On the identity of Festuca jubata Lowe (Poaceae) and the description of a new Festuca species in the Azores Islands

The majority of authors consider Festuca jubata Lowe as an endemic species common to Madeira and the Azores. Saint-Yves proposed that F. jubata was an Azorean endemic and described a geovicarious taxon in Madeira: F. filiformis C. Sm. ex Link in Buch ssp. mandonii St.-Yves. We undertook a complete bibliographical revision of the taxonomy, nomenclature, and chorology of F. jubata s.l., and contrasted it with morphological and anatomical studies performed on samples from the Azores and Madeira. Azorean plants usually identified as F. jubata had a character combination distinct from that of those with a Madeiran provenance. Saint-Yves’ proposal of two independent taxa was correct, but he erroneously considered F. jubata as an Azorean endemic because the name F. jubata was based on Madeiran plants. Consequently, F. jubata auct. pl. from the Azores belongs to a new species

On the identity of Festuca jubata Lowe (Poaceae) and the description of a new Festuca species in the Azores Islands

The majority of authors consider Festuca jubata Lowe as an endemic species common to Madeira and the Azores. Saint-Yves proposed that F. jubata was an Azorean endemic and described a geovicarious taxon in Madeira: F. filiformis C. Sm. ex Link in Buch ssp. mandonii St.-Yves. We undertook a complete bibliographical revision of the taxonomy, nomenclature, and chorology of F. jubata s.l., and contrasted it with morphological and anatomical studies performed on samples from the Azores and Madeira. Azorean plants usually identified as F. jubata had a character combination distinct from that of those with a Madeiran provenance. Saint-Yves’ proposal of two independent taxa was correct, but he erroneously considered F. jubata as an Azorean endemic because the name F. jubata was based on Madeiran plants. Consequently, F. jubata auct. pl. from the Azores belongs to a new species

Thermal analysis in drilling of ex vivo bovine bones

Bone drilling is a common procedure in Medicine, mainly in traumatology and orthopedic procedure for fractures fixation and in reconstructive surgery. The success of this surgical procedure is dependent on many factors, namely, on heat generation control during the bone drilling. The main concern in bone drilling is the mechanical and thermal damage of the bone induced by inappropriate parameters such as drill speed and feed-rate during the drilling. This study focuses on the temperature generated during drilling of cortical bone tissue (bovine origin) and solid rigid polyurethane foams with similar mechanical properties to the human bone tissue. Different parameters such as drill speed, feed-rate and hole depth were tested. All results showed that improvement of the drilling parameters and the drill temperatures can be estimated. It was concluded that when the drill speed and feed-rate were higher, the bone temperature increase was lower. The obtained results of temperature in the drilling process of polyurethane foam blocks or bovine bone were compared with a good agreement in between both. © 2017 World Scientific Publishing Company.This research was supported by the Portuguese Foundation of Science and Technology under research project UID/EMS/50022/2013.info:eu-repo/semantics/publishedVersio

Temperature evaluation in ex-vivo bovine bones submitted to drilling processes

A necrose óssea induzida durante o processo de furação é um fenómeno frequente que contribui para problemas pós-operatórios. O calor de fricção gerado pelo contato entre a broca e a parede do furo é inevitável. No entanto, a utilização de técnicas avançadas para a obtenção do registo térmico durante a furação óssea é importante para a garantia da qualidade durante a furação. O objetivo deste estudo é apresentar dois métodos experimentais diferentes para analisar as condições de furação que geram as temperaturas mais baixas, evitando a ocorrência da necrose óssea. Foram utilizados ossos de bovino ex-vivo para simular o processo de furação considerando os efeitos do diâmetro da broca, velocidade de rotação e velocidade de avanço. Foram realizados diferentes testes experimentais para avaliar a sua repetibilidade. Os resultados identificaram o diâmetro da broca como o parâmetro mais crítico na indução de temperaturas mais elevadas durante a furação óssea.This research was supported by the Portuguese Foundation of Science and Technology under the research project UID/EMS/50022/2013. The third author acknowledges the funding of Project NORTE-01-0145-FEDER-000022-SciTech -Science and Technology for Competitive and Sustainable Industries, co-financed by Programa Operacional Regional do Norte (NORTE2020), through Fundo Europeu de Desenvolvimento Regional (FEDER).info:eu-repo/semantics/publishedVersio

Post-depositional processes of elemental enrichment inside dark nodular masses of an ancient aeolian dune from A Coruña, Northwest Spain

This paper focuses on a residual ancient aeolian climbing dune from Punta Penaboa (A Coruña, Northwest Spain) showing evidence of post-depositional weathering, particularly the presence of dark brown nodular masses. The partitioning of trace elements between nodular masses and host sand during post-depositional weathering of the dune is investigated in this work, with the main objective of studying the elemental enrichment patterns in the dark masses. Data of the concentrations of chemical elements were obtained by instrumental neutron activation analysis (INAA) and complemented by mineralogical and microchemical studies, using X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) / energy dispersive X-ray spectrometry (EDS). The dune was dated by optically stimulated luminescence (OSL) , yielding an age of 300ka B.P.. The dark nodular masses preserved the dune sand structure, without defined concentric layers, suggesting an early stage of formation. They consist mainly of quartz grains cemented by clay materials enriched in the majority of the elements studied, especially in Mn, Co, Ba, Sb, Ce, Tb, Th, As, Zr and Hf. The post-depositional transformations of the dune were most likely influenced by migration of chemical compounds from the surrounding slope deposits and granitic rocks, as well as microbial activity that promoted metals concentration in the solutions percolating through the pore network of the dune. Seasonal changes in the redox potential were required to produce the accumulation of Mn and other trace elements in the dune pore network and to promote the fractionation between Ce4+ and trivalent rare earth elements that was observed in the geochemical patterns

Economic Feasibility of Floating Offshore Wind Farms Considering Near Future Wind Resources: Case Study of Iberian Coast and Bay of Biscay

[Abstract] Wind energy resources are subject to changes in climate, so the use of wind energy density projections in the near future is essential to determine the viability and profitability of wind farms at particular locations. Thus, a step forward in determining the economic assessment of floating offshore wind farms was taken by considering current and near-future wind energy resources in assessing the main parameters that determine the economic viability (net present value, internal rate of return, and levelized cost of energy) of wind farms. This study was carried out along the Atlantic coast from Brest to Cape St. Vincent. Results show that the future reduction in wind energy density (2%–6%) mainly affects the net present value (NPV) of the farm and has little influence on the levelized cost of energy (LCOE). This study provides a good estimate of the economic viability of OWFs (Offshore Wind Farms) by taking into account how wind resources can vary due to climate change over the lifetime of the farm.Ministerio de Ciencia e Innovación; 10.13039/501100011033.Xunta de Galicia; ED431C 2017/6

Comparison between three-dimensional linear and nonlinear tsunami generation models

The modeling of tsunami generation is an essential phase in understanding tsunamis. For tsunamis generated by underwater earthquakes, it involves the modeling of the sea bottom motion as well as the resulting motion of the water above it. A comparison between various models for three-dimensional water motion, ranging from linear theory to fully nonlinear theory, is performed. It is found that for most events the linear theory is sufficient. However, in some cases, more sophisticated theories are needed. Moreover, it is shown that the passive approach in which the seafloor deformation is simply translated to the ocean surface is not always equivalent to the active approach in which the bottom motion is taken into account, even if the deformation is supposed to be instantaneous.Comment: 39 pages, 16 figures; Accepted to Theoretical and Computational Fluid Dynamics. Several references have been adde

The leading particle effect from light quark fragmentation in charm hadroproduction

The asymmetry of $D^-$ and $D^+$ meson production in $\pi^-N$ scattering observed by the E791 experiment is a typical phenomenon known as the leading particle effect in charm hadroproducton. We show that the phenomenon can be explained by the effect of light quark fragmentation into charmed hadrons (LQF). Meanwhile, the size of the LQF effect is estimated from data of the E791 experiment. A comparison is made with the estimate of the LQF effect from prompt like-sign dimuon rate in neutrino experiments. The influence of the LQF effect on the measurement of nucleon strange distribution asymmetry from charged current charm production processes is briefly discussed.Comment: 6 latex pages, 1 figure, to appear in EPJ

Trophic niche overlap between native freshwater mussels (Order: Unionida) and the invasive Corbicula fluminea

Freshwater mussels (Order Unionida) are highly threatened. Interspecific competition for food sources with invasive alien species is considered to be one of the factors responsible for their decline because successful invaders are expected to have wider trophic niches and more flexible feeding strategies than their native counterparts. In this study, carbon (δ13C: 13C/12C) and nitrogen (δ15N: 15N/14N) stable isotopes were used to investigate the trophic niche overlap between the native freshwater mussel species, Anodonta anatina, Potomida littoralis, and Unio delphinus, and the invasive bivalve Corbicula fluminea living in sympatry in the Tua basin (south-west Europe). The species presenting the widest trophic niches were C. fluminea and A. anatina, which indicate that they have broader diets than U. delphinus and P. littoralis. Nonetheless, all the species assimilated microphytobenthos, sediment organic matter, and detritus derived from vascular plants, although with interspecific variability in the assimilated proportions of each source. The trophic niche of the invasive species overlapped with the trophic niche of all the native species, with the extent varying between sites and according to the species. From the three native species analysed, Potomida littoralis may be at a higher risk for competition for food with C. fluminea in the Tua basin, if food sources become limited, because this native mussel presented the narrowest trophic niche across sites and the highest probability of overlapping with the trophic niche of C. fluminea. Given the global widespread distribution of C. fluminea, the implementation of management measures devoted to the control or even eradication of this invasive alien species should be a conservation priority given its potential for competition with highly threatened native freshwater mussels.V.M. and P.C. were supported by doctoral grants SFRH/BD/108298/2015 and SFRH/BD/131814/2017, respectively, from the Portuguese Foundation for Science and Technology—FCT through POPH/FSE funds. FCT also supported M.L.L. under contract (2020.03608.CEECIND). This study was conducted within the project FRESHCO – Multiple implications of invasive species on Freshwater Mussel coextinction processes, supported by FCT and COMPETE funds (contract: PTDC/AGRFOR/1627/2014). This study was also supported by national funds through FCT – Foundation for Science and Technology within the scope of UIDB/04423/2020 and UIDP/04423/2020. We thank Jacinto Cunha for providing Figure 1.info:eu-repo/semantics/publishedVersio

Advances in Antisense Oligonucleotide Development for Target Identification, Validation, and as Novel Therapeutics

Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene. As-ODNs are able to selectively bind cognate mRNA sequences by sequence-specific hybridization. This results in cleavage or disablement of the mRNA and, thus, inhibits the expression of the target gene. The specificity of the As approach is based on the probability that, in the human genome, any sequence longer than a minimal number of nucleotides (nt), 13 for RNA and 17 for DNA, normally occurs only once. The potential applications of As-ODNs are numerous because mRNA is ubiquitous and is more accessible to manipulation than DNA. With the publication of the human genome sequence, it has become theoretically possible to inhibit mRNA of almost any gene by As-ODNs, in order to get a better understanding of gene function, investigate its role in disease pathology and to study novel therapeutic targets for the diseases caused by dysregulated gene expression. The conceptual simplicity, the availability of gene sequence information from the human genome, the inexpensive availability of synthetic oligonucleotides and the possibility of rational drug design makes As-ODNs powerful tools for target identification, validation and therapeutic intervention. In this review we discuss the latest developments in antisense oligonucleotide design, delivery, pharmacokinetics and potential side effects, as well as its uses in target identification and validation, and finally focus on the current developments of antisense oligonucleotides in therapeutic intervention in various diseases