Inclusive workplaces : a review and model

Organizations continue to be challenged and enriched by the diversity of their workforces. Scholars are increasingly focusing on inclusion to enhance work environments by offering support for a diverse workforce. This article reviews and synthesizes the inclusion literature and provides a model of inclusion that integrates existing literature to offer greater clarity, as well as suggestions for moving the literature forward. We review the inclusion literature consisting of the various foci (work group, organization, leader, organizational practices, and climate) and associated definitions and how it has developed. We then describe themes in the inclusion literature and propose a model of inclusion. Finally, we end by discussing theoretical and practical implications

Cerrando la brecha entre nativos e inmigrantes digitales a través de las competencias informáticas e informacionales

En este texto hacemos una reflexión acerca de las diferencias entre los llamados "nativos" e "inmigrantes digitales", y aportamos datos que permitan identificar si un grupo tiene mayores ventajas sobre otro en relación con la enseñanza y el aprendizaje en esta era digital. Proponeos la adquisición y el desarrollo de competencias informáticas e informaciones en ambos grupos como estrategia para reducir la brecha digital "blanda" que priva en el sistema educativo e invitamos a resolver las interrogantes: ¿Los docentes estamos preparados para enseñar las nuevas asignaturas y las viejas materias, pero con nuevas formas?, y ¿los alumnos contamos con las tradicionales competencias informaciones requeridas para resolver nuevos problemas y tomar decisiones en escenarios futuros

Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer.

Triple-negative breast cancer (TNBC) occurs in 10-15% of all breast cancer patients, yet it accounts for about half of all breast cancer deaths. There is an urgent need to identify new antitumor targets to provide additional treatment options for patients afflicted with this aggressive disease. Preclinical evidence suggests a critical role for insulin-like growth factor-2 (IGF2) and androgen receptor (AR) in regulating TNBC progression. To advance this work, a panel of TNBC cell lines was investigated with all cell lines showing significant expression of IGF2. Treatment with IGF2 stimulated cell proliferation in vitro (p < 0.05). Importantly, combination treatments with IGF1R inhibitors BMS-754807 and NVP-AEW541 elicited significant inhibition of TNBC cell proliferation (p < 0.001). Based on Annexin-V binding assays, BMS-754807, NVP-AEW541 and enzalutamide induced TNBC cell death (p < 0.005). Additionally, combination of enzalutamide with BMS-754807 or NVP-AEW541 exerted significant reductions in TNBC proliferation even in cells with low AR expression (p < 0.001). Notably, NVP-AEW541 and BMS-754807 reduced AR levels in BT549 TNBC cells. These results provide evidence that IGF2 promotes TNBC cell viability and proliferation, while inhibition of IGF1R/IR and AR pathways contribute to blockade of TNBC proliferation and promotion of apoptosis in vitro

The Development of Archivist Culture in Mexico

Resumen: El presente trabajo aborda la evolución archivística en el contexto mexicano bajo cuatro ejes de análisis: las instituciones archivísticas, la legislación, la formación profesional y las asociaciones profesionales. Se hace una revisión cronológica de manera transversal y paralela con los hechos -dentro de este marco- que han marcado el devenir de la disciplina y evidencian la incipiente presencia de la archivística nacional a través de las acciones que se han emprendido y han hecho visible a la disciplina. El empalme sucesivo, natural y poco estructurado de principios a mediados del siglo pasado, ha servido de base para construir el andamiaje en el que, a través de la oferta educativa de carreras a nivel superior por un lado y, por otro, el desarrollo propio de la profesión mediante la inserción de Tecnologías de la Información y la Comunicación y su regulación a través de un marco legal, han ido gestando una Archivística nacional que ha incidido en un gremio profesional embrionario y más o menos organizado.Abstract: This paper addresses the evolution of archives in the Mexican context under four axes of analysis, archive institutions, legislation, professional training, and professional associations. A transverse and parallel chronological review of the facts is performed within this framework, which has marked the development of the discipline and shows the emerging presence of the national archives through the actions to be undertaken and made visible to the discipline. The successive, natural and unstructured during the beginning to the middle of the past century, have been the basis for building the scaffolding that through the education offered by universities on the one hand and,to the other hand the self-development of the profession through the integration of Information Technology and Communication and its regulation through a legal framework have been developing National Archives which has resulted in an embryonic professional association more or less organized

Manual de Procedimientos administrativos e Indicadores de Gestión

Manual of administrative procedures of the Center of Libraries of the University of Caldas (Manizales, Colombia). Includes several indicators of management as guide for the managers of the dependence

AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

The AMP-activated protein kinase (AMPK) is activated by phosphorylation at Thr172, either by the tumor suppressor kinase LKB1 or by an alternate pathway involving the Ca(2+)/calmodulin-dependent kinase, CAMKK2. Increases in AMP:ATP and ADP:ATP ratios, signifying energy deficit, promote allosteric activation and net Thr172 phosphorylation mediated by LKB1, so that the LKB1-AMPK pathway acts as an energy sensor. Many tumor cells carry loss-of-function mutations in the STK11 gene encoding LKB1, but LKB1 re-expression in these cells causes cell cycle arrest. Therefore, it was investigated as to whether arrest by LKB1 is caused by activation of AMPK or of one of the AMPK-related kinases, which are also dependent on LKB1 but are not activated by CAMKK2. In three LKB1-null tumor cell lines, treatment with the Ca(2+) ionophore A23187 caused a G1-arrest that correlated with AMPK activation and Thr172 phosphorylation. In G361 cells, expression of a truncated, CAMKK2 mutant also caused G1-arrest similar to that caused by expression of LKB1, while expression of a dominant negative AMPK mutant, or a double knockout of both AMPK-α subunits, also prevented the cell cycle arrest caused by A23187. These mechanistic findings confirm that AMPK activation triggers cell cycle arrest, and also suggest that the rapid proliferation of LKB1-null tumor cells is due to lack of the restraining influence of AMPK. However, cell cycle arrest can be restored by re-expressing LKB1 or a constitutively active CAMKK2, or by pharmacological agents that increase intracellular Ca(2+) and thus activate endogenous CAMKK2. IMPLICATIONS: Evidence here reveals that the rapid growth and proliferation of cancer cells lacking the tumor suppressor LKB1 is due to reduced activity of AMPK, and suggests a therapeutic approach by which this block might be circumvented

Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial.

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m(2) completed week 24. TxB2 increased in the RAL versus PI/NNRTI arm (+0.09 versus -0.02; P = 0.06). Baseline PGI-M was lower in the RAL arm (P = 0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho = 0.45; P = 0.04) and TxB2 (rho = 0.44; P = 0.005) changes, with a trend seen for PGE-M (rho = 0.41; P = 0.07). In an adjusted model, age ≥ 50 years (N = 8) was associated with increased PGE-M (P = 0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥ 50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study

DIGNITY AND RESPECT IN THE SALSA DANCE CLASSROOM: FOSTERING HEALTHY SELF- ESTEEM TO PROMOTE COMPASSION

Many students that have attempted to take salsa dance classes often express their disillusionment in the way in which they are treated by salsa dance instructors. Salsa dance classes have the possibility to function to awaken in the student greater integration with the society in which people live, while stimulating actions, improving self-esteem, and self-confidence, improving vocabulary, awakening sensitivity, attenuating shyness, as well as increasing communicative and social skills. If the content of a course is well designed and delivered with an intentional student-centered approach, it can positively contribute to greater and more sincere learning. In this sense, the objective of this study was to analyze and reflect on the ideas of dignity and self-respect in the context of the learning environment created. With these ideas in mind, the purpose of this research was to investigate the outcome of treating students with dignity and respect, specifically in the salsa dance classroom. This study was designed to employ an environment that would foster a healthy self-esteem and would promote compassion with students. Two groups of ten participants in each group were compared in this study. The participant responses to these teaching strategies were tracked via pre and post surveys, and interview questions which provided insight regarding best practices and approaches for building students’ strategies both in and out of the dance class

Caracterizaci?n de los pacientes inscritos al programa de control de la hipertenci?n arterial del hospital San Carlos de Salda?a Tolima del 2015 al 2017

117 p. Recurso Electr?nicoLa hipertensi?n, tambi?n conocida como tensi?n arterial alta o elevada, es un trastorno en el que los vasos sangu?neos tienen una tensi?n persistentemente alta, lo que puede da?arlos. Cada vez que el coraz?n late, bombea sangre a los vasos, que llevan la sangre a todas las partes del cuerpo. La tensi?n arterial normal en adultos es de 120 mm Hg cuando el coraz?n late (tensi?n sist?lica) y de 80 mm Hg cuando el coraz?n se relaja (tensi?n diast?lica). Cuando la tensi?n sist?lica es igual o superior a 140 mm Hg y/o la tensi?n diast?lica es igual o superior a 90 mm Hg, la tensi?n arterial se considera alta o elevada. (12) La hipertensi?n arterial se constituye como la segunda enfermedad (diagnosticada) despu?s de la diabetes con mayor prevalencia entre los habitantes del municipio de Salda?a, Tolima, por lo tanto, la convierte en el factor de riesgo m?s importante para las enfermedades cardiovasculares que asociada con otros trastornos, aumenta de forma exponencial la probabilidad de padecer graves complicaciones de tipo card?aco, renal, neurol?gica o de cualquier otro sistema. (11) El objetivo de este estudio fue describir los factores sociodemogr?ficos, antecedentes relacionados con la patolog?a, como antecedentes familiares de Hipertensi?n Arterial y de otras comorbilidades, tratamiento recibido, h?bitos de vida; y percepci?n del programa de los pacientes. Se dise?? un estudio de tipo descriptivo, ya que su prop?sito se orient? a la identificaci?n de las caracter?sticas de la poblaci?n que asiste al programa de control de la Hipertensi?n Arterial de la IPS San Carlos E.S.E del municipio de Salda?a. Este estudio presento una poblaci?n de 98 pacientes analizados, con una edad promedio de 62.81 a?os (IC 95% 60.22 ? 65.39), de los cuales el 53.1% de los pacientes se concentr? en la edad de 60 a 79 a?os, la distribuci?n por sexos evidencio que 69.4% (IC 95%, 59.68 ? 77.64) de los casos fueron de sexo femenino, el 45.9% provienen del ?rea rural y el 52.3% tienen educaci?n b?sica primaria. Seg?n el estado civil de las personas el 68.4% de los pacientes viven con una pareja estable y el 98% pertenecen a los estratos I y II y est?n afiliados al r?gimen subsidiado de afiliaci?n en salud. Referente a los antecedentes familiares un 79.8% expresaron como antecedente familiar de gran importancia la Hipertensi?n Arterial y el 17.5% presentaban alg?n tipo cl?nico de Diabetes; y la evaluaci?n del tratamiento farmacol?gico a la patolog?a antihipertensiva evidencio que 98% casos consumen en la actualidad antihipertensivos, de los cuales el 83,7% lo consumen m?s de una vez al d?a y el 88.8% lo hace de acuerdo a la formulaci?n m?dica Palabras clave: Hipertensi?n arterial, descriptivo, tensi?n arterial.Hypertension, also known as high or high blood pressure, is a disorder in which the blood vessels have a persistently high blood pressure, which can damage them. Each time the heart beats, it pumps blood to the vessels, which carry blood to all parts of the body. Normal blood pressure in adults is 120 mm Hg when the heart beats (systolic tension) and 80 mm Hg when the heart relaxes (diastolic tension). When systolic blood pressure is equal to or greater than 140 mm Hg and / or diastolic blood pressure is equal to or greater than 90 mm Hg, blood pressure is considered high or high. (12) Hypertension is the second (diagnosed) disease after diabetes with the highest prevalence among the inhabitants of the municipality of Salda?a, Tolima, making it the most important risk factor for cardiovascular diseases that is associated with other disorders, Increases exponentially the probability of suffering serious cardiac, renal, neurological or other system complications. (11) The objective of this study was to describe sociodemographic factors, antecedents related to the pathology, such as family history of Arterial Hypertension and other comorbidities, treatment received, life habits; And patient perception of the program. A descriptive study was designed, since its purpose was oriented to the identification of the characteristics of the population that attends to the program of control of the Arterial Hypertension of the San Carlos E.S.E of the municipality of Salda?a. A descriptive study was designed, since its purpose was oriented to the identification of the characteristics of the population that attends to the program of control of the Arterial Hypertension of the San Carlos ESE of the municipality of Salda?a, according to the prioritized categories, Corresponding to sociodemographic characteristics, comorbidities and family history of the same. In this study, we presented a population of 98 patients analyzed, with a mean age of 62.81 years (95% CI 60.22 - 65.39), of which 53.1% of the patients were concentrated in the age group of 60 to 79 years, Sex, 69.4% (95% CI, 59.68 - 77.64) of the cases were female and 30.6% (CI 95%, 22.36 -40.32) were male, 45.9% of which came from the rural area and 52.3% % Have primary basic education. According to the civil status of the people, 68.4% of the patients live with a stable partner and 98% belong to strata I and II and are affiliated to the subsidized health affiliation regime. Regarding family history, 79.8% expressed high blood pressure and 17.5% had a clinical type of Diabetes; And the evaluation of the pharmacological treatment to the antihypertensive pathology evidenced that 98% of cases currently consume antihypertensive, of which 83.7% consume it more than once a day and 88.8% do it according to the medical formulation. Keywords: Hypertension, descriptive, blood pressure

Machine Kinship: The impossible duet

Machine Kinship: The impossible duet What does it mean to vanish from earth when you are the last of your kind? In 1987 the Kauai OO was recorded singing his final song. It was meant to be a duet, but as the last of his kind his song hangs in the air, unanswered. The other half of the duet is forever lost. Built to sing at dawn, birds must wake up earlier to hear each other before human chaos interferes. So here, it is always almost sunrise. As a parallel past-future response, the last birdsong was fed into a machine learning model created to record human voices, but instead is listening to the song learning and recreating the response. This second song will join him in a technological afterlife. Contained in a ghost flower, whose color proteins were removed to replace it with the bird heartbeat. This is a moment frozen in time, of an impossible duet. The AI will try to learn the song before dawn