Search strategies for pair production of heavy Higgs bosons decaying invisibly at the LHC

The search for heavy Higgs bosons at the LHC represents an intense experimental program, carried out by the ATLAS and CMS collaborations, which includes the hunt for invisible Higgs decays and dark matter candidates. No significant deviations from the SM backgrounds have been observed in any of these searches, imposing significant constraints on the parameter space of different new physics models with an extended Higgs sector. Here we discuss an alternative search strategy for heavy Higgs bosons decaying invisibly at the LHC, focusing on the pair production of a heavy scalar H together with a pseudoscalar A, through the production mode qq¯→Z*→HA. We identify as the most promising signal the final state made up of 4b+EmissT, coming from the heavy scalar decay mode H→hh→bb¯bb¯ with h being the discovered SM-like Higgs boson with mh=125GeV, together with the invisible channel of the pseudoscalar. We work within the context of simplified MSSM scenarios that contain quite heavy sfermions of most types with O(10)TeV masses, while the stops are heavy enough to reproduce the 125 GeV mass for the lightest SM-like Higgs boson. By contrast, the gauginos/higgsinos and the heavy MSSM Higgs bosons have masses near the EW scale. Our search strategies, for a LHC center-of-mass energy of √s=14TeV, allow us to obtain statistical significances of the signal over the SM backgrounds with values up to ∼1.6σ and ∼3σ for total integrated luminosities of 300fb−1 and 1000fb−1, respectively.Facultad de Ciencias ExactasInstituto de Física La Plat

Search strategies for pair production of heavy Higgs bosons decaying invisibly at the LHC

The search for heavy Higgs bosons at the LHC represents an intense experimental program, carried out by the ATLAS and CMS collaborations, which includes the hunt for invisible Higgs decays and dark matter candidates. No significant deviations from the SM backgrounds have been observed in any of these searches, imposing significant constraints on the parameter space of different new physics models with an extended Higgs sector. Here we discuss an alternative search strategy for heavy Higgs bosons decaying invisibly at the LHC, focusing on the pair production of a heavy scalar H together with a pseudoscalar A, through the production mode qq¯→Z*→HA. We identify as the most promising signal the final state made up of 4b+EmissT, coming from the heavy scalar decay mode H→hh→bb¯bb¯ with h being the discovered SM-like Higgs boson with mh=125GeV, together with the invisible channel of the pseudoscalar. We work within the context of simplified MSSM scenarios that contain quite heavy sfermions of most types with O(10)TeV masses, while the stops are heavy enough to reproduce the 125 GeV mass for the lightest SM-like Higgs boson. By contrast, the gauginos/higgsinos and the heavy MSSM Higgs bosons have masses near the EW scale. Our search strategies, for a LHC center-of-mass energy of √s=14TeV, allow us to obtain statistical significances of the signal over the SM backgrounds with values up to ∼1.6σ and ∼3σ for total integrated luminosities of 300fb−1 and 1000fb−1, respectively.Facultad de Ciencias ExactasInstituto de Física La Plat

Behaviour of tail-docked lambs tested in isolation

peer-reviewedThe aims of the current study were to detect behavioural indicators of pain of tail-docked sheep tested in isolation and to determine the relationship between behaviour and the pain levels to which they were exposed. Twenty-four female lambs, randomly assigned to four pens, had their tail docked with a rubber ring (TD; n = 6) without pain control procedures, TD with anaesthesia (TDA; n = 6) or TD with anaesthesia and analgesia (TDAA; n = 6). Additionally, six lambs handled but without tail docking or application of pain relief measures were used as the control (C). On the day prior (Day –1) to the TD and on days 1, 3 and 5 post-procedure, each lamb was individually removed from its group and underwent a 2.5 min open field test in a separate pen. Frequencies of behaviours such as rest, running, standing, walking and exploring were directly observed. Frequencies of exploratory climbs (ECs) and abrupt climbs (ACs) over the testing pen’s walls were video-recorded. Data were analysed using generalised linear mixed models with repeated measurements, including treatment and day as fixed effects and behaviour on Day –1 as a linear covariate. Control and TDAA lambs stood more frequently than TD lambs. TD lambs performed significantly more ACs compared to all other treatment groups. No other treatment effects were detected. A day effect was detected for all behaviours, while the EC frequency was highest for all tail-docked lambs on Day 5. Findings suggest that standing, ACs and ECs could be used as potential indicators of pain in isolated tail-docked lambs. However, differences in ECs between treatments only appeared 3 d after tail docking

Spectral classification and properties of the O Vz stars in the Galactic O-Star Spectroscopic Survey (GOSSS)

On the basis of the Galactic O-Star Spectroscopic Survey (GOSSS), a detailed systematic investigation of the O Vz stars is presented. The currently used spectral classification criteria are rediscussed, and the Vz phenomenon is recalibrated through the addition of a quantitative criterion based on the equivalent widths of the He I 4471, He II 4542, and He II 4686 spectral lines. The GOSSS O Vz and O V populations resulting from the newly adopted spectral classification criteria are comparatively analyzed. The locations of the O Vz stars are probed, showing a concentration of the most extreme cases toward the youngest star forming regions. The occurrence of the Vz spectral peculiarity in a solar-metallicity environment, as predicted by the fastwind code, is also investigated, confirming the importance of taking into account several processes for the correct interpretation of the phenomenon.Comment: Accepted for publication in The Astronomical Journa

Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates

Chitin is an abundant polysaccharide used by many organisms for structural rigidity and water repulsion. As such, the insoluble crystalline structure of chitin poses significant challenges for enzymatic degradation. Acidic mammalian chitinase, a processive glycosyl hydrolase, is the primary enzyme involved in the degradation of environmental chitin in mammalian lungs. Mutations to acidic mammalian chitinase have been associated with asthma, and genetic deletion in mice increases morbidity and mortality with age. We initially set out to reverse this phenotype by engineering hyperactive acidic mammalian chitinase variants. Using a screening approach with commercial fluorogenic substrates, we identified mutations with consistent increases in activity. To determine whether the activity increases observed were consistent with more biologically relevant chitin substrates, we developed new assays to quantify chitinase activity with insoluble chitin, and identified a one-pot fluorogenic assay that is sufficiently sensitive to quantify changes to activity due to the addition or removal of a carbohydrate-binding domain. We show that the activity increases from our directed evolution screen were lost when insoluble substrates were used. In contrast, naturally occurring gain-of-function mutations gave similar results with oligomeric and insoluble substrates. We also show that activity differences between acidic mammalian chitinase and chitotriosidase are reduced with insoluble substrate, suggesting that previously reported activity differences with oligomeric substrates may have been driven by differential substrate specificity. These results highlight the need for assays against physiological substrates when engineering metabolic enzymes, and provide a new one-pot assay that may prove to be broadly applicable to engineering glycosyl hydrolases

Optimally designed quantum transport across disordered networks

We establish a general mechanism for highly efficient quantum transport through finite, disordered 3D networks. It relies on the interplay of disorder with centro-symmetry and a dominant doublet spectral structure, and can be controlled by proper tuning of only coarse-grained quantities. Photosynthetic light harvesting complexes are discussed as potential biological incarnations of this design principle.Comment: 7 pages (incl. 2 pages of suppl. mat.), 3 figure

Continuous Set Model Predictive Control for Energy Management of Modular Multilevel Matrix Converters

The Modular Multilevel Matrix Converter is an AC-AC power converter proposed for high power applications such as motor drive and wind energy conversion systems. The M 3C has 9 clusters, allowing 4 circulating currents for converter energy management. Control of the M 3C is frequently divided into Different Frequency Mode (DFM) and Equal Frequency Mode (EFM). EFM is more challenging, because of the larger capacitor voltage oscillations that can be produced. Conventional energy management control strategies for EFM/DFM are usually based on 8 energy control loops used to define four circulating current references composed of several predefined frequencies and positive/negative sequences. The control schemes are typically different for EFM/DFM operation increasing the complexity. In this paper, a Continuous-Control-Set Model Predictive Control (CCS-MPC) for energy management of the M 3C is proposed. The control scheme is based on solving an equality constrained quadratic programming problem, using a state variable model of the M3C, where the optimal solution is analytically obtained. The result is a single and simple control law to obtain circulating current references during EFM/DFM, ensuring a good performance with optimal current specifications. The proposed strategy is experimentally validated using a down-scaled M3C prototype composed of 27 power cells

Docking and Molecular Dynamic of Microalgae Compounds as Potential Inhibitors of Beta-Lactamase

Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with beta-lactam antibiotics. The increasing resistance to those antibiotics by bacterial pathogens generated the emergence of extended-spectrum beta-lactamases (ESBLs), an actual public health problem. This is due to rapid mutations of bacteria when exposed to antibiotics. In this case, beta-lactamases are enzymes used by bacteria to hydrolyze the beta-lactam rings present in the antibiotics. Therefore, it was necessary to explore novel molecules as potential beta-lactamases inhibitors to find antibacterial compounds against infection caused by ESBLs. A computational methodology based on molecular docking and molecular dynamic simulations was used to find new microalgae metabolites inhibitors of beta-lactamase. Six 3D beta-lactamase proteins were selected, and the molecular docking revealed that the metabolites belonging to the same structural families, such as phenylacridine (4-Ph), quercetin (Qn), and cryptophycin (Cryp), exhibit a better binding score and binding energy than commercial clinical medicine beta-lactamase inhibitors, such as clavulanic acid, sulbactam, and tazobactam. These results indicate that 4-Ph, Qn, and Cryp molecules, homologous from microalgae metabolites, could be used, likely as novel beta-lactamase inhibitors or as structural templates for new in-silico pharmaceutical designs, with the possibility of combatting beta-lactam resistanc