Leveraging SN Ia spectroscopic similarity to improve the measurement of H0H_0

Recent studies suggest spectroscopic differences explain a fraction of the variation in Type Ia supernova (SN Ia) luminosities after light-curve/color standardization. In this work, (i) we empirically characterize the variations of standardized SN Ia luminosities, and (ii) we use a spectroscopically inferred parameter, SIP, to improve the precision of SNe Ia along the distance ladder and the determination of the Hubble constant ($H_0$). First, we show that the \texttt{Pantheon+} covariance model modestly overestimates the uncertainty of standardized magnitudes by $\sim 7$%, in the parameter space used by the $\texttt{SH0ES}$ Team to measure $H_0$; accounting for this alone yields $H_0 = 73.01 \pm 0.92$ km s$^{-1}$ Mpc$^{-1}$. Furthermore, accounting for spectroscopic similarity between SNe~Ia on the distance ladder reduces their relative scatter to $\sim0.12$ mag per object (compared to $\sim 0.14$ mag previously). Combining these two findings in the model of SN covariance, we find an overall 14% reduction (to $\pm 0.85$km s$^{-1}$ Mpc$^{-1}$) of the uncertainty in the Hubble constant and a modest increase in its value. Including a budget for systematic uncertainties itemized by Riess et al. (2022a), we report an updated local Hubble constant with $\sim1.2$% uncertainty, $H_0 = 73.29 \pm 0.90$km s$^{-1}$ Mpc$^{-1}$. We conclude that spectroscopic differences among photometrically standardized SNe Ia do not explain the ``Hubble tension." Rather, accounting for such differences increases its significance, as the discrepancy against $\Lambda$CDM calibrated by the ${\it Planck}$ 2018 measurement rises to 5.7$\sigma$.Comment: 28 pages, 15 figures, accepted to JCA

A Broadband Study of the Emission from the Composite Supernova Remnant MSH 11-62

MSH 11-62 (G291.1-0.9) is a composite supernova remnant for which radio and X-ray observations have identified the remnant shell as well as its central pulsar wind nebula. The observations suggest a relatively young system expanding into a low density region. Here we present a study of MSH 11-62 using observations with the Chandra, XMM-Newton, and Fermi observatories, along with radio observations from the Australia Telescope Compact Array (ATCA). We identify a compact X-ray source that appears to be the putative pulsar that powers the nebula, and show that the X-ray spectrum of the nebula bears the signature of synchrotron losses as particles diffuse into the outer nebula. Using data from the Fermi LAT, we identify gamma-ray emission originating from MSH 11-62. With density constraints from the new X-ray measurements of the remnant, we model the evolution of the composite system in order to constrain the properties of the underlying pulsar and the origin of the gamma-ray emission.Comment: 12 Pages, 12 figures. Accepted for publication in the Astrophysical Journa

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals who were chronically infected with HCV, predominantly genotype 3. We show that both alleles of genes encoding human leukocyte antigen molecules and genes encoding components of the interferon lambda innate immune system drive viral polymorphism. Additionally, we show that IFNL4 genotypes determine HCV viral load through a mechanism dependent on a specific amino acid residue in the HCV NS5A protein. These findings highlight the interplay between the innate immune system and the viral genome in HCV control

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene

Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic cell lineages. Repressive histone modifications such as H3K9me3 or H3K27me3 have been investigated in detail, but the role of H4K20me3 in development is currently unknown. Here we show that Xenopus laevis Suv4-20h1 and h2 histone methyltransferases (HMTases) are essential for induction and differentiation of the neuroectoderm. Morpholino-mediated knockdown of the two HMTases leads to a selective and specific downregulation of genes controlling neural induction, thereby effectively blocking differentiation of the neuroectoderm. Global transcriptome analysis supports the notion that these effects arise from the transcriptional deregulation of specific genes rather than widespread, pleiotropic effects. Interestingly, morphant embryos fail to repress the Oct4-related Xenopus gene Oct-25. We validate Oct-25 as a direct target of xSu4-20h enzyme mediated gene repression, showing by chromatin immunoprecipitaton that it is decorated with the H4K20me3 mark downstream of the promoter in normal, but not in double-morphant, embryos. Since knockdown of Oct-25 protein significantly rescues the neural differentiation defect in xSuv4-20h double-morphant embryos, we conclude that the epistatic relationship between Suv4-20h enzymes and Oct-25 controls the transit from pluripotent to differentiation-competent neural cells. Consistent with these results in Xenopus, murine Suv4-20h1/h2 double-knockout embryonic stem (DKO ES) cells exhibit increased Oct4 protein levels before and during EB formation, and reveal a compromised and biased capacity for in vitro differentiation, when compared to normal ES cells. Together, these results suggest a regulatory mechanism, conserved between amphibians and mammals, in which H4K20me3-dependent restriction of specific POU-V genes directs cell fate decisions, when embryonic cells exit the pluripotent state

A Comprehensive Measurement of the Local Value of the Hubble Constant with 1 km/s/Mpc Uncertainty from the Hubble Space Telescope and the SH0ES Team

We report observations from HST of Cepheids in the hosts of 42 SNe Ia used to calibrate the Hubble constant (H0). These include all suitable SNe Ia in the last 40 years at z1000 orbits, more than doubling the sample whose size limits the precision of H0. The Cepheids are calibrated geometrically from Gaia EDR3 parallaxes, masers in N4258 (here tripling that Cepheid sample), and DEBs in the LMC. The Cepheids were measured with the same WFC3 instrument and filters (F555W, F814W, F160W) to negate zeropoint errors. We present multiple verifications of Cepheid photometry and tests of background determinations that show measurements are accurate in the presence of crowding. The SNe calibrate the mag-z relation from the new Pantheon+ compilation, accounting here for covariance between all SN data, with host properties and SN surveys matched to negate differences. We decrease the uncertainty in H0 to 1 km/s/Mpc with systematics. We present a comprehensive set of ~70 analysis variants to explore the sensitivity of H0 to selections of anchors, SN surveys, z range, variations in the analysis of dust, metallicity, form of the P-L relation, SN color, flows, sample bifurcations, and simultaneous measurement of H(z). Our baseline result from the Cepheid-SN sample is H0=73.04+-1.04 km/s/Mpc, which includes systematics and lies near the median of all analysis variants. We demonstrate consistency with measures from HST of the TRGB between SN hosts and NGC 4258 with Cepheids and together these yield 72.53+-0.99. Including high-z SN Ia we find H0=73.30+-1.04 with q0=-0.51+-0.024. We find a 5-sigma difference with H0 predicted by Planck+LCDM, with no indication this arises from measurement errors or analysis variations considered to date. The source of this now long-standing discrepancy between direct and cosmological routes to determining the Hubble constant remains unknown.Comment: 67 pages, 31 figures, replaced to match ApJ accepted version (March 2022), Table 6 distances included here, long form of photometry tables, fitting code, compact form of data, available from Github page, https://pantheonplussh0es.github.i

'To live and die [for] Dixie': Irish civilians and the Confederate States of America

Around 20,000 Irishmen served in the Confederate army in the Civil War. As a result, they left behind, in various Southern towns and cities, large numbers of friends, family, and community leaders. As with native-born Confederates, Irish civilian support was crucial to Irish participation in the Confederate military effort. Also, Irish civilians served in various supporting roles: in factories and hospitals, on railroads and diplomatic missions, and as boosters for the cause. They also, however, suffered in bombardments, sieges, and the blockade. Usually poorer than their native neighbours, they could not afford to become 'refugees' and move away from the centres of conflict. This essay, based on research from manuscript collections, contemporary newspapers, British Consular records, and Federal military records, will examine the role of Irish civilians in the Confederacy, and assess the role this activity had on their integration into Southern communities. It will also look at Irish civilians in the defeat of the Confederacy, particularly when they came under Union occupation. Initial research shows that Irish civilians were not as upset as other whites in the South about Union victory. They welcomed a return to normalcy, and often 'collaborated' with Union authorities. Also, Irish desertion rates in the Confederate army were particularly high, and I will attempt to gauge whether Irish civilians played a role in this. All of the research in this paper will thus be put in the context of the Drew Gilpin Faust/Gary Gallagher debate on the influence of the Confederate homefront on military performance. By studying the Irish civilian experience one can assess how strong the Confederate national experiment was. Was it a nation without a nationalism

Hydrogen Epoch of Reionization Array (HERA)

The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to measure 21 cm emission from the primordial intergalactic medium (IGM) throughout cosmic reionization ($z=6-12$), and to explore earlier epochs of our Cosmic Dawn ($z\sim30$). During these epochs, early stars and black holes heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is designed to characterize the evolution of the 21 cm power spectrum to constrain the timing and morphology of reionization, the properties of the first galaxies, the evolution of large-scale structure, and the early sources of heating. The full HERA instrument will be a 350-element interferometer in South Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz. Currently, 19 dishes have been deployed on site and the next 18 are under construction. HERA has been designated as an SKA Precursor instrument. In this paper, we summarize HERA's scientific context and provide forecasts for its key science results. After reviewing the current state of the art in foreground mitigation, we use the delay-spectrum technique to motivate high-level performance requirements for the HERA instrument. Next, we present the HERA instrument design, along with the subsystem specifications that ensure that HERA meets its performance requirements. Finally, we summarize the schedule and status of the project. We conclude by suggesting that, given the realities of foreground contamination, current-generation 21 cm instruments are approaching their sensitivity limits. HERA is designed to bring both the sensitivity and the precision to deliver its primary science on the basis of proven foreground filtering techniques, while developing new subtraction techniques to unlock new capabilities. The result will be a major step toward realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table