The Vice Chair of Education in Emergency Medicine: A Workforce Study to Establish the Role, Clarify Responsibilities, and Plan for Success

ObjectivesDespite increasing prevalence in emergency medicine (EM), the vice chair of education (VCE) role remains ambiguous with regard to associated responsibilities and expectations. This study aimed to identify training experiences of current VCEs, clarify responsibilities, review career paths, and gather data to inform a unified job description.MethodsA 40‐item, anonymous survey was electronically sent to EM VCEs. VCEs were identified through EM chairs, residency program directors, and residency coordinators through solicitation e‐mails distributed through respective listservs. Quantitative data are reported as percentages with 95% confidence intervals and continuous variables as medians with interquartiles (IQRs). Open‐ and axial‐coding methods were used to organize qualitative data into thematic categories.ResultsForty‐seven of 59 VCEs completed the survey (79.6% response rate); 74.4% were male and 89.3% were white. Average time in the role was 3.56 years (median = 3.0 years, IQR = 4.0 years), with 74.5% serving as inaugural VCE. Many respondents held at least one additional administrative title. Most had no defined job description (68.9%) and reported no defined metrics of success (88.6%). Almost 78% received a reduction in clinical duties, with an average reduction of 27.7% protected time effort (median = 27.2%, IQR = 22.5%). Responsibilities thematically link to faculty affairs and promotion of the departmental educational mission and scholarship.ConclusionGiven the variability in expectations observed, the authors suggest the adoption of a unified VCE job description with detailed responsibilities and performance metrics to ensure success in the role. Efforts to improve the diversity of VCEs are encouraged to better match the diversity of learners.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154254/1/aet210407_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154254/2/aet210407.pd

Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men

IntroductionAzoospermia, characterized by an absence of sperm in the ejaculate, represents the most severe form of male infertility. While surgical sperm retrieval in obstructive azoospermia (OA) is successful in the majority of cases, patients with non-obstructive azoospermia (NOA) show retrieval rates of only about 50% and thus frequently have unnecessary surgery. Surgical intervention could be avoided if patients without preserved spermatogenesis are identified preoperatively. This prospective study aimed to discover biomarkers in seminal plasma that could be employed for a non-invasive differential diagnosis of OA/NOA in order to rationalize surgery recommendations and improve success rates.MethodsAll patients signed written informed consent, underwent comprehensive andrological evaluation, received human genetics to exclude relevant pathologies, and patients with azoospermia underwent surgical sperm retrieval. Using label-free LC-MS/MS, we compared the proteomes of seminal plasma samples from fertile men (healthy controls (HC), n=8) and infertile men diagnosed with 1) OA (n=7), 2) NOA with successful sperm retrieval (mixed testicular atrophy (MTA), n=8), and 3) NOA without sperm retrieval (Sertoli cell-only phenotype (SCO), n=7). Relative abundance changes of two candidate markers of sperm retrieval, HSPA2 and LDHC, were confirmed by Western Blot.ResultsWe found the protein expression levels of 42 proteins to be significantly down-regulated (p ≤ 0.05) in seminal plasma from SCO NOA patients relative to HC whereas only one protein was down-regulated in seminal plasma from MTA patients. Analysis of tissue and cell expression suggested that the testis-specific proteins LDHC, PGK2, DPEP3, and germ-cell enriched heat-shock proteins HSPA2 and HSPA4L are promising biomarkers of spermatogenic function. Western blotting revealed a significantly lower abundance of LDHC and HSPA2 in the seminal plasma of men with NOA (SCO and MTA) compared to controls.DiscussionThe results indicate that certain testis-specific proteins when measured in seminal plasma, could serve as indicators of the presence of sperm in the testis and predict the success of sperm retrieval. Used in conjunction with conventional clinical assessments, these proteomic biomarkers may assist in the non-invasive diagnosis of idiopathic male infertility

Overview of CAPICE-Childhood and Adolescence Psychopathology:unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network

Abstract The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention deficit hyperactivity disorder. CAPICE brings together eight birth and childhood cohorts as well as other cohorts from the EArly Genetics and Life course Epidemiology (EAGLE) consortium, including twin cohorts, with unique longitudinal data on environmental exposures and mental health problems, and genetic data on participants. Here we describe the objectives, summarize the methodological approaches and initial results, and present the dissemination strategy of the CAPICE network. Besides identifying genetic and epigenetic variants associated with these phenotypes, analyses have been performed to shed light on the role of genetic factors and the interplay with the environment in influencing the persistence of symptoms across the lifespan. Data harmonization and building an advanced data catalogue are also part of the work plan. Findings will be disseminated to non-academic parties, in close collaboration with the Global Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe)

Widespread deoxygenation of temperate lakes

The concentration of dissolved oxygen in aquatic systems helps to regulate biodiversity, nutrient biogeochemistry, greenhouse gas emissions, and the quality of drinking water. The long-term declines in dissolved oxygen concentrations in coastal and ocean waters have been linked to climate warming and human activity, but little is known about the changes in dissolved oxygen concentrations in lakes. Although the solubility of dissolved oxygen decreases with increasing water temperatures, long-term lake trajectories are difficult to predict. Oxygen losses in warming lakes may be amplified by enhanced decomposition and stronger thermal stratification8,9 or oxygen may increase as a result of enhanced primary production. Here we analyse a combined total of 45,148 dissolved oxygen and temperature profiles and calculate trends for 393 temperate lakes that span 1941 to 2017. We find that a decline in dissolved oxygen is widespread in surface and deep-water habitats. The decline in surface waters is primarily associated with reduced solubility under warmer water temperatures, although dissolved oxygen in surface waters increased in a subset of highly productive warming lakes, probably owing to increasing production of phytoplankton. By contrast, the decline in deep waters is associated with stronger thermal stratification and loss of water clarity, but not with changes in gas solubility. Our results suggest that climate change and declining water clarity have altered the physical and chemical environment of lakes. Declines in dissolved oxygen in freshwater are 2.75 to 9.3 times greater than observed in the world’s oceans and could threaten essential lake ecosystem services

Obturations a retro (étude comparative de l'adaptation marginale d'un ciment de portland modifié vs IRM®)

TOULOUSE3-BU Santé-Centrale (315552105) / SudocSudocFranceF

An Examination of Unhealthy Eating Behaviors in Two College Samples

Eating disorders pose major health risks to today\u27s college age woman. The American Psychological Association estimates that one to three percent of the population suffers from bulimia nervosa and .5 percent suffers from anorexia nervosa (American Psychological Association, 2000). Women contribute to at least ninety percent of all cases of anorexia nervosa and bulimia nervosa (AP A, 2000). Characteristics of a person with eating disorder pathology include upper class social standing. This has led some people to assume that college women are prime candidates for these disorders. To effectively deal with the problem of eating disorders among college women, it is essential to look at social environments that may promote eating disordered behaviors in college. Many studies focus on the psychological aspects of eating disorders, but fewer focus on social groups in developing or maintaining an eating disorder. The goal of this study is to determine whether sororities, obvious social groups, have higher prevalence rates of eating disorders than does a group of college women not associated with such a clearly defined social group. The purpose of this study is to add to current research regarding sororities and eating disorders, as there is so little presently

Addressing and Reducing Inequality Through Developmental Science: Mini-Workshops

Mini-workshop

Biology Direct:celebrating 7 years of open, published peer review

Approved for review, but I'll leave this to the OAR manager's discretion whether or not this should be uploaded, as it is a journal editorial and not a peer-reviewed piece of literature

Morphology and star formation in IllustrisTNG: the build-up of spheroids and discs

Using the IllustrisTNG simulations, we investigate the connection between galaxy morphology and star formation in central galaxies with stellar masses in the range 10(9)-10(11.5)M(circle dot). We quantify galaxy morphology by a kinematical decomposition of the stellar component into a spheroidal and a disc component (spheroid-to-total ratio, S/T) and by the concentration of the stellar mass density profile (C-82). S/T is correlated with stellar mass and star formation activity, while C-82 correlates only with stellar mass. Overall, we find good agreement with observational estimates for both S/T and C-82. Low- and high-mass galaxies are dominated by random stellar motion, while only intermediate-mass galaxies (M-star approximate to 10(10)-10(10.5)M(circle dot)) are dominated by ordered rotation. Whereas higher mass galaxies are typical spheroids with high concentrations, lower mass galaxies have low concentration, pointing to different formation channels. Although we find a correlation between S/T and star formation activity, in the TNG model galaxies do not necessarily change their morphology when they transition through the green valley or when they cease their star formation, this depending on galaxy stellar mass and morphological estimator. Instead, the morphology (S/T and C-82) is generally set during the star-forming phase of galaxies. The apparent correlation between S/T and star formation arises because earlier forming galaxies had, on average, a higher S/T at a given stellar mass. Furthermore, we show that mergers drive in situ bulge formation in intermediate-mass galaxies and are responsible for the recent spheroidal mass assembly in the massive galaxies with M-star > 10(11)M(circle dot). In particular, these massive galaxies assemble about half of the spheroidal mass while star-forming and the other half through mergers while quiescent