El control de inventarios y su relación con la rentabilidad en la empresa Chemtools, 2021

La actual investigación planteo como objetivo principal establecer la relación entre el control de inventarios y la rentabilidad en la empresa CHEMTOOLS, 2021.Del mismo modo, se formuló la hipótesis principal que el control de inventarios se relaciona significativamente con la rentabilidad en la empresa CHEMTOOLS. El método enfocado en el aspecto metodológico fue cuantitativo, de tipo básica, nivel correlacional y diseño no experimental. La técnica empleada fue la encuesta a través de un cuestionario como herramienta principal para obtener datos a partir de la colaboración de encuestados. La población y muestra representa la cifra de 17 colaboradores que laboran en el área de contabilidad y logística de la empresa CHEMTOOLS. Los resultados mostraron que el 47,1 % estuvo totalmente de acuerdo el control de inventario es el adecuado que permite identificar la actualización de inventarios, permitiendo acelerar la rotación de los productos, asimismo el 47,1 % estuvo de acuerdo que los beneficios netos se relacionan con la rentabilidad de la empresa. Finalmente, se obtuvo como resultado principal que el control de inventarios se relaciona significativamente con la rentabilidad en la empresa CHEMTOOLS. 2021. El enunciado se logró corroborar mediante la aplicación de la correlación de Spearman 0,845, dicha cifra es alto.The main objective of the current research was to establish the relationship between inventory control and profitability in the company CHEMTOOLS, 2021, and to formulate the main hypothesis that inventory control is significantly related to profitability in the company CHEMTOOLS. The method focused on the methodological aspect was quantitative, basic type, correlational level and non-experimental design. The technique used was the survey accompanied by the questionnaire as the main tool to obtain data from the collaboration of respondents. The population and sample represents the number of 17 employees working in the accounting and logistics area of the company CHEMTOOLS. The results showed that 47.1 % totally agreed that the inventory control is the adequate one that allows to identify the inventory update, allowing to accelerate the rotation of the products, also 47.1 % agreed that the net benefits are related to the profitability of the company. Finally, it was obtained as main result that inventory control is significantly related to profitability in the company CHEMTOOLS. 2021. The statement was corroborated by the application of Spearman's correlation 0.845, this figure is high

El cambio de residencia del hijo menor de edad y la afectación a la ejecución de un régimen de visitas fijado

El presente trabajo de investigación tiene como finalidad determinar si el cambio de residencia del hijo menor de edad afecta la ejecución de un régimen de visitas fijado. Se justifica debido a la existencia de antecedentes tanto nacionales como internacionales en los cuales se plasma el interés superior del niño y la importancia de la ejecución del régimen de visitas fijado. El enfoque es cualitativo, tipo de investigación básica, diseño de teoría fundamentada, técnica entrevista, instrumento guía de entrevista conformada por 14 preguntas, se tuvo 6 participantes, Como resultado se obtuvo que si se vería afectado el derecho del menor a pasar tiempo de calidad con su progenitor no custodio, pues si en el caso de que el progenitor que cuente con la custodia del menor dificulte el régimen de visitas estaría restringiendo la comunicación entre el menor y su padre. Se concluyó que El cambio de residencia del hijo menor de edad no afecta el derecho del niño o adolescente a ser visitado por el padre solicitante y tampoco vulnera el derecho del padre solicitante a visitar a su hijo debido a que al establecerse un régimen de visitas se tendría que considerar el cambio de residencia del menor

La internacionalización curricular en Licenciaturas en Educación Infantil en el Caribe Colombiano: una perspectiva docente

This article shows conceptual approaches to the curriculum and curriculum internationalization, taking into account current strategies such as the use of new technologies for higher education. Likewise, the results of interviews with teachers of the Bachelor of Childhood Education on how to implement the internationalization process from the classroom are presented. The most important results are: teachers cooperate with peers abroad promoting strategies such as classes with universities from abroad through virtual platforms, videoconferences, virtual exchanges and international references in the classes. Blogs, international bibliography, as well as international databases are also used. Regarding intercultural competence, it is also promoted through the inclusion of national intercultural references, such as indigenous people and their culture.Este articulo muestra abordajes conceptuales sobre el currículo y la internacionalización curricular, teniendo en cuenta estrategias actuales como el uso de nuevas tecnologías para la educación superior. Igualmente se presentan los resultados de unas entrevistas realizadas a docentes del programa Licenciatura en Educación Infantil, sobre la implementación del proceso de internacionalización desde el aula de clase. Los resultados más importantes son: los docentes trabajan con pares en el exterior, promoviendo estrategias como las clases espejo, las videoconferencias, intercambios virtuales y referentes internacionales en las clases. Igualmente se usan blogs, bibliografía internacional, así como bases de datos internacionales. Frente a la interculturalidad, esta es promovida también por medio de la inclusión de referentes interculturales nacionales, como los indígenas y su cultura

Guia pràctica de la reproducció assistida

Reproducció humana assistida; Assisted Human Reproduction; Reproducción humana asistidaLa dificultat de concebre un infant de manera natural sovint genera dubtes a les persones. A més, el desconeixement d’alguns aspectes previs durant la realització de tractaments d’esterilitat es barregen amb els desitjos i les probabilitats reals. És per això que el Departament de Salut creu convenient contribuir a la millora de la informació de les persones que pensen en la possibilitat d’optar per l’ajuda d’aquestes tècniques amb la finalitat que les decisions que es prenguin siguin, consegüentment, més autònomes i encertades

Solvent neurotoxicity in vehicle collision repair workers in New Zealand.

OBJECTIVES: To assess whether solvent use and workplace practices in the vehicle collision repair industry are associated with symptoms of neurotoxicity in spray painters and panel beaters (auto body repair workers). METHODS: Neurobehavioural symptoms were assessed using a cross-sectional study design in 370 vehicle collision repair and 211 reference workers using the EUROQUEST questionnaire. Full-shift airborne solvent levels were measured in a subset (n=92) of collision repair workers. RESULTS: Solvent exposures were higher in spray painters than in panel beaters, but levels were below current international exposure standards. Collision repair workers were more likely to report symptoms of neurotoxicity than reference workers with ORs of 2.0, 2.4 and 6.4 (all p<0.05) for reporting ≥5, ≥10 and ≥15 symptoms respectively. This trend was generally strongest for panel beaters (ORs of 2.1, 3.3 and 8.2 for ≥5, ≥10 and ≥15 symptoms respectively). Associations with specific symptom domains showed increased risks for neurological (OR 4.2), psychosomatic (OR 3.2), mood (OR 2.1), memory (OR 2.9) and memory and concentration symptoms combined (OR 2.4; all p<0.05). Workers who had worked for 10-19 years or 20+ years in the collision repair industry reported consistently more symptoms than those who had only worked less than 10 years even after adjusting for age. However, those who worked more than 20 years generally reported fewer symptoms than those who worked 10-19 years, suggesting a possible healthy worker survivor bias. CONCLUSIONS: Despite low airborne solvent exposures, vehicle collision repair spray painters and panel beaters continue to be at risk of symptoms of neurotoxicity

Modification of neurobehavioral effcts of Mercury By a genetic polymorphism of coproporphyrinogen oxidase in children

Mercury (Hg) is neurotoxic, and children may be particularly susceptible to this effect. A current major challenge is the identification of children who may be uniquely susceptible to Hg toxicity because of genetic disposition. We examined the hypothesis that CPOX4, a genetic variant of the heme pathway enzyme coproporphyrinogen oxidase (CPOX) that affects susceptibility to mercury toxicity in adults, also modifies the neurotoxic effects of Hg in children. Five hundred seven children, 8–12 years of age at baseline, participated in a clinical trial to evaluate the neurobehavioral effects of Hg from dental amalgam tooth fillings in children. Subjects were evaluated at baseline and at 7 subsequent annual intervals for neurobehavioral performance and urinary mercury levels. Following the completion of the clinical trial, genotyping assays for CPOX4 allelic status were performed on biological samples provided by 330 of the trial participants. Regression modeling strategies were employed to evaluate associations between CPOX4 status, Hg exposure, and neurobehavioral test outcomes. Among girls, few significant CPOX4-Hg interactions or independent main effects for Hg or CPOX4 were observed. In contrast, among boys, numerous significant interaction effects between CPOX4 and Hg were observed spanning all 5 domains of neurobehavioral performance. All underlying dose-response associations between Hg exposure and test performance were restricted to boys with the CPOX4 variant, and all of these associations were in the expected direction where increased exposure to Hg decreased performance. These findings are the first to demonstrate genetic susceptibility to the adverse neurobehavioral effects of Hg exposure in children. The paucity of responses among same-age girls with comparable Hg exposure provides evidence of sexual dimorphism in genetic susceptibility to the adverse neurobehavioral effects of Hg in children and adolescents.info:eu-repo/semantics/publishedVersio

Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure

Background: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. Methods: We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. Results: During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P=0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro–B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. Conclusions: Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329. opens in new tab; EudraCT number, 2016-002299-28. opens in new tab.

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation