Benchmarking systems of seasonally adjusted time series according.

When a system of time series is seasonally adjusted, generally the accounting constraints originally linking the series are not fulfilled. To overcome this problem, we discuss an extension to a system of series linked by an accounting constraint of the classical univariate benchmarking procedure due to Denton (1971), which is founded on a movement preservation principle very appreciable in this case. The presence of linear dependence between the variables makes it necessary to conveniently deal with the whole set of contemporaneous and temporal aggregation relationships. The case of the one-way classified (e.g. by regions or by industries) and of two-ways classified (e.g., by regions and by industries) systems of series are studied. Moreover, simplified expressions of the matrices involved in the calculations are presented, which turn out useful in practical implementation of benchmatking for large systems of series. An empirical application of the Canadian retail trade series by province (12 series) and trade groups (18 series) is finally considered to show the capability of the proposed procedures

Defective Carbon for Next‐Generation Stationary Energy Storage Systems: Sodium‐Ion and Vanadium Flow Batteries

This review examines the role of defective carbon-based electrodes in sodium-ion and vanadium flow batteries. Methods for introducing defects into carbon structures are explored and their effectiveness in improving electrode performance is demonstrated. In sodium-based systems, research focuses primarily on various precursor materials and heteroatom doping to optimise hard carbon electrodes. Defect engineering increases interlayer spacing, porosity, and changes the surface chemistry, which improves sodium intercalation and reversible capacities. Heteroatom functionalisation and surface modification affect solid electrolyte interface formation and coulombic efficiencies. For flow batteries, post-fabrication electrode enhancement methods produce defects to improve electrode kinetics, although these methods often introduce oxygen functional groups as well, making isolation of defect effects difficult. Continued research efforts are key to developing carbon-based electrodes that can meet the unique challenges of future battery systems

Case report: Asp194Ala variant in MFN2 is associated with ALS-FTD in an Italian family

Background:MFN2 gene encodes the protein Mitofusin 2, involved in essential mitochondrial functions such as fusion, trafficking, turnover, and cellular interactions. We describe a family carrying a novel MFN2 mutation associated with ALS-frontotemporal dementia (FTD) clinical phenotype in the mother and Charcot-Marie-Tooth disease type 2A (CMT2A) in her son.Case presentation: The mother, a 67-year-old woman, referred to us for a three year-history of mood disturbance and gait impairment, and a more recent hypophonia, dysarthria, dysphagia, and diffuse muscle wasting. Family history was positive for psychiatric disorders and gait disturbances. Brain 18F-FDG PET showed severe hypometabolism in the fronto-temporal brain cortex bilaterally. Electrodiagnostic studies (EDX) showed severe motor axonopathy in the bulbar, cervical and lumbosacral districts. Her 41-year-old son had a history of mood depression and sensory disturbances in the limbs, along with mild muscle wasting, weakness, and reduced reflexes. Nerve conduction studies revealed a moderate sensory-motor polyneuropathy, while brain MRI was normal. Whole exome sequencing of the patients’ DNA identified the novel MFN2 (NM_014874.4) variant c.581A>C p.(Asp194Ala).Conclusion: Our findings provide evidence of heterogenous clinical manifestations in family members sharing the same MFN2 molecular defect. Additionally, we present the first documented case of ASL-FTD associated with an MFN2 mutation, thereby expanding the range of MFN-related disorders. Further research involving larger cohorts of patients will be needed to better understand the role of MFN2 as a contributing gene in the development of ALS-FTD

An Analysis of Preference Weights and Setting Priorities by Irrigation Advisory Services Users Based on the Analytic Hierarchy Process

Objective: Stakeholders-farmers from four different European areas (Campania (IT), Kujawsko-Pomorskie (PL), Limburg (NL), Andalusia (ES))-are asked to share, from the OPERA project, their opinions on five criteria that all aim at improving the use of irrigation advisory services (IASs). Each criterion has different characteristics that affect the way farmers rank it. The present study has two objectives. The first is to individuate the priorities of the preferences expressed by the stakeholders. The second objective is to carry out a ranking of the weights of the criteria by case study, ranking the groups and their associated properties among farmers' profiles. Methods: The answers to 120 questionnaires dispensed to the future users of IASs in the four agricultural sites were analyzed in detail, and then the given priorities were evaluated through the analytic hierarchy process (AHP). The AHP methodology was used to determine the relative weights of the five assessment criteria, and finally, to select the one with major value. Results and conclusions: The results show that A5 (assuring economic sustainability) was the most important criterion. The contributions provided by this study are twofold: Firstly, it presents an application of a methodology that involves the conversion of a linguistic judgement of farmers in a correspondence weight. Secondly, it tackles decision making regarding improving the use of IASs, evaluating the preferences expressed by the stakeholders. Irrigation advisory services can play a key role in assisting users to adopt new techniques and technologies for more efficient water use and increased production

Polymer-based photocathodes with a solution-processable cuprous iodide anode layer and a polyethyleneimine protective coating

Organic semiconductors are proven to efficiently drive photoelectrochemical water splitting

Multi-source statistics:Basic situations and methods

Many National Statistical Institutes (NSIs), especially in Europe, are moving from single‐source statistics to multi‐source statistics. By combining data sources, NSIs can produce more detailed and more timely statistics and respond more quickly to events in society. By combining survey data with already available administrative data and Big Data, NSIs can save data collection and processing costs and reduce the burden on respondents. However, multi‐source statistics come with new problems that need to be overcome before the resulting output quality is sufficiently high and before those statistics can be produced efficiently. What complicates the production of multi‐source statistics is that they come in many different varieties as data sets can be combined in many different ways. Given the rapidly increasing importance of producing multi‐source statistics in Official Statistics, there has been considerable research activity in this area over the last few years, and some frameworks have been developed for multi‐source statistics. Useful as these frameworks are, they generally do not give guidelines to which method could be applied in a certain situation arising in practice. In this paper, we aim to fill that gap, structure the world of multi‐source statistics and its problems and provide some guidance to suitable methods for these problems

Stabilizing organic photocathodes by low temperature atomic layer deposition of TiO2

Low-temperature atomic layer deposition forms a compact TiO2 film atop a polymer light absorber for stable and efficient organic–inorganic photo-driven H2 evolution.</p

The major barriers to evidence-informed conservation policy and possible solutions

Conservation policy decisions can suffer from a lack of evidence, hindering effective decision-making. In nature conservation, studies investigating why policy is often not evidence-informed have tended to focus on Western democracies, with relatively small samples. To understand global variation and challenges better, we established a global survey aimed at identifying top barriers and solutions to the use of conservation science in policy. This obtained the views of 758 people in policy, practice, and research positions from 68 countries across six languages. Here we show that, contrary to popular belief, there is agreement between groups about how to incorporate conservation science into policy, and there is thus room for optimism. Barriers related to the low priority of conservation were considered to be important, while mainstreaming conservation was proposed as a key solution. Therefore, priorities should focus on convincing the public of the importance of conservation as an issue, which will then influence policy-makers to adopt pro-environmental long-term policies.NERC (1653183) Grantham Foundation for the Protection of the Environment Kenneth Miller Trust (unknown) NERC (1653183) NERC (NE/L002507/1) European Commission (308454

Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson's disease in two European populations

BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recently, mutations in the PINK1 (PARK6) gene were shown to rarely cause autosomal-recessively transmitted, early-onset parkinsonism. In order to evaluate whether PINK1 contributes to the risk of common late-onset PD we analysed PINK1 sequence variations. A German (85 patients) and a Norwegian cohort (90 patients) suffering from late-onset PD were screened for mutations and single nucleotide polymorphisms (SNPs) in the PINK1 gene. Both cohorts consist of well-characterized patients presenting a positive family history of PD in ~17%. Investigations were performed by single strand conformation polymorphism (SSCP), denaturating high performance liquid chromatography (DHPLC) and sequencing analyses. SNP frequencies were compared by the χ(2 )test RESULTS: Several common SNPs were identified in our cohorts, including a recently identified coding variant (Q115L) in exon 1. Genotyping of the Q115L variation did not reveal significant frequency differences between patients and controls. Pathogenic mutations in the PINK1 gene were not identified, neither in the German nor in the Norwegian cohort. CONCLUSION: Sequence variation in the PINK1 gene appears to play a marginal quantitative role in the pathogenesis of the late-onset form of PD, in German and Norwegian cohorts, if at all