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Rivers have distinctive channel patterns such as multi-channel braiding and single-channel meandering. Why these different river patterns emerge is only qualitatively understood. Yet, we have not been able to retain dynamic meandering in laboratory experiments. The main objective of this thesis was to develop experimental settings in the laboratory that lead to dynamic meandering, in order to determine how rivers self-organize their morphology through interactions between channels, floodplain and vegetation. I unraveled these interactions in a series of controlled flume experiments. I found that classical similarity scaling as used in engineering scale models does not work well because the channel width-depth ratio that determines bar formation is a dependent parameter in self-formed channels. Therefore, I relaxed the scaling rules. Systematic small-scale tests showed that there is a narrow range of suitable conditions for continuous meandering regarding sediment mobility and bank strength. Initially, in a straight channel with a low width-depth ratio alternate bars develop and evolve into meander bends. An upstream perturbation is required to initiate bar formation, but the experiments showed that a static perturbation led to low amplitude bends. In contrast, a transversely moving inlet point caused high-amplitude dynamic meandering with scrolls bars and infrequent chute cutoffs. Floodplain development further defined the resulting river pattern. In experiments with only channel sediment, overbank flow led to chute cutoffs that terminated meander bend development and that were the onset of a braided river with multiple parallel channels. Bank erosion by bend migration is balanced by deposition of sediment forming new floodplains and cutoffs, as also confirmed by numerical modeling. I showed that vegetation and fine sediment on the floodplain decreased the number of chute cutoffs, allowing meander bends to grow further. The fine sediment adds cohesion to the floodplain and increased bank strength, while plants increased bank strength and roughness. The combination of flume experiments and numerical model results shows that channel dynamics are controlled by bankfull discharge conditions, but overbank flow is highly important in constructing and destroying the floodplain. The composition of the floodplain, e.g. cohesion of the banks and the presence of vegetation, determines whether a braided or a meandering river pattern develops

Огляд матеріалів всеукраїнської науково-теоретичної конференції «Ірраціональне підгрунтя раціональності»

Конференція відбулася 14 квітня 2009 року в приміщенні ПДПУ імені В.Г.Короленка. Організаторами конференції були кафедра філософії Полтавського державного педагогічного університету імені В.Г.Короленка, відділ філософської антропології інституту філософії імені Г.С.Сковороди НАН України, кафедра філософії Київського національного педагогічного університету імені М.П.Драгоманова

Bifurcation instability and chute cutoff development in meandering gravel-bed rivers

Chute cutoffs reduce sinuosity of meandering rivers and potentially cause a transition from a single to a multiple channel river. The channel bifurcation of the main channel and the mouth of the incipient chute channel controls sediment and flow partitioning and development of the chute. Recent channel bifurcation models suggest that upstream bend radius, gradient advantage, inlet step, and upstream sediment supply at the bifurcation are important factors in the evolution of bifurcations. Our objective is to unravel the relative importance of these factors for chute cutoff success and development. We compare results from a morphodynamic three-dimensional (3D) model and a one-dimensional (1D) model with nodal-point relation with field observations of chute cutoffs in a meandering gravel-bed river. The balance between increased gradient advantage and flow curvature upstream of the chute channel bifurcation was systematically investigated with the 1D model. The 3D model runs and the field observations show the development of two types of chute cutoffs: a scroll-slough cutoff and a bend cutoff. The morphodynamic 3D model demonstrates that chutes are initiated when flow depth exceeds the floodplain elevation. Overbank flow and a significant gradient advantage result in a bend cutoff. The outcome of the 1D model shows that channel curvature at the bifurcation determines the success or failure of the chute cutoff when the chute channel is located at the inner bend, as in the case of scroll-slough cutoffs. We conclude that chute initiation depends on floodplain characteristics, i.e., floodplain elevation, sediment composition, and the presence of vegetation. Chute cutoff success or failure is determined by the dynamics just upstream of the channel bifurcation and location of the chute channel in the bend, which determines channel curvature and gradient advantage. These findings have ramifications for the prediction of chute cutoff in a wide range of rivers under natural and managed conditions and for the understanding of stratigraphy and architecture of deposits

Bank pull or bar push: what drives scroll-bar formation in meandering river?

One of the most striking features of meandering rivers are quasi-regular ridges of the point bar, evidence of a pulsed lateral migration of meander bends. Scroll bars formed on the inner bend are preserved on the point-bar surface as a series of ridges as meanders migrate, and in the subsurface of the point bar as inclined heterolithic stratification with lateral accretion surfaces. It is necessary to understand the formation and sedimentary architecture of these point bars, which are fundamental geomorphic building blocks of meandering rivers and potential reservoirs for water, oil, and gas. However, it remains unresolved whether the scroll-bar pattern forms in response to outer bend bank erosion during floods (i.e., bank pull), or is forced by bank progradation (i.e., bar push). Here we use experimentally formed meandering rivers with a set of static and migrating bends to isolate the effects of sediment supply to the point bar, bank protection, and forced bank retreat. We find that channel widening caused by bank retreat near the bend apex causes deposition of new scroll ridges along the inner bend point bar, whereas scroll bars cannot be forced by sediment pulses. Thus channel width variations along meander bends cause bank pull, which is necessary for scroll-bar formation. Furthermore, we find that each newly attached scroll bar overlies a nonpermeable layer of finer-grained sediment caused by the temporary flow expansion, which explains the fining-upward tendency of point bars

Production of inflammatory mediators by human macrophages obtained from ascites

Ascites is a readily available source of human macrophages (Mø), which can be used to study Mø functions in vitro. We characterized the mediators of inflammation produced by human peritoneal Mø (hp-Mø) obtained from patients with portal hypertension and ascites. The production of the cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) was found to be lipopolysaccharide (LPS) concentration dependent (0–10 μg/ml) with a maximal production at 10 μg/ml and also dependent on the time of exposure to the stimulus (0–36 h). IL-1β, IL-6 and TNF-α production after LPS administration reached a plateau at 24 h. In vitro stimulation for 24 h with LPS does not influence the eicosanoid production from endogenous arachidonate. 13 min of exposure of the cells to the calcium ionophore A23187 gives a significant increase in eicosanoid production from both exogenous and endogenous arachidonate. The main eicosanoids produced are the 5-lipoxgenase products LTB4 and 5-hydroxyeicosatetraenoic acid (HETE). The increase in production of the other eicosanoids is not significant. The eicosanoid production depends on the stimulus concentration. The optimal A23187 concentration is 1 μM. Oxygen radical production was measured in the Mø by a flowcytometric method. The fluorescence intensity of phorbol 12-myristate 13-acetate stimulated and dihydro-rhodamine 123 loaded. hp-Mø increases significantly after 15 min. We conclude that LPS stimulation of hp-Mø from liver disease results in similar production of IL-1β, IL-6 and TNF-α, but that the profile of the eicosanoid production of these Mø stimulated with LPS and A23187 differs from Mø of other origin and species

Healthcare utilization patterns for knee and hip osteoarthritis before and after changes in national health insurance coverage:A data linkage study from the Netherlands

Introduction: Medical guidelines aim to stimulate stepped care for knee and hip osteoarthritis, redirecting treatments from hospitals to primary care. In the Netherlands, this development was supported by changing health insurance coverage for physio/exercise therapy. The aim of this study was to evaluate healthcare utilization patterns before and after health changes in health insurance coverage. Method: We analyzed electronic health records and claims data from patients with osteoarthritis in the knee (N =32,091) and hip (N = 16,313). Changes between 2013 and 2019 in the proportion of patients treated by the general practitioner, physio/exercise therapist or orthopedic surgeon within 6 months after onset were assessed. Results: Joint replacement surgeries decreased for knee (OR 0.47 [0.41–0.54]) and hip (OR 0.81 [0.71–0.93]) osteoarthritis between 2013–2019. The use of physio/exercise therapy increased (knee: OR 1.38 [1.24–1.53], hip: OR 1.26 [1.08–1.47]). However, the proportion treated by a physio/exercise therapist decreased for patients that had not depleted their annual deductibles (knee: OR 0.86 [0.79 – 0.94], hip: OR 0.90 [0.79 – 1.02]). This might be affected by the inclusion of physio/exercise therapy in basic health insurance in 2018. Conclusion:We have found a shift from hospitals to primary care in knee and hip osteoarthritis care. However, the use of physio/exercise therapy declined after changes in insurance coverage for patients that had not depleted their deductibles

Levels of soluble intercellular adhesion molecule 1, eicosanoids and cytokines in ascites of patients with liver cirrhosis, peritoneal cancer and spontaneous bacterial peritonitis

The levels of the eicosanoids leukotriene B4, prostaglandin E2, prostacycline and thromboxane B2, the cytokines interleukin-1β, interleukin-6 and tumour necrosis factor-α and soluble intercellular adhesion molecule 1 were measured in ascites and plasma samples of patients with liver cirrhosis (53), peritoneal cancer (26) and spontaneous bacterial peritonitis (10) to assess their value as a possible diagnostic and prognostic parameter in the course of the disease. Soluble intercellular adhesion molecule 1, of the eicosanoids prostaglandin E2 and leukotriene B4, and the protein concentration in ascites were all significantly elevated in ascites of patients with peritoneal cancer in comparison to ascites of patients with liver cirrhosis. In ascites of patients with spontaneous bacterial infection interleukin-6 concentration was significantly elevated and the protein concentration was significantly lower in comparison to the other two groups. None of these parameters, however, seems to be of practical use as a diagnostic parameter, as there is an overlap between all the levels of these mediators in ascites of liver cirrhosis, peritoneal cancer and spontaneous bacterial peritonitis group. Soluble intercellular adhesion molecule 1 levels were much higher in plasma than in ascites, in contrast to interleukin-6 levels which were much higher in ascites than in plasma. Soluble intercellular adhesion molecule 1 in ascites correlated with soluble intercellular adhesion molecule 1 in plasma (r = 0.6926, P = 0.0001). Soluble intercellular adhesion molecule 1, interleukin-6 and the number of polymorphonuclear cells in peritoneal fluid correlated during episodes of infection in patients with a peritonitis. For this reason soluble intercellular adhesion molecule 1 and interleukin-6 could be of prognostic value for patients with peritonitis

Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice

Background and aims Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement. The acuteness of this increased risk suggests abrupt enhancement in plaque vulnerability, which may be related to intra-plaque inflammation, thinner fibrous cap and/or necrotic core expansion. We hypothesized that acute systemic inflammation following major orthopedic surgery induces such changes. Methods ApoE−/− mice were fed a western diet for 10 weeks. Thereafter, half the mice underwent mid-shaft femur osteotomy followed by realignment with an intramedullary K-wire, to mimic major orthopedic surgery. Mice were sacrificed 5 or 15 days post-surgery (n = 22) or post-saline injection (n = 13). Serum amyloid A (SAA) was measured as a marker of systemic inflammation. Paraffin embedded slides of the aortic root were stained to measure total plaque area and to quantify fibrosis, calcification, necrotic core, and inflammatory cells. Results Surgery mice showed a pronounced elevation of serum amyloid A (SAA) and developed increased plaque and necrotic core area already at 5 days, which reached significance at 15 days (p = 0.019; p = 0.004 for plaque and necrotic core, respectively). Macrophage and lymphocyte density significantly decreased in the surgery group compared to the control group at 15 days (p = 0.037; p = 0.024, respectively). The density of neutrophils and mast cells remained unchanged. Conclusions Major orthopedic surgery in ApoE−/− mice triggers a systemic inflammatory response. Atherosclerotic plaque area is enlarged after surgery mainly due to an increase of the necrotic core. The role of intra-plaque inflammation in this response to surgical injury remains to be fully elucidated. © 2016 Elsevier Ireland Lt

The Coevolution of Phycobilisomes: Molecular Structure Adapting to Functional Evolution

Phycobilisome is the major light-harvesting complex in cyanobacteria and red alga. It consists of phycobiliproteins and their associated linker peptides which play key role in absorption and unidirectional transfer of light energy and the stability of the whole complex system, respectively. Former researches on the evolution among PBPs and linker peptides had mainly focused on the phylogenetic analysis and selective evolution. Coevolution is the change that the conformation of one residue is interrupted by mutation and a compensatory change selected for in its interacting partner. Here, coevolutionary analysis of allophycocyanin, phycocyanin, and phycoerythrin and covariation analysis of linker peptides were performed. Coevolution analyses reveal that these sites are significantly correlated, showing strong evidence of the functional and structural importance of interactions among these residues. According to interprotein coevolution analysis, less interaction was found between PBPs and linker peptides. Our results also revealed the correlations between the coevolution and adaptive selection in PBS were not directly related, but probably demonstrated by the sites coupled under physical-chemical interactions

Effects of oral meal feeding on whole body protein breakdown and protein synthesis in cachectic pancreatic cancer patients

Background: Pancreatic cancer is often accompanied by cachexia, a syndrome of severe weight loss and muscle wasting. A suboptimal response to nutritional support may further aggravate cachexia, yet the influence of nutrition on protein kinetics in cachectic patients is poorly understood. Methods: Eight cachectic pancreatic cancer patients and seven control patients received a primed continuous intravenous infusion of l‐[ring‐2H5]phenylalanine and l‐[3,3‐2H2]tyrosine for 8 h and ingested sips of water with l‐[1‐13C]phenylalanine every 30 min. After 4 h, oral feeding was started. Whole body protein breakdown, protein synthesis, and net protein balance were calculated. Results are given as median with interquartile range. Results: Baseline protein breakdown and protein synthesis were higher in cachectic patients compared with the controls (breakdown: 67.1 (48.1–79.6) vs. 45.8 (42.6–46.3) µmol/kg lean body mass/h, P = 0.049; and synthesis: 63.0 (44.3–75.6) vs. 41.8 (37.6–42.5) µmol/kg lean body mass/h, P = 0.021). During feeding, protein breakdown decreased significantly to 45.5 (26.9–51.1) µmol/kg lean body mass/h (P = 0.012) in the cachexia group and to 33.7 (17.4–37.1) µmol/kg lean body mass/h (P = 0.018) in the control group. Protein synthesis was not affected by feeding in cachectic patients: 58.4 (46.5–76.1) µmol/kg lean body mass/h, but was stimulated in controls: 47.9 (41.8–56.7) µmol/kg lean body mass/h (P = 0.018). Both groups showed a comparable positive net protein balance during feeding: cachexia: 19.7 (13.1–23.7) and control: 16.3 (13.6–25.4) µmol/kg lean body mass/h (P = 0.908). Conclusion: Cachectic pancreatic cancer patients have a higher basal protein turnover. Both cachectic patients and controls show a comparable protein anabolism during feeding, albeit through a different pattern of protein kinetics. In cachectic patients, this is primarily related to reduced protein breakdown, whereas in controls, both protein breakdown and protein synthesis alterations are involved