22 research outputs found
One Story, Many Lives: A Reflection on Dysfunctional Families and Their Consequences
When someone is born the individual is welcomed by their parents grandparents and other family members which means the first social contact It is through the relationship with family members that the child learns to deal socially to live in society following the established rules The present study analyzes the exceptions that is the dysfunctional family the emotional and behavioral problems of its members and the consequences for everyone Fundamentally the intention of this study is to emphasize the importance of the element love and the search for happiness in family relationships for the formation of individuals The research methodologies applied are qualitative and theoretical based on the philosophical Kant and Ricoeur s foundations The object of reflection will be a particular case that is significant and representative of the events that involve the psychological problems of dysfunctional familie
Projeto CEMEI - Centro de educação para a melhor idade
O CEMEI – Centro de Educação para a Melhor Idade é um projeto de Extensão em continuidade desde 2009, desenvolvido na Universidade FUMEC/FACE, que proporciona gratuitamente aos idosos moradores do entorno da FUMEC, bem como pertencentes ao Centro de Referência da Pessoa Idosa da DIRETORIA DE POLÍTICAS PÚBLICAS PARA PESSOAS IDOSAS (Prefeitura Municipal de Belo Horizonte) entidade parceira, a oportunidade de ampliar conceitos intelectuais e/ou sociais necessários ao convívio diário. Tem também o objetivo de sensibilizar esses idosos para a importância do constante aprendizado por meio de ações interdisciplinares nas oficinas de Direito, Musicalidade, Fotografia, Raciocínio Lógico, Inglês, Informática, Vivências e Design e Moda. O público de alunos é dividido em dois grupos de novatos e veteranos. Esses alunos frequentam aulas e atividades nos ambientes das salas de aula, laboratórios de Informática e Auditórios da Universidade FUMEC/FACE por três vezes na semana, no período da tarde.Em ambos os grupos, os alunos bolsistas e voluntários de extensão auxiliam nas oficinas e atividades pedagógicas, além disso, a coordenadora do projeto e colaboradores externos também ministram oficinas. Assim, o projeto, além de fornecer, aos idosos, teorias sobre os assuntos estudados, oferece também a oportunidade dos discentes da graduação da Universidade o desenvolvimento da docência e didática, praticando a inclusão social e cidadania. O CORAL CEMEI, na oficina de Musicalidade foi convidado para participar de eventos na FUMEC, “Seminário de Pesquisa e Extensão, bem como eventos promovidos pela PBH, como “O Dia da Responsabilidade Social” no Parque Municipal Professor Amílcar Vianna Martins”. A relevância do projeto tem sido destacada em comunidades do entorno da Universidade. Considerações e elogios feitos pelos idosos, pela entidade parceira; pela diretoria e pelo corpo administrativo da Instituição FUMEC
In Vitro Surfactant Structure-Toxicity Relationships: Implications for Surfactant Use in Sexually Transmitted Infection Prophylaxis and Contraception
Background
The need for woman-controlled, cheap, safe, effective, easy-to-use and easy-to-store topical applications for prophylaxis against sexually transmitted infections (STIs) makes surfactant-containing formulations an interesting option that requires a more fundamental knowledge concerning surfactant toxicology and structure-activity relationships.
Methodology/Principal Findings
We report in vitro effects of surfactant concentration, exposure time and structure on the viability of mammalian cell types typically encountered in the vagina, namely, fully polarized and confluent epithelial cells, confluent but non-polarized epithelial-like cells, dendritic cells, and human sperm. Representatives of the different families of commercially available surfactants – nonionic (Triton X-100 and monolaurin), zwitterionic (DDPS), anionic (SDS), and cationic (CnTAB (n = 10 to 16), C12PB, and C12BZK) – were examined. Triton X-100, monolaurin, DDPS and SDS were toxic to all cell types at concentrations around their critical micelle concentration (CMC) suggesting a non-selective mode of action involving cell membrane destabilization and/or destruction. All cationic surfactants were toxic at concentrations far below their CMC and showed significant differences in their toxicity toward polarized as compared with non-polarized cells. Their toxicity was also dependent on the chemical nature of the polar head group. Our results suggest an intracellular locus of action for cationic surfactants and show that their structure-activity relationships could be profitably exploited for STI prophylaxis in vaginal gel formulations. The therapeutic indices comparing polarized epithelial cell toxicity to sperm toxicity for all surfactants examined, except C12PB and C12BZK, does not justify their use as contraceptive agents. C12PB and C12BZK are shown to have a narrow therapeutic index recommending caution in their use in contraceptive formulations.
Conclusions/Significance
Our results contribute to understanding the mechanisms involved in surfactant toxicity, have a predictive value with regard to their safety, and may be used to design more effective and less harmful surfactants for use in topical applications for STI prophylaxis.Foundation for Science and
Technology of the Portuguese Ministry of Science and Higher Educatio
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Understanding and Reducing Web Delays
Different Internet sites have different performance characteristics. One of the most important characteristics that a regular Internet user readily notices is the vast performance differences between them. Research on web sites and its effects on users shows that the amount of time it takes for a web page to load is a significant factor on the success/failure of a web site. Slow performances cost e-commerce sites millions of dollars every year. Hence it is critical to identify the sources of performance bottlenecks associated with web content presentation. In this paper, the authors attempt to identify where such bottlenecks could occur and how to avoid or improve them without modifying the existing infrastructure. In order to identify the problems with the current implementations, it is very important to have a thorough understanding of the things that take place in the background when a web page is requested. This paper takes a detailed look at the processes that are taking place when a page is requested including IP address resolution, making a connection to the source, requesting different web elements and generation of dynamic web contents. It then tries to identify where performance bottlenecks could occur and how the existing technologies can be used to improve them. Finally the paper discusses the things and strategies that the content developer should have been aware of when developing or hosting sites, if he/she needs to have a web site with high performance
Developing High Performance Web Applications Using Open Source Products
With the advent of commercialization of the Internet and e-commerce, web-based applications are hitting the market almost daily. Users expect a lot more from such applications than from conventional websites. Developing a web-based application today has become a huge challenge to the developers, as they have to address the issues of performance, availability and cost all at the same time. Concentrating on one aspect would result in compromising on another. The cost of development is one of the most important factors as every development initiative is expected to meet certain standards within a limited budget
What Do Recreational Runners Think About Risk Factors for Running Injuries? A Descriptive Study of Their Beliefs and Opinions
R unning is one of the most popular types of physical activity worldwide. The benefits attributed to recreational running include improvements in physical and mental health, weight control, stress reduction, and social participation. T T OBJECTIVES: To describe the beliefs and opinions of runners about risk factors associated with running injuries. T T BACKGROUND: Despite the health benefits of running, a high prevalence of injury has been reported in runners. Preventive strategies for running injuries may be more successful with a better knowledge of runners' beliefs. T T METHODS: A semi-structured interview of recreational runners was based on the question, "What do you think can cause injuries in runners?" Analysis of the interviews was performed in 3 steps: (1) organizing the data into thematic units, (2) reading and reorganizing the data according to frequency of citation, and (3) interpreting and summarizing the data. The runner interviews were continued until no new beliefs and opinions of runners regarding injuries were being added to the data, indicating saturation of the topic. T T RESULTS: A total of 95 recreational runners (65 men, 30 women) between the ages of 19 and 71 years were interviewed. Of those interviewed, the average running experience was 5.5 years and approximately 45% had experienced a runningrelated injury in the past. The factors suggested by the runners were divided into extrinsic and intrinsic factors. The most cited extrinsic factors were "not stretching," "excess of training," "not warming up," "lack of strength," and "wearing the wrong shoes." For the intrinsic factors, the main terms cited were "not respecting the body's limitations" and "foottype changes." T T CONCLUSION: Recreational runners mainly attributed injury to factors related to training, running shoes, and exceeding the body's limits. Knowing the factors identified in this study may contribute to the development of better educational strategies to prevent running injuries, as some of the runners' beliefs are not supported by the research literature