Vlp-based vaccines as a suitable technology to target trypanosomatid diseases

Funding Information: This research was funded by Global Health and Tropical Medicine (Grant number IHMT UID/multi/04413/2013 and Grant number PTDC/CVT-CVT/28908/2017), Funda??o para Ci?ncia e Tecnologia (FCT), Portugal; Grant GIU18/172 Grupos de Investigaci?n de la UPV/EHU, and Grant from CSIC Programa I-COOP+2020 (ICOOPB20503), Spain.A.M.V.Q., J.W.d.F.O., and C.J.M. thanks to the financial support (PhD scholar-ships) provided by CNPq and CAPES, Brazil. M.S.S. thanks to CNPq for the Research Grant (Bolsa de Produtividade em Pesquisa). We are also grateful to Paulo Fanado and Laysa Ohanna for editing this manuscript. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need. Today, according to modern vaccinology, virus-like particle (VLP) technology is involved in many vaccines, including those undergoing studies related to COVID-19. The potential use of VLPs as vaccine adjuvants opens an opportunity for the use of protozoan antigens for the development of vaccines against diseases caused by Trypanosoma cruzi, Leishmania spp., and Trypanosoma brucei. In this context, it is important to consider the evasion mechanisms of these protozoa in the host and the antigens involved in the mechanisms of the parasite–host interaction. Thus, the immunostimulatory properties of VLPs can be part of an important strategy for the development and evaluation of new vaccines. This work aims to highlight the potential of VLPs as vaccine adjuvants for the development of immunity in complex diseases, specifically in the context of tropical diseases caused by trypanosomatids.publishersversionpublishe

Correlation between scientific production, r&d, innovation and patents in the functional food scenario

Patent filing is considered an index of a country\u27s industrial development, it contributes to the strengthening of research, innovation and production of technological knowledge, that is, patents are considered relevant indicators to assess the country\u27s ability to transform scientific knowledge into products or technological innovations. Thus, the study aimed to investigate whether scientific advancement, R&D and innovation in research institutions or companies are linked to the evolution of the quantity of patent filings in the area of functional food production. The methodology had a descriptive and quantitative nature, in relation to the study variables, they were obtained as follows: a) Patent variable was obtained from Espacenet; b) Scientific articles obtained from the Web of Science (WOS) database; c) The data on the variables (Innovation Index) were obtained by accessing the countryeconomy.com website; d) The variables (Manufactured Value Added, R&D, High Technology Exports) obtained from The World Bank DATA database. The data collection of the variables began in January/2021 and ended on March 22, 2021. To identify the correlation of these variables, Spearman\u27s correlation coefficient was used, and for a better interpretation of the data and answers, the research hypotheses were analyzed from the scatter plot using the logarithmic transformation of the patent variable. The results and discussion showed a weak correlation ρ = 0.3038 between scientific production (articles) x patent filing aimed at the production of functional foods; positive correlation and a moderate degree (ρ = 0.6413) regarding investments in research and development x patent filing and a positive and weak correlation (ρ = 0.2903) regarding the innovation index x quantitative patents. In the final considerations, it is essential that governments provide the right and necessary incentives to foster the development and dissemination of ideas by the private sector whose objective is to promote a political, economic and institutional environment that encourages companies to invest in science, technology, R&D, intellectual property and innovation

Fratura coronorradicular complicada: Relato de caso / Complicated coronorradicular fracture: Case report

O traumatismo dentário consiste em uma injúria que pode afetar diversas estruturas básicas de suporte dentário, variando quanto a gravidade e extensão, com caráter de urgência odontológica. A fratura coronorradicular consiste no envolvimento de esmalte, dentina e cemento, constituintes da coroa e raiz dentária, com ou sem envolvimento pulpar. O objetivo deste trabalho foi descrever o caso clínico de um paciente de 45 anos, do gênero masculino, que compareceu à clínica-escola do curso de odontologia de um Centro Universitário em Alagoas com queixa de trauma dentário em um incisivo permanente superior. Após exames clínico, radiográfico e tomográfico foi diagnosticado a presença de uma fratura coronorradicular de grande extensão do incisivo central superior (21), o qual mostrou sinais de grande perda de estrutura dentária. O tratamento de escolha foi a exodontia, uma vez que, o tratamento conservador mostrou-se inviável devido à extensão da lesão, além de comprimento radicular inadequado. A abordagem de uma fratura coronorradicular deve ser baseada em uma anamnese detalhada com o auxílio de exames complementares radiográficos que, quando comparados, expressam maior nível de confiabilidade para a escolha da conduta terapêutica, permitindo identificar a real situação e saúde do elemento atingido

SPACIAL VARIABILITY AND SAMPLING DENSITY OF CHEMICAL ATTRIBUTES IN ARCHAEOLOGICAL BLACK EARTH AND NATIVE FOREST SOIL IN MANICORÉ, AM

AbstractConsidering the lack of information about spatial behavior of the soil attributes in areas of archaeological black earth and native forest, the objective of this study was to evaluate the spatial variability of chemical attributes and determine the sampling density in soil with archaeological black earth and native forest in the region of Manicoré, AM. The study was conducted in a rural property located in the community of Santo Antônio do Matupi, at the margins of BR 230, Trans-amazon highway, in the region of Manicoré, AM. In these areas were established grids of 70 m x 70 m, with regular spacing of 10 x 10 m, totaling 64 points, then soil samples were collected at a depth of 0.0-0.20 m and 0 , 40 - 0,60 m. Chemical attributes were determined (pH, OM, P, K, Ca, Mg, SB, CTC, V% and H + Al). Data were analyzed using descriptive statistical techniques and geostatistics. Sampling density was determined basing on CV and on the range of the semivariograms. It was verified that the studied attributes showed spatial variability and the area of archaeological black earth presented greater spatial variability than the native forest. Its greater sampling density was determined basing on the range of the adjusted semivariograms.Keywords: Indian black earth; attributes of soil; geostatistics.

Infecção do trato urinário relacionada ao cateterismo vesical / Urinary tract infection related to bladder catheterism

Investigou-se a relação existente entre a infecção do trato urinário e o cateterismo vesical. Estudo com a abordagem qualitativa cujo método é a revisão integrativa. Os resultados apontaram 08 artigos que possibilitaram a resolução dos questionamentos iniciais, do qual a infecção do trato urinário tem relação com a inserção do cateterismo vesical e um padrão de atendimento comum a utilização do cateterismo é em pacientes neurológicos com problemas no trato urinário inferior. O estudo apontou também dois grupos de infecção: infecção afebril e infecção febril. Por fim, há como formas de prevenção para a promoção e prevenção a saúde, práticas que envolvam: manejo na técnica, higiene, limpeza, utilização de produtos descartáveis, uso de substâncias especificas e produtos na facilitação da técnica, diferentes tipos de cateteres e educação conjunta (paciente, equipe e família)

Insuficiência cardíaca aguda: revisão integrativa

A Insuficiência Cardíaca Aguda (AHF) é uma condição em que ocorre o agravamento ou surgimento de sintomas e sinais da insuficiência cardíaca, principalmente relacionados à congestão sistêmica. Isso pode ocorrer devido a fatores precipitantes que afetam uma disfunção cardíaca estrutural ou funcional subjacente. Embora possa ser causada diretamente por uma nova disfunção cardíaca, é mais comumente desencadeada por uma síndrome coronariana aguda. A fisiopatologia da AHF é altamente heterogênea, variando de acordo com a doença cardíaca subjacente e os fatores precipitantes envolvidos. A disfunção diastólica ou sistólica ventricular esquerda leva a um aumento da pré e pós-carga, o que causa congestão pulmonar e sistêmica. Essa congestão gera acúmulo de líquidos e pode levar à disfunção orgânica devido à hipoperfusão. O tratamento atual da AHF é principalmente sintomático e focado em drogas descongestivas, com pouca consideração às particularidades fisiopatológicas subjacentes. Como resultado, a AHF ainda apresenta altas taxas de mortalidade e readmissão hospitalar

Comparison of the nutritional status in children aged 5 to 10 years old on the Conditional Cash Transfer Programme in the States of Acre and Rio Grande do Sul, Brazil

Introduction: In recent years, there has been a reduction in cases of malnutrition in Brazil but this has been accompanied with an increase in the overweight and obesity rates. These changes, together with others, such as changes in eating patterns and lifestyle, characterise the process of nutritional transition. Objective: We aimed to compare the prevalence of nutritional status of beneficiary children of the Bolsa Família Program (PBF) in the states of Acre and Rio Grande do Sul, Brazil, and to analyse the changes in the anthropometric profile of these children during 5 years. Methods: This is an ecological study using secondary data from the Food and Nutrition Surveillance System (SISVAN) and Bolsa Família Department of SUS (DATASUS), which assessed the nutritional status of children over 5 years and under 10 years benefiting from the PBF in the years 2011 to 2015 in the states of Acre and Rio Grande do Sul. The sample consisted of 94,865 children from Acre and 342,462 children from Rio Grande do Sul. The Body Mass Index was used to classify the nutritional status. Results: The mean prevalence of eutrophic children aged 5 to 10 years in Acre was 70.42% and was 61.28% in Rio Grande do Sul. Overweight was 13.06% in Acre and 19.48% in Rio Grande do Sul. Obesity was 5.08% in Acre and 9.36% in Rio Grande do Sul. Severe obesity was 4.02% in Acre and 6.92% in Rio Grande do Sul. Conclusion: Overweight and obesity in children benefiting from the PBF has been growing in the last 5 years, notably in the state of Rio Grande do Sul. This is possibly due to the fact that the nutritional transition is at a more advanced stage here than in Acre State. 

Heterose e distância genética em híbridos intervarietais de milho

The objective of this work was to evaluate the performance of intervarietal corn (Zea mays) hybrids with topcross crosses between landrace populations, and to confirm whether genetic dissimilarity between populations is correlated with the heterosis of the intervarietal hybrids in the field. Nine topcross-corn hybrids were evaluated with their tester 'BRS Planalto', and the following landrace populations were used as parents: Argentino Branco, Dente de Ouro, Amarelão, Criolão, Caiano Rajado, Branco Oito Carreiras, Branco Roxo Índio, Cateto Branco, and Argentino Amarelo. The tester 'BRS Planalto' and the topcross hybrids Branco Oito Carreiras x 'BRS Planalto' and Criolão x 'BRS Planalto' showed higher per se potential for grain yield. The topcross hybrid Branco Oito Carreiras x 'BRS Planalto' showed a better performance for the number of grains per row, grain weight, and ear diameter, whereas Criolão x 'BRS Planalto' displayed a better performance for the number of grains per row and ear length. Greater estimates of genetic distance did not necessarily result in greater heterosis values and were exclusively correlated with grain ear length. Therefore, it is not possible to predict the effects of high heterosis on grain yield, based on the genetic distance between the populations involved the crosses.O objetivo deste trabalho foi avaliar o desempenho de híbridos de milho (Zea mays) intervarietais, a partir de cruzamentos topcross entre populações crioulas, além de confirmar se a dissimilaridade genética entre as populações é correlacionada à heterose dos híbridos intervarietais no campo. Nove híbridos topcross foram avaliados com seu testador 'BRS Planalto', e as seguintes populações crioulas foram utilizadas como genitores: Argentino Branco, Dente de Ouro, Amarelão, Criolão, Caiano Rajado, Branco Oito Carreiras, Branco Roxo Índio, Cateto Branco e Argentino Amarelo. O testador 'BRS Planalto' e os híbridos topcross Branco Oito Carreiras x 'BRS Planalto' e Criolão x 'BRS Planalto' apresentaram maior potencial per se quanto ao rendimento de grãos. O topcross Branco Oito Carreiras x 'BRS Planalto' apresentou melhor desempenho quanto ao número de grãos por fileira, massa de grãos da espiga e diâmetro de espiga, enquanto o Criolão x 'BRS Planalto' apresentou melhor desempenho quanto ao número de grãos por fileira e comprimento de espiga. As maiores estimativas de distância genética não implicaram, necessariamente, altos valores de heterose, e tiveram correlação apenas com o comprimento da espiga. Portanto, não é possível predizer os efeitos de alta heterose sobre o rendimento de grãos, com base na distância genética entre as populações envolvidas nos cruzamentos