135 research outputs found
Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system
The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Angiotensin II, atrial natriuretic peptide and intrarenal dopamine play a pivotal role in this interactive network. The balance between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide, by one side, and the prooxidant effect of the renin angiotensin system, by the other side, contributes to ensuring the normal function of the kidney. Different pathological scenarios, as nephrotic syndrome and hypertension, where renal sodium excretion is altered, are associated with an impaired interaction between two natriuretic systems as the renal dopaminergic system and atrial natriuretic peptide that may be involved in the pathogenesis of renal diseases. The aim of this review is to update and comment the most recent evidences about the intracellular pathways involved in the relationship between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide and the prooxidant effect of the renin angiotensin system in the pathogenesis of renal inflammation.Fil: Rukavina Mikusic, Natalia LucĂa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas; ArgentinaFil: Kravetz, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas; ArgentinaFil: Kouyoumdzian, NicolĂĄs MartĂn. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas; ArgentinaFil: Della Penna, S. L.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; ArgentinaFil: Roson, Maria Ines. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; ArgentinaFil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas; ArgentinaFil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. CĂĄtedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas; Argentin
Continuous measurement of global difference coupling using a phase-locked-loop tune meter in the Relativistic Heavy Ion Collider
We present a new technique to continuously measure and compensate the global difference coupling coefficient through the continuous measurements of eigenmode projection parameters, using a high resolution phase-locked-loop tune meter. First, four eigenmode projection parameters are defined as the observables for weak difference coupling. Then, their analytical expressions are obtained using the strict matrix treatment and the Hamiltonian perturbation theory of linear coupling. From these parameters, the complex global coupling coefficient can be fully determined and compensated. This method was successfully demonstrated in the Relativistic Heavy Ion Collider (RHIC) 2006 run
Asymmetric Organocatalysis Accelerated via Self-Assembled Minimal Structures
Self-assembling minimalistic peptides embedded with an organocatalytic moiety were designed. By controlling the formation of fibrils via external intervention, it was shown that the activation is accelerated when the organocatalyst is in its supramolecular state. The effect of the accelerated catalysis was demonstrated in a Michael benchmark reaction
Simultaneous tune and coupling feedback in the Relativistic Heavy Ion Collider, and possible implications for the Large Hadron Collider commissioning
Simultaneous tune and coupling feedback were successfully implemented during RHIC run 6. In this paper we describe the measurement and control hardware and software used to accomplish this, present some of the results, discuss areas that require further investigation, and finally offer a few comments on possible implications of these results for LHC commissioning
Fast room temperature very low field-magnetic resonance imaging system compatible with MagnetoEncephaloGraphy environment
In recent years, ultra-low field (ULF)-MRI is being given more and more attention, due to the possibility of integrating ULF-MRI and Magnetoencephalography (MEG) in the same device. Despite the signal-to-noise ratio (SNR) reduction, there are several advantages to operating at ULF, including increased tissue contrast, reduced cost and weight of the scanners, the potential to image patients that are not compatible with clinical scanners, and the opportunity to integrate different imaging modalities. The majority of ULF-MRI systems are based, until now, on magnetic field pulsed techniques for increasing SNR, using SQUID based detectors with Larmor frequencies in the kHz range. Although promising results were recently obtained with such systems, it is an open question whether similar SNR and reduced acquisition time can be achieved with simpler devices. In this work a room-temperature, MEG-compatible very-low field (VLF)-MRI device working in the range of several hundred kHz without sample pre-polarization is presented. This preserves many advantages of ULF-MRI, but for equivalent imaging conditions and SNR we achieve reduced imaging time based on preliminary results using phantoms and ex-vivo rabbits heads
Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry
BACKGROUND: Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and integrate descending control signals from the brain. Many molecules important for pain transmission have been demonstrated to be localized to the dorsal horn of the spinal cord. Further understanding of the molecular interactions and signaling pathways in the dorsal horn neurons will require a better knowledge of the molecular neuroanatomy in the dorsal spinal cord. RESULTS: A large scale screening was conducted for genes with enriched expression in the dorsal spinal cord using DNA microarray and quantitative real-time PCR. In addition to genes known to be specifically expressed in the dorsal spinal cord, other neuropeptides, receptors, ion channels, and signaling molecules were also found enriched in the dorsal spinal cord. In situ hybridization and immunohistochemistry revealed the cellular expression of a subset of these genes. The regulation of a subset of the genes was also studied in the spinal nerve ligation (SNL) neuropathic pain model. In general, we found that the genes that are enriched in the dorsal spinal cord were not among those found to be up-regulated in the spinal nerve ligation model of neuropathic pain. This study also provides a level of validation of the use of DNA microarrays in conjunction with our novel analysis algorithm (SAFER) for the identification of differences in gene expression. CONCLUSION: This study identified molecules that are enriched in the dorsal horn of the spinal cord and provided a molecular neuroanatomy in the spinal cord, which will aid in the understanding of the molecular mechanisms important in nociception and pain
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Reduction of beta* and increase of luminosity at RHIC
The reduction of {beta}* beyond the 1m design value at RHIC has been consistently achieved over the last 6 years of RHIC operations, resulting in an increase of luminosity for different running modes and species. During the recent 2007-08 deuteron-gold run the reduction to 0.70 from the design 1m achieved a 30% increase in delivered luminosity. The key ingredients allowing the reduction have been the capability of efficiently developing ramps with tune and coupling feedback, orbit corrections on the ramp, and collimation, to minimize beam losses in the final focus triplets, the main aperture limitations for the collision optics. We will describe the operational strategy used to reduce the {beta}*, at first squeezing the beam at store, to test feasibility, followed by the operationally preferred option of squeezing the beam during acceleration, and the resulting luminosity increase. We will conclude with future plans for the beta squeeze
Platform Dependent Verification: On Engineering Verification Tools for 21st Century
The paper overviews recent developments in platform-dependent explicit-state
LTL model checking.Comment: In Proceedings PDMC 2011, arXiv:1111.006
Response to Comment on âEstimating the reproducibility of psychological scienceâ
Gilbert et al. conclude that evidence from the Open Science Collaboration's Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.status: publishe
Source analysis of beta-synchronisation and cortico-muscular coherence after movement termination based on high resolution electroencephalography
We hypothesized that post-movement beta synchronization (PMBS) and cortico-muscular coherence (CMC) during movement termination relate to each other and have similar role in sensorimotor integration. We calculated the parameters and estimated the sources of these phenomena.We measured 64-channel EEG simultaneously with surface EMG of the right first dorsal interosseus muscle in 11 healthy volunteers. In Task1, subjects kept a medium-strength contraction continuously; in Task2, superimposed on this movement, they performed repetitive self-paced short contractions. In Task3 short contractions were executed alone. Time-frequency analysis of the EEG and CMC was performed with respect to the offset of brisk movements and averaged in each subject. Sources of PMBS and CMC were also calculated.High beta power in Task1, PMBS in Task2-3, and CMC in Task1-2 could be observed in the same individual frequency bands. While beta synchronization in Task1 and PMBS in Task2-3 appeared bilateral with contralateral predominance, CMC in Task1-2 was strictly a unilateral phenomenon; their main sources did not differ contralateral to the movement in the primary sensorimotor cortex in 7 of 11 subjects in Task1, and in 6 of 9 subjects in Task2. In Task2, CMC and PMBS had the same latency but their amplitudes did not correlate with each other. In Task2, weaker PMBS source was found bilaterally within the secondary sensory cortex, while the second source of CMC was detected in the premotor cortex, contralateral to the movement. In Task3, weaker sources of PMBS could be estimated in bilateral supplementary motor cortex and in the thalamus. PMBS and CMC appear simultaneously at the end of a phasic movement possibly suggesting similar antikinetic effects, but they may be separate processes with different active functions. Whereas PMBS seems to reset the supraspinal sensorimotor network, cortico-muscular coherence may represent the recalibration of cortico-motoneuronal and spinal systems
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