571 research outputs found

    Managerialism in international schools: a critical enquiry into the professional identity work of head teachers

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    With prior research suggesting that educational leaders in Western contexts are discomforted by managerialism, this thesis considers why, despite benign market forces and regulatory freedoms, international school Heads might find appeal in managerial identifications. The international school context, and the managers within, thereby offer a unique and important site of new theorisation. Contrasting with studies which see education and managerialism as opposed, a reprofessionalisation of Headship is proposed, not as old or new, but as something newer still – as hybridic. Theories of identity, professionalism and institutional work provide means of exploring how international school Heads separate and/or harmonise educational and managerial identities and to what potential ends. An industry analysis, online survey and recruitment documentation review bracket out formal and/or technical coercion towards managerial identifications. With those influences set aside, a critical discourse analysis of twenty-five faceto-face interviews gives attention to managerialism as resulting from the legitimacy of management identifications – managerialism, for some Heads, is as empowering and affirming as education. It is shown that i) educational and managerial identifications are resisted and/or adopted because Heads find benefit in both; and ii) that managerialism is moderated in ways which construct both schools and Headship (institutional work) and in ways which also construct individual Heads (identity work). The work Heads do on and for their selves connects, in a circulatory manner, with the work done on and for their schools. Relevant internationally and nationally, it is concluded that hybridity allows Heads to successfully accomplish management without abandoning educational identifications. While some Heads resist managerialism and others more readily embrace it, most seem to find an occupational and/or ontological balance. This study’s findings are important, therefore, to serving and aspiring Heads, to school recruitment panels, to policy makers developing Headship qualifications and to academics researching manager-hybrids in this and other professional contexts

    PENGARUH MODEL PEMBELAJARAN SAVI TERHADAP HASIL BELAJAR BAHASA ARAB (PENELITIAN EKSPERIMEN DI KELAS 7 SMP MUHAMMADIYAH 3 JAKARTA)

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    Penelitian ini dilaksanakan di SMP Muhammadiyah 3 Jakarta pada bulan Agustus hingga Desember 2021 untuk mengetahui pengaruh model pembelajaran SAVI terhadap hasil belajar bahasa Arab siswa kelas 7 di SMP Muhammadiyah 3 Jakarta. Jenis penelitian ini adalah penelitian kuantitatif dan metode penelitian yang diterapkan adalah penelitian eksperimen. Desain penelitian ini ialah pre-experimental design dengan One Group Pretest-Postest. Sampel penelitian ditetapkan sebanyak 1 kelas dengan jumlah 22 siswa yang ditentukan dengan cara Purposive Sampling. Data kemampuan hasil belajar bahasa Arab dikumpulkan dengan tes hasil belajar berbentuk soal pilihan ganda. Data dianalisis dengan perhitungan uji normalitas. Uji hipotesis penelitian menggunakan uji one sample t-test. Hasil penelitian menunjukkan bahwa t_hitung = 2,276 > t_tabel = 1,717 maka H_a diterima. H_a diterima dapat diartikan bahwa model pembelajaran SAVI berpengaruh terhadap hasil belajar bahasa Arab pada kelas eksperimen. Dengan perbandingan nilai rata-rata pretest sebesar 64,31 dan nilai rata-rata postest sebesar 76,36, hal ini menunjukkan bahwa model pembelajaran SAVI berpengaruh dalam meningkatkan hasil belajar bahasa Arab siswa kelas 7 di SMP Muhammadiyah 3 Jakarta. This research was conducted at SMP Muhammadiyah 3 Jakarta from August to December 2021 to determine the effect of the SAVI learning model on Arabic learning outcomes for 7th grade students at SMP Muhammadiyah 3 Jakarta. **** This type of research is quantitative research and the research method applied is experimental research. The design of this research is a pre-experimental design with One Group Pretest-Postest. The research sample was set at one class with a total of 22 students determined by Purposive Sampling. Data on the ability to learn Arabic is collected by means of a test of learning outcomes in the form of multiple choice questions. The data were analyzed by calculating the normality test. Test the research hypothesis using the one sample t-test. The results showed that t_hitung = 2.276 > t_tabel = 1,717 then H_a is accepted. H_a is accepted can mean that SAVI learning model has an effect on Arabic learning outcomes in the experimental class. With a comparison of the average pretest value is 64.31 and the average posttest value is 76.36, it shows that SAVI learning model has an effect on improving the Arabic language learning outcomes of 7th grade students at SMP Muhammadiyah 3 Jakarta

    Regulation of Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) by Serum- and Glucocorticoid-Inducible Kinase (Sgk1)

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    Background: Serum- and glucocorticoid-inducible kinase-1 (SGK1) increases CFTR Cl currents in Xenopus oocytes by an unknown mechanism. Because SGK increases the plasma membrane expression of other ion channels, the goal of this paper was to test the hypothesis that SGK1 stimulates CFTR Cl currents by increasing the number of CFTR Cl channels in the plasma membrane. Methods: CFTR Cl currents were measured in Xenopus oocytes by the two-electrode voltage clamp technique, and CFTR in the plasma membrane was determined by laser scanning confocal microscopy. Results: wt-SGK1 stimulated CFTR Cl currents by 42% and increased the amount of CFTR in the plasma membrane by 35%. A kinase-dead SGK mutant (K127N) had a dominant-negative effect on CFTR, reducing CFTR Cl currents by 38%. In addition, deletion of the C-terminal PDZ-interacting motif (SGK1-ΔSFL) increased CFTR Cl currents by 108%. Thus, SGK1-ΔSFL was more effective than wt-SGK1 in stimulating CFTR Cl currents. Neither wt-SGK nor the K127N mutant had any effect on Cl currents in oocytes when expressed alone in the absence of CFTR. Conclusion: SGK1 stimulates CFTR Cl currents in Xenopus oocytes by increasing the number of channels in the plasma membrane. Moreover, the effect of SGK may be mediated by protein-protein interactions involving the PDZ interacting motif

    Treatment With siRNA and Antisense Oligonucleotides Targeted to HIF-1α Induced Apoptosis in Human Tongue Squamous Cell Carcinomas

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    Overexpression of hypoxia inducible factor-1α (HIF-1α) in cancers has been correlated to a more aggressive tumor phenotype. We investigated the effect of HIF-1α knockout on the in vitro survival and death of human tongue squamous cell carcinomas (SCC-4 and SCC-9). Under normoxic condition, a basal level of HIF-1α protein was constitutively expressed in SCC-9 cells, albeit an undetectable level of HIF-1α messages. Exposure to hypoxia induced only a transient increase in mRNA transcript but a prolonged elevation of HIF-1α protein and its immediate downstream target gene product, VEGF. Under normoxic or hypoxic conditions, treatment of SCC-9 cells with AS-HIF-1α ODN suppressed both constitutive and hypoxia-induced HIF-1αa expression at both mRNA and protein levels; Knockout of HIF-αa gene expression via either AS-HIF-1α ODN or siRNA (siRNA HIF-1α treatment resulted in inhibition of cell proliferation and induced apoptosis in SCC-4 and SCC-9 cells. We also demonstrated that exposure of SCC-9 cells to hypoxia led to a time-dependent increase In the expression of bcl-2 and IAP-2, but not p53. The attenuated levels of bcl-2 and IAP-2, and the enhanced activity of caspase-3 after treatment with AS-HIF-1α ODN may contribute partly to the effects of HIF-1α blockade on SCC-9 cell death. Collectively, our data suggest that a constitutive or hypoxia-induced expression of HIF-1α In SCC-9 and SCC-4 cells is sufficient to confer target genes expression essential for tumor proliferation and survival. As a result, interfering with HIF-1α pathways by antisense or siRNA strategy may provide a therapeutic target for human tongue squamous cell carcinomas. © 2004 Wiley-Liss, Inc

    Estructura de comunidades de murciélagos como bio-indicadores del hábitat en la Reserva Biológica Indio Maíz

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    Bats are indispensable for the pollination of crops, the control of insects and of agricultural and human pests that can be zoonotic vectors. However, the status of the communities and their biological structure in the Indio Maíz Reserve, which in turn function as bioindicators of agroecosystem conservation, is unknown. For this purpose, the agroecosystems of the reserve were characterized. Fog nets were used to capture specimens recording weight, size, and sexual status. They were taxonomically identified by agroecosystem. The comparison between these is the result of the biodiversity and similarity indices. 384 individuals and 45 species distributed in eight families and ten subfamilies were captured. 71% of all individuals are in good health. The Shannon rain forest index was the highest of all agroecosystems. The Filostomidos subfamily was more representative in terms of species. This family appears with the most representativeness in terms of species that are distributed equally. This agrees with other studies carried out on the Phylostomid family since these groups of animals are more intolerant to habitat disturbance.Los murciélagos son indispensables para la polinización de cultivos, el control de insectos y de plagas agropecuarias y humanas que pueden ser vectores de zoonóticas. Sin embargo, se desconoce cuál es el estado de las comunidades y estructura biológica de estos en la Reserva Indio Maíz, que a su vez funcionan como bioindicadores de conservación de agroecosistemas. Para este fin se caracterizaron los agroecosistemas de la reserva. Se utilizaron redes de niebla para la captura de especímenes registrando peso, tamaño y estado sexual. Se identificaron taxonómicamente por agroecosistema. La comparación entre estos es resultado de los índices de biodiversidad y similitud. Se capturaron 384 individuos y 39 especies distribuidas en ocho familias y cinco subfamilias. El 71% del total de individuos se encuentran en un buen estado de salud. El índice de Shannon indica que el bosque húmedo fue el más alto de todos los agroecosistemas. La subfamilia Phyllostominae fue más representativa en cuanto a especies. Esta familia aparece con la más representatividad en cuanto a especies que se distribuyen de manera equitativa. Esto concuerda con otros estudios realizado sobre la familia de los Phyllostomidae ya que estos grupos de animales son más intolerantes a perturbación de hábitat

    Fretting fatigue wear behavior of Y-TZP dental ceramics processed by non-conventional microwave sintering

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    This is the peer reviewed version of the following article: PRESENDA-BARRERA, ALVARO, Salvador Moya, Mª Dolores, Vleugels, Jozef , Moreno, Rodrigo, Borrell Tomás, María Amparo. (2017). Fretting fatigue wear behavior of Y-TZP dental ceramics processed by non-conventional microwave sintering.Journal of the American Ceramic Society, 100, 5, 1842-1852. DOI: 10.1111/jace.14769, which has been published in final form at http://doi.org/10.1111/jace.14769. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving[EN] The fretting wear behavior of self-mated Y-TZP dental materials obtained by non-conventional microwave and conventional sintering has been investigated. Two 3Y-TZP materials, a widely utilized commercial dental ceramic (LAVA) and a lab-prepared 3Y-TZP powder based equivalent have been assessed. Relative density and mechanical properties as well as the grain size variations upon sintering have been evaluated. After exposure to selected gross slip regime fretting wear conditions, the wear tracks have been characterized allowing the measurement of the coefficient of friction, track profiles, and pit features. The results indicate thaT microwave sintering results in a similar fretting wear behavior as observed for conventional sintered 3YTZP, since the measured volumetric wear loss is of a comparable order of magnitude. Regarding the influence of the grain size, the analysis revealed that a large grain size (>300 nm) results in an increased wear volume and that a higher resistance to fretting wear is constrained to a midrange particle size. Since the fracture toughness of all investigated ceramic grades was comparable, the influence of the fracture toughness could not be assessed. Abrasive grooving, delamination and microcracking have been identified as major wear mechanisms inside the wear tracks for both conventional and microwave sintered 3Y-TZP. In general, microwave sintering can provide 3Y-TZP dental materials with a comparable fretting wear resistance as that observed for conventional sintering using lower dwell sintering temperatures and a shorter processing time.Spanish Ministry of Economy and Competitiveness MINECO, Grant/Award Number: MAT2015-67586-C3-R; Generalitat Valenciana, Grant/Award Number: GRI-SOLIA/2013/035, GV/2014/009; MINECO, Grant/Award Number: IJCI-2014-19839.Presenda-Barrera, A.; Salvador Moya, MD.; Vleugels, J.; Moreno, R.; Borrell Tomás, MA. (2017). Fretting fatigue wear behavior of Y-TZP dental ceramics processed by non-conventional microwave sintering. Journal of the American Ceramic Society. 100(5):1842-1852. https://doi.org/10.1111/jace.14769S18421852100
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