to predator populations. At the same time, there is low acute toxicity to many insecticides (Actara, Envidor, etc.) is exibited

ADVANCED AUSTENITIC CRYOGENIC STEEL: STRUCTURE AND PROPERTIES

В работе представлены исследования новой перспективной аустенитной хладостойкой стали Fe–0,025 % C–22 % Cr–10,2 % Ni–0,36 % N–6,2 % Mn–0,34 % Si–1,9 % Mo–0,003 % S–0,005 % P (вес. %). Оценены механические свойства, а именно, предел текучести, предел прочности, удлинение до разрушения, ударная вязкость при пониженных температурах от 20 °С до минус 196 °С.A new advanced austenitic cold-resistant steel, 0.025 % C–22 % Cr 10.2 % Ni–0.36 % N–6.2 % Mn–0.34 % Si–1.9 % Mo–0.003 % S–0.005 % P and the balance Fe (all in weight%), was investigated. The mechanical behavior of austenitic cold-resistant steel was studied by tension and Charpy impact tests in the temperature range of 20 °C to –196 °C.Работа выполнена при финансовой поддержке Министерства образования и науки России проекта № 14.575.21.0070 (ID No. RFMEFI57514X0070)

Patients with coronary artery disease and diabetes need improved management: a report from the EUROASPIRE IV survey: a registry from the EuroObservational Research Programme of the European Society of Cardiology

Background: In order to influence every day clinical practice professional organisations issue management guidelines. Cross-sectional surveys are used to evaluate the implementation of such guidelines. The present survey investigated screening for glucose perturbations in people with coronary artery disease and compared patients with known and newly detected type 2 diabetes with those without diabetes in terms of their life-style and pharmacological risk factor management in relation to contemporary European guidelines. Methods: A total of 6187 patients (18–80 years) with coronary artery disease and known glycaemic status based on a self reported history of diabetes (previously known diabetes) or the results of an oral glucose tolerance test and HbA1c (no diabetes or newly diagnosed diabetes) were investigated in EUROASPIRE IV including patients in 24 European countries 2012–2013. The patients were interviewed and investigated in order to enable a comparison between their actual risk factor control with that recommended in current European management guidelines and the outcome in previously conducted surveys. Results: A total of 2846 (46%) patients had no diabetes, 1158 (19%) newly diagnosed diabetes and 2183 (35 %) previously known diabetes. The combined use of all four cardioprotective drugs in these groups was 53, 55 and 60%, respectively. A blood pressure target of 9.0% (>75 mmol/mol). Of the patients with diabetes 69% reported on low physical activity. The proportion of patients participating in cardiac rehabilitation programmes was low (≈40%) and only 27% of those with diabetes had attended diabetes schools. Compared with data from previous surveys the use of cardioprotective drugs had increased and more patients were achieving the risk factor treatment targets. Conclusions: Despite advances in patient management there is further potential to improve both the detection and management of patients with diabetes and coronary artery disease

Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS

Genomic technologies such as next-generation sequencing (NGS) are revolutionizing molecular diagnostics and clinical medicine. However, these approaches have proven inefficient at identifying pathogenic repeat expansions. Here, we apply a collection of bioinformatics tools that can be utilized to identify either known or novel expanded repeat sequences in NGS data. We performed genetic studies of a cohort of 35 individuals from 22 families with a clinical diagnosis of cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS). Analysis of whole-genome sequence (WGS) data with five independent algorithms identified a recessively inherited intronic repeat expansion [(AAGGG)exp] in the gene encoding Replication Factor C1 (RFC1). This motif, not reported in the reference sequence, localized to an Alu element and replaced the reference (AAAAG)11 short tandem repeat. Genetic analyses confirmed the pathogenic expansion in 18 of 22 CANVAS-affected families and identified a core ancestral haplotype, estimated to have arisen in Europe more than twenty-five thousand years ago. WGS of the four RFC1-negative CANVAS-affected families identified plausible variants in three, with genomic re-diagnosis of SCA3, spastic ataxia of the Charlevoix-Saguenay type, and SCA45. This study identified the genetic basis of CANVAS and demonstrated that these improved bioinformatics tools increase the diagnostic utility of WGS to determine the genetic basis of a heterogeneous group of clinically overlapping neurogenetic disorders

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons