Abundances of Linear Carbon-Chain Molecules in Supernovae

This paper continues our effort to under-stand the condensation of carbon solids in a gas of pure C and O atoms when these exist within the interior of an expanding young supernova. This setting has a sufficiently large number of energetic electrons that the CO molecule is disrupted with a lifetime of a few months, causing the abundance of CO to be no greater than 1% or so of the C abundance. As a consequence, the CO molecule cannot consume the available C atoms, even when the O abundance exceeds that of

Supernova Reverse Shocks and SiC Growth

We present new mechanisms by which the isotopic compositions of X-type grains of presolar SiC are altered by reverse shocks in Type II supernovae. We address three epochs of reverse shocks: pressure wave from the H envelope near t = 10$^6$s; reverse shock from the presupernova wind near 10$^8-10^9$s; reverse shock from the ISM near 10$^{10}$s. Using 1-D hydrodynamics we show that the first creates a dense shell of Si and C atoms near 10$^6$s in which the SiC surely condenses. The second reverse shock causes precondensed grains to move rapidly forward through decelerated gas of different isotopic composition, during which implantation, sputtering and further condensation occur simultaneously. The third reverse shock causes only further ion implantation and sputtering, which may affect trace element isotopic compositions. Using a 25M$_{\odot}$ supernova model we propose solutions to the following unsolved questions: where does SiC condense?; why does SiC condense in preference to graphite?; why is condensed SiC $^{28}$Si-rich?; why is O richness no obstacle to SiC condensation?; how many atoms of each isotope are impacted by a grain that condenses at time t$_0$ at radial coordinate r$_0$? These many considerations are put forward as a road map for interpreting SiC X grains found in meteorites and their meaning for supernova physics.Comment: 28 pages, 14 figures, animation for Figure 3 and machine-readable Table 3 can be found at http://antares.steelangel.com/~edeneau/supernova/DHC_2003, Submitted to Ap

Parental sensitivity and child behavioral problems: A meta-analytic review

Meta-analytic associations between observed parental sensitivity and child behavioral problems were examined (children aged 0-17 years). Studies (k = 108, N = 28,114) contained sociodemographically diverse samples, primarily from North America and Europe, reporting on parent-child dyads (95% mothers; 54% boys). Sensitivity significantly related to internalizing (k = 69 studies; N = 14,729; r = -.08, 95% CI [-.12, -.05]) and externalizing (k = 94; N = 25,418; r = -.14, 95% CI [-.17, -.11]) problems, with stronger associations found for externalizing. For internalizing problems, associations were significantly stronger among samples with low socioeconomic status (SES) versus mid-high SES, in peer-reviewed versus unpublished dissertations, and in studies using composite versus single scale sensitivity measures. No other moderators emerged as significant

A role for GPx3 in activity of normal and leukemia stem cells

The determinants of normal and leukemic stem cell self-renewal remain poorly characterized. We report that expression of the reactive oxygen species (ROS) scavenger glutathione peroxidase 3 (GPx3) positively correlates with the frequency of leukemia stem cells (LSCs) in Hoxa9+Meis1-induced leukemias. Compared with a leukemia with a low frequency of LSCs, a leukemia with a high frequency of LSCs showed hypomethylation of the Gpx3 promoter region, and expressed high levels of Gpx3 and low levels of ROS. LSCs and normal hematopoietic stem cells (HSCs) engineered to express Gpx3 short hairpin RNA (shRNA) were much less competitive in vivo than control cells. However, progenitor cell proliferation and differentiation was not affected by Gpx3 shRNA. Consistent with this, HSCs overexpressing Gpx3 were significantly more competitive than control cells in long-term repopulation experiments, and overexpression of the self-renewal genes Prdm16 or Hoxb4 boosted Gpx3 expression. In human primary acute myeloid leukemia samples, GPX3 expression level directly correlated with adverse prognostic outcome, revealing a potential novel target for the eradication of LSCs

Optical and Infrared Analysis of Type II SN 2006BC

We present nebular phase optical imaging and spectroscopy and near/mid-IR imaging of the Type II SN 2006bc. Observations reveal the central wavelength of the symmetric H$\alpha$ line profile to be red-shifted with respect to the host galaxy H$\alpha$ emission by day 325. Such an phenomenon has been argued to result from an asymmetric explosion in the iron-peak elements resulting in a larger mass of $^{56}$Ni and higher excitation of hydrogen on the far side of the SN explosion. We also observe a gradual blue-shifting of this H$\alpha$ peak which is indicative of dust formation in the ejecta. Although showing a normal peak brightness, V $\sim$ -17.2, for a core-collapse SN, 2006bc fades by $\sim$6 mag during the first 400 days suggesting either a relatively low $^{56}$Ni yield, an increase in extinction due to new dust, or both. A short duration flattening of the light curve is observed from day 416 to day 541 suggesting an optical light echo. Based on the narrow time window of this echo, we discuss implications on the location and geometry of the reflecting ISM. With our radiative transfer models, we find an upper limit of 2 x 10$^{-3}$ M$_{\odot}$ of dust around SN 2006bc. In the event that all of this dust were formed during the SN explosion, this quantity of dust is still several orders of magnitude lower than that needed to explain the large quantities of dust observed in the early universe.Comment: 6 pages, 10 figures, accepted for publication in Ap

The first 20,000 strange situation procedures: A meta-analytic review

The Strange Situation Procedure (SSP) was developed five decades ago to assess infant–parent attachment relationships. Although the procedure itself has remained relatively constant in over 285 studies (20,720 dyads) conducted to date, there have been vast sociological changes during this time, and research foci shifts to studying diverse populations. Since its inception, the SSP has also been adopted in over 20 countries. In this meta-analysis, we collate this large body of work, with the objectives of producing reliable estimates of the distribution of the four SSP attachment classifications, assessing temporal trends and geographical differences, and determining if and when distributions are different across various populations. Results revealed that the global distribution of SSP attachment was 51.6% secure, 14.7% avoidant, 10.2% resistant, and 23.5% disorganized. There were no differences in the distribution among mothers and fathers, and no child age or sex differences. We found a temporal trend in which there was less avoidant attachment over time and there were attachment distribution differences between samples from North America versus other regions of the world, particularly Asia, Middle East/Israel and South America. We found higher rates of avoidant and disorganized attachment in populations with sociodemographic risks and higher rates of disorganized attachment in samples where parents had psychopathology and when the child experienced maltreatment or was adopted from foster or institutional care. The implications of these findings for future research and practice are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved

Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

This white paper provides updated International Transporter Consortium (ITC) recommendations on transporters that are important in drug development following the 3rd ITC workshop. New additions include prospective evaluation of organic cation transporter 1 (OCT1) and retrospective evaluation of organic anion transporting polypeptide (OATP)2B1 because of their important roles in drug absorption, disposition, and effects. For the first time, the ITC underscores the importance of transporters involved in drug-induced vitamin deficiency (THTR2) and those involved in the disposition of biomarkers of organ function (OAT2 and bile acid transporters)

Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway

Background: While the role of canonical (b-catenin-mediated) Wnt signaling in hematolymphopoiesis has been studied extensively, little is known of the potential importance of non-canonical Wnt signals in hematopoietic cells. Wnt4 is one of the Wnt proteins that can elicit non-canonical pathways. We have previously shown that retroviral overexpression of Wnt4 by hematopoietic cells increased thymic cellularity as well as the frequency of early thymic progenitors and bone marrow hematopoietic progenitor cells (HPCs). However, the molecular pathways responsible for its effect in HPCs are not known. Methodology/Principal Findings: Here we report that Wnt4 stimulation resulted in the activation of the small GTPase Rac1 as well as Jnk kinases in an HPC cell line. Jnk activity was necessary, while b-catenin was dispensable, for the Wnt4-mediated expansion of primary fetal liver HPCs in culture. Furthermore, Jnk2-deficient and Wnt4 hemizygous mice presented lower numbers of HPCs in their bone marrow, and Jnk2-deficient HPCs showed increased rates of apoptosis. Wnt4 also improved HPC activity in a competitive reconstitution model in a cell-autonomous, Jnk2-dependent manner. Lastly, we identified Fz6 as a receptor for Wnt4 in immature HPCs and showed that the absence of Wnt4 led to a decreased expression of four polarity complex genes. Conclusions/Significance: Our results establish a functional role for non-canonical Wnt signaling in hematopoiesis throug

The Role of Radioactivities in Astrophysics

I present both a history of radioactivity in astrophysics and an introduction to the major applications of radioactive abundances to astronomy

The HOXB4 Homeoprotein Promotes the Ex Vivo Enrichment of Functional Human Embryonic Stem Cell-Derived NK Cells

Human embryonic stem cells (hESCs) can be induced to differentiate into blood cells using either co-culture with stromal cells or following human embryoid bodies (hEBs) formation. It is now well established that the HOXB4 homeoprotein promotes the expansion of human adult hematopoietic stem cells (HSCs) but also myeloid and lymphoid progenitors. However, the role of HOXB4 in the development of hematopoietic cells from hESCs and particularly in the generation of hESC-derived NK-progenitor cells remains elusive. Based on the ability of HOXB4 to passively enter hematopoietic cells in a system that comprises a co-culture with the MS-5/SP-HOXB4 stromal cells, we provide evidence that HOXB4 delivery promotes the enrichment of hEB-derived precursors that could differentiate into fully mature and functional NK. These hEB-derived NK cells enriched by HOXB4 were characterized according to their CMH class I receptor expression, their cytotoxic arsenal, their expression of IFNγ and CD107a after stimulation and their lytic activity. Furthermore our study provides new insights into the gene expression profile of hEB-derived cells exposed to HOXB4 and shows the emergence of CD34+CD45RA+ precursors from hEBs indicating the lymphoid specification of hESC-derived hematopoietic precursors. Altogether, our results outline the effects of HOXB4 in combination with stromal cells in the development of NK cells from hESCs and suggest the potential use of HOXB4 protein for NK-cell enrichment from pluripotent stem cells