Geiger-Mode Avalanche Photodiodes in Particle Detection

It is well known that avalanche photodiodes operated in the Geiger mode above the breakdown voltage offer a virtually infinite sensitivity and time accuracy in the picosecond range that can be used for single photon detection. However, their performance in particle detection remains still unexplored. In this contribution, we are going to expose the different steps that we have taken in order to prove the efficiency of Geiger mode avalanche photodiodes in the aforementioned field. In particular, we will present an array of pixels of 1mmx1mm fabricated with a standard CMOS technology for characterization in a test beam.Comment: 7 pages, 2 figures, Proceedings of LCWS1

Ab initio study of the phase diagram of epitaxial BaTiO3

Using a combination of first-principles and effective-Hamiltonian approaches, we map out the structure of BaTiO3 under epitaxial constraints applicable to growth on perovskite substrates. We obtain a phase diagram in temperature and misfit strain that is qualitatively different from that reported by Pertsev et al. [Phys. Rev. Lett. 80, 1988 (1998)], who based their results on an empirical thermodynamic potential with parameters fitted at temperatures in the vicinity of the bulk phase transitions. In particular, we find a region of `r phase' at low temperature where Pertsev et al. have reported an `ac phase'. We expect our results to be relevant to thin epitaxial films of BaTiO3 at low temperatures and experimentally-achievable strains.Comment: 4 pages, with 4 postscript figures embedded. Uses REVTEX and epsf macros. Also available at http://www.physics.rutgers.edu/~dhv/preprints/od_epi/index.htm

Childhood sexual experiences with an older partner among men who have sex with men in Buenos Aires, Argentina

This study sought to describe childhood sexual experiences with older partners (CSEOP) among men who have sex with men (MSM) in Buenos Aires, Argentina. MSM were recruited through respondent driven sampling. They responded to a computer administered self-interview with questions on CSEOP, operationalized as manual, oral, genital, or anal contact prior to age 13 with a partner at least 4 years older. Of the 500 respondents, only 25% identified as gay. Eighteen percent of the respondents reported CSEOP, the majority of whom did not feel they were hurt by the experience and did not consider it to be childhood sexual abuse (CSA). Over two-thirds of MSM who reported CSEOP said that their older partner was a female. Only 4% of those with a female partner felt their experience was CSA compared to 44% of those who had a male partner. Among all men reporting CSEOP, those who felt sexually abused were more likely to have been physically forced or threatened, physically hurt, and emotionally hurt than those who did not feel sexually abused. Having CSEOP, being hurt by the experiences, and perceiving the experiences as sexual abuse were not associated with current HIV sexual risk or substance use behavior. In this sample of MSM in Argentina, a substantial minority reported CSEOP. Those who felt they had been sexually abused were much more likely to have had an older male partner than an older female partner, and were more likely to report having been physically forced and threatened by their older partner.Fil: Dolezal, Curtis. Columbia University; Estados UnidosFil: Carballo Diéguez, A.. Columbia University; Estados UnidosFil: Balán, Iván C.. Columbia University; Estados UnidosFil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Mabragaña, Marina. Columbia University; Estados UnidosFil: Marone, Ruben. Nexo Asociación Civil; ArgentinaFil: Barreda, Victoria. Nexo Asociación Civil; ArgentinaFil: Ávila, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

Comparación de métodos de estimación de ajuste de las funciones Weibull, SB de Johnson y beta a masas de Pinus pinaster, Pinus radiata y Pinus sylvestris en el noroeste de España

The purpose of this study was to compare the accuracy of the Weibull, Johnson’s SB and beta distributions, fitted with some of the most usual methods and with different fixed values for the location parameters, for describing diameter distributions in even-aged stands of Pinus pinaster, Pinus radiata and Pinus sylvestris in northwest Spain. A total of 155 permanent plots in Pinus sylvestris stands throughout Galicia, 183 plots in Pinus pinaster stands throughout Galicia and Asturias and 325 plots in Pinus radiata stands in both regions were measured to describe the diameter distributions. Parameters of the Weibull function were estimated by Moments and Maximum Likelihood approaches, those of Johnson’s SB function by Conditional Maximum Likelihood and by Knoebel and Burhart’s method, and those of the beta function with the method based on the moments of the distribution. The beta and the Johnson’s SB functions were slightly superior to Weibull function for Pinus pinaster stands; the Johnson’s SB and beta functions were more accurate in the best fits for Pinus radiata stands, and the best results of the Weibull and the Johnson’s SB functions were slightly superior to beta function for Pinus sylvestris stands. However, the three functions are suitable for this stands with an appropriate value of the location parameter and estimation of parameters method.El objetivo de este estudio fue comparar la precisión de las distribuciones Weibull, SB de Johnson y beta, ajustadas por alguno de los métodos más habituales y fijando diferentes valores para los parámetros de localización, para describir distribuciones diamétricas en masas regulares de Pinus pinaster, Pinus radiata y Pinus sylvestris en el noroeste de España. Se midieron un total de 155 parcelas permanentes en masas de Pinus sylvestris en Galicia, 183 parcelas de Pinus pinaster en Galicia y en Asturias y 325 parcelas de Pinus radiata en ambas regiones para describir sus distribuciones diamétricas. Los parámetros de la función Weibull fueron estimados por las aproximaciones de los Momentos y Máxima Verosimilitud, los de la función SB de Johnson por los estimadores condicionados de Máxima Verosimilitud y por el método de Knoebel y Burkhart, y los de la función beta por el método basado en los Momentos de la distribución. Las funciones beta y SB de Johnson fueron ligeramente superiores a la función Weibull en las masas de Pinus pinaster; las funciones SB de Johnson y beta fueron más precisas en los mejores ajustes en las masas de Pinus radiata, y los mejores resultados de las funciones Weibull y SB de Johnson fueron ligeramente superiores a los de la función beta en las masas de Pinus sylvestris. No obstante, las tres funciones son apropiadas para estas masas siempre que se elija un valor de localización y método de estimación de los parámetros apropiado

First passage times as a measure of hysteresis in stochastic gene regulatory circuits

GAIN Oportunius Grant from Xunta de Galicia.[Abstract]: In the context of phenotype switching and cell fate determination, numerousexperimental studies report hysteresis, despite the fact that the (forward) Chemical Master Equation governing the inherently stochastic underlying gene regulatory networks has a unique steady state (precluding memory effects and hysteresis). In previous works, we demonstrate thathysteresis is a transient phenomenon in systems far from the thermodynamic limit, using the convergence rates of the partial integro-differential equation associated to the forward master equation governing the stochastic process. Here, we make use of the backward master equationto quantify hysteresis and irreversibility based on First Passage Times. First, we derive the backward master equation for a gene regulatory network with protein production in bursts. Solving this equation, we obtain the probability distributions of the first times to reach some fixed final state from one starting state. The mean first passage time provides a measure to quantify how hysteresis and irreversibility in gene regulation at the singlecell level are transient effects that vanish at steady state. In addition, we provide a theoretical basis that reconciles phenotype coexistence and prevalence far from the thermodynamic limit. In fact, we substitute the notion of pseudo-potential (the so-called Waddington landscape) by a time evolving landscape built upon the Chemical Master Equation (CME) in which phenotypes,rather than prevail, persist with different intensities.Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación; FJC2019-041397-

Gene flow and genetic structure in the Galician population (NW Spain) according to Alu insertions

<p>Abstract</p> <p>Background</p> <p>The most recent <it>Alu </it>insertions reveal different degrees of polymorphism in human populations, and a series of characteristics that make them particularly suitable genetic markers for Human Biology studies. This has led these polymorphisms to be used to analyse the origin and phylogenetic relationships between contemporary human groups. This study analyses twelve <it>Alu </it>sequences in a sample of 216 individuals from the autochthonous population of Galicia (NW Spain), with the aim of studying their genetic structure and phylogenetic position with respect to the populations of Western and Central Europe and North Africa, research that is of special interest in revealing European population dynamics, given the peculiarities of the Galician population due to its geographical situation in western Europe, and its historical vicissitudes.</p> <p>Results</p> <p>The insertion frequencies of eleven of the <it>Alu </it>elements analysed were within the variability range of European populations, while Yb8NBC125 proved to be the lowest so far recorded to date in Europe.</p> <p>Taking the twelve polymorphisms into account, the GD value for the Galician population was 0.268. The comparative analyses carried out using the MDS, NJ and AMOVA methods reveal the existence of spatial heterogeneity, and identify three population groups that correspond to the geographic areas of Western-Central Europe, Eastern Mediterranean Europe and North Africa. Galicia is shown to be included in the Western-Central European cluster, together with other Spanish populations. When only considering populations from Mediterranean Europe, the Galician population revealed a degree of genetic flow similar to that of the majority of the populations from this geographic area.</p> <p>Conclusion</p> <p>The results of this study reveal that the Galician population, despite its geographic situation in the western edge of the European continent, occupies an intermediate position in relation to other European populations in general, and Iberian populations in particular. This confirms the important role that migratory movements have had in the European gene pool, at least since Neolithic times. In turn, the MDS and NJ analyses place Galicia within the group comprised of Western-Central European populations, which is justified by the influence of Germanic peoples on the Galician population during the Middle Ages. However, it should also be noted that some of the markers analysed have a certain degree of differentiation, possibly due to the region's position as a 'cul-de-sac' in terms of Iberian population dynamics.</p

Technological Innovation Inputs, Outputs and Performance: the moderating role of Family Involvement in Management

The objective of this article is to study the relationship between R&D intensity and continuous technological innovation and between technological innovation outcomes and sustained firm performance. We also analyse the moderating role of family management in both relationships. The results show that R&D intensity has a positive effect on continuous technological innovation and family management moderates negatively this relationship. Our findings also suggest that the influence of the family management significantly contribute to improve the effect of the technological innovation on sustained performance. It seems that some family-managed firms characteristics (nepotism,…) could hinder the efficient conversion of R&D expenditures into continuous technological innovation outcomes, but once family-managed firms have obtained technological innovation outcomes, they become riskier and put all its social capital to work to improve the conversion of innovation outcomes into performance. Therefore, family involvement in management looks influence technological innovation efficiency

Importancia del concepto de Empresa Familiar en investigación: utilización de la base de datos SABI para su clasificación

Este trabajo tiene que ver con aspectos conceptuales de la empresa familiar (EF) y su impacto en la investigación. Su objetivo es servir de guía en el desarrollo de trabajos empíricos que pretenden disociar la EF de la empresa no familiar (EnF) mediante la utilización de bases de datos, particularmente contables y, más concretamente, en el caso español, con la base SABI. En él se pone de manifiesto la importancia, en el ámbito empírico, de buscar un mecanismo que nos permita identificar la EF de forma eficiente, así como las dificultades existentes para ello con el uso de SABI. Trabajar con diferentes criterios de selección y el uso de apellidos nos permite proponer una tipología de EF.