83 research outputs found
Chaotic Diffusion on Periodic Orbits: The Perturbed Arnol'd Cat Map
Chaotic diffusion on periodic orbits (POs) is studied for the perturbed
Arnol'd cat map on a cylinder, in a range of perturbation parameters
corresponding to an extended structural-stability regime of the system on the
torus. The diffusion coefficient is calculated using the following PO formulas:
(a) The curvature expansion of the Ruelle zeta function. (b) The average of the
PO winding-number squared, , weighted by a stability factor. (c) The
uniform (nonweighted) average of . The results from formulas (a) and (b)
agree very well with those obtained by standard methods, for all the
perturbation parameters considered. Formula (c) gives reasonably accurate
results for sufficiently small parameters corresponding also to cases of a
considerably nonuniform hyperbolicity. This is due to {\em uniformity sum
rules} satisfied by the PO Lyapunov eigenvalues at {\em fixed} . These sum
rules follow from general arguments and are supported by much numerical
evidence.Comment: 6 Tables, 2 Figures (postscript); To appear in Physical Review
Occurrence of antibodies anti-Neospora spp. in cart horses and Crioula breed horses from Rio Grande do Sul state
Frequency of antibodies against Neospora caninum in stray and domiciled dogs from urban, periurban and rural areas from ParanĂĄ State, Southern Brazil
European Organization for Research and Treatment of Cancer (EORTC) open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme
BACKGROUND: Glufosfamide is a new alkylating agent in which the active
metabolite of isophosphoramide mustard is covalently linked to
beta-D-glucose to target the glucose transporter system and increase
intracellular uptake in tumor cells. We investigated this drug in a
multicenter prospective phase II trial in recurrent glioblastoma
multiforme (GBM). PATIENTS AND METHODS: Eligible patients had recurrent
GBM following surgery, radiotherapy and no more than one prior line of
chemotherapy. Patients were treated with glufosfamide 5000 mg/m(2)
administered as a 1-h intravenous infusion. Treatment success was defined
as patients with either an objective response according to Macdonald's
criteria or 6 months progression-free survival. Toxicity was assessed with
the Common Toxicity Criteria (CTC) version 2.0. RESULTS: Thirty-one
eligible patients were included. Toxicity was modest, the main clinically
relevant toxicities being leukopenia (CTC grade >3 in five patients) and
hepatotoxicity (in three patients). No responses were observed; one
patient (3%; 95% confidence interval 0 to 17%) was free from progression
at 6 months. Pharmacokinetic analysis showed a 15% decrease in area under
the curve and glufosfamide clearance in patients treated with
enzyme-inducing antiepileptic drugs, but no effect of these drugs on
maximum concentration and plasma half-life. CONCLUSION: Glufosfamide did
not show significant clinical antitumor activity in patients with
recurrent GBM
OcorrĂȘncia de anticorpos anti-Neospora caninum em cĂŁes da microrregiĂŁo da Serra de Botucatu, Estado de SĂŁo Paulo, Brasil
Neutrino Propagation in a Strongly Magnetized Medium
We derive general expressions at the one-loop level for the coefficients of
the covariant structure of the neutrino self-energy in the presence of a
constant magnetic field. The neutrino energy spectrum and index of refraction
are obtained for neutral and charged media in the strong-field limit () using the lowest Landau level
approximation. The results found within the lowest Landau level approximation
are numerically validated, summing in all Landau levels, for strong and weakly-strong fields. The neutrino energy in
leading order of the Fermi coupling constant is expressed as the sum of three
terms: a kinetic-energy term, a term of interaction between the magnetic field
and an induced neutrino magnetic moment, and a rest-energy term. The leading
radiative correction to the kinetic-energy term depends linearly on the
magnetic field strength and is independent of the chemical potential. The other
two terms are only present in a charged medium. For strong and weakly-strong
fields, it is found that the field-dependent correction to the neutrino energy
in a neutral medium is much larger than the thermal one. Possible applications
to cosmology and astrophysics are considered.Comment: 23 pages, 4 figures. Corrected misprints in reference
Comparação das tĂ©cnicas de ELISA indireto e ImunofluorescĂȘncia indireta na detecção de anticorpos anti-Neospora caninum em bĂșfalas (Bubalus bubalis)
Restauration morpho-dynamique et redynamisation de la section court-circuitée du Rhin en aval du barrage de Kembs (projet INTERREG / EDF)
National audienceThe Upper Rhine River has been heavily impacted by channelization for flood protection and navigation, and then by damming for hydropower generation. In normal non flooding conditions, most of the flows are diverted in a canalized section whereas the regulated âold Rhineâ bypassed reach runs a minimum flow. Between Huningue and Neuf-Brisach, engineering works induced simplification and stabilization of the channel pattern from a formerly braiding sector to a single incised channel, hydrological modifications, bottom armouring due to bedload decrease, and thus ecological alterations. Two complementary and interdisciplinary projects have been initiated to restore alluvial morphodynamics: i) the international âINTERREG IV - Redynamisation of the old Rhineâ project (2009-2012) coordinated by the Alsace region, France; ii) the left bank âcontrolled erosionâ project launched by ElectricitĂ© de France (EDF) within Kembs hydroelectric station relicensing process since 2003-2004. The purpose of these projects is to evaluate the feasibility of an important hydro-morphological and ecological restoration plan on a 45 km long reach, through both field testing of bank erosion techniques at favourable locations, and artificial sediments input from right bank excavations. This will help define possible long term prospective scenarios, in order to restore sustainable sediment transport, morphodynamics variability and associated ecological functions. The study will involve historical analysis, hydro-morphological / hydraulic physical and numerical modelling, physical and ecological monitoring, and sociological aspectsLe Rhin alsacien-allemand a enregistrĂ© de profondes modifications morphologiques et hydrologiques Ă la suite de sa correction et de sa rĂ©gularisation pour la protection contre les crues et la navigation, puis aprĂšs la construction de barrages hydro-Ă©lectriques. Les amĂ©nagements rĂ©alisĂ©s entre Huningue et Neuf-Brisach ont engendrĂ© une simplification et une stabilisation du style fluvial. Un fleuve en tresses a cĂ©dĂ© la place Ă un chenal unique incisĂ©. Le fond de chenal est devenu pavĂ© Ă cause dâune diminution des apports de charge de fond et des altĂ©rations Ă©cologiques ont Ă©tĂ© observĂ©es (simplification des habitats aquatiques et riverains). Deux projets complĂ©mentaires et interdisciplinaires ont Ă©tĂ© engagĂ©s afin de restaurer une dynamique des formes alluviales : i) le projet international INTERREG IV â Redynamisation du Vieux Rhin (2009-2012) sous lâimpulsion de la rĂ©gion Alsace ; ii) le projet dâĂ©rosion maitrisĂ©e des berges de la rive gauche conduit par ElectricitĂ© de France (EDF) dans le cadre du renouvellement de la concession de lâamĂ©nagement de Kembs. Lâobjectif des deux projets est de dĂ©finir un plan de restauration hydro-morphologique et Ă©cologique conduisant Ă la redynamisation dâun tronçon de 45 km. LâĂ©tude repose sur une analyse historique, lâexploitation de modĂšles Ă la fois physiques et numĂ©riques, et les suivis morphologiques in situ dâune recharge artificielle en sĂ©diments et dâĂ©rosions de berge contrĂŽlĂ©es. Ces Ă©tudes de faisabilitĂ© sont complĂ©tĂ©es par des analyses Ă©cologique et sociologique pour apprĂ©cier lâimpact socio-environnemental de ces projets
OcorrĂȘncia de anticorpos anti-Neospora spp. em jumentos (Equus asinus) no estado de Sucre - ColĂŽmbia
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