Heavy Metal Tolerance in Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is an aerobic, non-fermentative Gram-negative bacterium widespread in the environment. S. maltophilia Sm777 exhibits innate resistance to multiple antimicrobial agents. Furthermore, this bacterium tolerates high levels (0.1 to 50 mM) of various toxic metals, such as Cd, Pb, Co, Zn, Hg, Ag, selenite, tellurite and uranyl. S. maltophilia Sm777 was able to grow in the presence of 50 mM selenite and 25 mM tellurite and to reduce them to elemental selenium (Se0) and tellurium (Te0) respectively. Transmission electron microscopy and energy dispersive X-ray analysis showed cytoplasmic nanometer-sized electron-dense Se0 granules and Te0 crystals. Moreover, this bacterium can withstand up to 2 mM CdCl2 and accumulate this metal up to 4% of its biomass. The analysis of soluble thiols in response to ten different metals showed eightfold increase of the intracellular pool of cysteine only in response to cadmium. Measurements by Cd K-edge EXAFS spectroscopy indicated the formation of Cd-S clusters in strain Sm777. Cysteine is likely to be involved in Cd tolerance and in CdS-clusters formation. Our data suggest that besides high tolerance to antibiotics by efflux mechanisms, S. maltophilia Sm777 has developed at least two different mechanisms to overcome metal toxicity, reduction of oxyanions to non-toxic elemental ions and detoxification of Cd into CdS

Neurological manifestations of COVID-19 in adults and children

Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke. All in-hospital neurological complications were associated with increased odds of death. The likelihood of death rose with increasing age, especially after 25 years of age. In conclusion, adults and children have different neurological manifestations and in-hospital complications associated with COVID-19. Stroke risk increased with increasing age, while CNS infection and seizure risk decreased with age

i - Deciphering the Binary Code “Egyptian versus Foreigner” in Egyptian Cinema

In 2016, emigration is more than ever a massive phenomenon in Egypt which both strongly affects the everyday lives of Egyptians and is central in Egyptian cultural production. This article aims to explore how the Egyptian cinema contributes to forging a binary code that differentiates between “Egyptian” and “For-eigner”. It argues that Egyptians who live abroad may also be perceived as potential foreigners for those left in Egypt. After briefly describing the corpus of seven emigration films, the article sketches a cartog-raphy of the geographic imaginaries of migration, which is paradoxically more oriented toward the West, while in fact the majority of Egyptians abroad are in the Gulf. Finally, it demonstrates how movie directors have produced a very pessimistic vision of emigration, in a manner that is equally critical of the countries of arrival as of Egyptian society. Their discourse on the theme of the migrant’s identity, on the personal, familial and national levels, resonates with the social imaginary concerning migration, which is dominated by a nationalist paradigm. Are we nevertheless witnessing the emergence of a transnational cinema, that is, one that envisages the possibility of an identity that is simultaneously of here and elsewhere?Key words: Egypt, cinema, migration, transnational, foreigner</jats:p

Récidives de maladie thrombo-embolique veineuse après un premier épisode survenu sous contraception oestroprogestative

CLERMONT FD-BCIU-Santé (631132104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

i - Deciphering the Binary Code “Egyptian versus Foreigner” in Egyptian Cinema

In 2016, emigration is more than ever a massive phenomenon in Egypt which both strongly affects the everyday lives of Egyptians and is central in Egyptian cultural production. This article aims to explore how the Egyptian cinema contributes to forging a binary code that differentiates between “Egyptian” and “For-eigner”. It argues that Egyptians who live abroad may also be perceived as potential foreigners for those left in Egypt. After briefly describing the corpus of seven emigration films, the article sketches a cartog-raphy of the geographic imaginaries of migration, which is paradoxically more oriented toward the West, while in fact the majority of Egyptians abroad are in the Gulf. Finally, it demonstrates how movie directors have produced a very pessimistic vision of emigration, in a manner that is equally critical of the countries of arrival as of Egyptian society. Their discourse on the theme of the migrant’s identity, on the personal, familial and national levels, resonates with the social imaginary concerning migration, which is dominated by a nationalist paradigm. Are we nevertheless witnessing the emergence of a transnational cinema, that is, one that envisages the possibility of an identity that is simultaneously of here and elsewhere?Key words: Egypt, cinema, migration, transnational, foreigne

Modélisation de l’architecture racinaire dans FLORSYS et perspectives : Application à la modélisation du parasitisme par l’orobanche rameuse

National audienc

Migrants in Global Cities in Asia and the Gulf: Cosmopolitan Dialectics and Non-Integration

10.1080/13604813.2020.1843278City2405-06793-80