Inversion of multiconfiguration complex EMI data with minimum gradient support regularization: A case study

Frequency-domain electromagnetic instruments allow the collection of data in different configurations, that is, varying the intercoil spacing, the frequency, and the height above the ground. Their handy size makes these tools very practical for near-surface characterization in many fields of applications, for example, precision agriculture, pollution assessments, and shallow geological investigations. To this end, the inversion of either the real (in-phase) or the imaginary (quadrature) component of the signal has already been studied. Furthermore, in many situations, a regularization scheme retrieving smooth solutions is blindly applied, without taking into account the prior available knowledge. The present work discusses an algorithm for the inversion of the complex signal in its entirety, as well as a regularization method that promotes the sparsity of the reconstructed electrical conductivity distribution. This regularization strategy incorporates a minimum gradient support stabilizer into a truncated generalized singular value decomposition scheme. The results of the implementation of this sparsity-enhancing regularization at each step of a damped Gauss-Newton inversion algorithm (based on a nonlinear forward model) are compared with the solutions obtained via a standard smooth stabilizer. An approach for estimating the depth of investigation, that is, the maximum depth that can be investigated by a chosen instrument configuration in a particular experimental setting is also discussed. The effectiveness and limitations of the whole inversion algorithm are demonstrated on synthetic and real data sets

Anti-Gauss cubature rules with applications to Fredholm integral equations on the square

The purpose of this paper is to develop the anti-Gauss cubature rule for approximating integrals defined on the square whose integrand function may have algebraic singularities at the boundaries. An application of such a rule to the numerical solution of second-kind Fredholm integral equations is also explored. The stability, convergence, and conditioning of the proposed Nystr\"om-type method are studied. The numerical solution of the resulting dense linear system is also investigated and several numerical tests are presented

Geographies of Pain: The Mexican Movement for Peace with Justice and Dignity and the Configuration of Spaces of Victimhood

Since 2006, Mexico has been embedded in a severe humanitarian and social crisis brought about by Calderon's drug war security strategy. On March 2011, the Movement for Peace with Justice and Dignity (MPJD), a social movement of victims was created in reaction to the growing death toll of drug related violence, the increase in human rights violations and the perception of a systematic effort by the government to belittle social costs of the war by manipulating the official narrative. Through protest marches, the MPJD articulated spaces of shared victimhood and set the path for victims' pain to be collectivized and politicized. This thesis illustrates how the spatial aspects of the official narrative of the drug war are countered by the emotional geographies constructed by the MPJD. These spaces of pain allowed for distinct emotional geographies that capture media attention to motivate collective action setting the foundations for reconstructing the social pact.Master of Art

Titanium Carbide (TiC) Production by Mechanical Alloying

This chapter presents the process for obtaining titanium carbides (TiC) from elemental powders of titanium dioxide, aluminum, and graphite by means of the mechanical alloying technique, using a semi-industrial attritor mill. Three grindings were performing: a wet, a dry, and a vacuum grinding. The mass relations between grinding elements and powders used were 20:1 to wet grinding and 40:1 to dry and vacuum grinding. Each grinding took 36 h with a control stop at 18 h. The samples were analyzed using X-ray diffraction analysis and the characteristics peak were detected on 2θ = 41, 60, 72, and 76°. Targets of TiC were produced using compaction and sintering processes. The particle size (between 200 nm and 1 μm) was measure using a scanning electron microscopy (SEM). After the milling process, the particle size showed a huge distribution. However, after the sintered process, the particle size (lower than 5 μm) distribution had a low dispersion and their shape trends to be spherical. It is necessary to highlight that the precursors used were low cost compared to the high cost and purity powders used for this purpose; so this method is an excellent alternative to implement as a low-cost industrial process

A compressive review about Taxol® : history and future challenges

©2020. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Molecules. To access the final edited and published work see https://doi.org/10.3390/molecules25245986Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to treat over one million patients, making it one of the most widely employed antitumoral drugs. Taxol® was the first microtubule targeting agent described in the literature, with its main mechanism of action consisting of the disruption of microtubule dynamics, thus inducing mitotic arrest and cell death. However, secondary mechanisms for achieving apoptosis have also been demonstrated. Despite its wide use, Taxol® has certain disadvantages. The main challenges facing Taxol® are the need to find an environmentally sustainable production method based on the use of microorganisms, increase its bioavailability without exerting adverse effects on the health of patients and minimize the resistance presented by a high percentage of cells treated with paclitaxel. This review details, in a succinct manner, the main aspects of this important drug, from its discovery to the present day. We highlight the main challenges that must be faced in the coming years, in order to increase the effectiveness of Taxol® as an anticancer agent

Advancing Intraoperative Neurophysiological Monitoring With Human Reflexes

Brainstem reflexes; Intraoperative neurophysiological monitoring; Spinal reflexesReflexos del tronc cerebral; Monitorització neurofisiològica intraoperatòria; Reflexos espinalsReflejos del tronco cerebral; Monitorización neurofisiológica intraoperatoria; Reflejos espinalesHuman reflexes are simple motor responses that are automatically elicited by various sensory inputs. These reflexes can provide valuable insights into the functioning of the nervous system, particularly the brainstem and spinal cord. Reflexes involving the brainstem, such as the blink reflex, laryngeal adductor reflex, trigeminal hypoglossal reflex, and masseter H reflex, offer immediate information about the cranial-nerve functionality and the overall state of the brainstem. Similarly, spinal reflexes such as the H reflex of the soleus muscle, posterior root muscle reflexes, and sacral reflexes provide crucial information about the functionality of the spinal cord and peripheral nerves. One of the critical benefits of reflex monitoring is that it can provide continuous feedback without disrupting the surgical process due to no movement being induced in the surgical field. These reflexes can be monitored in real time during surgical procedures to assess the integrity of the nervous system and detect potential neurological damage. It is particularly noteworthy that the reflexes provide motor and sensory information on the functional integrity of nerve fibers and nuclei. This article describes the current techniques used for monitoring various human reflexes and their clinical significance in surgery. We also address important methodological considerations and their impact on surgical safety and patient outcomes. Utilizing these methodologies has the potential to advance or even revolutionize the field of intraoperative continuous monitoring, ultimately leading to improved surgical outcomes and enhanced patient care

A review of bioactive factors in human breastmilk: A focus on prematurity

Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option for the newborn. Its dynamic composition is influenced by diverse factors such as maternal age, lactation period, and health status. The aim of the present review is to summarize the current knowledge regarding some bioactive factors present in breastmilk, namely antioxidants, growth factors, adipokines, and cytokines, paying specific attention to prematurity. The revised literature reveals that the highest levels of these bioactive factors are found in the colostrum and they decrease along the lactation period; bioactive factors are found in higher levels in preterm as compared to full-term milk, they are lacking in formula milk, and decreased in donated milk. However, there are still some gaps and inconclusive data, and further research in this field is needed. Given the fact that many preterm mothers are unable to complete breastfeeding, new information could be important to develop infant supplements that best match preterm human milkThis work was supported by Ministerio de Economia y Competitividad (grant number FEM2015-63631-R) to SMA and the Ministerio de Ciencia, Innovación y Universidades (Spain) (grant number RTI2018-097504-B-100) to SMA and MAM-C. Both grants were co-financed with FEDER fund

Burden of epilepsy in Latin America and The Caribbean: a trend analysis of the Global Burden of Disease Study 1990 – 2019.

Background: The epilepsy prevalence in Latin America and the Caribbean (LAC) had remained high over the last 20 years. Data on the burden of epilepsy are needed for healthcare planning and resource allocation. However, no systematic analysis had been performed for epilepsy burden in LAC. Methods: We extracted data of all LAC countries from the Global Burden of Disease (GBD) study from 1990 to 2019. Epilepsy burden was measured as prevalence, mortality, and disability-adjusted life-years (DALYs; defined by the sum of years of life lost [YLLs] for premature mortality and years lived with disability [YLDs]), by age, sex, year, and country. Absolute numbers, rates, and 95% uncertainty intervals were reported. We performed correlational analyses among burden metrics and Socio-demographic Index (SDI). Findings: The burden of epilepsy decreased around 20% in LAC, led by YLLs reduction. In 2019, 6·3 million people were living with active epilepsy of all causes (95% UI 5·3 - 7·4), with 3·22 million (95% UI 2·21 - 4·03) and 3·11 million (95% UI 2·21 to 4·03) cases of epilepsy with identifiable aetiology and idiopathic epilepsy, respectively. The number of DALYs represented the 9·51% (1.37 million, 95% UI 0·99 -1·86) of the global epilepsy burden in 2019. The age-standardized burden was 175·9 per 100 000 population (95% UI 119·4 - 253·3), which tend to have a bimodal age distribution (higher in the youth and elderly) and was driven by high YLDs estimates. The burden was higher in men and older adults, primarily due to high YLLs and mortality. Alcohol use was associated with 17% of the reported DALYs. The SDI estimates significantly influenced this burden (countries with high SDI have less epilepsy burden and mortality, but not prevalence or disability). Interpretation: The epilepsy burden has decreased in LAC over the past 30 years. Even though, LAC is still ranked as the third region with the highest global epilepsy burden. This reduction was higher in children, but burden and mortality increased for older adults. The epilepsy burden is disability predominant; however, the mortality-related estimates are still higher than in other regions. Alcohol consumption and countries’ development are important determinants of this burden. There is an urgent need to improve access to epilepsy care in LAC, particularly for older adults. Strengthening primary care with online learning and telemedicine tools, and promoting risk factors modification should be prioritized in the region. Funding: This research was self-funded by the authors

Use of surgical bone cement to increase the projection of the nasomaxillary buttress in a case of orthognathic surgery. Technical note

The soft tissue outcome of the projection at the level of the nasomaxillary buttress is difficult to manage in cases of severe hypoprojection, being orthognathic surgery resolutive at the occlusal level but sometimes insufficient at the level of esthetic outcome. The literature describes the use of alloplastic prostheses and autologous bone grafts, but there are few documented cases of the use of premolded surgical cement for this purpose. The main advantage of the use of bone cement over the alternatives described is its ability to be premolded for customization, low cost, easy availability, speed of preparation and minimal comorbidity. This technical note describes the surgical steps and outcome of the use of surgical bone cement for projection augmentation at this level, including notes on preparation, premolding and fixation. Key words:Orthognathic surgery, maxillary surgery, surgical bone cement, nasomaxillary buttress

The Crust beneath Morocco: From the surface topography to the upper mantle a 700 km long seismic section across Morocco.

The most characteristic topographic features of Morocco are the Atlas Mountains and the Rif Coordillera. These two orogenic belts are the response of different geodynamic processes acting at lithospheric scale caused by a complex plate interaction. Both are located within the diffuse plate boundary zone separating Africa and Europe. The boundary zone is characterized by a relatively broad zone of deformation that includes mountain chains in southern Iberia, the Betics and in Morocco, the Rif Cordillera, separated by the Alboran basin. The zone delineates an arcuate arc system known as the Gibraltar arc. The area is characterized by a relatively large amount of earthquake activity at various depths and with a broad spectra of focal mechanisms. Within the last decade a large international effort have been devoted to the area. The topic has fostered a strong collaborations between Spanish and international research teams form Europe and USA. Key multi-seismic projects have been developed that aim to constrain the structure, composition and tectonic scenario from south of the Atlas to the Betics, across the Rif cordillera and the Alboran basin. The multidisciplinary research program included: natural source (earthquakes) recording with temporal deployments of broad band (BB) instrumentation and, controlled source seismic acquisition experiments where, spatially dense recording of wide-angle seismic reflection shot gathers were acquired. The natural source experiments consisted on a transect from Merzouga across the Gibraltar Arc and into the Iberian Peninsula (until south of Toledo) and, a nearly regular grid of BB. The controlled source data-sets were able to constrain the crustal structure and provide seismic P-wave propagation velocity models from the coast across the Rif and the Atlas. From south to north the crust features a relatively moderate crustal root beneath the Middle Atlas which can reach 40 km clearly differing from the 35 km thickness value observed at both sides of this root. Travel time inversion results position the crustal root just south of the High Atlas defining a thrusted mantle wedge and, also a limited crustal imbrication is suggested in the Middle Atlas. The most surprising feature is a prominent and unexpected crustal root (over 50 km) located beneath the external Rif and identified by both the wide-angle data and receiver function studies. To the east of this feature the crust thins rapidly by 20 km across the Nekkor fault zone, suggested to be related to the sharp change in crustal thickness. On shore-offshore recording of marine shots reveal further complexities in the transition to the Alboran basin. The low values of the Bouguer gravity anomalies beneath the Rif Cordillera are consistent with the crustal models derived from the new seismic data. The detailed knowledge on the crustal structure achieved by this high resolution imaging geophysical techniques is an asset to evaluate the earthquake and potential tsunami hazard for the coasts of North Africa and western Europe.This work has been primarily funded by the Spanish MEC project CGL2007–63889. Additional funding was provided by projects CGL2010–15416, CSD2006-00041, and CGL2009–09727 (Spain), CGL2008–03474-E, 07- TOPO_EUROPE_FP-006 (ESF Eurocores) and EAR-0808939 (US, NSF).Peer Reviewe