Consequences of child maltreatment victimisation in internalising and externalising mental health problems

Purpose: The literature on the prevalence of child maltreatment is extensive, but studies are required to assess the impact on mental health to enhance the effectiveness of intervention programs. Method: Thus, a field study was undertaken to evaluate depression, anxiety, and anger in 65 child victims of multiple types of maltreatment. Results: The results showed that child maltreatment victim (CM-V) reported more depressive (36%), anxiety (45%), and anger (69%) symptoms than the normative sample. However, subjects were asymptomatic in approximately 25% of depression, 20% anxiety, and 5% of anger. Epidemiologically, the results revealed that the probability of caseness among the CM-Vs sample increased to around 85% for depression and anxiety and 90% for anger.Conclusions: The clinical, social, and legal implications of the results are discussedThis research has been partially sponsored by a grant of the Consellería de Cultura, Educación e Ordenación Universitaria of the Xunta de Galicia (ED431B 2020/46), and by a grant of the Spanish Ministry of Science and Innovation (PSI2017-87278-R)S

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HTLV-1 infection in solid organ transplant donors and recipients in Spain

HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain. All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008. A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic. The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES) : comprehensive genetic analysis by next-generation sequencing of 480 patients

Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the VWF, including intronic and promoter regions, was achieved in the 556 individuals recruited via the development of a simple, innovative, relatively low-cost protocol based on microfluidic technology and next-generation sequencing. A total of 704 variants (237 different) were identified along VWF, 155 of which had not been previously recorded in the international mutation database. The potential pathogenic effect of these variants was assessed by in silico analysis. Furthermore, four short tandem repeats were analyzed in order to evaluate the ancestral origin of recurrent mutations. The outcome of genetic analysis allowed for the reclassification of 110 patients, identification of 37 asymptomatic carriers (important for genetic counseling) and re-inclusion of 43 patients previously excluded by phenotyping results. In total, 480 patients were definitively diagnosed. Candidate mutations were identified in all patients except 13 type 1 von Willebrand disease, yielding a high genotype-phenotype correlation. Our data reinforce the capital importance and usefulness of genetics in von Willebrand disease diagnostics. The progressive implementation of molecular study as the first-line test for routine diagnosis of this condition will lead to increasingly more personalized and effective care for this patient population

Trastornos de ansiedad-depresión en contingencia común en la ciudad de Málaga

Objetivo: Proporcionar un análisis epidemiológico de los pacientes atendidos por contingencias comunes en los Centros Asistenciales de Asepeyo de Málaga y Guadalhorce bajo el diagnostico de Trastorno Mixto ansioso-depresivo. Hemos hecho un breve repaso de la patología objeto de este estudio. Método: Se realiza estudio descriptivo retrospectivo de todos los pacientes atendidos por Trastorno ansioso-depresivo por contingencia común durante un período de 2 años, entre el 1 de Enero de 2007 hasta el 31 de Diciembre de 2008. El estudio abarca 670 pacientes. Se usa la clasificación internacional de enfermedades (CIE-10) en la identificación de la patología. Resultados: El 69,10% de los casos se trababa de mujeres. El 30,14% de los afectados se encontraba entre los 26 y los 35 años. El diagnostico más frecuente es el estado de ansiedad (51,79%). La profesión con más riesgo son las relacionadas con la atención al público (47,16%). La duración media de la baja es de 136,12 días. El total de días de trabajo perdidos son 91.201. Conclusiones: El prototipo es una baja por estado de ansiedad en una mujer de entre 26-35 años que trabaja de cara al público, cuya baja dura136 días y es pago delegado. El seguimiento por el especialista de mutua reduce la duración de la baja. Palabras claves: incapacidad temporal, contingencias comunes, Trastorno ansioso-depresivo, absentismo

Estudio de la eficacia de las categorías de realidad del testimonio del Sistema de Evaluación Global (SEG) en casos de violencia de género

Se diseñó un estudio para contrastar la eficacia de los criterios de realidad en la evaluación de la credibilidad del testimonio en casos de violencia de género. En concreto, se contrastó la efectividad del Sistema de Evaluación Global (SEG) para casos de violencia de género con el procedimiento estándar basado en el SVA/CBCA. Para ello, se tomaron las declaraciones de 25 mujeres víctimas de violencia de género, confirmadas por sentencia judicial, y 25 de mujeres no víctimas, que inventaban una declaración. Los resultados mostraron que los criterios de realidad discriminaban entre declaraciones reales e inventadas. Por lo que se refiere a la validez de las declaraciones, los resultados pusieron de manifiesto que los procedimientos basados en dos declaraciones (ie, SEG) eran más productivos en la detección de declaraciones inventadas que los basados en una declaración (ie, SVA). Finalmente, los resultados apoyaron que los criterios de realidad para casos de violencia de género del SEG eran más eficaces en la discriminación entre declaraciones reales e inventadas, que los criterios de realidad del CBCA