Northern European retired residents in nine southern European areas: characteristics, motivations and adjustment

During the last two decades, northern European retirement residence in the southern European sunbelt has grown strongly and its forms have rapidly changed, but standard demographic and social statistical sources provide no information about the flows, the migrants or their increasingly mobile and complex residential patterns. Considerable primary research has however recently been undertaken into the causes, conditions, experiences and consequences of international retirement migration (IRM) by investigators from Germany, Spain, Switzerland and the United Kingdom. Many collaborated when designing their studies and instruments, and all have subsequently worked together in a European Science Foundation Scientific Network. This paper compares the findings of six systematic social surveys in (to be more precise than the title) eight regions of southern Europe and the Canary Islands: all that have tackled similar research questions with similar methods and instruments. It presents interpretations of several comparative tables compiled from their original data, with a focus on the socio-economic backgrounds, motivations and behaviour of the various migrant groups and their relationship with the host and home countries. The paper presents new findings about the typical and variant forms of IRM, and additional understanding of the heterogeneity of the retirees of different nations and in the several regions

Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.

Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. We screened a human lung fibroblast cDNA library with an ovine PGG/HS cDNA and isolated a 2.3-kilobase clone (HCO-T9). Sequence analysis of this clone showed that (a) it contained the entire translated region of PGG/HS and (b) it displayed an in-frame splicing of the last 111 base pairs encoded by exon 9, which resulted in the elimination of the N-glycosylation site at residue 409. Polymerase chain reaction amplification with specific oligonucleotides of reverse-transcribed mRNA from diverse human tissues and cultured cells yielded 400- and 300-base pair fragments that corresponded, respectively, to the intact and spliced transcripts. The expression of these two transcripts in cultured human lung fibroblasts was differentially regulated by serum, transforming growth factor beta 1, interleukin 1 beta, tumor necrosis factor alpha, and phorbol 12-myristate 13-acetate, as each of these conditions stimulated preferentially the expression of the unspliced transcripts. The elimination of one of the four N-glycosylation sites by the alternative splicing of exon 9 and the differential regulation of this process by relevant cytokines and growth factors may represent a mechanism for the regulation of PGG/HS enzymatic activity under physiological or pathological conditions

Resolutions of Subsets of Finite Sets of Points in Projective Space

Given a finite set, $X$, of points in projective space for which the Hilbert function is known, a standard result says that there exists a subset of this finite set whose Hilbert function is ``as big as possible'' inside $X$. Given a finite set of points in projective space for which the minimal free resolution of its homogeneous ideal is known, what can be said about possible resolutions of ideals of subsets of this finite set? We first give a maximal rank type description of the most generic possible resolution of a subset. Then we show that this generic resolution is not always achieved, by incorporating an example of Eisenbud and Popescu. However, we show that it {\em is} achieved for sets of points in projective two space: given any finite set of points in projective two space for which the minimal free resolution is known, there must exist a subset having the predicted resolution.Comment: 17 page

In Vitro Incubation of Gills Isolated from the Gulf Killfish, Fundulus Grandis

The use of viable and reliable tissue preparations allows for experimental approaches in vitro that would not be possible in vivo. In this experiment, gills were isolated from gulf killifish, Fundulus grandis, and subjected to various incubation conditions. A combination of two types of media and two incubation apparatuses were compared in their ability to sustain tissues, as measured by the vital stain trypan blue (TB) and percent lactate dehydrogenase (LDH) leakage. Trypan Blue analysis indicated no significant difference in tissue viability, regardless of the treatment or incubation time. However, percent LDH leakage analysis revealed that the two most influential variables were the medium and apparatus in which the gills were incubated. Interestingly, incubation time did not have a statistically significant influence on gill viability as measured by LDH leakage. The results of LDH leakage analysis suggest that incubation using SW in the 4 ml apparatus is the best combination tested

Testing the Psychology of Working Theory Among Economically Marginalized Workers

ABSTRACT TESTING THE PSYCHOLOGY OF WORKING THEORY AMONG ECONOMICALLY MARGINALIZED WORKERS byWilly Anthony Diaz Tapia The University of Wisconsin-Milwaukee, 2022 Under the Supervision of Professor Kelsey Autin In 2018, the U.S. Census Bureau estimated that approximately 39.7 million U.S. Americans lived in poverty of which 6.9 million were considered the working poor. People from economically marginalized communities experience significant challenges in many areas of life and work is no exception; yet their work lives continue to be underrepresented in vocational literature. The Psychology of Working Theory (PWT) is one of the first vocational theories developed explicitly to better understand and support communities that experience marginalization and economic constraints, but it has yet to be tested among economically marginalized communities. This study is the first known examination to test PWT propositions among a sample representative of economically marginalized workers. Through conducting this study, I sought to answer two questions by testing 14 PWT propositions (see Figure 2 for hypothesized paths): (1) do contextual factors (i.e., economic constraints and marginalization) impact a person’s ability to secure decent work; and (2) does career adaptability and work volition mediate the relation from contextual barriers to attainment of decent work? I used structural equation modeling (SEM) to examine the 14 PWT propositions. Results generally supported PWT propositions and suggest that it is applicable and culturally attuned to the experiences of economically marginalized workers. Practical implications were discussed

Keep Your Differential Broad This Back Pain Season Penetrating Aortic Ulceration: A Case Report

Abstract: Keep Your Differential Broad this Back Pain Season, Kyle Diaz D.O., Anthony Colucci D.O. The chief complaint of back pain is a common occurrence in the emergency department. Our departments can often be inundated with this complaint especially now that the season of slips and falls is upon us. We are not only seeing traumatic back pain but chronic back pain and atraumatic acute back pain frequent the halls of the emergency department as well. While wading through the morass of these nonspecific and often menial complaints it may become difficult for a provider to maintain a broad differential. This case will serve as a reminder to remain vigilant while working up back pain. Additionally, information on an interesting diagnosis of aortic ulceration will be gleaned throughout the case review.The case is that of a 65 year old female with significant medical history including hypertension and remote history of smoking who presents to the emergency department complaining of back pain. The patient reports that she has been having mid thoracic back pain for the past 2-3 weeks. This pain is described as aching and is sharp with movement. Patient reports pain radiating to both sides with movement. Patient denies associated chest pain, shortness of breath, nausea, vomiting, neck pain, low back pain, sciatica, incontinence of stool, urinary retention. Patient does report that symptoms improve significantly with leaning forward.A thorough examination demonstrated Para spinal tenderness throughout the mid thoracic spine. Patient’s examination was otherwise normal save her vitals which showed hypertension to the degree of 180/95. Initial evaluation included AP chest, thoracic XR and basic lab work. Pain control was provided as well.On repeat examination patient’s back pain was well controlled however she remained hypertensive and was now having bilateral flank discomfort. At this point advanced imaging was obtained and a CTA of the chest was ordered. This demonstrate a broad based aortic ulceration about the ascending portion of the thoracic aorta.Immediate measures were taken to control patient\u27s elevated blood pressure and consultation was made to vascular surgery. Patient was admitted to the ICU for further management and evaluation. With strict impulse control repeat CTA was ordered at 48 hours. There was no progression of the disease and as such patient was discharged home with conservative medical management as she was not amenable to surgery at time of initial presentation.One month later the patient represented due to continued pain and was found to have a type B thoracic aortic dissection. At this time she underwent TEVAR and after an uncomplicated operation and post-operative course has followed with both family practice and vascular and is progressing well. As a conclusion of the case I would like to discuss the treatment and management of this finding of Aortic ulceration and the morbidity associated with this rare diagnosis. I believe that this interesting case will both add to the expansion of our differential when caring for back pain in addition to providing helpful information for diagnosis that does not have a mass of readily available data.https://scholarlycommons.henryford.com/merf2019caserpt/1087/thumbnail.jp

An Educational Module Explaining the Analgesic Efficacy of The PEC Block For a Radical Mastectomy: A Quality Improvement Project

Background: The use of regional anesthesia in combination with general anesthesia for patients undergoing radical mastectomy has shown to be efficacious anesthetic technique at reducing pain postoperatively. Prior to the discovery of the PEC 2 block in 2011, the common regional techniques for radical mastectomy consisted of a thoracic paravertebral block (TPVB) or Erector Spinae Plane Block (ESPB). The PEC 2 block is two separate injections of local anesthetic with the first injection between the pectoralis major muscle and the pectoralis minor muscle, and the second injection between the pectoralis minor and the serratus anterior muscle. Recent studies have aimed to evaluate the analgesic efficacy of the PEC block in comparison to the TPVB and ESPB in Radical Mastectomy Procedures. The research suggests that the PEC block provides superior analgesic efficacy with the radical mastectomy in comparison to the TPVB and ESPB. Methods: A concise search strategy was implemented to identify suitable randomized clinical trials (RCTs) and meta-analysis reviews (MARs) using CINAHL, PUBMED, and FIU’s library database. All RTCs and MARs comparing the analgesic efficacy PEC block and either the TPVB or ESPB in combination with general anesthesia for patients undergoing a radical mastectomy or modified radical mastectomy. Results: Amongst the total number of participants in the educational intervention (n=4), all participants demonstrated improved knowledge on the analgesic efficacy of the PEC block for radical mastectomy procedure. All four participants expressed increased willingness to implement the PEC block for radical mastectomy in combination with general anesthesia

An Educational Module Explaining the Use of The IPACK Block and The Adductor Canal Block to Relieve Pain After Total Knee Arthroplasty: A Quality Improvement Project

Background. Orthopedic arthroplasty surgeries are one of the most performed surgical procedures in the United States, with over 840,000 total knee replacement patient admissions in 2017.1 The quality improvement display will exhibit that the utilization of the IPACK block should be regularly applied to improve postoperative knee pain in combination with the ACB to enhance pain relief, increase mobility, decrease hospital stay, and reduce opioid consumption along with opioid side effects such as nausea and vomiting. Methods. The databases utilized for the search included The Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Google Scholar. library, with full-text availability. Exclusion criteria included the studies that were published more than 10 years ago, comparison with other peripheral nerve blocks such as sciatic or femoral, abstract only, inaccessible, or thirdparty accessible articles. Other terms utilized during the search was peripheral nerve block and TKA. The Boolean phrases were utilized and produced 116 articles. Ten articles were chosen for review based on the inclusion and exclusion criteria, and 8 were utilized. Conclusion and Discussion. All TKA patients should receive the ACB and IPACK block perioperatively to decrease opioid consumption, side effects of pain, pain scores, and hospital stay and increase mobility. The IPACK block is a technique that relieves pain on the posterior portion on the knee, which is vulnerable to pain when utilizing the ACB alone.2 The ACB provides a sensory block solely to the anterior and lateral portions of the knee.2 By utilizing both blocks for TKA patients, all areas of the knee are receiving an adequate sensory blockade. The IPACK should be routinely utilized in all TKA surgical patients to provide better patient outcomes

Sensemaking of narratives: informing the capabilities development process

This capstone project determines whether sensemaking of soldier narratives can inform the Department of Defense‘s (DOD) capability development process (CDP). Sensemaking is the process of creating awareness and understanding in situations of high complexity or uncertainty. The authors gathered service member narratives concerning their use of fielded equipment, which created metadata for both quantitative and qualitative research and analysis. This capstone compares results from sensemaking of narratives with results from the Warfighter Technology Tradespace Methodology (WTTM), a system designed for the rapid fielding of equipment for small forward operating bases (FOBs) and combat outposts (COPs). The capstone finds that 1) soldier narratives inform the fielding process by providing an additional layer of meaning and context, and 2) soldier narratives do not replace current feedback mechanisms; rather, they play a complementary role. This capstone finds that narratives as a feedback mechanism can be applied during operational testing of newly developed or fielded equipment for the DOD‘s CDP.http://archive.org/details/sensemakingofnar1094542657Major, United States Army;Major, United States Army;Major, United States ArmyApproved for public release; distribution is unlimited