In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of drosophila melanogaster larval brain

Agriculture commonly utilizes crop protection products to tackle infestations from fungi, parasites, insects, and weeds. Validamycin A, an inhibitor of trehalase, possesses antibiotic and antifungal attributes. Epidemiological evidence has led to concerns regarding a potential link between pesticide usage and neurodegenerative diseases. The fruit fly, Drosophila melanogaster, has been recognized as a reliable model for genetic research due to its significant genetic similarities with mammals. Here, we propose to use D. melanogaster as an effective in vivo model system to investigate the genotoxic risks associated with exposure to validamycin A. In this study, we performed a neurotoxic evaluation of validamycin A in D. melanogaster larvae. Several endpoints were evaluated, including toxicity, intracellular oxidative stress (reactive oxygen species), intestinal damage, larval behavior (crawling behavior, light/dark sensitivity assay, and temperature sensitivity assay), locomotor (climbing) behavior, and neurogenotoxic effects (impaired DNA via Comet assay, enhanced by Endo III and formamidopyrimidine DNA glycosylase [FPG]). The results showed that exposure to validamycin A, especially at higher doses (1 and 2.5 mM), induced DNA impairment in neuroblasts as observed by Comet assay. Both larvae and adults exhibited behavioral changes and produced reactive oxygen species. Most importantly, this research represents a pioneering effort to report neurogenotoxicity data specifically in Drosophila larval neuroblasts, thus underscoring the importance of this species as a testing model in exploring the biological impacts of validamycin A. The in vivo findings from the experiments are a valuable and novel addition to the existing validamycin A neurogenotoxicity database.No sponso

Assessment of Prospective Science Teachers’ Metacognition and Creativity Perceptions and Scientific Toys in Terms of Scientific Creativity

AbstractCreativity is a talent. On the other hand, opportunities should be given starting from young ages for its appearance and development. Creativity should be described as skills that involve working alone and cooperatively, giving time for listening, thinking and focusing, acting seriously when facing problems (Dağlıoğlu, 2010). The fundamentals for the development of scientific creativity can be defined as “a secure place, physiological freedom, a discipline that frees the person, intellectual argumentation methods, thinking of critical and creative thinking, authentic assessment” (Duman, 2009). A need, a necessity or desire for solving a problem comes forward in scientific creativity (Terzioğlu, 1993, cit. by Aktamış and Ergin, 2006). Hu and Adey (2002) define scientific creativity as a process that consists of imagination, thinking, fluency, flexibility, originality, scientific knowledge, scientific problem, scientific fact and technical product components. The aim of the study is to assess prospective science teachers’ metacognition and creativity perceptions and scientific toys in terms of scientific creativity. The qualitative and quantitative data gathered from the study were assessed comparatively with each other. The quantitative data were shown with percentages as well as qualitative data gathered from scientific toys were assessed in terms of scientific creativity dimensions: “fluency, flexibility, originality and scientific knowledge”. The results are shown in terms of four dimensions of scientific creativity for prospective science teachers’ metacognition and creativity perceptions and scientific toys as a result of qualitative and quantitative data of the study. In the light of these results, recommendations were made for researchers

A Comparatıve Look at the Concepts of Creatıvıty and Scıentıfıc Creatıvıty

This study was conducted with the participation of 32 pre-service science teachers attending the second year of a faculty of education in a Turkish university. Participants were asked two open-ended questions, the reliability of which was established by the two researchers. The main problem of the study concerns pre-service science teachers’ definitions of the concepts of creativity and scientific creativity. It was found that pre-service science teachers’ definitions of the two concepts were on the whole similar to those provided in the relevant literature, but the there were also missing points, especially in the definition of scientific creativity. Keywords: creativity, scientific creativity, science education, pre-service teacher

An Inquiry Concerning the Characterıstics of the Creative Person

This study was conducted with the participation of 20 pre-service science teachers. The study aims to examine pre-service science teachers’ views on the characteristics of the creative person. The data collected was analyzed by coding the answers. It was found that pre-service teachers mostly identified the following characteristics as the characteristics of a creative person: ‘thinks/interprets differently/originally’, ‘curious’, ‘enjoys research’, ‘has imagination’, ‘observant’, ‘self-confident’, ‘questions/enjoys questioning’, ‘sociable, not shy’, ‘open to new ideas’, ‘knowledgeable’, ‘farsighted’, ‘enjoys exploration’, ‘patient’, ‘enjoys learning’, ‘open to criticism’, and ‘talented’. These descriptions indicate that the creative person is considered to have a very wide and varied range of characteristics. This does not mean, however, that a creative person needs to have all of these characteristics at once. Keywords: creative personality characteristics, creativity, science educatio

Huzurevindeki geriatrik diyabetli bireylerde proprioseptif egzersizin denge ve duyusal fonksiyona etkisi: Randomize kontrollü çalışma

Objective: Diabetes is a chronic disease whose prevalence increases with age and causes severe damages in all systems of the body. The aim of our study was to assess the effects of proprioceptive exercises on balance and sensory function in the geriatric adults with Type 2 diabetes mellitus. Material and Methods: Forty individuals aged 65 and over with Type 2 diabetes mellitus were divided as a study group (n=20) and as a control group (n=20). All patients were evaluated at the baseline and after 8 weeks training. Balance was mea-sured using Berg Balance Scale and Nintendo Wii system. Balance and gait were evaluated by Tinetti Balance and Gait Test. Semmes-Wein-stein monofilament test was used for assessing tactile sensory, diapa-son for vibration and active matching test for joint position sense. Study group received 45 minutes long proprioceptive exercise training 3 times/week for 8 weeks and the control group only received diabetic patient education. Results: Study group demonstrated significant differences in Berg Balance Scale, Wii Fit balance age and Tinetti Balance and Gait Test scores (p<0.05). Vibration perception duration yielded a higher duration in the study group after treatment (p<0.05). Active matching movement and tactile sensory of the sole showed statistically improvement in the study group (p<0.05). Conclusion: Proprioceptive exercises recommended to individuals with geriatric diabetes can be a beneficial approach to increase balance ability to prevent falling and somatosensory loss.Amaç: Diyabet, prevalansı yaşla birlikte artan ve vücudun tüm sistemlerinde ciddi hasarlara neden olan kronik bir hastalıktır. Çalışmamızın amacı, Tip 2 diabetes mellituslu geriatrik erişkinlerde proprioseptif egzersizlerin denge ve duyusal fonksiyon üzerine etkilerini değerlendirmektir. Gereç ve Yöntemler: Tip 2 diabetes mellituslu 65 yaş ve üzeri 40 birey çalışma grubu (n=20) ve kontrol grubu (n=20) olarak ayrıldı. Tüm hastalar başlangıçta ve 8 haftalık eğitimden sonra değerlendirildi. Denge, Berg Denge Ölçeği ve Nintendo Wii sistemi kullanılarak ölçüldü. Denge ve yürüme, Tinetti Denge ve Yürüyüş Testi ile değerlendirildi. Dokunma duyusunu değerlendirmek için SemmesWeinstein monofilament testi, titreşim için diyapazon ve eklem pozisyon duyusu için aktif eşleştirme testi kullanıldı. Çalışma grubu 8 hafta boyunca haftada 3 kez 45 dk’lık proprioseptif egzersiz eğitimi aldı ve kontrol grubuna sadece diyabetik hasta eğitimi verildi. Bulgular: Çalışma grubu, Berg Denge Ölçeği, Wii Fit denge yaşı ve Tinetti Denge ve Yürüyüş Testi puanlarında anlamlı farklılıklar gösterdi (p<0,05). Titreşim algılama süresi, tedaviden sonra çalışma grubunda daha yüksek bir süre ile sonuçlandı (p<0,05). Aktif eşleştirme hareketi ve tabanın taktil duyusu, çalışma grubunda istatistiksel olarak gelişme gösterdi (p<0,05). Sonuç: Geriatrik diyabetli bireylere önerilen proprioseptif egzersizler, düşme ve somatosensoriyel kaybı önlemek için denge becerisini artırmada faydalı bir yaklaşım olabilir

Aşağı Sakarya Nehri Adapazarı kesimi taşkın risk tayini

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Anahtar kelimeler: Aşağı Sakarya Nehri, Tekerrürlü Taşkın Debisi, Taşkın Risk Haritası, MIKE 11 Taşkın yatakları, çoğu zaman düşük eğimli ve yeşil alan olmasından dolayı yerleşim yeri olarak kullanılmaktadır. Bu da taşkınların sebep olduğu zararların artmasına neden olmaktadır. Türkiye'de bu zararlardan en çok etkilenen yerlerden biri de Aşağı Sakarya Havzasıdır. Bu çalışmada Havzanın hidrolojik özellikleri incelenmiş ve taşkın yayılım haritaları üretilmiştir. Bu amaçla bölgenin SYM ArcGIS ortamında sayısallaştırılmış ve oluşturulan veriler MIKE 11 programına aktarılmıştır. Kesit ve kesitlerdeki pürüzlülük değerleri revize edilmiş ve model kalibrasyonu tamamlanmıştır. Hidrolojik veriler kullanılarak 2,5, 10, 25, 50, 100, 200 ve 500 yıllık tekerrürlü taşkın debileri hesaplanmıştır. Bu debiler için çalışma sahasına ait taşkın yayılım haritaları üretilerek risk altında kalan alanlar belirlenmiştir. Bu çalışma ile bölgede yapılacak olan yapılaşma faaliyetleri ve mevcut yapılaşmalar için risk değerlendirmesi konusunda faydalı bir veri elde edilmiş olacaktır.Key Words: Lower Sakarya River, Return-Period Discharges, Flood Inundation Maps, MIKE 11 Generally floodplains are used as a settlement due to low slope and grassland. This has led to an increase in flood damage. One of the places which is most affected by this damage, is also The Lower Sakarya River Basin. In this study, hydrological characteristics of basin have been examined and flood inundation maps have been produced. For that purpose, digital elevation model (DEM) have been digitized using ArcGIS and data which created by ArcGIS is exported to MIKE 11. Roughness coefficient values revised and model calibration completed for cross-sections. 2, 5, 10, 25, 50, 100, 200 and 500-years return period discharges were calculated using hydrological data. For this calculated discharges, areas which is under risk, are determined using created flood inundation maps. Useful information for evaluating risk of new settlement and existing structures will be obtained

Effect of non-surgical periodontal therapy on the degree of gingival inflammation and stress markers related to pregnancy

Objectives: The purpose of this study was to determine the impact of nonsurgical periodontal therapy considering the salivary stress-related hormone and cytokine levels in the gingival crevicular fluid (GCF) on pregnant and nonpregnant women. Material and Methods: Thirty non-pregnant (control group) and 30 pregnant women (test group) that met the study inclusion criteria were chosen. Only participants with gingivitis were included. Clinical data and samples of GCF and saliva were collected at baseline and after periodontal therapy. The levels of interleukin-1 beta (Κ-1β) and IL-10, and concentration of salivary chromogranin A (CgA) hormone were analyzed by enzyme-linked immunosorbent assay (ELISA). The repeated measures analysis of variance was used for intragroup and intergroup analyses. Results: A major decrease in the gingival inflammation was observed in both groups after periodontal therapy (p&lt;0.05). Periodontal treatment decreased the level of IL-1β in GCF (p&lt;0.05) in control group, but no statistical difference was determined for GCF IL-1β in the test group. However, after periodontal therapy, the CgA hormone concentration was reduced in both groups (p&lt;0.05). However, there was no difference in salivary CgA concentration, GCF IL-10 levels, and perceived stress scale (PSS)-10 between the groups (p&gt;0.05). Conclusions: Within the limitations of this study, periodontal therapy significantly improved the periodontal status and stress level. In addition, the severity of the gingival inflammation during pregnancy was related to stress. However, further studies will be needed to substantiate these early finding

Experimental Evaluation of Meta-Heuristics for Multi-Objective Capacitated Multiple Allocation Hub Location Problem

Multi-objective capacitated multiple allocation hub location problem (MOCMAHLP) is a variation of classic hub location problem, which deals with network design, considering both the number and the location of the hubs and the connections between hubs and spokes, as well as routing of flow on the network. In this study, we offer two meta-heuristic approaches based on the non-dominated sorting genetic algorithm (NSGA-II) and archived multi-objective simulated annealing method (AMOSA) to solve MOCMAHLP. We attuned AMOSA based approach to obtain feasible solutions for the problem and developed five different neighborhood operators in this approach. Moreover, for NSGA-II based approach, we developed two novel problem-specific mutation operators. To statistically analyze the behavior of both algorithms, we conducted experiments on two well-known data sets, namely Turkish and Australian Post (AP). Hypervolume indicator is used as the performance metric to measure the effectiveness of both approaches on the given data sets. In the experimental study, thorough tests are conducted to fine-tune the proposed mutation types for NSGA-II and proposed neighborhood operators for AMOSA. Fine-tuning tests reveal that for NSGA-II, mutation probability does not have a real effect on Turkish data set, whereas lower mutation probabilities are slightly better for AP data set. Moreover, among the AMOSA based neighborhood operators, the one which adds/removes a specific number of links according to temperature (NS-5) performs better than the others for both data sets. After analyzing different operators for both algorithms, a comparison between our NSGA-II based and AMOSA based approaches is performed with the best settings. As a result, we conclude that both of our algorithms are able to find feasible solutions of the problem. Moreover, NSGA-II performs better for larger, whereas AMOSA performs better for smaller size networks

A New Model for The Multi-Objective Multiple Allocation Hub Network Design and Routing Problem

In this paper, we propose a new model for the multi-objective multiple allocation hub network design and routing problem which contains determining the location of hubs, the design of hub network, and the routing of commodities between source-destination pairs in the given network. The selected hubs are not assumed to be fully connected, and each node and arc in the network has capacity constraints. The multiple objectives of the problem are the minimization of total xed and transportation costs and the minimization of the maximum travel time required for routing. We propose a mathematical formulation for the multiobjective problem and present a meta-heuristic solution based on a well-known multi-objective evolutionary algorithm. Using the proposed formulation, we are able to nd the optimal solution for small networks of ve nodes and seven nodes. To evaluate the performance of our heuristic approach on real data, the computational experiments are conducted on Turkish postal system data set. The results demonstrate that our heuristic approach can nd feasible solutions to the problem in reasonable execution time, which is less than 10 min

A Study on Determining Preferences of University Students' Purchasing Smartphone

Gelişen teknolojinin etkilediği tüm sektörlerde olduğu gibi sosyal hayatta da teknolojinin beraberinde getirdiği bütün araçlara talep gün geçtikçe artmaktadır. Özellikle değişimlere karşı adaptasyonu daha kolay olan üniversite öğrencilerinin, iletişim ve bilişim teknolojilerine duyduğu merak ve ilgi, akıllı telefon gibi işlevselliği daha yüksek olan araçların tüketimini gittikçe arttırmaktadır. Bu bakış açısıyla, araştırmanın amacı üniversite öğrencilerinin akıllı telefon satın alma tercihlerini etkileyen faktörlerin belirlenmesidir. Araştırma kapsamında anket uygulaması yapılmış ve elde edilen veriler ışığında faktör analizi, korelasyon analizi ve regresyon analizi yapılarak analizler gerçekleştirilmiştir. Bulgulara göre üniversite öğrencilerinin akıllı telefon satın alma tercihlerini; ürün özellikleri, marka ve reklam çabalarının etkilediği ortaya çıkmıştır. Influences of emerging technologies in all sectors as well as in social life brought about preferences for all devices is increasing more and more. Particularly, since university students' adaptation is easier than others, their curiosity and concern about communication and information technologies make the preferences of purchasing advanced technologic devices such as smartphones steadily enhanced. With this standpoint, the aim of this study is to determine preferences of university students' purchasing smartphone. In the scope of this study, questionnaire was applied and factor analysis, correlation analysis, regression analysis were performed in the light of obtained data. According to findings, it was found out that product features, brand and advertising efforts affected the preferences of purchasing smartphones