The Delphi and GRADE methodology used in the PSOGI 2018 consensus statement on Pseudomyxoma Peritonei and Peritoneal Mesothelioma

Pseudomyxoma Peritonei (PMP) and Peritoneal Mesothelioma (PM) are both rare peritoneal malignancies. Currently, affected patients may be treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy offering long-term survival or even cure in selected patients. However, many issues regarding the optimal treatment strategy are currently under debate. To aid physicians involved in the treatment of these patients in clinical decision making, the PSOGI executive committee proposed to create a consensus statement on PMP and PM. This manuscript describes the methodology of the consensus process. The Delphi technique is a reliable method for attaining consensus on a topic that lacks scientific evidence through multiple voting rounds which feeds back responses to the participants in between rounds. The GRADE system provides a structured framework for presenting and grading the available evidence. Separate questionnaires were created for PMP and PM and sent during two voting rounds to 80 and 38 experts, respectively. A consensus threshold of 51.0% was chosen. After the second round, consensus was reached on 92.9%–100.0% of the questions. The results were presented and discussed in the plenary session at the PSOGI 2018 international meeting in Paris. A third round for the remaining issues is currently in progress. In conclusion, using the Delphi technique and GRADE methodology, consensus was reached in many issues regarding the treatment of PM and PMP amongst an international panel of experts. The main results will be published in the near future

Archival Research Project: History of SUNY Cortland Varsity Sports, 1950-2024

Students in History and Philosophy of Physical Education and Sport classes conducted archival research to compile a history of varsity sports at SUNY Cortland from 1950-2024. Student groups of three to four chose their topic from a list prepared by professor Nancy Kane. Working with the Cortland Memorial Library Archivist Brian Jirout and Cortland Sport Information Director Fran Elia, students created a spiral-bound collection of research papers detailing sports, facilities, and funders who have made the Cortland Varsity Sports program a SUNY success story. The project was begun and completed during the fall semester of 2024. Students met with the Archivist and the Sport Information Director to discover resources, and worked throughout the semester with student assistant editors on this scaffolded learning experience. Funded by a Cortland Teaching Innovation Award granted to Dr. Kane, the final product was printed at Ithaca College and distributed to all who worked on it, as well as to the Cortland President, Director of the Library, Director of Alumni Relations, and Department Chairs in Kinesiology, Physical Education, and Sport Management. In addition to gaining insight into local history research methods and historical writing, students gained project-based learning skills in group dynamics, cooperation, and conflict resolution. They worked on competencies for a career-ready workforce, based on the National Association of Colleges and Employers (NACE) list of real-world skills needed for hiring and promotion.https://digitalcommons.cortland.edu/slides/1032/thumbnail.jp

Stratigraphic relationship between the Quebrada de los Colorados and Angastaco Formations (Paleogene-Neogene), Calchiquies Valleys, Salta (Argentina): its significance in the analysis of the Pallogastilla Group basin

El Grupo Payogastilla representa el registro sedimentario de la cuenca de antepaís andina en los Valles Calchaquíes. La Formación Quebrada de los Colorados, unidad basal, es de singular importancia debido a que preserva evidencias de los primeros episodios de contracción con deformación intracuencal, cambios en las áreas de aporte y asociaciones de fósiles que la datan paleógena pre-oligocena, hecho que llevó a replantear el modelo de cuenca de antepaís propuesto para el Noroeste argentino. Asimismo, la suprayacente Formación Angastaco, además de contener similar registro tectono-sedimentario, documenta el inicio del magmatismo en el borde oriental de la Puna. Los recientes trabajos de investigación llevados a cabo en estas unidades han permitido identificar y mapear superficies de discontinuidad sedimentaria, incluso de discordancias que obligan a modificar el cuadro estratigráfico existente. En la presente contribución se describen las relaciones estratigráficas de la Formación Quebrada de los Colorados con el objetivo de actualizar el conocimiento sobre la misma y discutir el esquema estratigráfico actualmente vigente. Esta formación se asienta en relación de discordancia y de disconformidad sobre las Formaciones Lumbrera, Maíz Gordo y Mealla (Subgrupo Santa Bárbara) y sobre el Subgrupo Pirgua, del Grupo Salta. Asimismo, se describe y discute el alcance de la identificación de una discontinuidad sedimentaria intra-Quebrada de los Colorados, señalada por el cambio abrupto de facies sedimentarias y la presencia de una superficie de meteorización con desarrollo de una calcreta. Esta superficie separa una sucesión netamente fluvial de otra fluvio-eólica con características sedimentarias distintivas. Por último, se describen las relaciones de transición y de concordancia entre la sucesión fluvio-eólica con la suprayacente Formación Angastaco. En base a estas relaciones se propone redefinir la Formación Angastaco con la incorporación de la sucesión fluvio-eólica con el rango de Miembro Tin Tin y retomar la definición original del Miembro Las Flechas. Finalmente y en base la nueva información disponible se propone a la quebrada Grande (área de cerro Tin Tin) como hipoestratotipo para la Formación Quebrada de los Colorados, localidad que servirá como complemento de las descripciones originales.The sedimentary record of the Andean orogenic basins in the Calchaquies Valleys (Fig. 1), consists of nearly 6000 m of an overall coarsening and thickening upward clastic succession (Díaz and Malizzia, 1983) known as the Payogastilla Group. The Payogatilla Group is composed of the Quebrada de los Colorados, Angastaco, Palo Pintado and San Felipe Formations (Díaz and Malizzia, 1983; Díaz et al., 1987 - see Fig. 2). Our investigation and previous research in the Quebrada de los Colorados Formation (e.g. Galli and Hernández, 1999; Coutand et al., 2006; Carrapa et al., 2011a,b; Galli et al., 2011) allowed the identification of several unconformity surfaces, including an angular relationship between the Quebrada de los Colorados Formation and the underlying Salta Group. Moreover, the identification of an intra-formational unconformity led us to the reconsideration of the stratigraphic scheme of the Payogastilla Group. Here, we address the regional stratigraphic relations of the Quebrada de los Colorados Formation, the lower unit of the Payogastilla Group, in order to update the knowledge and to discuss the validity of the present stratigraphic framework. Along the Calchaquies Valleys, the Quebrada de los Colorados Formation rests on different units of the Salta Group. The more frequent relation is with the uppermost unit, the Lumbrera Formation (Fig. 3), but in some areas, for example at Saladillo, the Quebrada de los Colorados Formation rests in angular relationship on the Maíz Gordo Formation (del Papa et al., 2004), as in the Esquina Azul locality (Fig. 4). In the cerro Bayo site, the Quebrada de los Colorados Formation lies also upon the Maíz Gordo Formation but few meters laterally directly overlays the Mealla Formation (Figs. 2 and 4). In other places, like in the Pucará valley (Fig. 1), the Quebrada de los Colorados overlays the Pirgua Subgroup (Villanueva García, 1992; Sabino, 2004). These variable stratigraphic relationships are key features that document the tectonic inversion of the Salta Group contemporaneous with the Quebrada de los Colorados sedimentation. The Quebrada de los Colorados Formation consists of red fine-grained floodplain facies and sandy to gravelly clastic fluvial channels facies (Fig. 6). The original description of this unit includes an eolian succession in the upper section (Díaz and Malizzia, 1983). In some localities, like at Tin Tin and Tonco (Fig. 1), the eolian and fluvio-eolian successions have thicknesses ranging from 450 to 600 m (Starck and Vergani, 1996; del Papa et al., 2013) representing a very distinctive erg record. The contact with the underlying fluvial deposits is sharp and a calcrete paleosol (Fig. 5) is locally recognized suggesting the presence of an unconformity within the Quebrada de los Colorados Formation. Moreover, this fluvio-eolian succession has a transitional contact with the overlying fluvial conglomeratic facies of the Angastaco Formation. This stratigraphic relation suggests that the former could be formally included within the Angastaco Formation. Thus we propose a redefinition of the Angastaco Formation (Díaz and Malizzia, 1983; nom. transl. Díaz et al., 1987); including the fluvio-eolian succession as the basal Tin Tin Member and to return to the previously defined Las Flechas Member. We propose the Tin Tin area (25º13'51.6'' Lat. S and 66º00'58.5'' Log. W - 25°16'12'' Lat. S and 66°2'39.45'' Log. W) as stratotype area (Fig. 7). In this locality, pale red silty sandstones to siltstones overlie coarse conglomeratic strata (Figs. 5 and 6) and are overlain by white eolian sandstones that grade to gray conglomeratic strata of the Angastaco Formation sensu Díaz and Malizzia (1983). The age of the Tin Tin Member is considered late Oligocene to early Miocene according to the 21 Ma U/Pb zircon datings (Carrapa et al., 2011a; del Papa et al., 2013). Finally we propose the Quebrada Grande locality (25º12'59.1'' Lat. S and 66º01'33.1'' Log. W), along state route Nº 42, Tin Tin area, Calchaquí Valley (Fig. 7) as hypostratotype of the Quebrada de los Colorados Formation. In this locality, this unit rests unconformably, and locally through an angular unconformity, on the Lumbrera Formation (Salta Group, Figs. 2, 3 and 4). In this area the formation is 792 m thick and is characterized by two coarsening upward successions of red siltstone, lenticular to shallow lenticular coarse sandstones and horizontally stratified conglomerates (Fig. 5). Based on mammalian biostratigraphy recorded at sites in Cerro Bayo, Tin Tin and Luracatao (Fig. 1) the age of the Quebrada de los Colorados Formation is Casamayoran (sub-age Barrancan), SALMA, suggesting a Middle Eocene age for the basal levels (Powell et al., 2011). In summary, we propose that the fluvio-eolian section of the Quebrada de los Colorados Formation should be incorporated into the Angastaco Formation, as the Tin Tin Member. This modification will simplify recognition in the field, mapping, and genetic interpretation of these foreland basin deposits.Fil: del Papa, Cecilia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Ciencias de la Tierra; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Hongn, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Bio y Geociencias del Noroeste Argentino; Argentina. Universidad Nacional de Salta; ArgentinaFil: Payrola Bosio, Patricio Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Bio y Geociencias del Noroeste Argentino; Argentina. Universidad Nacional de Salta; ArgentinaFil: Powell, Jaime Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Deraco, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Herrera, Claudia Marcela Reina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; Argentin

MicroArray Facility: a laboratory information management system with extended support for Nylon based technologies

BACKGROUND: High throughput gene expression profiling (GEP) is becoming a routine technique in life science laboratories. With experimental designs that repeatedly span thousands of genes and hundreds of samples, relying on a dedicated database infrastructure is no longer an option. GEP technology is a fast moving target, with new approaches constantly broadening the field diversity. This technology heterogeneity, compounded by the informatics complexity of GEP databases, means that software developments have so far focused on mainstream techniques, leaving less typical yet established techniques such as Nylon microarrays at best partially supported. RESULTS: MAF (MicroArray Facility) is the laboratory database system we have developed for managing the design, production and hybridization of spotted microarrays. Although it can support the widely used glass microarrays and oligo-chips, MAF was designed with the specific idiosyncrasies of Nylon based microarrays in mind. Notably single channel radioactive probes, microarray stripping and reuse, vector control hybridizations and spike-in controls are all natively supported by the software suite. MicroArray Facility is MIAME supportive and dynamically provides feedback on missing annotations to help users estimate effective MIAME compliance. Genomic data such as clone identifiers and gene symbols are also directly annotated by MAF software using standard public resources. The MAGE-ML data format is implemented for full data export. Journalized database operations (audit tracking), data anonymization, material traceability and user/project level confidentiality policies are also managed by MAF. CONCLUSION: MicroArray Facility is a complete data management system for microarray producers and end-users. Particular care has been devoted to adequately model Nylon based microarrays. The MAF system, developed and implemented in both private and academic environments, has proved a robust solution for shared facilities and industry service providers alike

Middle Eocene deformation and sedimentation in the Puna–Eastern Cordillera transition (23°–26°S): Control by preexisting heterogeneities on the pattern of initial Andean shortening

The Quebrada de los Colorados Formation, at the north end of Calchaquí Valley in Salta Province, northwest Argentina, preserves evidence of syndepositional deformation since the middle Eocene (ca. 40 Ma) that includes (1) an angular unconformity with the under- ying Salta Group (Paleogene), and (2) internal unconformities and changes in vertical facies succession and provenance. Its fossil record [mammalian (notoungulates), middle Eocene] is correlatable to the Casa Grande Formation, which also unconformably overlies the Salta Group; both units record middle Eocene deformation along the eastern border of the Puna Plateau and outline previous fi rst-order mechanical heterogeneities related to the Cretaceous rift basin border. Along the western margin of the Puna, Eocene deformation coincides with ther- mal (magmatic arc) and mechanical (basin inversion) heterogeneities. Thus, the distribution of Eocene deformation followed an irregular pat- tern as a consequence of the heritage of preexisting heterogeneities. Keywords: Eocene deformation, initial foreland, preexisting hetero- geneities, Central Andes.Fil: Hongn, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: del Papa, Cecilia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Powell, Jaime Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Petrinovic, Ivan Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Mon, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Deraco, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Fundación Miguel Lillo. Dirección de Geología. Instituto de Palentologia; Argentin

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colorectal cancer at high risk for the development of peritoneal metastases. A matched case-control study

n/

Postcranial remains of basal typotherian notoungulates from the eocene of Northwestern Argentina

Notoungulates represent the most taxonomically diverse and temporally and geographically widespread group among South American native ungulates. Here, we analyze anatomical and systematic aspects of proximal tarsal bones recovered from the Lower and Upper Lumbrera formations (middle and late middle Eocene) in northwestern Argentina. We provide detailed descriptions, comparisons, and infer foot stances and range of movements for the taxa implicated. Material studied includes astragali belonging to the oldfieldthomasiid Colbertia lumbrerense (Lower Lumbrera Formation), a set of proximal tarsals referred as Typotheria indet. (Lower Lumbrera Formation), and tarsals (also including navicular and cuboid) of the informal taxon “Campanorco inauguralis” (Upper Lumbrera Formation). The comparison of the tarsals of Colbertia lumbrerense (middle Eocene of Argentina) with Colbertia magellanica (early Eocene of Brazil) reveals several differences including variations on the development and arrangement of articular facets, and the size of the dorsal astragalar foramen in the Argentinean species. The specimen of Typotheria indet. shows morphological affinities with basal interatheriid taxa. However, its larger size contrasting with the overall small body sizes of Eocene interatheriids precludes an indisputable taxonomic assignment. Concerning “Campanorco inauguralis”, our observations indicate that there is no morphological evidence for a close phylogenetic relationship with Mesotheriidae. It presents a “reversed alternating tarsus” condition, which is also observed in Leontiniidae, “Notohippidae”, Toxodontidae, and some typotherians. However, the spectrum of singularities exhibited by this form precludes the assessment of its relationships in the context of the Paleogene radiation of Typotheria and it is necessary to extend the comparison to Eocene notoungulates. Finally, in a morphofunctional context a plantigrade foot posture is inferred for the specimens here reported. These observations have the potential to provide functional proxies for paleoecological reconstructions to be applied to the study of the early radiation of these notoungulate faunas.Fil: Armella, Matías Alberto. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Garcia Lopez, Daniel Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Babot, María Judith. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Deraco, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Herrera, Claudia Marcela Reina. Fundación Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Saade, Luis Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Bertelli, Sara Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; Argentin

New mandibular remains of Callistoe (Metatheria, Sparassodonta) reveal unexpected anatomical, functional, and evolutionary aspects of this carnivorous genus

We present a detailed description of the anatomy of the dentary and lower teeth of a new specimen of Callistoe vincei, a large carnivorous metatherian from the Eocene (?Ypresian) of northwestern Argentina. The recently collected specimen is a young adult represented by a partial right dentary with the canine, p1, roots of p3, and very well-preserved m1 to m4. The description includes a comparison with the holotype specimen, a much older individual, and other closely related large sparassodonts (e.g., Arminiheringia). The analysis of this new material allowed identifying plesiomorphic molar features in Callistoe, such as the presence of a reduced metaconid on the m3 and a tricuspated, basined talonid on m1–m3. We also described the mesowear facets in the lower dentition, showing that the self-sharpening facet typically present in extinct and extant placental and some marsupial carnivorous forms, was absent in Callistoe. The presence of a short-term cutting edge in the trigonid related to the thinness of the enamel layer, and the associated tooth wear susceptibility, were likely compensated by a dental mechanism (overeruption) to maintain occlusal contact among antagonist teeth. This process could explain the marked extrusion of the tooth roots observed in Callistoe as well as in other large closely related members of the group.Fil: Babot, María Judith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Miguel Lillo; ArgentinaFil: Rougier, Guillermo Walter. University of Louisville; Estados UnidosFil: Garcia Lopez, Daniel Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Bertelli, Sara Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Herrera, Claudia Marcela Reina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Deraco, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Giannini, Norberto Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentin

Clinical and Pathological Risk Factors for Peritoneal Metastases in a Surgical Series of T4 Colorectal Cancers

Background: T4 colorectal cancer (CRC) is associated with an increased risk of peritoneal metastases (PM), but it is currently not possible to accurately predict which patients with T4 CRC develop PM. We investigated the occurrence and risk factors for PM in these patients. Methods: A mono-institutional prospective database of 352 patients undergoing T4 primary CRC resection from 2012 to 2021 was reviewed. Clinico-pathological variables potentially associated with synchronous or metachronous PM were tested by univariate and multivariate analyses. Results: The prevalence of synchronous PM was 73/352 (20.7%) and was significantly associated with age (p = 0.037), primary site (p = 0.002), positive nodes (p = 0.005), elevated CA19.9 (p = 0.001), and non-intestinal histology (p = 0.001). After a median follow-up of 35.9 months (95% confidence interval [CI] = 29.5-44.9), metachronous CRC-PM occurred in 36/164 patients (22.0%) with available data, accounting for a three-year cumulative incidence of 21.5% (95% CI = 14.3-28.1). Metachronous CRC-PM occurred in 3/48 patients (6.2%) with negative nodes and normal CEA, as compared with 33/116 patients (28.4%) with positive nodes and/or elevated CEA (p < 0.001). Combined nodal and CEA status (hazard ratio [HR] = 1.27; 95% CI = 1.02-1.59; p = 0.033), postoperative chemotherapy (HR= 0.51; 95% CI = 0.33-0.77; p = 0.001), and positive resection margins (HR = 2.01; 95% CI = 1.20-3.39; p = 0.008) were significantly associated with PM. Conclusions: The peritoneum is a major site for treatment failure in T4 CRC. Patients with normal CEA and negative lymph nodes are associated with a significantly lower risk for metachronous CRC-PM. These findings may help in refining patient selection for integrated approaches aiming at the prevention or early treatment of CRC-PM, which are pending validation in prospective studies