340 research outputs found
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control
Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. Here we will discuss the current insights on the role of DA in motor control and reward learning mechanisms and its involvement in the modulation of synaptic dynamics through different pathways. In particular, we will consider the role of DA as neuromodulator of two forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD) in several cortical and subcortical areas. Finally, we will delineate how the effect of DA on dendritic spines places this molecule at the interface between the motor and the cognitive systems. Specifically, we will be focusing on PD, vascular dementia, and schizophrenia
Optimization of the geometrical stability in square ring laser gyroscopes
Ultra sensitive ring laser gyroscopes are regarded as potential detectors ofthe general relativistic frame-dragging effect due to the rotation of theEarth: the project name is GINGER (Gyroscopes IN GEneral Relativity), aground-based triaxial array of ring lasers aiming at measuring the Earthrotation rate with an accuracy of 10^-14 rad/s. Such ambitious goal is nowwithin reach as large area ring lasers are very close to the necessarysensitivity and stability. However, demanding constraints on the geometricalstability of the laser optical path inside the ring cavity are required. Thuswe have started a detailed study of the geometry of an optical cavity, in orderto find a control strategy for its geometry which could meet the specificationsof the GINGER project. As the cavity perimeter has a stationary point for thesquare configuration, we identify a set of transformations on the mirrorpositions which allows us to adjust the laser beam steering to the shape of asquare. We show that the geometrical stability of a square cavity stronglyincreases by implementing a suitable system to measure the mirror distances,and that the geometry stabilization can be achieved by measuring the absolutelengths of the two diagonals and the perimeter of the ring
Optical response of a misaligned and suspended Fabry-Perot cavity
The response to a probe laser beam of a suspended, misaligned and detuned
optical cavity is examined. A five degree of freedom model of the fluctuations
of the longitudinal and transverse mirror coordinates is presented. Classical
and quantum mechanical effects of radiation pressure are studied with the help
of the optical stiffness coefficients and the signals provided by an FM
sideband technique and a quadrant detector, for generic values of the product
of the fluctuation frequency times the cavity round trip. A
simplified version is presented for the case of small misalignments. Mechanical
stability, mirror position entanglement and ponderomotive squeezing are
accommodated in this model. Numerical plots refer to cavities under test at the
so-called Pisa LF facility.Comment: 14 pages (4 figures) submitted to Phys. Rev.
Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study
Phytosterols are known to reduce plasma cholesterol levels and thereby reduce cardiovascular risk. Studies conducted on human and animal models have demonstrated that these compounds have also anti-inflammatory effects. Recently, an experimental colitis model (dextran sulphate sodium-induced) has shown that pre-treatment with phytosterols decreases infiltration of inflammatory cells and accelerates mucosal healing. This study aims to understand the mechanism underlying the colitis by analysing the end-products of the metabolism in distal colon and liver excised from the same mice used in the previous work. In particular, an unsupervised gas chromatography-mass spectrometry (GC-MS) and NMR based metabolomics approach was employed to identify the metabolic pathways perturbed by the dextran sodium sulphate (DSS) insult (i.e. Krebs cycle, carbohydrate, amino acids, and nucleotide metabolism). Interestingly, phytosterols were able to restore the homeostatic equilibrium of the hepatic and colonic metabolome
Measurement of 1323 and 1487 keV resonances in 15N({\alpha}, {\gamma})19F with the recoil separator ERNA
The origin of fluorine is a widely debated issue. Nevertheless, the
^{15}N({\alpha},{\gamma})^{19}F reaction is a common feature among the various
production channels so far proposed. Its reaction rate at relevant temperatures
is determined by a number of narrow resonances together with the DC component
and the tails of the two broad resonances at E_{c.m.} = 1323 and 1487 keV.
Measurement through the direct detection of the 19F recoil ions with the
European Recoil separator for Nuclear Astrophysics (ERNA) were performed. The
reaction was initiated by a 15N beam impinging onto a 4He windowless gas
target. The observed yield of the resonances at Ec.m. = 1323 and 1487 keV is
used to determine their widths in the {\alpha} and {\gamma} channels. We show
that a direct measurement of the cross section of the
^{15}N({\alpha},{\gamma})^{19}F reaction can be successfully obtained with the
Recoil Separator ERNA, and the widths {\Gamma}_{\gamma} and {\Gamma}_{\alpha}
of the two broad resonances have been determined. While a fair agreement is
found with earlier determination of the widths of the 1487 keV resonance, a
significant difference is found for the 1323 keV resonance {\Gamma}_{\alpha} .
The revision of the widths of the two more relevant broad resonances in the
15N({\alpha},{\gamma})19F reaction presented in this work is the first step
toward a more firm determination of the reaction rate. At present, the residual
uncertainty at the temperatures of the ^{19}F stellar nucleosynthesis is
dominated by the uncertainties affecting the Direct Capture component and the
364 keV narrow resonance, both so far investigated only through indirect
experiments.Comment: 8 pages, 11 figures. Accepted for publication in PR
A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis
Atherosclerosis disease is a leading cause for mortality and morbidity. The narrowing/rupture of a vulnerable atherosclerotic plaque is accountable for acute cardiovascular events. However, despite of an intensive research, a reliable clinical method which may disclose a vulnerable patient is still unavailable
The GINGER Project and status of the ring-laser of LNGS
A ring-laser attached to the Earth measures the absolute angular velocity of the Earth summed
to the relativistic precessions, de Sitter and Lense-Thirring. GINGER (Gyroscopes IN GEneral
Relativity) is a project aiming at measuring the LenseThirring effect with a ground based detector;
it is based on an array of ring-lasers. Comparing the Earth angular velocity measured
by IERS and the measurement done with the GINGER array, the Lense-Thirring effect can be
evaluated. Compared to the existing space experiments, GINGER provides a local measurement,
not the averaged value and it is unnecessary to model the gravitational field. It is a proposal,
but it is not far from being a reality. In fact the GrossRing G of the Geodesy Observatory of
Wettzell has a sensitivity very close to the necessary one. G ofWettzell is part of the IERS system
which provides the measure of the Length Of the DAY (LOD); G provides information on the fast
component of LOD. In the last few years, a roadmap toward GINGER has been outlined. The
experiment G-GranSasso, financed by the INFN Commission II, is developing instrumentations
and tests along the roadmap of GINGER. In this short paper the main activities of G-GranSasso
and some results will be presented. The first results of GINGERino will be reported, GINGERino
is the large ring-laser installed inside LNGS and now in the commissioning phase. Ring-lasers
provide as well important informations for geophysics, in particular the rotational seismology,
which is an emerging field of science. GINGERino is one of the three experiments of common
interest between INFN and INGV
Deep underground rotation measurements: GINGERino ring laser gyroscope in Gran Sasso
GINGERino is a large frame laser gyroscope investigating the ground motion in
the most inner part of the underground international laboratory of the Gran
Sasso, in central Italy. It consists of a square ring laser with a m
side. Several days of continuous measurements have been collected, with the
apparatus running unattended. The power spectral density in the seismic
bandwidth is at the level of . A maximum
resolution of is obtained with an integration time of few
hundred seconds. The ring laser routinely detects seismic rotations induced by
both regional earthquakes and teleseisms. A broadband seismic station is
installed on the same structure of the gyroscope. First analysis of the
correlation between the rotational and the translational signal are presented.Published0345027TM. Sviluppo e Trasferimento TecnologicoJCR Journa
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