Mathematical modeling of bovine brucellosis control by vaccination

As fêmeas bovinas, por sua importância na transmissão e na manutenção da brucelose, constituíram o alvo dos inquéritos do Programa Nacional de Controle e Erradicação da Brucelose e da Tuberculose Animal. Com base em informações obtidas em unidades federativas onde foram realizados inquéritos sorológicos e observadas prevalências de animais acima de 2%, elaborou-se um modelo para simular a dinâmica da brucelose em rebanhos bovinos formados exclusivamente por fêmeas, analisando o efeito de estratégias de vacinação. Para baixa cobertura vacinal, da ordem de 30%, o tempo para reduzir a prevalência a 2%, valor adotado como referência, pode ser longo, aproximando-se do dobro do tempo necessário para uma cobertura mais alta, de 90%. De acordo com o modelo, o tempo para reduzir a prevalência a 1% ou 2%, que permitam passar à fase de erradicação, pode chegar a uma década. Recomenda-se a intensificação do esforço para a vacinação de fêmeas, procurando atingir alta cobertura vacinal.Due to the important role played by female bovines in the transmission and maintenance of brucellosis, they were the target of the serological surveys of the Brazilian National Program for the Control and Eradication of Bovine Brucellosis and Tuberculosis. Based on the information obtained in Brazilian states, where the serological surveys were carried out and prevalences higher than 2% were observed, a model to simulate the dynamics of brucellosis in herds of female bovines was developed to analyze the effects of vaccination strategies. For low vaccination coverage (around 30%), the time to reduce the prevalence to 2%, adopted as a reference, may be long, approximately twice as long as the time observed for a higher coverage (90%). According to the model, the time to reduce the prevalence to levels of 1% or 2%, adequate to start the eradication phase, may reach a decade. It is recommended an intensification of the effort to vaccinate females, aiming at attaining high vaccination coverage.FAPESPCNPqMAPA Ministério da Agricultura, Pecuária e Abasteciment

Production and quality evaluation of herbal tea mixtures from Phyllanthus Debilis, Osbeckia octandra, and Artrocarpus heterophyllus leaves

Abstract. Introduction: This study investigated the acceptability and quality of herbal tea mixtures prepared using Phyllanthus debilis, Osbeckia octandra, and Artrocarpus heterophyllus leaves powders in different proportions. Preference for different sensory attributes of tea samples was evaluated using thirty untrained panelists. Proximate composition, tea quality parameters, and microbial counts of tea samples were evaluated as per AOAC and ISO standard methods. The amount of major and trace minerals was evaluated using atomic absorption spectrophotometer. Results revealed that dark-colored samples were much preferred by the consumers. A significant positive correlation (r=0.920) showed among redness (a*) of teas and color preference. Yet, the overall preference was reduced in more bitter and astringent samples. Overall acceptability scores highest for A. heterophyllus tea (M9), yet the color preference was highest in P. debilis tea (M8) and mix of P. debilis and O. octandra (M4). The tea samples were rich in nutrients, yet crude fiber and moisture contents exceed the required maximum limits. Heavy metal concentrations and microbial counts lay within the standard limits. This study showed mixing herbs can enhance the acceptability and quality of herbal infusions. With such optimizations, these novel tea mixtures can thrive commercially in the tea market.   Keywords: Herbal tea, Quality parameters, Sensory attribute

Diastereoselective Reduction Of Acyclic N-aryl-β-amino Ketones

A stereoselective route to anti- and syn-N-aryl-γ-amino alcohols is reported featuring the reduction of the corresponding β-amino ketones with Et3BHLi or Zn(BH4)2, respectively.41213121

Epidemiological status of bovine brucellosis in the Federal District, Brazil

Realizou-se um estudo para caracterizar a situação epidemiológica da brucelose bovina no Distrito Federal (DF). No total foram amostrados 2.019 animais, provenientes de 278 propriedades. Em cada propriedade visitada aplicou-se um questionário epidemiológico para verificar o tipo de exploração e as práticas de criação e sanitárias que poderiam estar associadas ao risco de infecção pela doença. O protocolo utilizado foi o da triagem com o teste do antígeno acidificado tamponado e a confirmação dos positivos com o teste do 2-mercaptoetanol. O rebanho foi considerado positivo quando pelo menos um animal foi reagente às duas provas sorológicas. A prevalência no DF foi de 2,5% [1,0-5,1%] para propriedades e de 0,16% [0,04-0,28%] para animais. Em razão dos resultados encontrados, que permitem pensar em estratégias de erradicação, recomenda-se que o DF intensifique o diagnóstico de brucelose, tanto na forma de testes sorológicos sistemáticos como pela introdução de mecanismos de detecção rápida em laticínios, em ambos os casos a fim de aumentar o número de propriedades certificadas como livres da doença e melhorar a sensibilidade do sistema de vigilância ativa.A study to characterize the epidemiological status of brucellosis was carried out in the Federal District of Brazil. A total of 2,019 serum samples from 278 herds were collected. In each herd, it was applied an epidemiological questionnaire focused on herd traits as well as husbandry and sanitary practices that could be associated with the risk of infection. The serum samples were screened for antibodies against Brucella spp. by the Rose-Bengal Test (RBT), and all positive sera were re-tested by the 2-mercaptoethanol test (2-ME). The herd was considered positive if at least one animal was positive on both RBT and 2-ME tests. Herd prevalence was estimated as 2.5% [1.0-5.1%] whereas animal prevalence was 0.16% [0.04-0.28%]. Given these results, that may warrant the implementation of eradication strategies, there is a case for intensifying the serological testing in the Federal District, coupled with the introduction of rapid detection methods by the dairy industries, with a view to increasing the number of accredited free herds and improving the sensitivity of the surveillance system..FAPESPCNPqSEAP-DFMAPA Ministério da Agricultura, Pecuária e Abasteciment

Encapsulation efficiency of Lactobacillus plantarum microencapsulado in Acrycoat S100

Several studies have attributed health benefits to probiotics, as the contribution to intestinal microflora activity (Khan et al. 2013). However, adverse conditions in gastrointestinal transit can reduce the viability of probiotics as Lactobacillus plantarum. Acrycoat S100 is a co-polymer from methacrylic acid and methyl methacrylate, water insoluble and soluble in pH ≥ 7. Therefore, microencapsulation of probiotic in Acrycoat S100 could allow microorganism protection until it reach the intestine. The objective of this study was to determine the encapsulation efficiency of L. plantarum microencapsulated in Acrycoat S100.info:eu-repo/semantics/publishedVersio

Theory of small aspect ratio waves in deep water

In the limit of small values of the aspect ratio parameter (or wave steepness) which measures the amplitude of a surface wave in units of its wave-length, a model equation is derived from the Euler system in infinite depth (deep water) without potential flow assumption. The resulting equation is shown to sustain periodic waves which on the one side tend to the proper linear limit at small amplitudes, on the other side possess a threshold amplitude where wave crest peaking is achieved. An explicit expression of the crest angle at wave breaking is found in terms of the wave velocity. By numerical simulations, stable soliton-like solutions (experiencing elastic interactions) propagate in a given velocities range on the edge of which they tend to the peakon solution.Comment: LaTex file, 16 pages, 4 figure

Fenótipo De Fragilidade: Influência De Cada Item Na Determinação Da Fragilidade Em Idosos Comunitários - Rede Fibra

The phenotype of frailty is used to assess frailty among the elderly by examining the following items: weight loss; exhaustion; low level of physical activity; weakness; and slow gait speed. The aim of the study was to evaluate the contribution of each item to determine the frailty syndrome among elderly Brazilians. The analysis was done using Multinomial Logistic Regression. The total sample of 5532 randomly selected elderly people in many cities in Brazil between December 2008 and September 2009 was assessed using the phenotype of frailty. The most frequent items were level of physical activity, followed by muscular weakness and slow gait speed. Items that were more likely to develop frailty, when positive, were slow gait speed (OR = 10.50, 95%CI 8.55 - 12.90, p <0.001) and muscular weakness (OR = 7.31, 95%CI 6,02 - 8,86, p <0.001). The final model with five items explained 99.6% of frailty in the sample. These results suggested that the level of physical activity, weakness and slow gait speed were the items that most influence the determination of frailty, however the application of all items of the phenotype of frailty is the best way to assess frailty. © 2016, Associacao Brasileira de Pos - Graduacao em Saude Coletiva. All rights reserved.21113483349

The Landau Pole and Z′Z^{\prime} decays in the 331 bilepton model

We calculate the decay widths and branching ratios of the extra neutral boson $Z^{\prime}$ predicted by the 331 bilepton model in the framework of two different particle contents. These calculations are performed taken into account oblique radiative corrections, and Flavor Changing Neutral Currents (FCNC) under the ansatz of Matsuda as a texture for the quark mass matrices. Contributions of the order of $10^{-1}-10^{-2}$ are obtained in the branching ratios, and partial widths about one order of magnitude bigger in relation with other non- and bilepton models are also obtained. A Landau-like pole arise at 3.5 TeV considering the full particle content of the minimal model (MM), where the exotic sector is considered as a degenerated spectrum at 3 TeV scale. The Landau pole problem can be avoid at the TeV scales if a new leptonic content running below the threshold at $$ TeV is implemented as suggested by other authors.Comment: 20 pages, 5 figures, LaTeX2