Seismic stratigraphy of the north-western Sea of Marmara shelf along the North Anatolian Fault system

The Ganos Fault, a part of the Northern strand of the North Anatolian Fault system, is an active- strike slip fault and divides the narrow NW shelf of the Sea of Marmara into two parts near the town of Gaziköy. This paper presents recently collected shallow high-resolution seismic data to discriminate the sedimentary successions, each characterized by distinctive stratigraphic patterns on both sides of the Ganos Fault. Two main units, namely U1 and U2, and three para-sequences (U1a, U1b and U1c) were identified, depending on their internal reflection patterns, accommodation depths as well as the presence of conformity and the unconformity surfaces. The thickness of Unit U1 reaches its maximum at the northern side of the Ganos Fault; it is much thinner to the south. The para-sequences of U1b and U1c have “progradation” and “aggradation to progradation” depositional characters, respectively. This probably implies fluvial deposition controlled by sea- level fluctuations. Unit U1b can only be observed at the northern side of the Ganos Fault, while Unit U1c at the southern side. Units U1a and U1b were deposited during the transgressive system tract, while Unit U1c was deposited during a sea-level fall and/or a lowstand phase marked by an erosional surface. The marine terraces in the study area are shallower than those along the northern shelf of the Sea of Marmara, possibly due to successive tectonic displacements along the Ganos Fault, which also controls the distribution and thickness of the parasequences identified in this study

Sıçanlarda altlık değişim sıklığının lipid peroksidasyon, antioksidan durum ve histopatolojik değişiklikler üzerine etkileri

The aim of this research was to evaluate the effect of bedding change frequency on oxidative stress parameters of rats. In the experiment; animals were randomly and equally divided into 4 groups, each group consisted of 6 male rats. Group 1; bedding change every day, Group 2; bedding change once in 2 days, Group 3; bedding change once in 4 days, and Group 4; bedding change once in a week. Dust-free wood shavings were used as bedding material and the study lasted for 2 months. At the end of experimental period, MDA levels were found to be increased in blood, liver, kidney, heart, brain, and lung of groups with longer intervals of bedding change whereas GSH levels of these tissues were decreased. It was also found that SOD and CAT activities were higher in erythrocyte and lung tissues in Group 1 than the other groups. Moreover, notable histopathological alterations were observed in the tissues of longer intervals of bedding change (especially, group 3 and 4). As a result, it has been determined that long periods of bedding change in animals causes oxidative stress, tissues damages, and these alterations adversely affect the life quality of laboratory animals.Bu araştırmanın amacı sıçanlarda altlık değişim sıklığının oksidatif stres parametreleri üzerine etkisi değerlendirmektir. Çalışmada hayvanlar her grupta 6 erkek sıçan olacak şekilde rastgele ve eşit olarak 4 gruba ayrıldı. Gruplar: Grup 1; her gün altlığı değişen, Grup 2; 2 günde bir altlığı değişen, Grup 3; 4 günde bir altlığı değişen ve Grup 4; haftada bir altlığı değişen şeklinde oluşturuldu. Çalışma 2 ay olacak şekilde planlandı ve altlık malzemesi olarak tozsuz ağaç talaşı kullanıldı. Çalışmanın sonunda, daha uzun aralıklarla altlık değişimi olan gruplarda kan, karaciğer, böbrek, kalp, beyin ve akciğer dokularında MDA düzeylerinin arttığı, bu dokulardaki GSH düzeylerinin ise azaldığı görülmüştür. Ayrıca, eritrosit ve akciğer dokularında SOD ve CAT aktivitelerinin Grup 1'de, diğer gruplardan daha yüksek olduğu belirlendi. Ayrıca, daha uzun aralıklarla altlıkları değişen grupların (özellikle grup 3 ve 4) beyin, akciğer, kalp, karaciğer ve böbrek dokularında histopatolojik değişiklikler gözlendi. Sonuç olarak, hayvanlarda uzun aralıklarla altlık değişiminin oksidatif strese, doku hasarlarına yol açarak laboratuvar hayvanlarının yaşam kalitesini olumsuz etkilediği belirlenmiştir

Potential protective effect of boron against gentamicin-induced oxidative stress on rat tissues

Çalışmada gentamisin maruziyeti ile toksisite oluşturulan ratlarda borun (B) muhtemel koruyucu etkisinin belirlenmesi amaçlandı. Bu amaçla Wistar albino 56 erkek rat kullanıldı. Her grupta 7 hayvan olacak şekilde, kontrol, gentamisin (100 mg/kg i.p.), B-5 (5 mg/kg B, i.p.), B-10 (10 mg/kg B, i.p.), B-20 (20 mg/kg B, i.p.), B-5 + gentamisin (5 mg/kg B ve 100 mg/kg gentamisin, i.p.), B-10 + gentamisin (10 mg/kg B ve 100 mg/kg gentamisin, i.p.), B-20 + gentamisin (20 mg/kg B ve 100 mg/kg gentamisin, i.p.) olarak 8 gruba ayrıldı. Ratlara B uygulaması gentamisin enjeksiyonundan 4 gün önce verilmeye başlandı. Gentamisin uygulamasına 4. gün başlandı ve 12. gün bu uygulama sonlandırıldı. Gentamisin uygulamasının bitişinden itibaren hayvanlara 2 gün daha B verildi. Uygulama sonunda hayvanlardan anestezi altında karaciğer, kalp, beyin, akciğer ve testis dokuları alındı. Gentamisinin karaciğer dokusunda malondialdehid düzeylerini arttırdığı, buna karşın redükte glutatyon düzeylerini, superoksid dismutaz ve katalaz aktivitelerini azalttığı tespit edildi. Histopatolojik incelemede gentamisinin dokularda hasar oluşturduğu gözlendi. Buna karşın, B uygulamasının gentamisin ile indüklenen hasarı azalttığı tespit edildi.The objective of this study was to determine the protective effects of boron on gentamicin induced toxicity in rats. Rats were divided into eight experimental groups containing seven animals in each group. Experimental groups were as follows; control group (fed without B), gentamicin group (100 mg/kg, i.p.), B-5 group (5 mg/kg B, i.p.), B-10 group (10 mg/kg B, i.p.), B-20 group (20 mg/kg B, i.p.), B-5 + gentamicin group (5 mg/kg B and 100 mg/kg gentamicin, i.p.), B-10 + gentamicin group (10 mg/kg B and 100 mg/kg gentamicin, i.p.), and B-20 + gentamicin group (20 mg/kg B and 100 mg/kg gentamicin, i.p.). B was given to rats before four days. Gentamicin was given to rats on the fourth day and finished on the twelfth day. Also, administration of B was completed the fourteenth day. End of the experiment, liver, hearth, brain, lung, and testis tissues were collected from animals under anaesthesia. Administration of gentamicin increased malondialdehyde levels whereas decreased reduce glutathione levels, superoxide dismutase and catalase activities in the liver. Histopathologically, damages were detected in the tissues of gentamicin group. However, treatment of boron resulted in a reversal of gentamicin-induced damages

Post-traumatic stress disorder after terrorist attack in healthcare professionals

INTRODUCTION: On the date of 15 July 2016 a terrorist organization launched a terrorist attack using helicopters and heavy combat weapons in the city centers of Istanbul and Ankara simultaneously. Numerous civilian were hurt and many of them lost their lives during the attacks. Terrorism is a form of combat designed to cause the highest psychological influence on the masses. Post-traumatic stress disorder (PTSD) is one of the most common psychological disorders after such disasters. The aim of this study is to determine the associated risk factors and PTSD rates in healthcare professionals who were on call during the 15 July 2016 terrorist attacks. METHOD: Since the hospital is in a neighbouring the street to where terror attacks occurred, all healthcare professionals ≥ 18 years of age who were on duty that night in the Dr. Ridvan Ege Training and Research Hospital and were auditory or visual witnesses of the event were included in the study as the first group while healthcare professionals who work in the same hospital but were not on duty that night were included as the control group. RESULTS: The mean post-traumatic diagnostic scale stress score of the control group was 11.87. The mean post-traumatic diagnostic scale stress score of the Group 1 was 21.91. There was a significant difference between the groups in terms of posttraumatic diagnostic scale stress score (p < 0.05). While the healthcare professionals on duty on July 15, 2016 (Group 1) had moderate-severe (21.91 ± 5.11) stress disorder, the healthcare professionals who were not at the hospital on July 15, 2016 (Control Group) had moderate stress disorder (11.87 ± 6.86). CONCLUSION: Our country is at risk from the fact that such attacks may be experienced again because of its unique conditions. The results of our work support the data on the high level of exposure to PTSD when exposed to a terrorist attack. For this reason, the identification of the characteristics of pre-traumatic health individuals at risk is useful in planning the presentation of preventive and curative health services. At the same time, there is a need for longer-term work and wider samples to reveal the psychological consequences of such attacks

Protective effect of taurine against acrylamide-induced oxidative stress in rats

Bu çalışmada, sıçanlarda akrilamid ile oluşturulan oksidatif strese karşı antioksidan ajan olan taurinin koruyucu etkisinin araştırılması amaçlandı. Toplam 35 Wistar erkek sıçan standart rodent yemiyle beslendi ve 5 eşit gruba ayrıldı. I. Grup: kontrol grubu, II. Grup: sadece 15 mg/kg akrilamid 60 gün boyunca gastrik gavaj yolu ile verildi. III., IV. ve V. gruplara sırasıyla akrilamid (15 mg/kg) ve taurin 50, 100 ve 200 mg/kg/gün olacak şekilde ağızdan gastrik gavaj ile verildi. Akrilamid uygulaması sıçanların kan ve dokularında malondialdehid seviyelerinde önemli bir artışa ve glutatyon seviyelerinde azalmaya neden oldu. Buna ilave olarak, akrilamid uygulaması ile süperoksid dismutaz ve katalaz aktivitelerinin sıçan eritrosit ve dokularında azaldığı belirlendi. Taurin uygulamasının akrilamid ile indüklenen oksidatif stres ve lipid peroksidasyonu azaltarak vücudun antioksidan savunma sistemini iyileştirdiği belirlendi. Bunun yanı sıra, taurin uygulaması ile akrilamid verilen sıçanların karaciğer ve beyin dokularındaki IFN-γ, IL-1β, TNF-α ve NFĸB mRNA ekspresyon düzeylerinin azaldığı gözlendi. Ayrıca, taurin dokularda akrilamid ile indüklenen oksidatif stres sonucu oluşan histopatolojik değişikliklere karşı koruyucu etki gösterdi. Sonuçta doza bağlı olarak taurinin sıçanlarda antioksidan savunma mekanizmasını artırarak akrilamidle indüklenen oksidatif strese karşı koruyucu etki gösterdiği belirlendi.The aim of the present study was to evaluate the protective effect of taurine on acrylamide-induced oxidative stress in rats. Totally, 35 Wistar albino male rats were fed standard rodent diet and divided into 5 equal groups. I. Group: control group, II. Group: only 15 mg/kg acrylamide treated by gastric gavage for 60 days. III., IV., and V. group received 15 mg/kg acrylamide with taurine at dose of 50, 100 and 200 mg/kg/day by gastric gavage. Treatment with acrylamide significantly increased malondialdehyde levels and decreased glutathione levels in blood and tissues of rats. Additionally, acrylamide treatment decreased superoxide dismutase and catalase activities in erythrocyte and tissues of rats. However, treatment of taurine inhibited acrylamide-induced oxidative stress, lipid peroxidation, and enhanced the antioxidant enzymes activities. Besides, mRNA expression levels of IFN-γ, IL-1β, TNF-α, and NFĸB in liver and brain of acrylamide exposed rats were decreased with taurine treatment. Moreover, taurine exhibited protective action against the acrylamide-induced histopathological changes in tissues. In conclusion, it was determined that taurine in a dose-dependent manner has a protective effect against acrylamide induced oxidative stress by increasing antioxidant defense mechanism in rats

Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study

Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk