Signatures of four-particle correlations associated with exciton-carrier interactions in coherent spectroscopy on bulk GaAs

Transient four-wave mixing studies of bulk GaAs under conditions of broad bandwidth excitation of primarily interband transitions have enabled four-particle correlations tied to degenerate (exciton-exciton) and nondegenerate (exciton-carrier) interactions to be studied. Real two-dimensional Fourier-transform spectroscopy (2DFTS) spectra reveal a complex response at the heavy-hole exciton emission energy that varies with the absorption energy, ranging from dispersive on the diagonal, through absorptive for low-energy interband transitions to dispersive with the opposite sign for interband transitions high above band gap. Simulations using a multilevel model augmented by many-body effects provide excellent agreement with the 2DFTS experiments and indicate that excitation-induced dephasing (EID) and excitation-induced shift (EIS) affect degenerate and nondegenerate interactions equivalently, with stronger exciton-carrier coupling relative to exciton-exciton coupling by approximately an order of magnitude. These simulations also indicate that EID effects are three times stronger than EIS in contributing to the coherent response of the semiconductor

Rapid diffusion of electrons in GaMnAs

We report ultrafast transient-grating measurements, above and below the Curie temperature, of the dilute ferromagnetic semiconductor (Ga,Mn)As containing 6% Mn. At 80 K (15 K), we observe that photoexcited electrons in the conduction band have a lifetime of 8 ps (5 ps) and diffuse at about 70 cm2/s (60 cm2/s). Such rapid diffusion requires either an electronic mobility exceeding 7,700 cm2/Vs or a conduction-band effective mass less than half the GaAs value. Our data suggest that neither the scattering rate nor the effective mass of the (Ga,Mn)As conduction band differs significantly from that of GaAs.Comment: 5 pages, 3 figures. Differs from the previous version in incorporating additional data and changes made during the review process. Differs from the published version in including section headings and in omitting AIP copy-edits. No substantial differences in scientific conclusions from either versio

How could nanobiotechnology improve treatment outcomes of anti-TNF-α therapy in infammatory bowel disease? Current knowledge, future directions

Despite significant advances in therapeutic possibilities for the treatment of inflammatory bowel disease (IBD) in recent years, there is still a big room for improvement. In particular, biological treatment can induce not only clinical remission but also mucosal healing of the gastrointestinal tract. Among these therapeutic molecules, anti-tumor necrosis factor-alpha (anti-TNF-$\alpha$) antibodies were the first to revolutionize treatment algorithms in IBD. However, due to the parenteral route of administration and systemic mode of action, TNF-$\alpha$ blockers are characterised by high rates of immunogenicity-related loss of response and serious adverse events. Moreover, intravenous or subcutaneous therapy is not considered patient-friendly and requires occasional, direct contact with healthcare centres. To overcome these limitations, several attempts have been made to design oral pharmaceutical formulations of these molecules. It is hypothesized that oral anti-TNF-$\alpha$ antibodies therapy can directly provide a targeted and potent anti-inflammatory effect in the inflamed gastrointestinal tissues without significant systemic exposure, improving long-term treatment outcomes and safety. In this review, we discuss the current knowledge and future perspectives regarding different approaches made towards entering a new era of oral anti-TNF-$\alpha$ therapy, namely, the tailoring of biocompatible nanoparticles with anti-TNF-$\alpha$ antibodies for site-specific targeting to IBD. In particular, we discuss the latest concepts applying the achievements of nanotechnology-based drug design in this area.Portuguese Science and Technology Foundation (FCT/MCT), European Funds (PRODUCER/COMPETE)—project UIDB/04469/2020 (strategic fund), co-fnanced by FEDER, under the Partnership Agreement PT2020. The study was also supported by the National Science Centre within the MINIATURA 4 for a single research activity (Grant No. 2020/04/X/ST5/00789) and by the START 2021 Program of the Foundation for Polish Science (FNP) granted to Aleksandra Zielińska.info:eu-repo/semantics/publishedVersio

Evaluation of the health behaviors of women in multiple pregnancies — a preliminary study

Objectives: The aim of the paper was to assess which health behavior indicators were characteristic for women with a multiple pregnancy. Material and method: The study involved 35 women in multiple pregnancies. The inclusion criteria were: the completion of the 22nd week of pregnancy (22 Hbd, i.e., 22 weeks and 1/7) and the consent of the women to participate in the study. We used an original questionnaire devised by us specifically for our study, as well as a standardized research tool, Juczyński’s Health Behavior Inventory questionnaire, for the assessment of the pregnant women’s health behaviors. Results: The overall rate of health behaviors was high and was on average 93.9 ± 10.8 points (7 sten scores). Indicators of the health behaviors of women in multiple pregnancies were high across all categories. However, the highest rate was observed in preventive behaviors. Conclusions: The overall rate of health behaviors of women with a multiple pregnancy and all the individual behavior category indicators were high. However, the highest rate was for preventive behaviors. The indicator values of the health behaviors of the pregnant women in the study were not dependent on the variables adopted in this paper

Primary humoral immune deficiencies: overlooked mimickers of chronic immune-mediated gastrointestinal diseases in adults

In recent years, the incidence of immune-mediated gastrointestinal disorders, including celiac disease (CeD) and inflammatory bowel disease (IBD), is increasingly growing worldwide. This generates a need to elucidate the conditions that may compromise the diagnosis and treatment of such gastrointestinal disorders. It is well established that primary immunodeficiencies (PIDs) exhibit gastrointestinal manifestations and mimic other diseases, including CeD and IBD. PIDs are often considered pediatric ailments, whereas between 25 and 45% of PIDs are diagnosed in adults. The most common PIDs in adults are the selective immunoglobulin A deficiency (SIgAD) and the common variable immunodeficiency (CVID). A trend to autoimmunity occurs, while gastrointestinal disorders are common in both diseases. Besides, the occurrence of CeD and IBD in SIgAD/CVID patients is significantly higher than in the general population. However, some differences concerning diagnostics and management between enteropathy/colitis in PIDs, as compared to idiopathic forms of CeD/IBD, have been described. There is an ongoing discussion whether CeD and IBD in CVID patients should be considered a true CeD and IBD or just CeD-like and IBD-like diseases. This review addresses the current state of the art of the most common primary immunodeficiencies in adults and co-occurring CeD and IBD.(undefined)info:eu-repo/semantics/publishedVersio

Aktywność fizyczna dziewcząt w okresie dojrzewania = Physical activity in girls at puberty

Pilewska–Kozak Anna B., Łepecka–Klusek Celina, Stadnicka Grażyna, Dobrowolska Beata, Pawłowska–Muc Agnieszka K., Kozak Łukasz A., Ulan Agnieszka, Wagner Emilia. Aktywność fizyczna dziewcząt w okresie dojrzewania = Physical activity in girls at puberty. Journal of Education, Health and Sport. 2015;5(9):305-316. ISSN 2391-8306. DOI10.5281/zenodo.30805http://dx.doi.org/10.5281/zenodo.30805http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%289%29%3A305-316https://pbn.nauka.gov.pl/works/623257Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 25.08.2015. Revised 05.09.2015. Accepted: 08.09.2015. Aktywność fizyczna dziewcząt w okresie dojrzewaniaPhysical activity in girls at puberty Anna B. Pilewska–Kozak1, Celina Łepecka–Klusek1, Grażyna Stadnicka2, Beata Dobrowolska3, Agnieszka K. Pawłowska–Muc4, Łukasz A. Kozak5, Agnieszka Ulan6, Emilia Wagner6 1Katedra i Klinika Ginekologii i Endokrynologii Ginekologicznej Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie2Samodzielna Pracownia Umiejętności Położniczych Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie3Katedra Rozwoju Pielęgniarstwa Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie4Ośrodek Kształcenia Podyplomowego Pielęgniarek i Położnych Radomski Szpital Specjalistyczny im. dr Tytusa Chałubińskiego w Radomiu5Oddział Chirurgii Urazowo – Ortopedycznej z Chirurgią Kręgosłupa, Samodzielny Publiczny Zakład Opieki Zdrowotnej w Puławach6Studentka III roku kierunku położnictwo, Studenckie Koło Naukowe przy Katedrze i Klinice Ginekologii i Endokrynologii Ginekologicznej, Wydział Nauk o Zdrowiu Uniwersytet Medyczny w Lublinie Streszczenie Wstęp         Sprawność fizyczna ukształtowana w wieku młodzieńczym ma swoje odzwierciedlenie w życiu dorosłym. Wpływa na ogólny dobrostan, na elastyczne przystosowywanie się do ról w życiu zawodowym, na równowagę emocjonalną i większą odporność na stres. Warunkuje odpowiedzialność, wytrwałość w dążeniu do wyznaczonych celów oraz zdyscyplinowanie, a także pozwala na podtrzymanie dobrej kondycji w wieku dojrzałym i w okresie starości.Cel pracy         Sprawdzenie, czy dziewczęta w okresie dojrzewania ćwiczą na lekcjach wychowania fizycznego i są aktywne ruchowo poza szkołą oraz czy ma to związek z miejscem ich zamieszkania.Materiał i metoda         Badaniami ankietowymi objęto 169 uczennic gimnazjów (80 mieszkających w mieście i 89 na wsi) w województwie lubelskim. Wiek dziewcząt wahał się w granicach od 11 lat do 17 lat (Mediana = 15 lat). Kryterium włączenia było wystąpienie menarche. Na prowadzenie badań uzyskano zgody Komisji Bioetycznej Uniwersytetu Medycznego w Lublinie nr KE-0254/224/2013 z dnia 26 września 2013r. oraz nr KE-0254/246/2013 z dnia 24 października 2013r.Wyniki badań         Większość uczennic, zarówno ze wsi, jak i z miasta (odpowiednio 66; 74.1% i 59; 73.8%), oświadczyła, że prowadzi aktywny tryb życia. Innych - analogicznie 10 (11.2%) i 8 (10.0%) było przeciwnego zdania, a co piąta (19; 21.3%) dziewczynka z terenów wiejskich i 13 (16,3%) z miejskich nie potrafiła tego ocenić. Regularne uczęszczanie na lekcje wychowania fizycznego potwierdziły 94 (55,6%) badane. Pozostałe oświadczyły, iż czynią to nieregularnie (68; 40.2%) lub mają zwolnienie lekarskie z tych zajęć (7; 4.1%).  Stwierdzono istotną statystycznie zależność między uczęszczaniem na lekcje wychowania fizycznego a miejscem zamieszkania uczennic (p<0,05), na korzyść mieszkanek miast, które częściej czyniły to regularnie. Ponadto stwierdzono istotne statystycznie zależności pomiędzy preferowanymi formami wypoczynku w okresie szkolnym i wakacyjnym (p<0,001). Różnice zarysowały się także, gdy wzięto pod uwagę miejsce zamieszkania badanych – w okresie zajęć szkolnych formy czynne istotnie częściej, niż bierne preferowały mieszkanki miast niż wsi (p=0.005), a w okresie wakacji odwrotnie (p<0.001).WnioskiWiele dziewcząt w okresie dojrzewania nie ćwiczy regularnie na lekcjach wychowania fizycznego, przy czym częściej mieszkanki wsi niż miast.Aktywne formy wypoczynku w okresie szkolnym preferują częściej mieszkanki miast niż wsi, a w okresie wakacji odwrotnie. Słowa kluczowe: aktywność fizyczna, dojrzewanie, dziewczęta. Summary Introduction         Fitness formed in adolescence is reflected in adulthood. It affects general wellbeing, flexibility to adapt to future roles in professional life, emotional balance and greater resistance to stress. It determines responsibility, persistent pursuit of targets and discipline, and also allows to maintain good health through adulthood and old age.Objective         To verify that girls at puberty do physical exercises at physical education (PE) classes and are physically active outside school, and to establish whether it is related to their place of residence.Material and Methods         The survey was conducted in 169 junior high school students, 80 living in the urban area and89 inthe rural region, aged 11 -17 years (median = 15 years) in The Lublin Province. The inclusion criterion was the occurrence of menarche. The  research was approved by the Bioethics Committee of the Medical University of Lublin No. KE-0254/224/2013 of 26 September 2013 and No. KE-0254/246/2013 of 24 October 2013.Results         Most of the students, both from the country as well as from the city (respectively 66, 74.1% and 59; 73.8%) admitted to leading an active lifestyle. The others, respectively 10 (11.2%) and 8 (10.0%) respondents were of the opposite opinion;  in the group of country girls, one girl in five (19; 21.3%), and 13 girls from the town group (16.3%) were unable to evaluate that. Regular attendance at PE classes was confirmed by 94 (55.6%) respondents. Others stated that they did not do it regularly (68; 40.2%) or were exempted from PE classes due to medical reasons (7; 4.1%). A statistically significant correlation between attending PE and place of residence of students was found (p <0.05) in favor of the inhabitants of the cities who more often did exercise regularly. In addition, statistically significant relationship was determined between preferred forms of rest during the school year and in the summer (p <0.001). Differences also emerged when the place of respondents’ residence was taken into account, i.e. in the period of school, the girls from towns preferred active forms to passive significantly more frequently in comparison to the girls from rural areas (p = 0.005); the situation reversed during the holiday period (p <0.001).ConclusionsMany girls at puberty do not exercise regularly at physical education classes, it is more frequent among the girls from rural regions compared to the girls living in town.During the period of school year, the girls living in urban areas more often prefer active forms of recreation compared to the girls from rural regions and the situation is reversed  during the holiday period. Key words: physical activity, girls, puberty