Specifying Adaptations through a DSL with an Application to Mobile Robot Navigation

Developing applications for resource-constrained embedded systems is a challenging task specially when applications must adapt to changes in their operating conditions or environment. To ensure an appropriate response at all times, it is highly desirable to develop applications that can dynamically adapt their behavior at run-time. In this paper we introduce an architecture that allows the specification of adaptable behavior through an external, high-level and platform-independent domain-specific language (DSL). The DSL is used here to define adaptation rules that change the run-time behavior of the application depending on various operational factors, such as time constraints. We illustrate the use of the DSL in an application to mobile robot navigation using smartphones, where experimental results highlight the benefits of specifying the adaptable behavior in a flexible and external way to the main application logic

Candidatus Bartonella merieuxii, a potential new zoonotic Bartonella species in canids from Iraq.

Bartonellae are emerging vector-borne pathogens infecting erythrocytes and endothelial cells of various domestic and wild mammals. Blood samples were collected from domestic and wild canids in Iraq under the United States Army zoonotic disease surveillance program. Serology was performed using an indirect immunofluorescent antibody test for B. henselae, B. clarridgeiae, B. vinsonii subsp. berkhoffii and B. bovis. Overall seroprevalence was 47.4% in dogs (n = 97), 40.4% in jackals (n = 57) and 12.8% in red foxes (n = 39). Bartonella species DNA was amplified from whole blood and representative strains were sequenced. DNA of a new Bartonella species similar to but distinct from B. bovis, was amplified from 37.1% of the dogs and 12.3% of the jackals. B. vinsonii subsp. berkhoffii was also amplified from one jackal and no Bartonella DNA was amplified from foxes. Adjusting for age, the odds of dogs being Bartonella PCR positive were 11.94 times higher than for wild canids (95% CI: 4.55-31.35), suggesting their role as reservoir for this new Bartonella species. This study reports on the prevalence of Bartonella species in domestic and wild canids of Iraq and provides the first detection of Bartonella in jackals. We propose Candidatus Bartonella merieuxii for this new Bartonella species. Most of the Bartonella species identified in sick dogs are also pathogenic for humans. Therefore, seroprevalence in Iraqi dog owners and bacteremia in Iraqi people with unexplained fever or culture negative endocarditis requires further investigation as well as in United States military personnel who were stationed in Iraq. Finally, it will also be essential to test any dog brought back from Iraq to the USA for presence of Bartonella bacteremia to prevent any accidental introduction of a new Bartonella species to the New World

A subida do nível do mar durante o Holocénico no Golfo de Cadiz – tendência regional e diferenças locais

In Guadiana River Estuary, the Holocene sequence is underlain by pebbly delta fan formed in two stages, prior to 5E and 3 highstands. The Holocene sedimentary sequence was lain either directly on gravels or on top of fluvial sands deposited between 11000 and 10000 yr. BP. An accelerated phase of infilling of the estuary by clayey sediments, containing marsh foraminifer Trochammina, began at ca. 9800 yr. BP when the sea level was about 39 m below the present.At ca. 7000 BP the central part of the estuary started to accommodate coarser sediments, partially introduced from the shelf. The first phase of the Holocene sea level rise at a rate of 0.85 m/century terminated at ca 6500yr. BP. Since then, the lagoonal bodies in the vicinity of estuary started to enclose behind sand spits and predominantly sandy sedimentation initiated within the estuary. After the second phase of a slower rise at the rate of 0.3 m/century, which lasted until ca. 5000 yr.BP, the sea approached the present level. Data from Guadalete Estuary published in Spain set the beginning of Holocene transgression at shallower level (ca 10m)than in Guadiana Estuary.This discrepancy may be explained by isostatic uplift of Betic Cordillera or slumping of Guadiana terrace on which the Holocene sediments are lain. Since 7500 yr. BP the data from Odiel-Tinto, Guadalete and Guadiana are in a relatively good agreement.INTERREG I

A domain-specific aspect language for transforming MATLAB programs

Aspect-oriented programming provides powerful ways to augment programs with information out of the scope of the base language while avoiding harming code readability and thus portability. MATLAB is a popular modeling/programming language that will strongly benefit of aspect-oriented programming features. For instance, MATLAB programmers could use aspects to provide information such as restrictions on allowed data types and/or values, monitoring specific aspects of the execution such as the effective dataset sizes or if a given variable ever assumes a specific value, without “polluting” the code with “check code”. This paper describes the main concepts of a domain-specific aspect language (DSAL) for specifying transformations of MATLAB programs in view of supporting optimizations by facilitating the experimentation of alternative implementations. This DSAL specifies aspect modules structured in three sections: intersections equivalent to AspectJ poincuts, actions equivalent to AspectJ advice, and conditions that control triggering of actions. Support for aspect composition strategies and aspect parameterization of tokens from the base program are also supported. We believe the described features complement and enhance MATLAB programming in substantial and valuable ways

Obesity and brain cancer: proteomic analyzes of the influence of the adipocyte secretome on glioma Gl261 cells

Glioma is the most frequent form of malignant brain tumor in the adults and childhood. There is a global tendency toward a higher incidence of gliomas in highly developed and industrialized countries. Simultaneously obesity is reaching epidemic proportions in such developed countries. It has been highly accepted that obesity may play an important role in the biology of several types of cancer. We have developed an in vitro method for the understanding of the influence of obesity on glioma mouse cells (Gl261).info:eu-repo/semantics/publishedVersio

Adipocyte proteome and secretome influence inflammatory and hormone pathways in glioma

Gliomas represent the most common primary malignant brain tumors in adults, with an extremely poor prognosis. Among several risk factors, lifestyle was also recently identified as a major risk factor for the development of primary glioma. In the present study, we explore the relationship between obesity and glioma in a cellular model. Thus, we have study the influence of adipocytes secretome on glioma cell line GL261. Using the 3T3-L1 adipocyte cell line, and its conditioned medium (adipokines-enriched medium), we showed that adipocyte-released factors relate with glioma angiogenic, growth, hormones and metabolic behavior by MALDI-TOF-MS and proteomic array analysis. In a first view, STI1, hnRNPs and PGK1 are under expressed on CGl. Similarly, both carbonic anhydrase and aldose reductase are even suppressed in glioma cells that grown under adipokines-enriched environment. Contrariwise, RFC1, KIF5C, ANXA2, N-RAP and RACK1 are overexpressed in GL261 cell the in the presence of the adipokines-enriched medium. We further identified the factors that are released by adipocyte cells, and revealed that several pro-inflammatory and angiogenic factors, such as IL-6, IL-11, LIF, PAI-1, TNF-α, endocan, HGF, VEGF IGF-I, were secreted to the medium into a high extent, whereas TIMP-1 and SerpinE1 were under expressed on CGl. This study discloses an interesting in vitro model for the study of glioma biology under a "obesity" environment, that can be explored for the understanding of cancer cells biology, for the search of biomarkers, prognostic markers and therapeutic approaches.info:eu-repo/semantics/publishedVersio

The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria

Infection with Plasmodium vivax results in strong activation of monocytes, which are important components of both the systemic inflammatory response and parasite control. The overall goal of this study was to define the role of monocytes during P. vivax malaria. Here, we demonstrate that P. vivax-infected patients display significant increase in circulating monocytes, which were defined as CD14(+)CD16- (classical), CD14(+)CD16(+) (inflammatory), and CD14loCD16(+) (patrolling) cells. While the classical and inflammatory monocytes were found to be the primary source of pro-inflammatory cytokines, the CD16(+) cells, in particular the CD14(+)CD16(+) monocytes, expressed the highest levels of activation markers, which included chemokine receptors and adhesion molecules. Morphologically, CD14(+) were distinguished from CD14lo monocytes by displaying larger and more active mitochondria. CD14(+)CD16(+) monocytes were more efficient in phagocytizing P. vivax-infected reticulocytes, which induced them to produce high levels of intracellular TNF-alpha and reactive oxygen species. Importantly, antibodies specific for ICAM-1, PECAM-1 or LFA-1 efficiently blocked the phagocytosis of infected reticulocytes by monocytes. Hence, our results provide key information on the mechanism by which CD14(+)CD16(+) cells control parasite burden, supporting the hypothesis that they play a role in resistance to P. vivax infection

Aparência anatômica e radiográfica da cavidade torácica do macaco-prego (Cebus apella)

The capuchin monkey is widespread both north and south of the Legal Amazon and in the Brazilian cerrado. Ten clinically healthy capuchin monkeys were submitted to an anatomical and radiographic study of their thoracic cavities. The radiographic evaluation allowed the description of biometric values associated with the cardiac silhouette and thoracic structures. Application of the VHS (vertebral heart size) method showed positive correlation (P&lt;0.05) with depth of the thoracic cavity, as well as between the body length of vertebrae T 3, T 4, T 5 and T 6 and the cardiac length and width. The lung fields showed a diffuse interstitial pattern, more visible in the caudal lung lobes and a bronchial pattern in the middle and cranial lung lobes. The radiographic examination allowed preliminary inferences to be made concerning the syntopy of the thoracic structures and modifiication of the pulmonary patterns and cardiac anatomy for the capuchin monkey.O macaco-prego é muito comum tanto no norte, quanto no sul da Amazônia Legal e no cerrado brasileiro. Dez macacos-prego clinicamente saudáveis foram submetidos a um estudo anatômico e radiográfico de suas cavidades torácicas. A avaliação radiográfica permitiu a descrição de valores biométricos associados à silhueta cardíaca e estruturas torácicas. A aplicação do método de VHS (vertebral heart size) demonstrou correlação positiva (P <0,05) com a profundidade da cavidade torácica, assim como entre o comprimento do corpo de vértebras T3, T4, T5 e T6 e do comprimento e largura cardíaca. Os campos pulmonares apresentaram padrão intersticial difuso, mais visível nos lobos pulmonares caudais e um padrão brônquial em lobo pulmonar médio e cranial. O exame radiográfico permitiu inferências preliminares a serem realizadas no âmbito da sintopia das estruturas torácicas e de modificação dos padrões pulmonares e anatomia cardíaca para o macaco-prego