Features of the Use of Software and Hardware of the Educational Process in the Conditions of Blended Learning

The paper reveals the results of a study of the feasibility of using software and hardware for the educational process in a blended learning environment in secondary, higher and vocational education. The author conducted an analysis of domestic and international research on distance learning (distance learning needs, requirements for distance learning platforms, experience in implementing distance and blended learning). In the course of the research, the author revealed the standard composition of modern software and hardware of the educational process in the conditions of blended learning and analyzed the market of Ukraine for the availability of ready-made complexes of the company. Recommendations for approaches to teaching in each age group of students and approaches to choosing a complex for implementation in a mixed and distance learning environment, taking into account the individual needs of each educational institution or educational organization. The research is theoretical in nature and designed to create a basis for further research in a given vector

Acetabular Implant Finite Element Simulation with Customised Estimate of Bone Properties

The goal of the study is to analyse the strength and stability of a system comprising the pelvis and a customised implant under functional loads using the finite element method. We considered a technique for assessing the elastic properties of bone tissue via computer tomography, constructing finite element models of pelvic bones and a customised endoprosthesis based on the initial geometric models obtained from the National Medical Research Centre for Oncology n.a. N.N. Blokhin (Moscow, Russia). A series of calculations were carried out for the stress-strain state of the biomechanical system during walking, as well as at maximum loads when ascending and descending stairs. The analysis provided conclusions about the strength and stability of the studied device

Finite Element Analysis of Customized Acetabular Implant and Bone after Pelvic Tumour Resection throughout the Gait Cycle

The aim of this paper is to investigate and compare the stress distribution of a reconstructed pelvis under different screw forces in a typical walking pattern. Computer-aided design models of the pelvic bones and sacrum made based on computer tomography images and individually designed implants are the basis for creating finite element models, which are imported into ABAQUS software. The screws provide compression loading and bring the implant and pelvic bones together. The sacrum is fixed at the level of the L5 vertebrae. The variants of strength analyses are carried out with four different screw pretension forces. The loads equivalent to the hip joint reaction forces arising during moderate walking are applied to reference points based on the centres of the acetabulum. According to the results of the performed analyses, the optimal and critical values of screw forces are estimated for the current model. The highest stresses among all the models occurred in the screws and implant. As soon as the screw force increases up to the ultimate value, the bone tissue might be locally destroyed. The results prove that the developed implant design with optimal screw pretension forces should have good biomechanical characteristics

Calculation of the movement trajectory of the grain mass in the field stripper

The work is devoted to the study of the dynamics of the grain mass in a field stripper for grain separation. At the first stage, a model of the movement of the air mass in the considered installation is built and based on a mathematical model that takes into account the turbulence of the movement of the air mass, using the method of finite volumes in the ANSYS package, the field of velocities and pressures is calculated. At the second stage, the movement of a fragment of the grain mass in this flow is considered, its trajectory is built taking into account the interaction with the upper deck of the installation. The performed calculations allow us to choose rational geometric and kinematic parameters at which no stagnant zones appear in the chamber, the grain mass interacts with the upper one, which contributes to the release of grain in the installation chamber

αmβ \u3csub\u3e2\u3c/sub\u3e Is Antiatherogenic in Female but Not Male Mice

Atherosclerosis is a complex inflammatory process characterized by monocyte recruitment into the arterial wall, their differentiation into macrophages, and lipid accumulation. Because integrin αMβ 2 (CD11b/CD18) mediates multiple diverse functions of leukocytes, we examined its role in atherogenesis. αM -/- /ApoE -/- and ApoE -/- mice were fed a control or high fat diet for 3 or 16 wk to induce atherogenesis. Unexpectedly, αM deficiency accelerated development of atherosclerosis in female but not in male mice. The size of aortic root lesions was 3-4.5-fold larger in female αM -/- /ApoE -/- than in ApoE -/- mice. Monocyte and macrophage content within the lesions was increased 2.5-fold in female αM -/- /ApoE -/- mice due to enhanced proliferation. αMβ 2 elimination promoted gender-dependent foam cell formation due to enhanced uptake of cholesterol by αM -/- /ApoE -/- macrophages. This difference was attributed to enhanced expression of lipid uptake receptors, CD36 and scavenger receptor A1 (SR-A1), in female mice. Macrophages from female αM -/- /ApoE -/- mice showed dramatically reduced expression of FoxM1 transcription factor and estrogen receptors (ER) a and b. As their antagonists inhibited the effect of 17b-estradiol (E2), E2 decreased CD36, SR-A1, and foam cell formation in ApoE -/- macrophages in an ERa- and ERb-dependent manner. However, female αM -/- /ApoE -/- macrophages failed to respond to E 2 and maintained elevated CD36, SR-A1, and lipid accumulation. FoxM1 inhibition in ApoE -/- macrophages reduced ERs and enhanced CD36 and SR-A1 expression, whereas FoxM1 overexpression in αM -/- /ApoE -/- macrophages reversed their proatherogenic phenotype.We demonstrate a new, surprising atheroprotective role of αMβ 2 in female ApoE -/- mice. αMβ 2 maintains ER expression in macrophages and E 2 -dependent inhibition of foam cell formation

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Atherosclerosis is a complex inflammatory process characterized by monocyte recruitment into the arterial wall, their differentiation into macrophages, and lipid accumulation. Because integrin αMβ 2 (CD11b/CD18) mediates multiple diverse functions of leukocytes, we examined its role in atherogenesis. αM -/- /ApoE -/- and ApoE -/- mice were fed a control or high fat diet for 3 or 16 wk to induce atherogenesis. Unexpectedly, αM deficiency accelerated development of atherosclerosis in female but not in male mice. The size of aortic root lesions was 3-4.5-fold larger in female αM -/- /ApoE -/- than in ApoE -/- mice. Monocyte and macrophage content within the lesions was increased 2.5-fold in female αM -/- /ApoE -/- mice due to enhanced proliferation. αMβ 2 elimination promoted gender-dependent foam cell formation due to enhanced uptake of cholesterol by αM -/- /ApoE -/- macrophages. This difference was attributed to enhanced expression of lipid uptake receptors, CD36 and scavenger receptor A1 (SR-A1), in female mice. Macrophages from female αM -/- /ApoE -/- mice showed dramatically reduced expression of FoxM1 transcription factor and estrogen receptors (ER) a and b. As their antagonists inhibited the effect of 17b-estradiol (E2), E2 decreased CD36, SR-A1, and foam cell formation in ApoE -/- macrophages in an ERa- and ERb-dependent manner. However, female αM -/- /ApoE -/- macrophages failed to respond to E 2 and maintained elevated CD36, SR-A1, and lipid accumulation. FoxM1 inhibition in ApoE -/- macrophages reduced ERs and enhanced CD36 and SR-A1 expression, whereas FoxM1 overexpression in αM -/- /ApoE -/- macrophages reversed their proatherogenic phenotype.We demonstrate a new, surprising atheroprotective role of αMβ 2 in female ApoE -/- mice. αMβ 2 maintains ER expression in macrophages and E 2 -dependent inhibition of foam cell formation

Advantages of nuclear fusion with polarized fuel

The use of nuclear polarized fuel, i.e. polarized D, T or 3He, for coming fusion reactors promises to increase their energy output and to optimize the complete fusion process in various ways. But before these advantages can be utilized, several questions must be answered and technical issues must be overcome. Among others, the members of the PREFER collaboration started to investigate the different challenges of 'polarized fusion'