The effect of exposure to low frequency electromagnetic fields (EMF) as an integral part of the housing system on anxiety-related behaviour, cognition and welfare in two strains of laboratory mouse.

Electromagnetic field (EMF) technology has the potential to improve scientific data capture and welfare assessment by allowing automated data collection from individual cages. How- ever, it is important to determine any impact that a new technology itself may have on animal welfare, and previous studies have found contrasting results of EMF on laboratory rodent anxiety-like behaviour and cognition. We therefore investigated whether there was an effect of low frequency EMF experienced continuously over a six-week period, as an integral part of the animal housing system, on measures of mouse anxiety-related behaviour, cognition and welfare. We housed mice (N = 80) of two strains (BALB/cAnNCrl and C57BL/6NCrl) separately in Individually Ventilated Cages (IVCs) in groups of four, either with the EMF plate turned ‘on’ or ‘off’ (n = 5). Some measures, e.g. food and water utilisation, were col- lected at regular intervals, whereas measures of anxiety-like behaviour (e.g. open field test) and cognitive performance (novel-object recognition test) were collected only at the end of the study. We found expected strong strain differences in most measures, e.g. latency to leave the starting square in an open field test, with C57BL/6NCrl mice moving away sooner, and interactions between strain and time for those measures recorded at more than one time point, e.g. significant weight gain over time for both strains, but with BALB/cAnNCrl mice weighing more. However, we found no significant effects of treatment (EMF ‘on’/‘off’) for any of the measures collected. These results indicate that, for the measures recorded here, there was no measurable impact on the behaviour and welfare of low frequency EMF exposure experienced continuously over a six-week period. Housing systems that include EMF monitoring technology may therefore be suitable for use without influencing either ani- mal welfare or scientific outcomes

Diversification versus specialization in complex ecosystems

By analyzing the distribution of revenues across the production sectors of quoted firms we suggest a novel dimension that drives the firms diversification process at country level. Data show a non trivial macro regional clustering of the diversification process, which underlines the relevance of geopolitical environments in determining the microscopic dynamics of economic entities. These findings demonstrate the possibility of singling out in complex ecosystems those micro-features that emerge at macro-levels, which could be of particular relevance for decision-makers in selecting the appropriate parameters to be acted upon in order to achieve desirable results. The understanding of this micro-macro information exchange is further deepened through the introduction of a simplified dynamic model

Supersymmetry breaking with quasi-localized fields in orbifold field theories

We study the Scherk-Schwarz supersymmetry breaking in five-dimensional orbifold theories with five-dimensional fields which are not strictly localized on the boundaries (quasi-localized fields). We show that the Scherk-Schwarz (SS) mechanism, besides the SS parameter \omega, depends upon new parameters, e.g. supersymmetric five-dimensional odd mass terms, governing the level of localization on the boundaries of the five-dimensional fields and study in detail such a dependence. Taking into account radiative corrections, the value of \omega is dynamically allowed to acquire any value in the range 0< \omega < 1/2.Comment: 13 pages, 3 figure

Anomalies in orbifold field theories

We study the constraints on models with extra dimensions arising from local anomaly cancellation. We consider a five-dimensional field theory with a U(1) gauge field and a charged fermion, compactified on the orbifold S^1/(Z_2 x Z_2'). We show that, even if the orbifold projections remove both fermionic zero modes, there are gauge anomalies localized at the fixed points. Anomalies naively cancel after integration over the fifth dimension, but gauge invariance is broken, spoiling the consistency of the theory. We discuss the implications for realistic supersymmetric models with a single Higgs hypermultiplet in the bulk, and possible cancellation mechanisms in non-minimal models.Comment: 10 pages, 2 figures, LaTex; v2: final version to be published in Phys. Lett.

From innovation to diversification: A simple competitive model

This is the final version. Avaialable from Public Library of Science via the DOI in this record.The raw data about export flows has been purchased from CEPII (http://www.cepii.fr/CEPII/en/bdd_modele/presentation.asp?id=1), see BACI dataset. However, the use of this dataset is not exclusive and anyone can purchase it. A free version for academic and research institutions is available on the United Nations COMTRADE website (http://comtrade.un.org/), see the Trade Dataset.3 Dec 2015: The PLOS ONE Staff (2015) Correction: From Innovation to Diversification: A Simple Competitive Model. PLOS ONE 10(12): e0144564. https://doi.org/10.1371/journal.pone.0144564Few attempts have been proposed in order to describe the statistical features and historical evolution of the export bipartite matrix countries/products. An important standpoint is the introduction of a products network, namely a hierarchical forest of products that models the formation and the evolution of commodities. In the present article, we propose a simple dynamical model where countries compete with each other to acquire the ability to produce and export new products. Countries will have two possibilities to expand their export: innovating, i.e. introducing new goods, namely new nodes in the product networks, or copying the productive process of others, i.e. occupying a node already present in the same network. In this way, the topology of the products network and the country-product matrix evolve simultaneously, driven by the countries push toward innovation.Growthcom Project FP7Crisis La

Physically based estimation of rainfall thresholds triggering shallow landslides in volcanic slopes of Southern Italy

On the 4th and 5th of March 2005, about 100 rainfall-induced landslides occurred along volcanic slopes of Camaldoli Hill in Naples, Italy. These started as soil slips in the upper substratum of incoherent and welded volcaniclastic deposits, then evolved downslope according to debris avalanche and debris flow mechanisms. This specific case of slope instability on complex volcaniclastic deposits remains poorly characterized and understood, although similar shallow landsliding phenomena have largely been studied in other peri-volcanic areas of the Campania region underlain by carbonate bedrock. Considering the landslide hazard in this urbanized area, this study focused on quantitatively advancing the understanding of the predisposing factors and hydrological conditions contributing to the initial landslide triggering. Borehole drilling, trial pits, dynamic penetrometer tests, topographic surveys, and infiltration tests were conducted on a slope sector of Camaldoli Hill to develop a geological framework model. Undisturbed soil samples were collected for laboratory testing to further characterize hydraulic and geotechnical properties of the soil units identified. In situ soil pressure head monitoring probes were also installed. A numerical model of two-dimensional variably saturated subsurface water flow was parameterized for the monitored hillslope using field and laboratory data. Based on the observed soil pressure head dynamics, the model was calibrated by adjusting the evapotranspiration parameters. This physically based hydrologic model was combined with an infinite-slope stability analysis to reconstruct the critical unsaturated/saturated conditions leading to slope failure. This coupled hydromechanical numerical model was then used to determine intensity–duration (I-D) thresholds for landslide initiation over a range of plausible rainfall intensities and topographic slope angles for the region. The proposed approach can be conceived as a practicable method for defining a warning criterion in urbanized areas threatened by rainfall-induced shallow landslides, given the unavailability of a consistent inventory of past landslide events that prevents a rigorous empirical analysis

Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L

Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single-chain (type-1) RIPs named sodins were isolated from the seeds (five proteins), edible leaves (one protein) and roots (one protein) of Salsola soda L. Sodins are able to release Endo’s fragment when incubated with rabbit and yeast ribosomes and inhibit protein synthesis in cell-free systems (IC50 = 4.83–79.31 pM). In addition, sodin 5, the major form isolated from seeds, as well as sodin eL and sodin R, isolated from edible leaves and roots, respectively, display polynucleotide:adenosine glycosylase activity and are cytotoxic towards the Hela and COLO 320 cell lines (IC50 = 0.41–1200 nM), inducing apoptosis. The further characterization of sodin 5 reveals that this enzyme shows a secondary structure similar to other type-1 RIPs and a higher melting temperature (Tm = 76.03 ± 0.30 °C) and is non-glycosylated, as other sodins are. Finally, we proved that sodin 5 possesses antifungal activity against Penicillium digitatum

Diversification versus specialization in complex ecosystems

This is the final version. Available from Public Library of Science via the DOI in this record.The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. The dataset to reproduce all the main findings of the article is available in the zip file enclose in the submission. The authors confirm that they recieved the permission from Bloomberg to share and publish the data attached as a Supporting Information file. The whole worldwide database is available to anyone after a paid subscription to Bloomberg services http://www.bloomberg.com/professional/.By analyzing the distribution of revenues across the production sectors of quoted firms we suggest a novel dimension that drives the firms diversification process at country level. Data show a non trivial macro regional clustering of the diversification process, which underlines the relevance of geopolitical environments in determining the microscopic dynamics of economic entities. These findings demonstrate the possibility of singling out in complex ecosystems those micro-features that emerge at macro-levels, which could be of particular relevance for decision-makers in selecting the appropriate parameters to be acted upon in order to achieve desirable results. The understanding of this micro-macro information exchange is further deepened through the introduction of a simplified dynamic model.EUItalian PNR project “CRISIS-Lab

Stillbirth and loss: family practices and display

This paper explores how parents respond to their memories of their stillborn child over the years following their loss. When people die after living for several years or more, their family and friends have the residual traces of a life lived as a basis for an identity that may be remembered over a sustained period of time. For the parent of a stillborn child there is no such basis and the claim for a continuing social identity for their son or daughter is precarious. Drawing on interviews with the parents of 22 stillborn children, this paper explores the identity work performed by parents concerned to create a lasting and meaningful identity for their child and to include him or her in their families after death. The paper draws on Finch's (2007) concept of family display and Walter's (1999) thesis that links continue to exist between the living and the dead over a continued period. The paper argues that evidence from the experience of stillbirth suggests that there is scope for development for both theoretical frameworks