Staff Report Coastal Development Application

Subject: Addendum to Staff Report E-11-018 – Class B and C-Waste Storage Facility at Humboldt Bay Power Plant, adjacent to Humboldt Bay south of Eureka, Humboldt County (Pacific Gas & Electric Company) APPLICATION FILE NO.: E-11-01

Southern California Edison SONGS ISFSI Project

Tu14a Addendum to 9-15-0228 - This addendum provides correspondence on the above-referenced staff report, ex parte communications, proposed revisions to the staff report, and staff’s response to comments. The proposed modifications to the staff report do not change staff’s recommendation that the Commission approve CDP # 9-15-0228, as conditioned

Staff Report Coastal Development Application

Subject: Addendum to Staff Report E-11-018 – Class B and C-Waste Storage Facility at Humboldt Bay Power Plant, adjacent to Humboldt Bay south of Eureka, Humboldt County (Pacific Gas & Electric Company) APPLICATION FILE NO.: E-11-01

Trafficking modulator TENin1 inhibits endocytosis, causes endomembrane protein accumulation at the pre-vacuolar compartment and impairs gravitropic response in Arabidopsis thaliana

Auxin gradients are established and maintained by polarized distribution of auxin transporters that undergo constitutive endocytic recycling from the PM (plasma membrane) and are essential for the gravitropic response in plants. The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. Short-term TE1 treatment causes accumulation of PM proteins, including the BR (brassinosteroid) receptor BRI1 (BR insensitive 1), PIP2a (PM intrinsic protein 2a) and the auxin transporter PIN2 (PIN-FORMED 2) in a PVC (pre-vacuolar related compartment), which is sensitive to BFA (Brefeldin A). This compound inhibits endocytosis from the PM and promotes trafficking to the vacuole, consistent with inhibition of retrieval of proteins to the TGN (trans-Golgi network) from the PVC and the PM. However, trafficking of newly synthesized proteins to the PM is unaffected. The short-term protein trafficking inhibition and long-term effect on plant growth and survival caused by TE1 were fully reversible upon drug washout. Structure-activity relationship studies revealed that only minor modifications were possible without loss of biological activity. Diversity in Arabidopsis ecotypes was also exploited to identify two Arabidopsis accessions that display reduced sensitivity to TE1. This compound and the resistant Arabidopsis accessions may be used as a resource in future studies to better understand endomembrane trafficking in plants

Imaging of bronchial pathology in antibody deficiency: Data from the European Chest CT Group

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20 years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease

Correction to: Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

In the original version of this article unfortunately two authors were missing: Dr. Jürgen Weidemann and Dr. Daniel Berthold. The correct list of authors is presented above

Responding to terrorism across the technological spectrum

In April 1994, the Army War College\u27s Strategic Studies Institute held its annual Strategy Conference. This year\u27s theme was The Revolution in Military Affairs: Defining an Army for the 21st Century. Dr. Bruce Hoffman presented this paper as part of a panel examining New Technologies and New Threats. Terrorism, of course, is not new. Hoffman warns, however, of the changing nature of terrorism. In the past, terrorists have been motivated by limited political and ideological objectives. Popular images fostered by terrorist events like the bombing of PAN AM Flight 103 and the attack on the Marine Barracks in Beirut notwithstanding, in the past the preponderance of terrorist attacks targeted specific individuals or small groups. The weapons of choice were the pistol, knife, and, on occasion, dynamite. Often the terrorist was a highly-trained individual, a professional in pursuit of specific political or ideological objectives. Hoffman warns that, by comparison, the terrorists of today and tomorrow are amateurs. Furthermore, they are likely to act from religious and racial convictions rather than radical political or ideological motivations. Their objective may be to kill large numbers of people. Indeed, they may want to annihilate an entire race or religious group. Not only are these amateurs less predictable and, therefore, more difficult to apprehend before the incident occurs, they have at their disposal lethal devices that range from the relatively simple fertilizer bomb to biologically-altered viruses. Military professionals and civilian planners must contend with warfare at every level. The threat posed by the changing nature of terrorism falls very much within their purview.https://press.armywarcollege.edu/monographs/1257/thumbnail.jp