Caracterización molecular y análisis de diversidad genética en variedades de pimiento autóctonas de Galicia

Traballo fin de mestrado (UDC.CIE). Biotecnoloxía avanzada. Curso 2012/201

Association of frailty status in older adults with immunological endocrine and oxidative stress biomarkers

Programa Oficial de Doutoramento en Bioloxía Celular e Molecular . 5004V01[Resumen] La fragilidad es un síndrome geriátrico multidimensional caracterizado por una pérdida de homeostasis y un incremento de la vulnerabilidad. Actualmente, la identificación de la fragilidad se basa en características fenotípicas. Dada su reversibilidad, la identificación de la fragilidad mediante biomarcadores sería primordial para posibilitar una detección más temprana y precisa de los individuos frágiles. Debido a esto, el objetivo de este estudio fue investigar la posible asociación de diferentes biomarcadores con la fragilidad en personas mayores. Para ello, se llevó a cabo un estudio transversal en una población de mayores de 65 años, clasificados de acuerdo a su estado de fragilidad, determinando un conjunto de biomarcadores relacionados con la activación inmune y la inflamación, el sistema endocrino y el estrés oxidativo. Los resultados obtenidos mostraron diferencias significativas en los niveles de varios biomarcadores inmunológicos y el cortisol entre individuos frágiles y no frágiles, pero no se encontró asociación alguna entre los biomarcadores de estrés oxidativo y el estado de fragilidad. Los datos presentados en este trabajo apoyan la hipótesis de que el estado de fragilidad en personas mayores está relacionado con la estimulación inmune y la inflamación, así como con la desregulación del eje hipotalámico-pituitario-adrenal dependiente de la edad.[Resumo] A fraxilidade é un síndrome xeriátrico multidimensional caracterizado por unha pérdida de homeostase e un incremento da vulnerabilidade. Actualmente, a identificación da fraxilidade basease en características fenotípicas Dada a súa reversibilidade, a identificación da fraxilidade mediante biomarcadores sería primordial para posibilitar unha detección máis temperá e precisa dos individuos fráxiles. Debido a isto, o obxectivo deste estudo foi investigar a posible asociación de diversos biomarcadores coa fraxilidade en persoas maiores. Para iso, levóuse a cabo un estudo transversal nunha poboación de maiores de 65 anos, clasificados de acordo ao seu estado de fraxilidade, determinando un conxunto de biomarcadores relacionados coa activación inmune e a inflamación, o sistema endócrino e o estrés oxidativo. Os resultados obtidos amosaron diferencias significativas nos niveis de varios biomarcadores inmunolóxicos e o cortisol entre individuos fráxiles e non fráxiles, pero non se atopou asociación algunha entre os biomarcadores de estrés oxidativo e o estado de fraxilidade. Os datos presentados neste traballo apoian a hipótese de que o estado de fraxilidade en persoas maiores está relacionado coa estimulación inmune e a inflamación, así como coa desregulación do eixo hipotalámico-pituitario-adrenal dependente da idade.[Abstract] Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to stressors. Currently, frailty identification is based on phenotypic characteristics. Due to the well-known reversibility of frailty, early identification is crucial. Biomarkers can be useful tools for the early and accurate detection of frail individuals. Thus, the main objective of this study was to investigate the possible relationship of different biomarkers with frailty in older adults. To that aim, a cross-sectional study was conducted in a population of older adults (aged 65 years and over) classified according to their frailty status, determining a set of biomarkers related to immune activation and inflammation, to endocrine system, and to oxidative stress. Results obtained revealed significant differences in the levels of several immunological biomarkers and cortisol between frail and non-frail individuals, but no association was found between any oxidative stress biomarker and frailty status Data presented in this study provide support to the hypothesis that frailty status in older adults is associated with an additional degree of immune stimulation and inflammation, and with agerelated hypothalamic pituitary adrenal axis dysregulation

The ecology of the Mar Menor coastal lagoon: A fast changing ecosystem under human pressure

The Mar Menor is a hypersaline coastal lagoon, with a surface area of 135 km2 and a perimeter of 59.51 km. It is located on the southwestern Mediterranean coastline (3742′00′′N, 0047′00′′W) with a mean depth of 3.6 m and a maximum depth of 6 m. “La Manga,” a sandy bar 22 km long and 100–900 m wide, acts as a barrier between the lagoon and the Mediterranean Sea. It is crossed by five more or less functional inlets called golas. Four are shallow (less than 1 m deep) and one of them, El Estacio, was widened and dug to a 5-m depth to make it a navigational channel. Altogether a total width of lagoon entrances is about 645 m, giving Mar Menor a restriction ratio of 0.015. Mar Menor is therefore a restricted lagoon according to the classification proposed by Kjerfve1 (see Chapter 6). There are two main islands and three other smaller islands, one of which is artificially connected to La Manga

TÉCNICAS DE RECOLECCIÓN Y ESTUDIO EN LA CLASE HOLOTHUROIDEA. 1. GENERALIDADES, SISTEMÁTICA, ECOLOGÍA, BIOLOGÍA Y COMPORTAMIENTO

Studies about holothunans in Spain are scarce and they are reduced to some faunistic or systematic notes. In this paper some of the methods habitually employed in the different aspects of the systematic (sampling and preservation, preparation of spicules. calcareous ring, etc.), biological (reproduction, development, growth, nutrition and activity) and ecological (evaluation of the populations, incidence of the environmental factors) studies of this group of echinoderms are presented.En España los estudios sobre las holoturias son escasos y se reducen a algunas notas faunísticas o sistemáticas. En este trabajo se presentan algunas de las técnicas empleadas habitualmente por los investigadores en los distintos aspectos de la sistemática (recolección y conservación, preparación de espículas, anillo calcáreo, etc.), biología (reproducción, desarrollo, crecimiento, nutrición, actividad) y ecología (evaluación de las poblaciones. incidencia de los factores ambientales) de este grupo de equinodermos

SOA-Based Model for Value-Added ITS Services Delivery

Integration is currently a key factor in intelligent transportation systems (ITS), especially because of the ever increasing service demands originating from the ITS industry and ITS users. The current ITS landscape is made up of multiple technologies that are tightly coupled, and its interoperability is extremely low, which limits ITS services generation. Given this fact, novel information technologies (IT) based on the service-oriented architecture (SOA) paradigm have begun to introduce new ways to address this problem. The SOA paradigm allows the construction of loosely coupled distributed systems that can help to integrate the heterogeneous systems that are part of ITS. In this paper, we focus on developing an SOA-based model for integrating information technologies (IT) into ITS to achieve ITS service delivery. To develop our model, the ITS technologies and services involved were identified, catalogued, and decoupled. In doing so, we applied our SOA-based model to integrate all of the ITS technologies and services, ranging from the lowest-level technical components, such as roadside unit as a service (RS S), to the most abstract ITS services that will be offered to ITS users (value-added services). To validate our model, a functionality case study that included all of the components of our model was designed

Network service providing by means of embedded systems

In this paper we present an embedded device able to manage the remote boot of network nodes by means of Wake on LAN (WoL) through Internet and wide area network, presenting it as a Web service. The service is known as WoLI and comprises a network device, a group of embedded software applications in that device and an application protocol known as WoLIP. This device is small and requires only minimal maintenance, and is able to communicate via Wide Area Networks through embedded applications, using the WoLIP application protocol defined on SOAP massages and defined by means of WSDL documents. The mechanism used for booting up the devices is compatible with WoL technology. The service can be perfectly integrated with remote management systems based on SO A. The management and control of the device and the service may be carried out via Internet, using a standard Web browser. This approach is an example of the application of a more general proposal for managing network services, based on the use of small embedded network devices which provide specific functionalities for common use, and which are as autonomous and self sufficient as possible

Robust asynchronous control of ERP-Based brain-Computer interfaces using deep learning

Producción CientíficaBackground and Objective. Brain-computer interfaces (BCI) based on event-related potentials (ERP) are a promising technology for alternative and augmented communication in an assistive context. However, most approaches to date are synchronous, requiring the intervention of a supervisor when the user wishes to turn his attention away from the BCI system. In order to bring these BCIs into real-life applications, a robust asynchronous control of the system is required through monitoring of user attention. Despite the great importance of this limitation, which prevents the deployment of these systems outside the laboratory, it is often overlooked in research articles. This study was aimed to propose a novel method to solve this problem, taking advantage of deep learning for the first time in this context to overcome the limitations of previous strategies based on hand-crafted features. Methods. The proposed method, based on EEG-Inception, a novel deep convolutional neural network, divides the problem in 2 stages to achieve the asynchronous control: (i) the model detects user’s control state, and (ii) decodes the command only if the user is attending to the stimuli. Additionally, we used transfer learning to reduce the calibration time, even exploring a calibration-less approach. Results. Our method was evaluated with 22 healthy subjects, analyzing the impact of the calibration time and number of stimulation sequences on the system’s performance. For the control state detection stage, we report average accuracies above 91% using only 1 sequence of stimulation and 30 calibration trials, reaching a maximum of 96.95% with 15 sequences. Moreover, our calibration-less approach also achieved suitable results, with a maximum accuracy of 89.36%, showing the benefits of transfer learning. As for the overall asynchronous system, which includes both stages, the maximum information transfer rate was 35.54 bpm, a suitable value for high-speed communication. Conclusions. The proposed strategy achieved higher performance with less calibration trials and stimulation sequences than former approaches, representing a promising step forward that paves the way for more practical applications of ERP-based spellers.Ministerio de Ciencia, Innovación y Universidades - Agencia Estatal de Investigación (grants PID2020-115468RB-I00 and RTC2019-007350-1)Comisión Europea - Fondo Europeo de Desarrollo Regional (cooperation programme Interreg V-A Spain-Portugal POCTEP 2014–2020

Anomaly detection and virtual reality visualisation in supercomputers

Anomaly detection is the identification of events or observations that deviate from the expected behaviour of a given set of data. Its main application is the prediction of possible technical failures. In particular, anomaly detection on supercomputers is a difficult problem to solve due to the large scale of the systems and the large number of components. Most research works in this field employ machine learning methods and regression models in a supervised fashion, which implies the need for a large amount of labelled data to train such systems. This work proposes the use of autoencoder models, allowing the problem to be approached with semi-supervised learning techniques. Two different model training approaches are compared. The former is a model trained with data from all the nodes of a supercomputer. In the latter approach, observing significant differences between nodes, one model is trained for each node. The results are analysed by evaluating the positive and negative aspects of each approach. On the other hand, a replica of the Marconi 100 supercomputer is developed in a virtual reality environment that allows the data from each node to be visualised at the same time.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. We would like to thank “A way of making Europe” European Regional Development Fund (ERDF) and MCIN/AEI/10.13039/501100011033 for supporting this work under the MoDeaAS project (grant PID2019-104818RB-I00). Furthermore, we would like to thank the University of Skövde and to ASSAR Innovation Arena for their support to develop this work

A new paradigm: cloud agile manufacturing

Cloud Agile Manufacturing is a new paradigm proposed in this article. The main objective of Cloud Agile Manufacturing is to offer industrial production systems as a service. Thus users can access any functionality available in the cloud of manufacturing (process design, production, management, business integration, factories virtualization, etc.) without knowledge — or at least without having to be experts — in managing the required resources. The proposal takes advantage of many of the benefits that can offer technologies and models like: Business Process Management (BPM), Cloud Computing, Service Oriented Architectures (SOA) and Ontologies. To develop the proposal has been taken as a starting point the Semantic Industrial Machinery as a Service (SIMaaS) proposed in previous work. This proposal facilitates the effective integration of industrial machinery in a computing environment, offering it as a network service. The work also includes an analysis of the benefits and disadvantages of the proposal

Sermones funerales catorce, y de animas de purgatorio siete

Sign.: [ ]\p4\s, A-Z\p8\s, 2A-2B\p8\s, 2C\p2\s.Texto a dos col.Port. con grab. xil. de la Compañía de Jesús