Comparative study of the power transferred from satellite-magnetosphere interactions to auroral emissions

Io's interaction with the Jovian magnetosphere generates a power of about 1012 W which propagates as Alfvn waves along the magnetic field lines and is partly transferred to electrons, resulting in intense auroral emissions. A recent study of the power transmission along the Io flux tube and of the electron acceleration at high latitudes showed that the power of the observed emissions is well explained by assuming filamentation of the Alfvn waves in the torus and the acceleration of the electrons at high latitude. At Jupiter, UV footprints related to Europa and Ganymede have also been observed. At Saturn recent observations revealed a weak UV footprint of Enceladus. We apply the Io interaction model to the Europa and Enceladus interactions. We show that the Alfvn wave filamentation leads to a precipitating electron power consistent with the power of the observed UV footprints

Saturn's neutral torus versus Jupiter's plasma torus

With the recent discovery of an atmospheric plume of H2O it is thought that Enceladus could deliver as much a 300 kg/s of neutral gas to Saturn's inner magnetosphere. Io is the source of roughly 1 ton/s of sulfur and oxygen gas at Jupiter. Despite the apparent similarity, the neutral/ion ratio at Saturn is 3 orders of magnitude higher than at Jupiter. We explore the flow of mass and energy at Saturn and Jupiter using a simplified homogeneous physical chemistry model to understand why these two system are so different. Our results suggest that ionization at Saturn is fundamentally limited by the slower corotational flow velocity at Enceladus, resulting in a factor of 4 lower ion pickup temperature. The net result of cooler ions at Enceladus is a cooler thermal electron population (∼2 eV) that is insufficient to generate significant ionization

Kolb in de klas: vijf docenten in het hoger onderwijs onderzoeken de waarde van Kolbs leerstijlen voor hun eigen onderwijspraktijk

Deze bundel bevat de resultaten van vijf kortlopende onderzoeken door deelnemers aan de masteropleiding Teaching in Higher Education, allen docenten in het hoger onderwijs, naar de waarde van de leerstijlen van Kolb voor hun eigen lespraktijk. Uit de onderzoeken komt naar voren dat het onderwijsaanbod niet geheel bepaald wordt door de leerstijl van de docent, maar dat het zou kunnen zijn dat het wel deels hierdoor beïnvloed wordt. Ook zijn vier manieren geïdentificeerd waarop docenten rekening houden met individuele verschillen tussen studenten. Ten aanzien van het verrichten van dit type onderzoek blijkt een noodzaak om het vóórkomen van en voorkeuren voor bepaalde leerstijlen op verschillende manieren te meten en om zowel met kwalitatieve als kwantitatieve methoden te werken; daarbij kan de Chi-square goodness-of-fit test voor één groep, goede diensten bewijzen. Ook lijkt het dat aangetroffen verschillen in leerstijlen wel eens veroorzaakt zouden kunnen zijn tussen verschillen in wat en hoe men meet, en geen reflectie zijn van feitelijke verschillen in leerstijlen

Generation of parallel electric fields in the Jupiter-Io torus wake region

Infrared and ultraviolet images have established that auroral emissions at Jupiter caused by the electromagnetic interaction with Io not only produce a bright spot, but an emission trail that extends in longitude from Io's magnetic footprint. Electron acceleration that produces the bright spot is believed to be dominated by Alfvén waves whereas we argue that the trail or wake aurora results from quasi-static parallel electric fields associated with large-scale, field-aligned currents between the Io torus and Jupiter's ionosphere. These currents ultimately transfer angular momentum from Jupiter to the Io torus. We examine the generation and the impact of the quasi-static parallel electric fields in the Io trail aurora. A critical component to our analysis is a current-voltage relation that accounts for the low-density plasma along the magnetic flux tubes that connect the Io torus and Jupiter. This low-density region, ∼2 Rj from Jupiter's center, can significantly limit the field-aligned current, essentially acting as a "high-latitude current choke." Once parallel electric fields are introduced, the governing equations that couple Jupiter's ionosphere to the Io torus become nonlinear and, while the large-scale behavior is similar to that expected with no parallel electric field, there are substantial deviations on smaller scales. The solutions, bound by properties of the Io torus and Jupiter's ionosphere, indicate that the parallel potentials are on the order of 1 kV when constrained by peak energy fluxes of a few milliwatts per square meter. The parallel potentials that we predict are significantly lower than earlier reports

Modeling the Enceladus plume--plasma interaction

We investigate the chemical interaction between Saturn's corotating plasma and Enceladus' volcanic plumes. We evolve plasma as it passes through a prescribed H2O plume using a physical chemistry model adapted for water-group reactions. The flow field is assumed to be that of a plasma around an electrically-conducting obstacle centered on Enceladus and aligned with Saturn's magnetic field, consistent with Cassini magnetometer data. We explore the effects on the physical chemistry due to: (1) a small population of hot electrons; (2) a plasma flow decelerated in response to the pickup of fresh ions; (3) the source rate of neutral H2O. The model confirms that charge exchange dominates the local chemistry and that H3O+ dominates the water-group composition downstream of the Enceladus plumes. We also find that the amount of fresh pickup ions depends heavily on both the neutral source strength and on the presence of a persistent population of hot electrons.Comment: 10 pages, 1 table, 2 figure

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

The involvement of Amyloid-β (Aβ) in the pathogenesis of Alzheimer’s disease (AD) is well established. However, it is becoming clear that the amyloid load in AD brains consists of a heterogeneous mixture of Aβ peptides, implying that a thorough understanding of their respective role and toxicity is crucial for the development of efficient treatments. Besides the well-studied Aβ and Aβ species, recent data have raised the possibility that Aβ peptides might be instrumental in AD pathogenesis, because they are frequently observed in both dense and diffuse amyloid plaques from human AD brains and are highly amyloidogenic in vitro. However, whether Aβ is toxic in vivo is currently unclear. Using Drosophila transgenic models of amyloid pathology, we show that Aβ peptides are mainly insoluble and highly toxic in vivo, leading to the progressive loss of photoreceptor neurons, altered locomotion and decreased lifespan when expressed in the adult fly nervous system. In addition, we demonstrate that Aβ species are able to trigger the aggregation of the typically soluble and non-toxic Aβ, leading to synergistic toxic effects on fly lifespan and climbing ability, further suggesting that Aβ peptides could act as a nucleating factor in AD brains. Altogether, our study demonstrates high pathogenicity of Aβ species in vivo and supports the idea that Aβ contributes to the pathological events leading to neurodegeneration in AD

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins generated by repeat-associated, non-ATG translation. To address this question we developed in vitro and in vivo models to dissect repeat RNA and dipeptide repeat protein toxicity. Expression of pure repeats in Drosophila caused adult-onset neurodegeneration attributable to poly-(glycine-arginine) proteins. Thus, expanded repeats promoted neurodegeneration through neurotoxic proteins. Expression of individual dipeptide repeat proteins with a non-GGGGCC RNA sequence showed both poly-(glycine-arginine) and poly-(proline-arginine) proteins caused neurodegeneration. These findings are consistent with a dual toxicity mechanism, whereby both arginine-rich proteins and repeat RNA contribute to C9orf72-mediated neurodegeneration

The roles of charge exchange and dissociation in spreading Saturn's neutral clouds

Neutrals sourced directly from Enceladus's plumes are initially confined to a dense neutral torus in Enceladus's orbit around Saturn. This neutral torus is redistributed by charge exchange, impact/photodissociation, and neutral-neutral collisions to produce Saturn's neutral clouds. Here we consider the former processes in greater detail than in previous studies. In the case of dissociation, models have assumed that OH is produced with a single speed of 1 km/s, whereas laboratory measurements suggest a range of speeds between 1 and 1.6 km/s. We show that the high-speed case increases dissociation's range of influence from 9 to 15 Rs. For charge exchange, we present a new modeling approach, where the ions are followed within a neutral background, whereas neutral cloud models are conventionally constructed from the neutrals' point of view. This approach allows us to comment on the significance of the ions' gyrophase at the moment charge exchange occurs. Accounting for gyrophase: (1) has no consequence on the H2O cloud; (2) doubles the local density of OH at the orbit of Enceladus; and (3) decreases the oxygen densities at Enceladus's orbit by less than 10%. Finally, we consider velocity-dependent, as well as species-dependent cross sections and find that the oxygen cloud produced from charge exchange is spread out more than H2O, whereas the OH cloud is the most confined.Comment: Accepted to the Journal of Geophysical Research, 49 pages, 10 figure

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

OBJECTIVE: Apathy symptoms are defined as a lack of interest and motivation. Patients with late-life depression (LLD) also suffer from lack of interest and motivation and previous studies have linked apathy to vascular white matter hyperintensities (WMH) of the brain in depressed and nondepressed patients. The aim of this study was to investigate the relationship between apathy symptoms, depressive symptoms, and WMH in LLD. We hypothesize that late-onset depression (LOD; first episode of depression after 55 years of age) is associated with WMH and apathy symptoms. METHODS: Apathy scores were collected for 87 inpatients diagnosed with LLD. Eighty patients underwent brain magnetic resonance imaging. Associations between depressive and apathy symptoms and WMH were analyzed using linear regression. RESULTS: All 3 subdomains of the 10-item Montgomery–Åsberg Depression Rating Scale correlated significantly with the apathy scale score (all P < .05). In the total sample, apathy nor depressive symptoms were related to specific WMH. In LOD only, periventricular WMH were associated with depression severity (β = 5.21, P = .04), while WMH in the left infratentorial region were associated with apathy symptoms (β coefficient = 5.89, P = .03). CONCLUSION: Apathy and depressive symptoms are highly overlapping in the current cohort of older patients with severe LLD, leading to the hypothesis that apathy symptoms are part of depressive symptoms in the symptom profile of older patients with severe LLD. Neither apathy nor depressive symptoms were related to WMH, suggesting that radiological markers of cerebrovascular disease, such as WMH, may not be useful in predicting these symptoms in severe LLD