Autoria institucional e tradução de textos técnicos na área de saúde

Monografia (graduação)—Universidade de Brasília, Instituto de Letras, Curso de Letras - Tradução Espanhol, 2013.O presente trabalho, que compõe o Projeto Final para conclusão do curso de Bacharelado em Letras/Tradução Espanhol, da Universidade de Brasília, consiste na tradução para português de um texto especializado da área técnica de saúde, identificando problemas e dificuldades possíveis no exercício da atividade tradutória e utilizando as teorias de tradução existentes para as correspondentes soluções. O texto de partida selecionado é uma publicação técnica da macro área de saúde pública, denominado: Condiciones de Trabajo y Salud de los Trabajadores de la Salud, en Argentina, Brasil, Costa Rica y Perú. Foi produzido pela Oficina Panamericana de Salud/OPS, como produto gerado de investigação conduzida por esse organismo internacional, com objetivo de analisar os determinantes da situação de trabalho e saúde dos trabalhadores desse setor, e gerar indicadores para monitoramento e avaliação de sua situação laboral e de saúde. Em relação a esse texto, foram discutidas as implicações da autoria institucional para a prática tradutória, inserindo a dicotomia autor/tradutor em um campo em que a questão não costuma ser colocada pelos Estudos de Tradução: o dos textos técnicos. __________________________________________________________________________ RESUMENEl objeto primordial del presente trabajo, que constituye el Proyecto Final del curso de bachillerato en Letras/Traducción Español, de la Universidad de Brasilia, consiste en la traducción de un texto especializado de la área técnica de salud, con detección de los posibles problemas y dificultades que se plantean al realizar la actividad traductora y con la aplicación de teorías de traducción existentes a la hora de ofrecer las soluciones correspondientes. El texto de partida que se eligió fue una publicación técnica de la macro área de salud pública, titulado: Condiciones de Trabajo y Salud de los Trabajadores de la Salud, en Argentina, Brasil, Costa Rica y Perú. Fue producido por la Oficina Panamericana de Salud/OPS, como producto generado a partir de la investigación coordinada por este organismo internacional, con el objetivo de analizar los determinantes de la situación de trabajo y salud de los trabajadores del sector, y de obtener indicadores para monitoreo y evaluación de la situación laboral y de salud. Con relación a este texto, se discutieron implicaciones de la autoría institucional en la práctica traductora, a través de la inserción de la dicotomía autor/traductor en un campo en el que los Estudios de Traducción no suelen plantearse dicha cuestión: el de los textos técnicos

Alterations in early auditory evoked potentials in multiple sclerosis patients

SummaryAlterations in early auditory evoked potentials (EAEP) in individuals with demyelinating disease are suggestive of lesions in the brainstem.Aimthis study aims to evaluate the prevalence of hearing disorders and altered EAEP in multiple sclerosis (MS) patients.Materials and methodsixteen female and nine male patients with a defined diagnosis of multiple sclerosis took part in this study. All individuals underwent hearing and EAEP tests. The wave forms were categorized according to Jerger (1986).Resultsfifty EAEP tests were carried out; 70% were classified as type I (normal response) according to Jerger's criteria. Altered EAEP results in at least one ear were classified into types II, III, IV or V according to Jerger. Females accounted for 31.25% of alterations, and males 44.44%, adding up to 36% of all cases.Conclusionsthese findings stress the importance of looking at EAEP in cases where there is suspicion of demyelinating disease and in patients with a defined diagnosis for MS

Lutzomyia longipalpis (Diptera: Psychodidae) Argentina-Bolivia border: new report and genetic diversity

American visceral leishmaniasis (AVL) has two main scenarios of transmission as follows: scattered cases in rural areas andurban outbreaks. Urban AVL is in active dispersion from the northeastern border of Argentina-Paraguay-Brazil to the South.The presence of Lutzomyia longipalpis was initially reported in urban environments in the northwestern border of the country.The presence of Lu. longipalpis, environmental variables associated with its distribution, and its genetic diversity were assessedin Salvador Mazza, Argentina, on the border with Bolivia. The genetic analysis showed high haplotype diversity, low nucleotidediversity, and low nucleotide polymorphism index. We discuss the hypothesis of an expanding urban population with introgressivehybridisation of older haplogroups found in their path in natural forest or rural environments, acquiring a new adaptability tourban environments, and the possibility of changes in vector capacity.Fil: Quintana, María Gabriela. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Red de Investigación de la Leishmaniasis en la Argentina; ArgentinaFil: Pech May, Angélica del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Red de Investigación de la Leishmaniasis en la Argentina; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; ArgentinaFil: Fuenzalida, Ana Denise. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Red de Investigación de la Leishmaniasis en la Argentina; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Direni Mancini, José Manuel. Red de Investigación de la Leishmaniasis en la Argentina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Barroso, Paola Andrea. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Yadon, Zaida Estela. Ministerio de Salud. Instituto Nacional de Medicina Tropical; ArgentinaFil: Zaideneberg, Mario. Ministerio de Salud y Acción Social; ArgentinaFil: Salomón, Oscar Daniel. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Red de Investigación de la Leishmaniasis en la Argentina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentin

Bovine pestivirus is a new alternative virus for multiple myeloma oncolytic virotherapy

The oncolytic viruses have shown promising results for the treatment of multiple myeloma. However, the use of human viruses is limited by the patients' antiviral immune response. In this study, we investigated an alternative oncolytic strategy using non-human pathogen viruses as the bovine viral diarrhea virus (BVDV) that were able to interact with CD46

Management of infantile hemangiomas during the COVID pandemic

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.The COVID‐19 pandemic has caused significant shifts in patient care including a steep decline in ambulatory visits and a marked increase in the use of telemedicine. Infantile hemangiomas (IH) can require urgent evaluation and risk stratification to determine which infants need treatment and which can be managed with continued observation. For those requiring treatment, prompt initiation decreases morbidity and improves long‐term outcomes. The Hemangioma Investigator Group has created consensus recommendations for management of IH via telemedicine. FDA/EMA‐approved monitoring guidelines, clinical practice guidelines, and relevant, up‐to‐date publications regarding initiation and monitoring of beta‐blocker therapy were used to inform the recommendations. Clinical decision‐making guidelines about when telehealth is an appropriate alternative to in‐office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. The importance of communication with caregivers in the context of telemedicine is discussed, and online resources for both hemangioma education and propranolol therapy are provided

Proteasome Inhibitors Block Myeloma-Induced Osteocyte Death in Vitro and in Vivo in Multiple Myeloma Patients

Multiple myeloma (MM) is characterized by a severe unbalanced and uncoupling bone remodeling leading to osteolysis. We have recently shown that osteocytes are involved in MM-induced osteolysis through an increased cell death. Accordingly MM patients are characterized by a reduced number of viable osteocytes related to the presence of bone lesions. Proteasome inhibitors currently used in the treatment of MM are able to stimulate osteoblast formation but their potential effects on osteocyte death are not known and have been investigated in this study both in vitro and in vivo. Osteocytic MLO-Y4 cells or human pre-osteocytic HOB-01 cells were co-cultured for 48 hours in the presence or absence of the human myeloma cell lines (HMCLs) JJN3 or RPMI-8226 placed in a transwell insert. A significantly reduction of ostecyte viability was observed (median percent reduction of MLO-Y4 viability: -16% and -30%, respectively). The treatment for 12–24 hours with Bortezomib (BOR) (2nM) or other proteasome inhibitors such as MG262 (10nM) or MG132 (100nM) significantly blunted MLO-Y4 and HOB-01 cell death. Similarly, Dexamethasone (DEX)-induced MLO-Y4 apoptosis, obtained at pharmacological doses (10–4–10–5 M), was significantly reduced by the treatment with proteasome inhibitors. To translate our in vitro data into a clinical perspective we performed a retrospective histological evaluation on bone biopsies of a cohort of 40 newly diagnosis MM patients (24 male and 16 female, median age: 68 years) 34 of them with symptomatic MM and 6 with smoldering MM (SMM). The 58% of patients with symptomatic MM have evidence of osteolytic lesions at the X-rays survey. Bone biopsies were obtained in both symptomatic MM and SMM at diagnosis and after an average time of 12 months of treatment or observation, respectively. The 68% of patients with symptomatic MM were treated with a BOR-based regimen while 42% do not. Moreover the 58% of MM patients received DEX and the 59% Thalidomide (TAL). Zoledronic acid (ZOL) was infused monthly in the 60% of MM patients. Osteocyte viability was evaluated in a total of 500 lacunae per histological sections, corresponds to the total number of osteocyte lacunae in the bone biopsies. The number of viable osteocytes and the number of degenerated or apoptotic osteocytes and empty lacunae have been evaluated. In patients with SMM no significant change was observed in the number of viable osteocytes in the two histological evaluations carried out (median percent change: +1.2, p=0.68, NS). In symptomatic MM patients the mean percent change of the osteocyte viability was not correlated with the response rate to treatment (R2 0.01, p=NS). A significant increase of the number of viable osteocytes was demonstrated in MM patients treated with BOR-based regimen as compared to those treated without BOR (% median increase of osteocyte viability: +6% vs. +1.30%, Mann-Whitney test: p=0.017). Patients treated with BOR alone showed the highest increase of osteocyte viability that was statistical significant in comparison with that observed either in patients treated without BOR (+11.6% vs. +1.3%, p=0.0019) or in those treated with BOR plus DEX (+11.6% vs. +4.4%, p=0.01). On the contrary, no significant difference was observed in patients treated with TAL than in those treated without TAL (p= 0.7, NS) as well as patients treated with ZOL compared to those untreated showed no significant difference in the number of viable osteocytes (p=0.18, NS). To confirm the role of the different drug treatment on the osteocyte viability we perform a multiple regression non-parametric analysis showing that BOR had a significant positive impact on osteocyte viability (p=0.042) whereas ZOL and TAL have not (p>0.2,NS) and it counterbalanced the negative effect of DEX treatment (p=0.035). In conclusion our in vitro and in vivo data suggest the proteasome inhibitors block osteocyte death induced by MM cells could have a positive impact on bone integrity in MM patients

Actividad ovicida de la lavandina sobre huevos de Aedes aegypti (diptera: culicidae)

Introducción: Diversos productos de uso doméstico pueden ayudar en el saneamientode nuestro hábitat. Algunos autores señalan la efectividad del cloro puro en laremoción del corion del huevo de Aedes aegypti, produciéndose una menor eclosión alaplicarlo sobre las paredes de los contenedores donde son depositados. Objetivo:evaluar la susceptibilidad de huevos de Ae. aegypti a diferentes concentraciones delavandina, para valorar su actividad ovicida. Materiales y método: Se utilizó agualavandina concentrada (AYUDIN, 2,2 %, 55g Cl/ 1l), en cuatro concentraciones: L1(100 %), L2 (50 %), L3 (25 %) y L4 (12,5 %). Se trataron 40 huevos para cada unidady, luego de 48 hs, inundaron con agua declorada para inducir la eclosión. Paraobservar diferencias entre el control y el tratamiento, se realizó un test de KruskalWallis y un Boxplot, utilizando la plataforma R-medic. Resultados: Se observarondiferencias significativas (p< 0.001) con el control (Me= 95.8), registrándose unaelevada mortalidad de huevos al aplicar lavandina, sin importar la concentración usada(Me≤ 2.5). L4 fue la única dosis que registró supervivencia (Me= 2.5). Conclusiones:Estos resultados pueden ser útiles en la lucha antivectorial contra Ae. aegypti,reforzando las acciones comunitarias durante las campañas de fumigación ysaneamiento ambiental para la prevención de las enfermedades transmitidas por él.Consideramos que recomendar el empleo de la lavandina para el lavado de losrecipientes vacíos, enfatizando en la limpieza de las paredes, puede ayudar a ladisminución de las poblaciones del vector, especialmente durante los periodosinterepidémicos, ideales para la aplicación de medidas de control vectorial.Fil: Rodriguez, Gabriela Alejandra. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Herrera, V. G.. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Pomares, M. A.. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Fuenzalida, Ana Denise. Secretaria de Gobierno de Salud. Instituto Nacional de Medicina Tropical. Instituto Nacional de Medicina Tropical - Sede Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Direni Mancini, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Diaz Briz, L. M.. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Claps, Guillermo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; ArgentinaFil: Quintana, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Superior de Entomología; Argentina. Secretaria de Gobierno de Salud. Instituto Nacional de Medicina Tropical. Instituto Nacional de Medicina Tropical - Sede Tucumán; ArgentinaXIV Jornadas Internas de Comunicaciones en Investigación, Docencia y ExtensiónSan Miguel de TucumánArgentinaUniversidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lill

Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 Infection

This contribution explores in a new statistical perspective the antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 141 coronavirus disease 2019 (COVID-19) patients exhibiting a broad range of clinical manifestations. This cohort accurately reflects the characteristics of the first wave of the SARS-CoV-2 pandemic in Italy. We determined the IgM, IgA, and IgG levels towards SARS-CoV-2 S1, S2, and NP antigens, evaluating their neutralizing activity and relationship with clinical signatures. Moreover, we longitudinally followed 72 patients up to 9 months postsymptoms onset to study the persistence of the levels of antibodies. Our results showed that the majority of COVID-19 patients developed an early virus-specific antibody response. The magnitude and the neutralizing properties of the response were heterogeneous regardless of the severity of the disease. Antibody levels dropped over time, even though spike reactive IgG and IgA were still detectable up to 9 months. Early baseline antibody levels were key drivers of the subsequent antibody production and the long-lasting protection against SARS-CoV-2. Importantly, we identified anti-S1 IgA as a good surrogate marker to predict the clinical course of COVID-19. Characterizing the antibody response after SARS-CoV-2 infection is relevant for the early clinical management of patients as soon as they are diagnosed and for implementing the current vaccination strategies

A Downstream CpG Island Controls Transcript Initiation and Elongation and the Methylation State of the Imprinted Airn Macro ncRNA Promoter

A CpG island (CGI) lies at the 5′ end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. In addition to being modified on maternally inherited chromosomes by a DNA methylation imprint, the Airn CGI shows two unusual organization features: its position immediately downstream of the Airn promoter and transcription start site and a series of tandem direct repeats (TDRs) occupying its second half. The physical separation of the Airn promoter from the CGI provides a model to investigate if the CGI plays distinct transcriptional and epigenetic roles. We used homologous recombination to generate embryonic stem cells carrying deletions at the endogenous locus of the entire CGI or just the TDRs. The deleted Airn alleles were analyzed by using an ES cell imprinting model that recapitulates the onset of Igf2r imprinted expression in embryonic development or by using knock-out mice. The results show that the CGI is required for efficient Airn initiation and to maintain the unmethylated state of the Airn promoter, which are both necessary for Igf2r repression on the paternal chromosome. The TDRs occupying the second half of the CGI play a minor role in Airn transcriptional elongation or processivity, but are essential for methylation on the maternal Airn promoter that is necessary for Igf2r to be expressed from this chromosome. Together the data indicate the existence of a class of regulatory CGIs in the mammalian genome that act downstream of the promoter and transcription start