Exploring the concept of interaction computing through the discrete algebraic analysis of the Belousov–Zhabotinsky reaction

Interaction computing (IC) aims to map the properties of integrable low-dimensional non-linear dynamical systems to the discrete domain of finite-state automata in an attempt to reproduce in software the self-organizing and dynamically stable properties of sub-cellular biochemical systems. As the work reported in this paper is still at the early stages of theory development it focuses on the analysis of a particularly simple chemical oscillator, the Belousov-Zhabotinsky (BZ) reaction. After retracing the rationale for IC developed over the past several years from the physical, biological, mathematical, and computer science points of view, the paper presents an elementary discussion of the Krohn-Rhodes decomposition of finite-state automata, including the holonomy decomposition of a simple automaton, and of its interpretation as an abstract positional number system. The method is then applied to the analysis of the algebraic properties of discrete finite-state automata derived from a simplified Petri net model of the BZ reaction. In the simplest possible and symmetrical case the corresponding automaton is, not surprisingly, found to contain exclusively cyclic groups. In a second, asymmetrical case, the decomposition is much more complex and includes five different simple non-abelian groups whose potential relevance arises from their ability to encode functionally complete algebras. The possible computational relevance of these findings is discussed and possible conclusions are drawn

Experimental study on the influence of drill wear in CFRP drilling processes

CO2 laser machining represents a flexible technique for the rapid fabrication of miniaturized polymer structures such as polymethylmethacrilate (PMMA) microfluidic devices. A model to estimate the main dimensions (depth and width) of laser machined channels is presented, depending on process parameters (incident power, scanning speed). Blind cavities, to be used as fluid collectors, are machined layer by layer using multiple overlapping sequences of straight grooves with different scanning directions. The proposed technique shows that the removal depth varies proportionally with the number of layers machined, while surface roughness is influenced by the grooves spacing and the orientation of the scanning direction between successive layers. A method for thermally bonding the PMMA sheets, constituting the 3D structure of the chip, is also presented. The combination of high temperatures and a low bonding pressures makes it possible to generate a bulk junction enabling good performances in terms of sealing characteristic

Respon Pertumbuhan Embrio Somatik Kedelai (Glycine Max) Varietas Argomulyo dan Wilis terhadap Cekaman NaCl secara In-vitro

Penelitian ini bertujuan untuk mengetahui pertumbuhan embrio somatik kedelai varietas Argomulyo dan Wilis sebagai respon interaksi antara varietas dan konsentrasi cekaman NaCl. Parameternya adalah jumlah embrio somatik yang terbentuk pada akhir induksi pembentukan embrio somatik setelah satu bulan masa subkultur. Data dianalisis dengan uji Anova Two-Way kemudian dilanjutkan uji Tukey tingkat kepercayaan 95%. Varietas yang digunakan adalah varietas Argomulyo dan varietas Wilis. Konsentrasi NaCl yang digunakan adalah 0 mM, 50 mM, 100 mM, dan 200 mM dengan penambahan ZPT 2,4-D dan NAA 5 mg/L.Hasil penelitian ini adalah interaksi antara varietas dan konsentrasi NaCl tidak berpengaruh nyata terhadap pembentukan embrio somatik kedela

SARS-CoV-2 and extracellular vesicles: An intricate interplay in pathogenesis, diagnosis and treatment

Extracellular vesicles (EVs) are widely recognized as intercellular communication mediators. Among the different biological processes, EVs play a role in viral infections, supporting virus entrance and spread into host cells and immune response evasion. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became an urgent public health issue with significant morbidity and mortality worldwide, being responsible for the current COVID-19 pandemic. Since EVs are implicated in SARS-CoV-2 infection in a morphological and functional level, they have gained growing interest for a better understanding of SARS-CoV-2 pathogenesis and represent possible diagnostic tools to track the disease progression. Furthermore, thanks to their biocompatibility and efficient immune activation, the use of EVs may also represent a promising strategy for the development of new therapeutic strategies against COVID-19. In this review, we explore the role of EVs in viral infections with a focus on SARS-CoV-2 biology and pathogenesis, considering recent morphometric studies. The common biogenesis aspects and structural similarities between EVs and SARS-CoV-2 will be examined, offering a panoramic of their multifaceted interplay and presenting EVs as a machinery supporting the viral cycle. On the other hand, EVs may be exploited as early diagnostic biomarkers and efficient carriers for drug delivery and vaccination, and ongoing studies will be reviewed to highlight EVs as potential alternative therapeutic strategies against SARS-CoV-2 infection

Biological systems interact with Engineered NanoMaterials (ENMs): Possible environmental risks

There is a growing and controversial public debate on the potential risk of NanoMaterials (NMs) to living organisms, including humans. In particular, the processes of dispersion and bioaccumulation of Engineered NanoMaterials (ENMs) into the environment are poorly investigated. Biological systems interact with ENMs in a very complex dynamic way whose comprehension is still at its infancy. Thus the evaluation of the environmental impact of ENMs may be useful to minimize or eliminate ENMs toxicity and/or ecotoxicity, and to help authorities to draw directives and regulations for a safe production and use of ENMs. Here we briefly review biotoxicity and environmental risks of ENMs (like carbon- and metalnanoparticles) reporting also our experience in the cytotoxicity of carbon (C) and silver (Ag) NanoParticles (NPs) on HeLa cells and nanoecotoxicity on Paracentrotus lividus

The Role of Notaries in Making Agreements for the Sharing of Joint Assets for Supplies who will Divorce without a Marriage Agreement

Property as a life support for the bride and groom in the marriage bond. Where the property is obtained before the marriage (innate property) and obtained during the marriage (joint property). If the marriage bond is dissolved or broken, then each of them will defend their rights to the joint property so that the joint property is often a serious problem and often creates debate between the two parties (husband and wife).The research approach method used in this thesis is sociological juridical. This research specification uses descriptive analysis. The type of data used in this research is primary data which includes the 1945 Constitution; Act No. 2 of 2014 concerning the Position of a Notary; Act No. 16 of 2019 on the amendment to Act No. 1 of 1974 concerning Marriage; Code of Civil law; Compilation of Islamic Law, as well as secondary data containing books and other supporting documents. Collecting research data with interview techniques and study of documents or library materials. The data analysis method used is qualitative analysis.The results of the research and discussion that: First; the division of joint property for couples who are going to divorce in the concept of justice, namely dividing joint property equally or equally. This is in line with what has been regulated in the Marriage Law, the Civil Code and the compilation of Islamic Law which states that if there is a divorce, the joint assets are divided equally. Second; The role of a notary in making a deed of a joint property distribution agreement for a divorced couple without a marriage agreement, namely a notary as a public official who has the authority to make an authentic deed including a deed of a joint property distribution agreement based on the will of both parties who agree to share their assets in accordance with the law. applicable

Komposisi Dan Sebaran Patotipe Xanthomonas Oryzae Pv. Oryzae, Penyakit Pada Padi Di Nusa Tenggara Barat

A study was carried out to identify the composition and distribution of Xanthomonas oryzae pv. oryzae (Xoo) pathotypes on rice crop in West Nusa Tenggara, during the 2012 planting season. Three activities were conducted, namely collection of rice leaf samples from the fields, isolation of Xoo from the leaf samples at the laboratory, and testing pathotypes of Xoo at the screen house. Rice leaves showing typical bacterial leaf blight (BLB) symptom were collected from various farmers' fields. The samples were detached and put into paper envelopes, and were taken to the laboratory for isolation of Xoo, at the Laboratory of Pythopathology of Indonesian Center for Rice Research (ICRR), Sukamandi. Pathotype testing was done in the ICRR screen house by inoculating the leaves of five differential rice varieties using inocula of the Xoo isolates. Resistance of the rice differential varieties was determined based on the BLB disease severity. Inoculated plant with disease severity ≤11% was considered resistant (R) and disease severity >11% was susceptible (S). From the 240 samples of rice leaf infected with BLB collected from West Nusa Tenggara, 232 Xoo isolates were obtained. The Xoo pathotype identification showed that pathotype IV was the most dominant in West Nusa Tenggara during the 2012 planting season, numbering 118 isolates or 51.0% out of the total isolates, followed by pathotype VIII (67 isolates or 29.0%), and pathotype III (47 isolates or 20.0%)

Performance evaluation of attribute-based encryption in automotive embedded platform for secure software over-the-air update

This paper aims to show that it is possible to improve security for over the air update functionalities in an automotive scenario through the use of a cryptographic scheme, called “Attribute-Based-Encryption” (ABE), which grants confidentiality to the software/firmware update done Over The Air (OTA). We demonstrate that ABE is seamlessly integrable into the state of the art solutions regarding the OTA update by showing that the overhead of the ABE integration in terms of computation time and its storage is negligible w.r.t. the other overheads that are introduced by the OTA process, also proving that security can be enhanced with a minimum cost. In order to support our claim, we report the experimental results of an implementation of the proposed ABE OTA technique on a Xilinx ZCU102 evaluation board, which is an automotive-oriented HW/SW platform that is equipped with a Zynq UltraScale+ MPSoC chip that is representative of the computing capability of real automotive Electronic Control Units (ECUs)