Working Futures 2017-2027 : Long-run labour market and skills projections headline report

This report provides a concise overview of Working Futures 2017-2027 results for the UK. It presents historical trends and future prospects by sector for the UK and its constituent nations and the English regions. The prime focus of Working Futures is on the demand for skills as measured by employment by occupation and qualification, although the supply side is also considered. Its prime objective is to provide useful labour market information that can help to inform policy development and strategy around skills, careers and employment, for both policy makers and a much wider audience. The results are intended to provide a sound statistical foundation for reflection and debate among all those with an interest in the demand for and supply of skills. It is aimed at the general reader and focuses on the key messages from this very detailed study. It complements the more detailed outputs and results from the project available from the gov.uk website2 and cover sectors, occupations, geography and qualifications

A long-lasting controversy : Western democracy promotion in Jordan

Since the end of the cold war and, in particular, the Al Qaeda attacks of 11 September 2001 in the United States, Western governments have in their rhetoric stressed democratization in the Middle East and North Africa (MENA) region as a key policy goal. 1 The EU, the US and other Western countries have developed and extended their democracy promotion activities in the region, in particular democracy assistance to civil society, independent media, the judiciary, parliament and political parties. 2 Such assistance has at times been complemented with public criticism of perceived non-democratic behaviour and political conditionalities, i.e. making democratic reform a precondition for granting favours such as trade deals and development assistance.peer-reviewe

Rapid 13(c) urea breath test to identify Helicobacter pylori infection in emergency department patients with upper abdominal pain

Introduction: In emergency department (ED) patients with upper abdominal pain, management includes ruling out serious diseases and providing symptomatic relief. One of the major causes of upper abdominal pain is an ulcer caused by Helicobacter pylori (H. pylori), which can be treated and cured with antibiotics. We sought to estimate the prevalence of H. pylori infection in symptomatic patients using a convenience sample at a single urban academic ED and demonstrate the feasibility of ED-based testing. Methods: We prospectively enrolled patients with a chief complaint of pain or discomfort in the upper abdomen for 1 year from February 2011 until February 2012 at a single academic urban ED. Enrolled subjects were tested for H. pylori using a rapid point of care 13C Urea Breath Test (UBT) [Exalenz Bioscience]. We compared patient characteristics between those who tested positive versus negative for the disease. Results: A total of 205 patients with upper abdominal pain were tested over 12 months, and 24% (95% confidence interval: 19% to 30%) tested positive for H. pylori. Black subjects were more likely to test positive than white subjects (28% v. 6%, P \u3c 0.001). Other factors, such as age and sex, were not different between the 2 groups. Conclusion: In our ED, H. pylori infection was present in 1 in 4 patients with epigastric pain, and testing with a UBT was feasible. Further study is needed to determine the risk factors associated with infection, the prevalence of H. pylori in other EDs, the effect of the test on ED length of stay and the cost-effectiveness of an ED-based test-and-treat strategy. [West J Emerg Med. 2013;14(3):278–282.

A Novel Mechanism for Zika Virus Host-Cell Binding

Zika virus (ZIKV) recently emerged in the Western Hemisphere with previously unrecognized or unreported clinical presentations. Here, we identify two putative binding mechanisms of ancestral and emergent ZIKV strains featuring the envelope (E) protein residue asparagine 154 (ASN154) and viral phosphatidylserine (PS). Synthetic peptides representing the region containing ASN154 from strains PRVABC59 (Puerto Rico 2015) and MR_766 (Uganda 1947) were exposed to neuronal cells and fibroblasts to model ZIKV E protein/cell interactions and bound MDCK or Vero cells and primary neurons significantly. Peptides significantly inhibited Vero cell infectivity by ZIKV strains MR_766 and PRVABC59, indicating that this region represents a putative binding mechanism of ancestral African ZIKV strains and emergent Western Hemisphere strains. Pretreatment of ZIKV strains MR_766 and PRVABC59 with the PS-binding protein annexin V significantly inhibited replication of PRVABC59 but not MR_766, suggesting that Western hemisphere strains may additionally be capable of utilizing PS-mediated entry to infect host cells. These data indicate that the region surrounding E protein ASN154 is capable of binding fibroblasts and primary neuronal cells and that PS-mediated entry may be a secondary mechanism for infectivity utilized by Western Hemisphere strains

Asteroseismology of massive stars with the TESS mission: the runaway Beta Cep pulsator PHL 346 = HN Aqr

We report an analysis of the first known Beta Cep pulsator observed by the TESS mission, the runaway star PHL 346 = HN Aqr. The star, previously known as a singly-periodic pulsator, has at least 34 oscillation modes excited, 12 of those in the g-mode domain and 22 p modes. Analysis of archival data implies that the amplitude and frequency of the dominant mode and the stellar radial velocity were variable over time. A binary nature would be inconsistent with the inferred ejection velocity from the Galactic disc of 420 km/s, which is too large to be survivable by a runaway binary system. A kinematic analysis of the star results in an age constraint (23 +- 1 Myr) that can be imposed on asteroseismic modelling and that can be used to remove degeneracies in the modelling process. Our attempts to match the excitation of the observed frequency spectrum resulted in pulsation models that were too young. Hence, asteroseismic studies of runaway pulsators can become vital not only in tracing the evolutionary history of such objects, but to understand the interior structure of massive stars in general. TESS is now opening up these stars for detailed asteroseismic investigation.Comment: accepted for ApJ

Reducing Electronic Information Overload

College students receive a wealth of information through electronic communications that they are unable to process efficiently. This information overload negatively impacts their affect, which is officially defined in the field of psychology as the experience of feeling or emotion. To address this problem, we postulated that we could create an application that organizes and presents incoming content in a manner that optimizes users’ ability to process information. First, we conducted surveys that quantitatively measured each participant’s psychological affect while handling electronic communications, which was used to tailor the features of the application to what the user’s desire. After designing and implementing the application, we again measured the user's affect using this product. Our goal was to find that the program promoted a positive change in affect. Our application, Brevitus, was able to match Gmail on affect reduction profiles, while succeeding in implementing certain user interface specifications

The continuum of fetal alcohol spectrum disorders in four rural communities in south africa: Prevalence and characteristics

Prevalence and characteristics of the continuum of diagnoses within fetal alcohol spectrum disorders (FASD) were researched in previously unstudied rural, agricultural, lower socioeconomic populations in South Africa (ZA)

On State-Space Reduction in Multi-Strain Pathogen Models, with an Application to Antigenic Drift in Influenza A

Many pathogens exist in phenotypically distinct strains that interact with each other through competition for hosts. General models that describe such multi-strain systems are extremely difficult to analyze because their state spaces are enormously large. Reduced models have been proposed, but so far all of them necessarily allow for coinfections and require that immunity be mediated solely by reduced infectivity, a potentially problematic assumption. Here, we suggest a new state-space reduction approach that allows immunity to be mediated by either reduced infectivity or reduced susceptibility and that can naturally be used for models with or without coinfections. Our approach utilizes the general framework of status-based models. The cornerstone of our method is the introduction of immunity variables, which describe multi-strain systems more naturally than the traditional tracking of susceptible and infected hosts. Models expressed in this way can be approximated in a natural way by a truncation method that is akin to moment closure, allowing us to sharply reduce the size of the state space, and thus to consider models with many strains in a tractable manner. Applying our method to the phenomenon of antigenic drift in influenza A, we propose a potentially general mechanism that could constrain viral evolution to a one-dimensional manifold in a two-dimensional trait space. Our framework broadens the class of multi-strain systems that can be adequately described by reduced models. It permits computational, and even analytical, investigation and thus serves as a useful tool for understanding the evolution and ecology of multi-strain pathogens